31 results about "Chronic arthritis" patented technology

A pharmaceutical preparation for preventing and / or treating hypertrophic scars, keloid or chronic arthritic diseases comprising as an effective component an erythropoietin antagonist. More specifically, there is provided a pharmaceutical preparation for preventing and / or treating hypertrophic scars, keloid or chronic arthritic diseases comprising as an effective component an erythropoietin antagonist such as an anti-erythropoietin antibody, an erythropoietin receptor protein, etc. This pharmaceutical preparation has excellent prophylactic and / or therapeutic effects on collagenous hyperproliferation such as hypertrophic scars, keloid, etc., or chronic arthritic diseases such as rheumatoid arthritis, etc.

The present invention is directed to carbocyclic hydrazino compounds that function as inhibitors of copper-containing amine oxidases commonly known as semicarbazide-sensitive amine oxidases (SSAO), including the human SSAO known as Vascular Adhesion Protein-I (VAP-1). These SSAO inhibitors have therapeutic utility as drugs to treat conditions and diseases including, but not limited to, a number of inflammatory conditions and diseases (in particular chronic inflammatory conditions such as chronic arthritis, inflammatory bowel diseases, and chronic skin dermatoses), diseases related to carbohydrate metabolism and to aberrations in adipocyte differentiation or function and smooth muscle cell function, and vascular diseases. The novel compounds have the general formula: or a pharmaceutically acceptable solvate, hydrate, or salt thereof wherein R1 to R11 are as defined herein.

The compositions of this invention comprise a mixture of (1) phenylanine and a dietary food supplement, (2) leucine and a dietary food supplement, and (3) hydrocinnamic acid and a dietary food supplement. The compositions are used for medicinal purposes, to alleviate acute and chronic arthritis and other painful conditions.

The invention belongs to the technical field of nutrient health-care foods, and particularly relates to a marine polypeptide special dietary food for patients suffering from chronic arthritis to eat.The special dietary food comprises the following raw material components in parts by weight: 4.5-6.5 parts of marine oligopeptide, 1.0-2.0 parts of marine ogranism activity polysaccharide, 1.0-1.5 parts of dried marine algae powder, 0.5-1.5 parts of olive oil, 0.5-1.0 part of an antioxidant, 0.1-0.5 part of a nutrient, 0.1-0.5 part of royal jelly and 0.1-0.5 part of curcumin. The raw materials arehigh in safety, so that after the special dietary food is eaten for a long term, no side effects are generated, and the special dietary food can be eaten by the patients suffering from the chronic arthritis for a long term to supplement nutrition and relieve a pain.

A DNA sequence is described for the gene therapy of diseases associated with the immune system. In its essential elements, the DNA sequence is composed of an activator sequence, a promoter module and a gene for the active substance. The activator sequence is activated in a cell-specific or virus-specific manner and this activation is regulated by the promoter module in a cell cycle-specific manner. The choice of activator sequence and active substance depends on the indication area. The DNA sequence is inserted into a viral or non-viral vector which is supplemented by a ligand having affinity for the target cell. Depending on the choice of activator sequence and active substance, the following can be treated by administering the DNA sequence: defective formation of blood cells autoimmune diseases and allergies and, in addition, rejection reactions against transplanted organs chronic arthritis viral and parasitic infections and, in addition, prophylaxis of viral, bacterial and parasitic infections, and leukaemias.

The invention discloses application of a salt formed by combining tri(hydroxymethyl)aminomethane and acid radicals or an aqueous solution of the salt to preparing of a medicine for treating hyperuricemia, gout, acute and chronic arthritis, urinary calculus diseases and related diseases. The treatment action mechanism is as follows: tri(hydroxymethyl)aminomethane and uric acid are combined throughhydrogen bonds to generate a uric acid-tri(hydroxymethyl)aminomethane conjugate, uric acid crystallization is prevented, and uric acid crystals (calculi) are dissolved; meanwhile, the combination of uric acid with macromolecular substances such as blood fat and blood sugar is reduced, and the influence of uric acid on blood fat and blood sugar is reduced. Compared with existing three action mechanisms of 1, intake reduction, 2, endogenous synthesis inhibition and 3, kidney excretion promotion for treating hyperuricemia, the action mechanism of the invention can be called as a fourth action mechanism. The invention can also be referred to as a fourth treatment method for hyperuricemia. And the problems of uric acid crystallization and influence of uric acid on blood fat and blood sugar aresolved in a targeted manner. The action mechanism is clear; the curative effect is good; and the side effect is small.

The invention belongs to the technical field of medical treatment, and discloses a chronic arthritis patient follow-up visit management system based on a block chain, which comprises a user registration module for user registration; a login module which performs user login; an identity verification module which verifies the identity of a logged-in user by using a block chain technology; a patientinformation data acquisition module which acquires and collects related information data of a patient; a data analysis module which analyzes the data and judges whether the data is abnormal or not; afollow-up visit management module which generates or intelligently generates a follow-up visit scheme and a follow-up visit information table in a user-defined manner and acquires follow-up visit data; a state evaluation module which evaluates the state of the patient; and a follow-up visit scheme adjustment module which performs self-adaptive follow-up visit scheme adjustment based on the evaluated patient state. The system can better follow up the illness state of a patient, accumulate accurate and detailed clinical data, and assist a doctor in making a more targeted treatment scheme so as to relieve the pain of the patient and relieve family and social pressure.

The invention belongs to the technical fields of plasters and preparation thereof. The invention discloses an externally applied plaster for treating arthralgia and arthritis, and a preparation method of the externally applied plaster. The plaster is prepared from the following raw materials: capsicum annuum, menthol, borneol, rubber, lanolin, zinc oxide, rosin, beeswax, a coating agent, gasoline, and the like. The preparation method comprises the steps of preparing the raw materials, carrying out medicine preparation, refining rubber, coating, mashing, gluing, drying, carrying out aftertreatment, and the like. The externally applied plaster for treating the arthralgia and the arthritis has the effects of expelling wind and removing cold, relaxing tendons and activating collaterals, relieving swelling and pain, and the like, can be used for treating the arthralgia, backache and sprain bruise as well as diseases such as chronic arthritis and chilblain being not broken; furthermore, the externally applied plaster has good air permeability and is long in drug onset time; the externally applied plaster for treating the arthralgia and the arthritis is simple in preparation method and can be easily realized on the existing equipment.

The present invention is directed to 1,3,4-hydrazino compounds that functions as inhibitors of copper-containing amine oxidases commonly known as semicarbazidesensitive amine oxidases (SSAO), including the human SSAO known as Vascular Adhesion Protein-1 (VAP-1). These SSAO inhibitors have therapeutic utility as drugs to treat conditions and diseases including, but not limited to, a number of inflammatory conditions and diseases (in particular chronic inflammatory conditions such as chronic arthritis, inflammatory bowel diseases, and chronic skin dermatorses), diseases related to carbohydrate metabolism and to aberrations in adipocyte differentiation or function and smooth muscle cell function, and vascular diseases. The compounds, their tautomers, isomers, hydrazine alcohol degradation product, and a pharmaceutically acceptable solvate, hydrate, or salt thereof, have general formula (I), wherein R<1> to R<8> are as defined herein.

The invention discloses a loin-strengthening and bone-reinforcing herbal wine with effective therapeutic effect for bone pain, comprising herbal ingredients with the following weight portions: scarlet kadsura 5g to 30g, cherokee rose 5g to 30g, radix flemingiae philippinensis 5 to 30g, shinyleaf pricklyash root 10g to 40g, ovateleaf holly bark 5g to 30g, radix fici simplicissmae 10g to 40g, mountain blackberry lily 10g to 40g, mountain aniseed (Illicium verum) 10g to 40g, safflower 10g to 40g, angelica sinensis 10g to 30g, panpax notoginseng 10g to 40g; which have the function of expelling wind and removing dampness, nourishing blood, promoting blood circulation, removing blood stasis, relieving pain, and particularly has specific effect for strain of lumbar flesh, hemiplegia, rheumatic, articular pain and traumatic injury; which is characterized that the herbal ingredients are immersed in liquor to develop resistance fully. The herbal wine has the functions of promoting blood circulation, expelling wind and removing dampness, strengthening muscle and bone, dispelling swollen and removing pain, and has specific therapeutic effect for chronic arthritis, articular pain, strain of lumbar flesh, hemiplegia and traumatic injury if drank every morning and evening at suitable amount.

The invention discloses health care medicated bath powder for treating eczema and arthritis and a preparation method thereof. The powder is prepared from the following components in parts by weight: 1 to 10 parts of cacumen biotae, 1 to 10 parts of myricaria bracteata, 1 to 10 parts of herba artemisiae scopariae, and 1 to 10 parts of ilex pubescens. The preparation method comprises the following steps: firstly, cleaning and sorting; secondly, drying; thirdly, crushing; fourthly, sieving to obtain finished powder. The powder has the efficacies of reducing fever, eliminating damp, treating exterior cold syndrome, and promoting eruption; the powder is applied to measles without adequate eruption, treats fever and cough, has the effects of sterilization and detoxification, and treats symptoms of arthralgia, beriberi, scalp itch, dermatitis, ringworm sores and jaudice due to wetness-heat evil, and has good effects for treating eczema and acute and chronic arthritis; when the powder is matched with a medicated bath method, the preparation steps of boiling for oral agentia is canceled, the powder is convenient to use and carry, the application cost is low, meanwhile the effect range of the powder can be expanded when the medicated bath method is adopted, so that the powder is more direct, the transdermal effect of the powder is good, and the curative effect is brought into full play.

The invention provides a traditional Chinese medicine composition for treating chronic diseases. The traditional Chinese medicine composition is prepared from the following raw materials by weight: 18g-22g of radix angelicae pubescentis, 18g-22g of radix gentianae macrophyllae, 18g-22g of radix saposhnikoviae, 4g-8g of Chinese wild ginger, 18g-22g of angelica, 18g-22g of radix rehmanniae preparata, 18g-22g of radix paeoniae alba, 18g-22g of rhizoma chuanxiong, 18g-22g of poria, 18g-22g of cortex eucommiae, 18g-22g of radix codonopsis, 18g-22g of radix cyathulae, 13g-17g of radix astragali, 13g-17g of radix dipsaci, 13g-17g of radix clematidis, 18g-22g of fructus chaenomelis, 27g-33g of semen coicis, 13g-17g of ramulus cinnamomi, 18g-22g of incised notopterygium and 8g-12g of raw licorice. The preparation method comprises the following steps: soaking the raw materials in 1800ml-2200ml of water for 30 minutes; boiling with high fire; after the water is boiling, immediately switching the high fire into soft fire, and carrying out decoction for 10 minutes; and respectively containing decoction liquid by virtue of 230ml contains. The traditional Chinese medicine composition has the efficacies of expelling wind-damp, stopping arthralgia spasm pain, benefiting livers and kidneys and tonifying vital energy and blood and has excellent treatment effects to chronic arthritis, rheumatoid arthritis, rheumatic sciatica, lumbar muscle degeneration and prolapse of lumbar intervertebral discs.

The invention provides a carbon fiber or resistance wire heating electrode phototherapy instrument which comprises a phototherapy instrument body. The phototherapy instrument body is provided with anirradiation light source, a carbon fiber or resistance wire heating layer and electrode slices. The carbon fiber or resistance wire heating electrode phototherapy instrument further comprises a circuit controller or a Bluetooth circuit controller. The Bluetooth circuit controller is controlled through a mobile phone APP. The irradiation light source irradiates infrared ray or red light. The carbonfiber or resistance wire heating layer comprises a carbon fiber or resistance wire electric heating heat insulating layer and heat insulating cloth. The circuit controller or the Bluetooth circuit controller performs controlling on the carbon fiber or resistance wire heating layer, the irradiation light source and the electrode slices. The carbon fiber or resistance wire heating layer and the irradiation light source are arranged at the middle part, and the electrode slices are arranged at two sides. The carbon fiber or resistance wire heating electrode phototherapy instrument is particularlyeffective for treating symptoms such as arthritis, rheumatoid arthritis, acute arthritis and chronic arthritis, nervous pain and muscle ache.

The invention discloses the application of the miRNA-C compound in the preparation of clinical diagnostic markers for chronic pain diseases and in the preparation of medicines for treating chronic pain. The present invention screens through a large number of experiments, and the experimental results show that the expression of miRNA-C in the blood of chronic arthritis pain models and chronic pain patients is down-regulated, and the occurrence and formation of chronic pain can be significantly inhibited by up-regulating miRNA-C, further improving the blood of chronic pain patients. Quantitative analysis of clinical samples demonstrated that miRNA‑C could serve as a marker of chronic pain development.

The invention provides an external traditional Chinese medicine composition and powder for treating acute and chronic arthritis and application of the external traditional Chinese medicine compositionand powder. The traditional Chinese medicine composition is prepared from, by weight, 70-90 parts of radix trichosanthis, 35-50 parts of lignum dalbergiae odoriferae, 35-45 parts of radix et rhizomarhei, 30-50 parts of cortex phellodendri chinensis, 35-45 parts of rhizoma curcumae longae, 30-50 parts of radix angelicae, 10-25 parts of rhizoma arisaematis, 10-25 parts of garden balsam stem, 10-20parts of peach kernels, 10-20 parts of flos carthami and 10-25 parts of chinaroot greenbrier rhizome. The external traditional Chinese medicine composition and powder for treating the acute and chronic arthritis and the application of the external traditional Chinese medicine composition and powder have the advantages that all the components are scientific in compatibility and have a mutually synergistic effect, and the external traditional Chinese medicine composition and powder nourish blood and activate collaterals, dredge paralysis and remove blood stasis, relieve swelling and pain, relaxthe muscles and activate blood circulation and smooth joints, and a therapeutic effect on treating the acute and chronic arthritis is significant.

The invention is directed to a compound of the formula I wherein the variables are as defined herein, or a stereoisomeric form thereof, mixture of stereoisomeric forms, in any ratio, or a salt thereof. Another aspect of the present invention is directed to a pharmaceutical composition comprising, a pharmaceutically effective amount of one or more compounds of formula I according to claim 1 in admixture with a pharmaceutically acceptable carrier. The invention is also directed to a method for effecting the prophylaxis and therapy of degenerative joint diseases such as osteoarthroses, spondyloses, cartilage loss following joint trauma or a relatively long period of joint immobilization following meniscus or patella injuries or ligament ruptures, diseases of the connective tissue such as collagenoses, periodontal diseases, wound healing disturbances and chronic diseases of the locomotory apparatus such as inflammatory, immunological or metabolism-associated acute and chronic arthritides, arthropathies, myalgias and disturbances of bone metabolism, for the treatment of ulceration, atheroscleroses and stenoses, and for the treatment of inflammations, cancer diseases, tumor metastasis formation, cachexia, anorexia, cardiac insufficiency and septic shock or for the prophylaxis of myocardial and cerebral infarctions, in a patient in need thereof, comprising administering to the patient a pharmaceutically effective amount of the compound of formula I according to claim 1, or a pharmaceutically acceptable salt, solvate or prodrug thereof. Furthermore the invention is directed to a method for preparing a compound of formula I.

The invention belongs to the technical field of plaster and its preparation. The invention discloses an external plaster for treating joint pain and arthritis and a preparation method thereof. The plaster is composed of capsicum, menthol, borneol, rubber, lanolin, zinc oxide, rosin, beeswax, coating agent and gasoline and other raw materials, and its preparation method consists of steps such as material preparation, pharmacy, rubber mixing, coating, beating, glue coating, drying and post-treatment. (1) The external plaster used for the treatment of joint pain and arthritis in the present invention has the functions of dispelling wind and cold, relaxing tendons and activating collaterals, reducing swelling and relieving pain, etc., and can be used for joint pain, backache, sprain, bruise and chronic arthritis and the treatment of diseases such as non-ulcerated chilblains; at the same time, it has good air permeability, has a good sustained-release effect, and the drug has a long onset time; the preparation method of the external plaster for treating joint pain and arthritis in the present invention is simple, Easy to implement on existing equipment.

The invention discloses a Tongbi pill and a preparation method thereof. The Tongbi pill comprises safflower, pilose antler, gastrodia elata, toad, lucid ganoderma, centipede, scorpion, agkistrodon, raw astragalus membranaceus, roasted rhizoma atractylodis macrocephalae, codonopsis pilosula, angelica sinensis, radix stephaniae tetrandrae, salvia miltiorrhiza, radix paeoniae alba, frankincense, myrrh, cassia twigs, rheum officinale, pawpaw, eucommia ulmoides, berba aristolochiae mollissimae, rhizoma drynariae, rhizoma cibotii, rhizoma corydalis and radix achyranthis bidentatae. The Tongbi pill has the beneficial effects that the Tongbi pill can relieve the acute or continuous joint swelling and pain symptoms of various chronic arthritis such as rheumatism, rheumatoid arthritis, gouty arthritis, osteoarthritis, spinal arthropathy and the like, can also relieve various soft tissue rheumatic pains and acute light and moderate pains, and has no side effects.

The invention provides a novel polypeptide with an amino acid sequence as shown in SEQ ID NO:2 or obtained by adding, deleting and / or substituting one or more amino acid residues on the sequence as shown in SEQ ID NO:2. The invention further provides a pharmaceutical composition comprising the polypeptide, preferably a phlogenzym tablet which is used for relieving edema after trauma or operation, shortening blood clot coagulation time, relieving pains caused by swelling and inflammation, treating thrombophlebitis, inflammation of genitourinary tract, arthritis (for example chronic arthritis) or soft tissue rheumatism.

The invention relates to an application of total dendrobium crepidatum alkaloids in preparing a medicament for treating acute and chronic inflammation, acute and chronic arthritis or rheumatoid arthritis diseases, and the content of the total dendrobium crepidatum alkaloids is 80-91 percent; and shown through a great amount of experiments by an inventor, the total dendrobium crepidatum alkaloids have a good effect on inflammation treatment. The total dendrobium crepidatum alkaloids have better stability and good anti-inflammation activity, and can be used for preparing medicaments for treating corresponding diseases. The total dendrobium crepidatum alkaloids have clear activity, and the experimental materials come from plants, so that the cost is low.

The present invention describes a method for completely extracting the alkaloid fraction (montanine) of Rhodophiala bifida (Herb.) Traub from bulbs of Rhodophiala bifida. The present invention further describes a method for treating inflammation using pharmaceutical compositions containing the alkaloid fraction of Rhodophiala bifida as the active ingredient. The present invention therefore comprises an extraction method that is faster than other extraction methods described in the literature for the alkaloid fraction of Rhodophiala bifida, dispensing with numerous changes of solvent in order to strain the plant, and the use thereof as an anti-inflammatory. The present invention is further characterised by the development of an anti-inflammatory medicinal drug for treating and preventing diseases involving inflammation and / or the local increase in the number of fibroblasts as its etiopathogenesis, such as: rheumatoid arthritis, ulcerative colitis, sepsis, acute pulmonary disease, inflammatory infections, in particular inflammatory and fibrosing diseases related to the lungs and kidneys, osteoporosis, Castleman disease, psoriatic arthritis, juvenile chronic arthritis and other non-specific inflammatory joint diseases.

The present invention is directed to hydrazino compounds that functions as inhibitors of copper-containing amine oxidases commonly known as semicarbazidesensitive amine oxidases (SSAO), including the human SSAO known as Vascular Adhesion Protein-1 (VAP-1). These SSAO inhibitors have therapeutic utility as drugs to treat conditions and diseases including, but not limited to, a number of inflammatory conditions and diseases (in particular chronic inflammatory conditions such as chronic arthritis, inflammatory bowel diseases, and chronic skin dermatorses), diseases related to carbohydrate metabolism and to aberrations in adipocyte differentiation or function and smooth muscle cell function, and vascular diseases. The compounds have general formula: or a pharmaceutically acceptable solvate, hydrate, or salt thereof, wherein R<1> to R<8> and X are as defined herein.

The invention discloses a Chinese herbal medicine for treating chronic arthritis, which is prepared from the following raw materials in parts by weight: 25-30 parts of Saposhnikovia divaricata, 25-30 parts of Homalomena occulta, 25-30 parts of Angelica pubescens, 25-30 parts of Taxillus chinensis, 15-25 parts of Stephania tetrandra, 25-30 parts of Stauntonia elliptica, 25-30 parts of Pheretima, 15-25 parts of Zaocys dhumnades, 35-40 parts of Humata tyermanni, 25-30 parts of Gentiana sino-ornata, 9-25 parts of Semiliquidambar cathayensis, and 6-9 parts of Solanum torvum by the steps of adding water 1,800 mL, boiling with mild fire for 20-30 min, filtering, collecting supernatant, adding water, decocting for three times, mixing supernatants, subpackaging in bottles, and sterilizing at high temperature. Saposhnikovia divaricata is used as monarch drug; Homalomena occulta and Angelica pubescens are used as ministerial drug; Taxillus chinensis, Stephania tetrandra, Stauntonia elliptica and Pheretima are used as adjuvant drug; Zaocys dhumnades, Humata tyermanni, Gentiana sino-ornata, Semiliquidambar cathayensis and Solanum torvum are used as cionductant drug. The Chinese herbal medicine has the advantages of good safety and low cost, and treatment of both symptoms and root causes.

The invention discloses the application of the miRNA-Pa compound in the preparation of clinical diagnostic markers for chronic pain diseases and in the preparation of medicines for treating chronic pain. The present invention screens through a large number of experiments, and the experimental results show that the expression of miRNA-Pa is down-regulated in the blood of chronic arthritis pain models and chronic pain patients. By up-regulating miRNA-Pa, the occurrence and formation of chronic pain can be significantly inhibited, and the blood Quantitative analysis of clinical samples demonstrated that miRNA‑Pa could serve as a marker of chronic pain development.

The invention discloses lotus seed powder for relieving and conditioning chronic arthritis and a preparation method thereof. The lotus seed powder is prepared from pseudo-ginseng powder, pollen, lotus seed powder, prepared rehmannia roots, garden burnet, radix geutianae, herba ephedra, safflowers, tylophora mollissima, common leafflower herb with roots, semen strychni, limacia sagittata, adder tongue herb, roots or leaves of cochinchina raspberry, apocynum venetum, rhizoma alismatis, herba centellae, alpine cladonia, radix polygni multiflori, tuber fleeceflower stems, globe amaranth flowers and roughhaired holly roots. All the traditional Chinese medicine is mixed in proportion, water is added for decocting, medicine liquid is obtained, then pseudo-ginseng powder, pollen and lotus seed powder are added, the mixture is stirred to be uniform, the mixture is subjected to vacuum concentration till paste is obtained, drying under reduced pressure is carried out, and the mixture is smashed into powder; the powder is mixed with flour or rice flour, and biscuits or bread or steamed sponge cakes are made. The traditional Chinese medicine and food are combined, the good dietary therapy function of food is achieved, the treatment and conditioning function of the traditional Chinese medicine is achieved, and the lotus seed powder has a good treatment effect on chronic arthritis and is free of toxic and side effects, safe and effective.

The present invention relates to methods for identifying patients that will respond to treatment with anti-TNF-therapy, i.e., anti-TNF responder patients. In particular, the present invention relates to determining response to an inhibitor of tumor necrosis factor (TNF) in a patient with a chronic inflammatory disease by determining the activity of type I interferon in the patient. The invention further relates to quantification of type I interferon as a measure of predicting responsiveness to anti-TNF therapy in patients with a chronic inflammatory disease such as rheumatoid arthritis (RA), psoriatic arthritis, ankylosing spondylitis, juvenile chronic arthritis, lupus, Crohn's disease, as well as for cardiovascular disease.

A Chinese medicine in the form of dripping pill for treating rheumatic arthritis, rheumatoid arthritis, chronic arthritis, lupus erythematosus, etc is prepared from Yunnan begonia herb and medicinal carrier. Its preparing process is also disclosed.

The invention discloses a blood-activating and stasis-removing paste as well as a preparation method and an application thereof, which belong to the technical field of traditional Chinese medicines. The blood-activating and stasis-removing paste comprises sesame oil, a traditional Chinese medicine composition and yellow lead, the traditional Chinese medicine composition is prepared from the following components: angelica dahurica, rhizoma sparganii, curcuma zedoary, angelica sinensis, pawpaw, ligusticum wallichii, teasel root, rheum officinale, lycopodium clavatum, garden balsam stem, dioscorea nipponica makino, schizonepeta, divaricate saposhnikovia root, flos rhododendri mollis, radix angelicae pubescentis, radix clematidis, Zoumajin, cynanchum paniculatum, geranium wilfordii, achyranthes bidentata, notopterygium root, akebia stem, stephania tetrandra, eupolyphaga, safflower, monkshood, radix aconiti agrestis, nux vomica, rhizoma arisaematis, dragon's blood, frankincense, myrrh, garter snake, scorpion, rosin, camphor, leech, garden balsam, borneol, menthol, pseudo-ginseng and gadfly. The paste capable of promoting blood circulation to remove blood stasis provided by the embodiment of the invention is convenient to use, is suitable for people and diseases, has the effects of promoting blood circulation to remove blood stasis, dispelling wind and relieving pain, and can be usedfor effectively treating diseases such as bone diseases, pain toxin, chronic arthritis, lumbago, heel spur and the like.

The invention provides a novel polypeptide with an amino acid sequence as shown in SEQ ID NO:2 or obtained by adding, deleting and / or substituting one or more amino acid residues on the sequence as shown in SEQ ID NO:2. The invention further provides a pharmaceutical composition comprising the polypeptide, preferably a phlogenzym tablet which is used for relieving edema after trauma or operation, shortening blood clot coagulation time, relieving pains caused by swelling and inflammation, treating thrombophlebitis, inflammation of genitourinary tract, arthritis (for example chronic arthritis) or soft tissue rheumatism.