1533 results about "Delivery vehicle" patented technology

The present invention is directed to compounds, compositions, and methods useful for delivering polynucleotides or other cell-impermeable molecules to mammalian cells. Described are polyconjugates systems that incorporate targeting, anti-opsonization, anti-aggregation, and transfection activities into small biocompatible in vivo delivery vehicles. The use of multiple reversible linkages connecting component parts provides for physiologically responsive activity modulation.

Methods and associated systems for autonomous package delivery utilize a UAS / UAV, an infrared positioning senor, and a docking station integrated with a package delivery vehicle. The UAS / UAV accepts a package for delivery from the docking station on the delivery vehicle and uploads the delivery destination. The UAS / UAV autonomously launches from its docked position on the delivery vehicle. The UAS / UAV autonomously flies to the delivery destination by means of GPS navigation. The UAS / UAV is guided in final delivery by means of a human supervised live video feed from the UAS / UAV. The UAS / UAV is assisted in the descent and delivery of the parcel by precision sensors and if necessary by means of remote human control. The UAS / UAV autonomously returns to the delivery vehicle by means of GPS navigation and precision sensors. The UAS / UAV autonomously docks with the delivery vehicle for recharging and preparation for the next delivery sequence.

Various aspects and embodiments of the invention are directed to methods and compositions for reversing antibiotic resistance or virulence in and / or destroying pathogenic microbial cells such as, for example, pathogenic bacterial cells. The methods include exposing microbial cells to a delivery vehicle with at least one nucleic acid encoding an engineered autonomously distributed circuit that contains a programmable nuclease targeted to one or multiple genes of interest.

Crosslinked compositions formed from water-insoluble copolymers are disclosed. These compositions are copolymers having a bioresorbable region, a hydrophilic region and at least two cross-linkable functional groups per polymer chain. Crosslinking of these polymers can be effected in solution in organic solvents or in solvent-free systems. If crosslinking occurs in a humid environment, a hydrogel will form. If crosslinking occurs in a non-humid environment, a xerogel will form which will form a hydrogel when exposed to a humid environment and the resulting crosslinked materials form hydrogels when exposed to humid environments. These hydrogels are useful as components in medical devices such as implantable prostheses. In addition, such hydrogels are useful as delivery vehicles for therapeutic agents and as scaffolding for tissue engineering applications.

A method and apparatus are provided for sorting items to a plurality of sort destinations. The items are loaded onto one of a plurality of independently controlled delivery vehicles. The delivery vehicles follow a track that guides the delivery vehicles to the sort destinations, which are positioned along the track. Once at the appropriate sort destination, the delivery vehicle ejects the item to the sort destination and returns to receive another item to be delivered.

Various polymers, including cationic polyamine polymers and dendrimeric polymers, are shown to possess anti-proliferative activity, and may therefore be useful for treatment of disorders characterised by undesirable cellular proliferation such as neoplasms and tumours, inflammatory disorders (including autoimmune disorders), psoriasis and atherosclerosis. The polymers may be used alone as active agents, or as delivery vehicles for other therapeutic agents, such as drug molecules or nucleic acids for gene therapy. In such cases, the polymers' own intrinsic anti-tumour activity may complement the activity of the agent to be delivered.

Methods and systems are provided to automate inventory and dispatch procedures at a staging area by automatically detecting the arrival or departure of delivery vehicles, container devices and other such items. Detection of these items is facilitated by the use of automatic identification tags, and other such devices, that are physically associated with each such item. According to one aspect of the invention, the detection of inbound vehicles and related container devices triggers a series of automated communications that facilitate the dispatch of such items within the staging area. Additionally, when a delivery vehicle or container device departs, the system can be configured to check the tag or device associated with each such item so as to confirm that the correct container device(s) are associated with the correct outbound delivery vehicle. The system further provides a method of tracking inventories of such items in real time.

A method and system for auctioning or sales of deliverable prepared food via the Internet permit customers to purchase or bid on prepared food items. A food preparation and delivery portion of the system includes a delivery vehicle, which may have a mobile kitchen for the preparation of food items en-route. The location of the delivery vehicle is determined from a global positioning system (GPS) receiver in the vehicle or via another location-finding mechanism. Food items with an estimated time of arrival (ETA) is displayed on a web page that provides an interface for purchase or bidding. Bidding may be made for the actual food item purchase or for a scheduled delivery time. Items may be re-auctioned, causing the delivery of a food item to be transferred to another bidder. Audio and / or visual communication with an ordering point and / or delivery vehicle may be provided in the user interface.

An animal feedlot management system is disclosed, wherein each feed delivery vehicle employed therein uses real-time virtual reality (VR) modelling and coordinate acquisition techniques supported upon an Internet-based (i.e., Cyberspace) communications platform in order to carry out various types of feedlot operations. Each feedlot vehicle has an on-board computer system which includes a VR subsystem, for accessing a VR database maintaining information representative of a VR model of the feedlot and the objects present therein (eg., tagged animals, pens, alley ways, feedbunks, buildings, vehicles, etc.

A shelving and package locating system for delivery vehicles includes one or more shelves for storing packages within a delivery vehicle during delivery. Each package is associated with both a geographic delivery address and an assigned location on a particular shelf within the delivery vehicle. A GPS unit determines the location of the delivery vehicle during delivery, and a computer provides the shelf location of a particular package when that package's delivery-location information substantially corresponds to vehicle location information. Several embodiments exist for registering the location of the package in the vehicle at load time, such as scanned location indicia, light sensors on shelves, pressure sensors on shelves, pressure sensors on the floor of the vehicle, and light spot. Several embodiments exist for locating the package in the vehicle at delivery time, such as a pick-to-light system that employs variable length lighting and a light pointer system that generates a light spot.

The present invention relates to biscarbodiimides, thiourea derivatives, urea derivatives, and cross-linked hyaluronan derivatives having at least one intramolecular disulfide bond, and methods of preparation thereof. The invention also includes thiolated hyaluronan derivatives and salts thereof having at least one pendant thiol group or a modified pendant thiol group, and methods of preparation thereof. An example of a modified pendant thiol group is a sulfhydryl group linked to a small molecule such as a bioactive agent, for example a drug or pharmaceutically active moiety. A hyaluronan derivative having a sulfhydryl group linked to a pharmaceutically active moiety is useful as a sustained or controlled release drug delivery vehicle. Compositions containing the hyaluronan derivatives of the invention can reversibly viscosify in vivo or in vitro, in response to mild changes in condition, and are thus useful in ophthalmic surgery and in tissue engineering.

Methods and systems disclosed herein are used to automate inventory and dispatch procedures at a staging area by automatically detecting the arrival or departure of delivery vehicles, container devices and other such items. Detection of these items is facilitated by the use of automatic identification tags, and other such devices, that are physically associated with each such item. According to one aspect of the invention, the detection of inbound vehicles and related container devices triggers a series of automated communications that facilitate the dispatch of such items within the staging area. Additionally, when a delivery vehicle or container device departs, the system can be configured to check the tag or device associated with each such item so as to confirm that the correct container device(s) are associated with the correct outbound delivery vehicle. The system further provides a method of tracking inventories of such items in real time.

System for providing a virtual vehicle boundary. The system includes a method for activating a virtual fence for use with a delivery vehicle. The method comprises steps of detecting a protection event, determining that the protection event is an activation event, and activating a selected virtual fence based the activation event.

The present invention encompasses a solid dose delivery vehicle for ballistic administration of a bioactive material to subcutaneous and intradermal tissue, the delivery vehicle being sized and shaped for penetrating the epidermis. The delivery vehicle further comprises a stabilizing polyol glass loaded with the bioactive material and capable of releasing the bioactive material in situ. The present invention further includes methods of making and using the solid dose delivery vehicle of the invention.

The present invention is directed to compounds, compositions, and methods useful for delivering polynucleotides or other cell-impermeable molecules to mammalian cells. Described are polyconjugates systems that incorporate targeting, anti-opsonization, anti-aggregation, and transfection activities into small biocompatible in vivo delivery vehicles. The use of multiple reversible or labile linkages connecting component parts provides for physiologically responsive activity modulation.

The present invention relates to the compositions, methods, and applications of a novel approach to selective cellular targeting. The purpose of this invention is to enable the selective delivery and / or selective activation of effector molecules to target cells for diagnostic or therapeutic purposes. The present invention relates to multi-functional prodrugs or targeting vehicles wherein each functionality is capable of enhancing targeting selectivity, affinity, intracellular transport, activation or detoxification. The present invention also relates to ultra-low dose, multiple target, multiple drug chemotherapy and targeted immunotherapy for cancer treatment.

An improved meal delivery system and a method for delivery of pre-cooked, chilled meals from a central distribution station to a plurality of remote locations in cooperation with an Automatic Guided Vehicle system, and in particular a one-piece, molded, insulated meal-delivery cart for transportation of chilled meals.

The present invention provides a synthetic, poorly crystalline apatite (PCA) calcium phosphate containing a biologically active agent and / or cells (preferably tissue-forming or tissue-degrading cells). The compositions provided by the present invention are useful for a variety of in vivo and in vitro applications, including drug delivery (for example, to bony sites, the central nervous system, intramuscular sites, subcutaneous sites, interperitoneal sites, and occular sites) tissue growth (preferably bone or cartilage) osseous augmentation, and methods of diagnosing disease states by assaying tissue forming potential of cells isolated from a host. The invention also provides methods of preparing delivery vehicles, of altering delivery vehicle characteristics, and of delivering biologically active agents to a site. The invention further provides in vitro cell culture systems and cell encapsulation materials. The invention is useful for both medical and veterinary applications.

This invention provides for a process of rapidly forming silk fibroin gelation through ultrasonication. Under the appropriate conditions, gelation can be controlled to occur within two hours after the ultrasonication treatment. Biological materials, including viable cells, or therapeutic agents can be encapsulated in the hydrogels formed from the process and be used as delivery vehicles.

An on-demand robotic food assembly line can include one or more conveyors and one or more robots, operable to assemble food items in response to received orders for food items, and one or more ovens operable to, for example, partially cook assembled food items. The on-demand robotic food assembly line can optionally package the assembled and partially cooked food items in packaging, and optionally load the packaged partially cooked food items into portable cooking units (e.g., ovens) that are optionally loaded into racks that are, in turn, optionally loaded into delivery vehicles, where the food items are individually cooked under controlled conditions while en route to consumer destinations, such the cooking of each food item is completed just prior to arrival at the consumer destination location. A dynamic fulfillment queue for control of assembly is maintained based at least in part on estimated transit time for orders.

A system for delivery of payload at a precise location by autonomous delivery vehicle. A machine-readable unique identifier is laid at a place where a user wants delivery of an item. User opens a precise delivery app on smartphone, activates the scanner and standing near the unique identifier scans it. Precise delivery app reads the unique identity of the unique identifier and collects the geophysical location of the smartphone. Third party system feeds this information of the target unique identifier to the autonomous vehicle. The autonomous delivery vehicle includes a first prior art navigator and a second scanner navigator. The autonomous vehicle determines its route to the approximate location of the target unique identifier with the help of the first prior art navigator and the second scanner navigator scans every unique identifier that may be present around that location and guides the autonomous vehicle to the target unique identifier.

Methods and compositions for inhibiting articular cartilage degradation. The compositions preferably include multiple chondroprotective agents, including at least one agent that promotes cartilage anabolic activity and at least one agent that inhibits cartilage catabolism. The compositions may also include one or more pain and inflammation inhibitory agents. The compositions may be administered systemically, such as to treat patients at risk of cartilage degradation at multiple joints, and suitably may be formulated in a carrier or delivery vehicle that is targeted to the joints. Alternatively the compositions may be injected or infused directly into the joint.

A system for managing a concrete delivery vehicle having a mixing drum 14 and hydraulic drive 16 for rotating the mixing drum, including a rotational sensor 20 configured to sense a rotational speed of the mixing drum, a hydraulic sensor 22 coupled to the hydraulic drive and configured to sense a hydraulic pressure required to turn the mixing drum, a temperature sensor for sensing temperature of the drum, and a communications port 26 configured to communicate a slump calculation to a status system 28 commonly used in the concrete industry, wherein the sensing of the rotational speed of the mixing drum is used to qualify a calculation of current slump based on the hydraulic pressure required to turn the mixing drum. Temperature readings are further used to qualify or evaluate a load. Also, water purge connections facilitate cold weather operation.

Asymmetric bifunctional silyl (ABS) monomers comprising covalently linked pharmaceutical, chemical and biological agents are described. These agents can also be covalently bound via the silyl group to delivery vehicles for delivering the agents to desired targets or areas. Also described are delivery vehicles which contain ABS monomers comprising covalently linked agents and to vehicles that are covalently linked to the ABS monomers. The silyl modifications described herein can modify properties of the agents and vehicles, thereby providing desired solubility, stability, hydrophobicity and targeting.

A nanoparticle delivery vehicle, comprising a nanoparticle, an active agent and a nuclear localization signal and methods of modulating gene expression and protein expression employing the nanoparticle delivery vehicle. A representative method includes providing a nanoparticle delivery vehicle comprising a nanoparticle having a diameter of about 30 nm or less, an active agent and a nuclear localization signal; and contacting a target cell with the nanoparticle delivery vehicle, whereby an active agent is delivered to the nucleus of a target cell. Another representative method includes providing a nanoparticle delivery vehicle comprising a nanoparticle having a diameter greater than or equal to about 30 nm, an active agent and a nuclear localization signal; and contacting a target cell with the nanoparticle delivery vehicle, whereby an active agent is delivered to the cytoplasm of a cell.

A system for managing a concrete delivery vehicle having a mixing drum 14 and hydraulic drive 16 for rotating the mixing drum, including a rotational sensor 20 configured to sense a rotational speed of the mixing drum, a hydraulic sensor 22 coupled to the hydraulic drive and configured to sense a hydraulic pressure required to turn the mixing drum, a temperature sensor for sensing temperature of the drum, and a communications port 26 configured to communicate a slump calculation to a status system 28 commonly used in the concrete industry, wherein the sensing of the rotational speed of the mixing drum is used to qualify a calculation of current slump based on the hydraulic pressure required to turn the mixing drum. Temperature readings are further used to qualify or evaluate a load. Also, water purge connections facilitate cold weather operation.

System for providing a virtual vehicle boundary. The system includes a method for activating a virtual fence for use with a delivery vehicle. The method comprises steps of detecting a protection event, determining that the protection event is an activation event, and activating a selected virtual fence based the activation event.

The present invention relates to a film-forming barrier composition useful for protecting the skin from body fluids, such as urine, feces, menses. The composition comprises a skin conditioning agent, a viscosity enhancing agent and an oleophilic film-forming agent. Optionally, the lotion may comprise skin care ingredients for treating or maintaining skin health. The composition may be applied to the skin by suitable delivery vehicles, such as absorbent articles or components thereof, sheet materials, pads, bandages, sponges, foam pads, pumps, sprays, depending on the viscosity of the composition.