84 results about "Curcumenol" patented technology

The invention provides a curcumenol solid lipid nanoparticle and its preparation method, which comprises curcumenol 1 part, phospholipids 3-10 parts, grease material 5-100 parts, surface active agent 10-200 parts and excipient 10-400 parts.

The extraction method of curcumenol includes the following steps: pulverizing rhizoma curcumae, using steam to make distillation at normal pressure and making separation to obtain oil of aromatic turmeric, further rectification under the condition of vacuum, removing low boiling point substances of borneol and element, etc. taking out bottoms, cooling, filtering to obtain crystal crude product, adding ethyl alcohol to dissolve it, adding active carbon, uniformly stirring, filtering and cooling so as to obtain curcumenol, utilizing curcumenol and cotton seed cake to make bait; adding grain crops of corn or bran and soybean cake, uniformly mixing them, granulating and forming so as to obtain rat antifertility drug.

A process of preparing 3 beta- hydroxy curcumenol compound of curcumenol which could be used to prepare resisting virus medicine. Strain is Aspergillus niger(AS3.739), extract product in fermented solution using acetic ester. Separate the product using silica gel chromatography.

The invention relates to a curcumenol nanosuspension, and a preparation method and application thereof, and belongs to the field of pharmaceutical preparations. According to the invention, the curcumenol nanosuspension is prepared by adopting a precipitation method in combination with high-speed shearing and high-pressure homogenization. The prescription is optimized by using particle size and polydispersity index (PDI) as indicators, the form of the preparation is inspected by means of a transmission electron microscope, and the dissolution of the drug is inspected by means of in-vitro release experiments. The curcumenol nanosuspension provided by the invention is characterized in that the curcumenol nanosuspension comprises curcumenol, lecithin and PVP (polyvinyl pyrrolidone), wherein the mass ratio of the curcumenol to the lecithin to the PVP is 1:(0.4-0.6):(0.25-4); the particle size of drug in the suspension is 50-500 nm; and the curcumenol concentration in the suspension is 0.25-1 mg / ml. The nanosuspension preparation method provided by the invention is simple, controllable and suitable for industrial production, and improves the drug dissolution.

The invention discloses a comprehensive extraction method of Curcuma wenyujin active ingredients. The method comprises the following steps of: 1) total extraction of Curcuma wenyujin; 2) concentration of total extract; 3) extraction of beta-elemene in total extract; 4) extraction of curcumenol in total extract; 5) extraction of curcumin in total extract; 6) preparation of Curcuma wenyujin polysaccharide; 7) refining of curcumenol; 8) refining of beta-elemene. According to the invention,the active ingredients are extracted simultaneously by the comprehensive extraction method, and then, the extract is further separated and purified, the comprehensive extraction method has the advantages of high extraction rate, advanced and special technology, high daily capacity, high yield and low cost, and is suitable for industrialized production.

The invention discloses a curcumenol derivative as well as a preparation method and application thereof in antitumor drugs. The curcumenol derivative disclosed by the invention has a structure of a general formula (I). The curcumenol derivative with antitumor activity disclosed by the invention takes a chemical structure of curcumenol as a basis, introduces different nitrogen-containing substituent groups, has the effects of inhibiting the activities of human cervical carcinoma cells, human liver cancer cells and human lung cancer cells and has high antitumor activity. The structural formula is shown in the specification.

The invention belongs to the field of cell biology and medicine, and relates to the application of curcumol in the preparation of antitumor drug sensitizers. Curcumol is a natural product, which has the effect of reversing the multidrug resistance of tumor cells and can be used as a reversal agent for tumor multidrug resistance; Curcumol also has the effect of increasing the sensitivity of tumor multidrug-resistant cells to anti-tumor drugs, and can be used as chemotherapy Sensitizers are used. The present invention also provides a method for inhibiting the proliferation of tumor multidrug-resistant cells by using the pharmaceutical composition of the antitumor drug and curcumol in combination. The small-molecule compound curcumitol in the present invention is developed as a new anti-tumor drug or its auxiliary components, has obvious tumor-inhibiting effect, is green and environmentally friendly, and will provide a new approach and means for treating and curing tumors.

Disclosed is a curcumenol self-emulsifying capsule preparation and its preparing process, wherein the capsule preparation is prepared from curcumenol, oil and emulsifying agent through dissolving curcumenol into oil through agitating or ultrasonic sound at 25-85 deg C, charging emulsifying agent, stirring homogeneously and encapsulating. The preparation can be made into soft capsules or hard capsules having better stability, higher biological availability, easier body absorption, improved curative effect and easier administration.

The invention belongs to the technical field of medical technology, and relates to novel compounds, which are shown in a general formula (I) and have the activity of resisting influenza A(H1N1) virus, wherein R1 and R2 are defined as in the specification. The invention also relates to application and a preparation method of the compounds, and clinically acceptable medicines for treating infectious diseases of influenza A(H1N1) virus, which are prepared by combining the compounds with pharmaceutically acceptable carriers. The structure of formula (I) is shown in the specification.

The invention discloses a medicine composition for treating nephropathy. The medicine composition is prepared by taking piptostegia root, herba delphinii, picris japonica, didehydrotuberostemonine, curcumenol and protostemonine as crude drugs through a proper ratio; the medicine composition can be prepared into various dosages according to the conventional preparation technology, and has an obvious effect in treating nephropathy.

The invention relates to a pharmaceutical composition used for treating liver cancer. The pharmaceutical composition is prepared by taking peimine, curcumenol, hinokiflavone, and justicidin A as drug substances via mixing. Different dosage forms can be obtained via conventional pharmaceutical technology. The pharmaceutical composition possesses significant importance on preparation of medicines used for treating liver cancer.

The invention relates to curcumenol derivatives and application of the curcumenol derivatives in preparing an antitumor drug. By performing structure modification on the curcumenol derivatives, aftera furfuryl amine fragment is introduced at a hydroxy group site of curcumenol, amine is further introduced through Mannich reaction to obtain a series of the curcumenol derivatives of a structure of aformula (I) as well as pharmaceutically acceptable salts, hydrates, solvates or prodrugs of the curcumenol derivatives which are not reported. Verified by an in vitro bioactivity experiment, the newcurcumenol derivatives have the inhibitory activity to a cervical cancer, a liver cancer, a lung cancer and the like, and the compound activity of most of the new curcumenol derivatives are remarkablyhigher than that of curcumenol as a parent of the new curcumenol derivatives. In addition, the polarity of the vast majority of the synthesized curcumenol derivatives is remarkably improved comparedwith the curcumenol; according to the similarity and intermiscibility principle, the phenomenon that the solubility of the synthesized curcumenol derivatives is higher than that of the curcumenol of aparent compound is proved to a certain degree, and a basic theoretical basis is provided for better performing preparation research and exerting efficacy. The formula (I) is shown in the description.

The invention provides a curcuma total sesquiterpene and tri-sesquiterpene monomer as well as a preparation method and application on an aspect of resisting diabetes. A curcuma plant is taken as a raw material and is subjected to supercritical CO2 extraction or organic solvent extraction, then, low-polarity organic solvent is used for extraction to obtain a low-polarity total sesquiterpene extractive, and the low-polarity total sesquiterpene extractive is subjected to further chromatographic separation to obtain three types of sesquiterpene pure products of curcumenol, curdione and zedoary epoxy ketone. Activity research indicates that the total sesquiterpene, the curcumenol, the curdione and the zedoary epoxy ketone can be used for effectively increasing the consumption of glucose of HepG2 cells so as to obtain antidiabetic activity, and the total sesquiterpene, the curcumenol, the curdione and the zedoary epoxy ketone can be used for preparing antidiabetic medicines, antidiabetic health care food, functional foods and the like. The invention researches and develops new application of the diabetes resistance of the sesquiterpene in curcuma plants, the medicine function range of the curcuma plant is expanded, a basis is provided for carrying out popularization, utilization and deep processing on traditional Chinese medicinal materials, and a new application direction is provided.

The invention discloses a process for extracting curcumenol by a molecular distillation method. The process comprises the following steps of: adding zedoary oil into a feeding unit; firstly carrying out normal-temperature degassing under vacuum degree, and then opening condensed water and an oil-bath heater; after the temperature is stable, starting scraping-film stirring; then dripping the zedoary oil into a distiller; after the dripping is finished, collecting direct condensation fractions, external condensation fractions, unevaporated residual parts and degassed light components and losing; after the unevaporated residual parts are placed for one day, precipitating a great amount of crystals, using petroleum ether to carry out milliliter pulping, filtering, and drying to obtain white crystal; using alcohol with the mass concentration being 95% to recrystallize the crystal, and obtaining the curcumenol crystal with the gas chromatography GC being larger than 99%. The process disclosed by the invention has the advantages that according to the molecular distillation principle, the zedoary oil is treated by molecular distillation, the liquid part is condensed into liquid on an internal condenser by short-process distillation, then the discharged material is discharged, the zedoary oil can be rapidly separated from the curcumenol, and by combination with the recrystallizing technology, the curcumenol with high purity can be obtained.

The invention discloses a new curcumenol glycoside compound and making method and application to treat cancer, bacteria and virus, which is characterized by the following: decorating curcumenol through glycoside; possessing excellent tumour resistant and virus resistant activity.

The invention discloses an application of curcumenol and TRAIL in preparation of an anti-tumor combined drug. The application finds that curcumenol is capable of sensitizing TRAIL-tolerant tumor cellsunder the concentration without cytotoxicity and enhancing the induction effect of TRAIL to cell apoptosis. The application further finds that the molecular mechanism for curcumenol to sensitize theTRAIL-tolerant tumor cells is that curcumenol is capable of promoting the up-regulation of the expression of a receptor DR5 of TRAIL so as to enhance the induction effect of TRAIL to cell apoptosis, so that curcumenol can be taken as a sensitizing agent for TRAIL-tolerant lung cancer cell strains. Besides, the application further finds that by virtue of the combined use of curcumenol and TRAIL, the action concentration of TRAIL can be decreased, and the TRAIL-tolerant tumor cells can be well killed. Therefore, curcumenol and TRAIL can be simultaneously taken as an effectively lung cancer treatment scheme and has wide application prospects in the treatment of lung cancer.

The invention relates to a pharmaceutical composition for treating liver cancer. The pharmaceutical composition is prepared from raw materials of peimine, curcumenol, cucurbitacin and sweroside in certain proportion; and the pharmaceutical composition can be prepared into various dosage forms according to the conventional preparation process. The pharmaceutical composition provided by the invention has great significance to the preparation of medicaments for the treatment of liver cancer.

The invention belongs to the technical field of medicines, and provides a medical compound containing borneol. The medical compound contains germacrone, furanodiene, curdione, beta-elemene, curcumenol, curzerene and borneol. The medical compound containing borneol is definite in ingredients and controllable in quality; the content of camphol in the borneol is controlled, so that the blood concentration and the mucosa absorbing rate of the medical compound are improved; the medical compound provided by the invention can be used for preparing suppository, ointment, capsules, effervescent tablets, gels, lotions, film agents or foaming agents; and the medical compound provided by the invention can well treat HR-HPV (high-risk human papilloma virus) and / or LR-HPV (low-risk human papilloma virus), cervical disease and the like, and is suitable for wide clinical application.

The invention discloses a traditional Chinese medicine active component curcumenol derivative, curcumenol exocyclic double bonds are subjected to structural modification, and non-steroidal anti-inflammatory drugs with benzoic acid structures are combined with curcumenol to form two types of compounds. Curcumenol, which is very wide in clinical application, safe and low in toxicity is selected, an exocyclic double bond of curcumenol is structurally modified, the non-steroidal anti-inflammatory drug with a benzoic acid structure is combined with the curcumenol through an ester bond, the synthesis method is green and environment-friendly, the reaction condition is mild, heating is not needed, the reaction can be completed by stirring at room temperature for 3 hours, and high efficiency and high yield are achieved. The compound active molecules formed after modification can relieve the side effects of the non-steroidal anti-inflammatory drugs, and also can enhance the pharmacological activity of curcumenol.

The invention belongs to the technical field of medicine, and provides a drug composition, which comprises germacrone, furanodiene, curdione, beta-elemene, curcumenol, curzerene and borneol. The drug composition has characteristics of definite components and controllable quality. With the drug composition, weights of curcumenol and curzerene are controlled so as to reduce drug irritation. The drug composition can be adopted for preparing suppositories, ointments, capsules, effervescent tablets, gelatas, lotions, pellicles or foam agents, provides good treatment effects for HR-HPV and / or LR-HPV and cervical diseases, and is suitable for wide clinical applications.

The invention relates to a method for resolving curcumenol epoxy chirality isomer by ionic liquid. Quaternary ammonium salt type ionic liquid containing boron tetrafluoride or phosphorus hexafluoride anion is taken as resolving agent, the principle that complexes formed by two optically pure curcumenol epoxidation enantiomers with ionic liquid has obviously different solubility properties in the ionic liquid is utilized, the two complexes are conveniently separated, decomposition and purification are respectively carried out on the complexes, so as to respectively obtain two high quality and high enantiomeric excess (e. e%) optically pure curcumenol epoxidation enantiomers. The invention has simple post treatment, requires no conventional optically pure chirality compound to be taken as resolving agent, has low ionic liquid consumption, can recycle the ionic liquid and is applicable to mass production.

The invention discloses curcumenol solid dispersion and an oral solid preparation thereof. The solid dispersion is composed of curcumenol and a carrier material, wherein a weight ratio of the curcumenol to the carrier material is 1:1 to 1:11. The oral solid preparation can be tablets, capsules or granules and has the advantages of low side effects, high bioavailability, high safety, small toxic and side effects, convenience in application and the like.

The invention relates to a pharmaceutical composition used for treating liver cancer. The pharmaceutical composition is prepared by taking oleuropein, curcumenol, hemslecin, and justicidin A as drug substances via mixing. Different dosage forms can be obtained via conventional pharmaceutical technology. The pharmaceutical composition possesses significant importance on preparation of medicines used for treating liver cancer.

The invention belongs to the technical field of medicines, and provides a drug combination containing borneol. The drug combination comprises germacrone, furanodiene, curdione, Beta-elemene, curcumenol, curzerene and borneol. The drug combination contains definite components which is controllable in quality; the drug combination can control the content of camphol in borneol so as to improve the plasma concentration and the mucous membrane absorption rate of the drug combination; the drug combination can be used for preparing suppository, ointments, capsules, effervescent tablets, gelata, lotion, film agents or foaming agents; and the drug combination can achieve an excellent therapeutic effect on diseases such as HR-HPV (High Risk-Human PapillomaVirus) and / or LR-HPV (Low Risk-Human PapillomaVirus) and cervical diseases, and is suitable for clinical wide application.

The invention discloses application of a curcumenol derivative in preparation of antitumor drugs. Curcumenol is an important component of traditional Chinese medicine curcuma zedoary volatile oil, andis separated from various plants at present. Researches show that curcumenol has various activities and can inhibit proliferation of various tumor cells. It is found that the curcumenol derivative 4awith the chemical structure shown in the figure 1 has good inhibitory activity on glioma U251 cells and has the prospect of being developed into anti-glioma drugs.

The invention discloses a detection method and application of common analgesic components in four base source curcuma aromatica decoction parts. The detection method comprises the following steps: preparing a curcumenol standard substance into a reference substance solution; taking a curcuma aromatica, cinnamomum cassia presl, curcuma aromatica or curcuma aromatica decoction part powder sample tobe subjected to temperature measurement, extracting with water, and taking a water extract as a test solution; injecting the reference substance solution and the test solution into a high performanceliquid chromatograph, and measuring and calculating the content of curcumenol in radix curcumae. According to the method, curcumenol which is a common analgesic component in radix curcumae is creatively taken as a reference substance, a new Qingjin quality control standard is provided, the content of curcumenol which is a common analgesic component in the four base source Qingjin water extracts can be determined through the detection method, and guidance is further provided for clinical medication.

The invention discloses a preparation method of a granzyme B activator curcumenol. It is found that eiprocurcumenol, curcumenol, physagulin A, physagulin F and withangulatin A can activate the expression of granzyme B in CIK cells and are effective granzyme B activators; the granzyme B activators of eiprocurcumenol, curcumenol, physagulin A, physagulin F and withangulatin A can significantly improve the killing capability of CIK cells on tumor cells. The invention further provides methods for preparing eiprocurcumenol, curcumenol, physagulin A, physagulin F and withangulatin A. The methods areindependent of repeated column chromatography and suitable for industrialized large-scale preparation. The technical scheme disclosed by the invention has not been disclosed in the prior art yet.

The invention discloses a method for measuring volatile components of medicinal material radix curcumae by QAMS (Quantitative Analysis of Multi-components by Single-marker). The method comprises the following steps: (1) preparation of a test liquor: taking the medicinal material radix curcumae, extracting a volatile oil by a steam distillation method, passing through a C8 or C18 stationary phase column, abandoning effluent, eluting with methanol, and collecting a methanol eluent for fixing a volume and being used as the test solution; (2) preparation of a reference liquor: taking curdione, dissolving with methanol, fixing the volume and using as the reference solution; (3) taking the test solution and the reference solution, respectively injecting into a high performance liquid chromatograph to obtain a chromatogram; and (4) first, using the reference product curdione as a reference, using a one-point external standard method or a working curve method to calculate the content of curdione in the test solution, then using a correction factor to calculate contents of curcumene ketone, curcumenol, curzerenone and germacrone. The method realizes simultaneous measurement of five sesquiterpenoids, reduces production cost, improves production efficiency and economic benefits, is fast and accurate, and can more comprehensively cover the quality of the medicinal materials.

The invention belongs to the technical field of medicine, and provides a medicine compound for curing cervical diseases. The medicine compound contains germacrone, furanodiene, curdione, beta-elemene, curcumenol, curzerene and borneol. The medicine compound has the advantages of clear composition and mass controllability; in the medicine compound, the weight parts of the curzerene and curcumenol are controlled, so the irritation of the medicine is reduced; and the medicine compound provided by the invention can be used for preparing suppositories, ointment, capsules, effervescent tablets, gels, lotions, membranes or foaming agents, achieves a good curative effect on HR-HPV (high-risk human papillomavirus) and / or LR-HPV (low-risk human papillomavirus) and the cervical diseases, and is suitable for clinical extensive use.