The invention provides a 
mechanics analysis device for piezomodulated and sensed single 
cell, comprising a piezoelectric 
chip, a detecting tank, and a controlling and detecting 
system. The 
mechanics analysis device is characterized in that the piezoelectric 
chip is encapsulated in the detecting tank; the mechanic dynamic analysis on the piezomodulated and sensed single 
cell is carried out by controlling an detecting 
system; the piezoelectric 
chip consists of a piezoelectric sheet and at least one group of electrodes arranged on the surface of the piezoelectric sheet; one group of 
electrode pairs and the piezoelectric sheet form a piezoelectric 
resonator; the 
electrode pair comprises at least one micro-
electrode with the area matched with that of the single 
cell and surface decorated chemically; the single cell is naturally fixed on the chemically decorated micro-electrode in a bonding way; the 
microelectrode can generate vibration by the controlling and detecting 
system and can interact with the bonding cell, thus synchronously realizing the 
dynamic modulation and real-time induction of the single 
cell mechanics. The device and the method aim at solving the problem of difficulty on modulation and monitoring of the 
cell mechanics in the single 
cell mechanics technology and have the characteristics of no existence of non-mechanic interference, high simpleness and flexibility, 
high flux and the like; the bio-mechanic characteristics of the cell can be discovered on 
cell layer, time and space; and the 
mechanics analysis device can be suitable for application in the wide fieldssuch as 
biomechanics, 
tissue engineering, 
drug screening, clinical 
medicine, and the like.