The present invention pertains generally to the field of coolants and 
medical therapy. More particularly, the present invention relates to certain anti-nociceptive agents, such as [((1R,2S,5R)-2-
isopropyl-5-methyl-cyclohexanecarbonyl)-amino]-
acetic acid isopropyl ester, that are potent and long-acting and selectively cooling for non-keratinized epithelial tissues as compared to keratinized epithelial tissues, and are useful, for example, for the treatment of (e.g., the alleviation of symptoms of; the amelioration of) 
sensory discomfort of non-keratinized stratified epithelial (NKSE) tissue; and so for treatment of: 
sensory discomfort of an 
ocular surface, an 
eyelid, a margin of an 
eyelid, an anterior part of an eyeball, a 
conjunctiva, a lachrymal 
system, a pre-corneal film, or a 
cornea, a lining of the 
oral cavity, an internal portion of the lips, a pharyngeal surface, an esophageal surface, or an anogenital surface; eye discomfort, e.g., caused by 
extended wear of contact lenses, by eye strain and / or fatigue, by 
air pollutants, by excessive 
exposure to the sun, by conjunctivitis, by dry eye syndrome; 
sensory discomfort associated with oral 
mucositis; 
airway (e.g., 
larynx, trachea, and / or bronchi) tightness, discomfort in the airways (e.g., 
larynx, trachea, and / or bronchi), 
choking, cough, and / or dyspnea, e.g., associated with 
asthma and / or chronic 
obstructive pulmonary diseases (
COPD).