The invention discloses a COVID19 
antigen detection card as well as a preparation method and application thereof, and belongs to the field of nano materials and nano 
medicine, an adopted 
rare earth nano probe is 
erbium fluoride sodium coated 
sodium yttrium fluoride with a core-shell structure, the particle size is 20nm-30nm, the composition of the 
rare earth nano probe is NaErF4@NaYF4, and NaErF4 is a full 
erbium doped core structure, NaYF4 is a shell layer, and @ represents that the NaYF4 is coated on the surface of the NaErF4. The nano-probe is a 
rare earth fluoride nano-material and has the advantages of low background, long 
luminescence life, strong 
fluorescence signal, high 
signal-to-
noise ratio and the like, the probe is connected with a new crown 
monoclonal antibody through a 
covalent bond for marking, a marking product is stable, and the COVID19 
antigen detection card has the characteristics of high sensitivity, high accuracy, rapid and simple detection and the like, and can be used for screening and detection of early-stage COVID19 suspected patient 
throat swabs, nasal swabs, nasopharyngeal swabs and 
saliva samples, so that clinical definite diagnosis can be quickly and specifically assisted.