89 results about "Lauroyl glutamate" patented technology

The invention relates to a conditioning shampoo composition free of sulfates and dioxan. The conditioning shampoo composition is characterized in that the conditioning shampoo composition comprises 4.5%-15% of an amino acid type anionic surfactant and a thickening composition; the amino acid type anionic surfactant is one of a cocoyl alaninate, a lauroyl glutamate, a cocoyl glycinate, a lauroyl sarcosinate, a methyl cocoyl taurate or a mixture thereof; the above mentioned salts are potassium salts or sodium salts or triethanolamine salts; the thickening composition comprises 0.2-4.0% of glyceryl cocoate, 0.05%-1.00% of trihydroxystearin, 0.05-1.50% of polyhydroxystearic acid and 0.2-3.0% of an acrylic (acrylate) copolymer; and the above percentages are both weight percentages. The conditioning shampoo composition is advantageous in that the conditioning shampoo composition has a viscosity range of 3000-30000 cps and is shown as long flowing deformation; the conditioning shampoo composition can be poured out easily from a container; the conditioning shampoo composition is liable to spread on hair; foams of the conditioning shampoo composition are uniform and comfortable; the conditioning shampoo composition is free of the sulfates and the dioxan, and the conditioning shampoo composition has beneficial effects of safety and little irritation.

The invention discloses an emulsified lipstick and a preparation method thereof, and belongs to the technical field of cosmetics. The emulsified lipstick is prepared from the following components in percentage by weight: 51 to 71% of skin moisturizer, 13 to 17% of hardener, 4 to 10% of brightener, 2 to 3% of polyglycerol-2 triisostearate, 0.5 to 1% of dipoly-pentaerythritol tri-polyhydroxyl stearate, 2 to 5% of phytosterol / octyl dodecyl lauryl glutamate, 2 to 5% of water, 2.01 to 4.02% of water-soluble moisturizer, and 0.5 to 2.5% of water-soluble plant extract. The emulsified lipstick has the advantages that by adopting two types of emulsifiers, and matching with the ultrasonic demulsifying technology, the production of air bubbles due to evaporation of water phase is avoided, and the finished rate is improved; the moisturizer, cornflower flower extract, ginko leaf extract and golden chamomile flower extract can be added into the lipstick, so that the lip wrinkles can be lightened, the skin elasticity is improved, the toxicity is effectively removed, the circulation of micro-blood vessels is stimulated, the skins are nourished, and the functions of the lipstick are widened; under the synergistic function of glycerin, hyaluronic acid and polyquaternium-51, the natural skin bionic moisturizing film is formed, and the lip skin is moisturized and smooth.

The invention relates to an aliphatic polyester grafted polyamino acid copolymer and a preparation method thereof. A preparation process of the grafted copolymer comprises the following steps of: performing a ring-opening reaction on amino acid-N-inner carboxylic acid anhydride by taking triethylamine, n-hexylamine and the like as initiators, and removing a protecting group to obtain polyamino acid; and grafting aliphatic polyester obtained by performing ring opening polymerization on initiating esters such as hydroxyethyl acrylate, cinnamic alcohol, coumarin and the like to obtain the aliphatic polyester grafted polyamino acid copolymer. The aliphatic polyester is preferably polylactic acid or poly(epsilon-caprolactone) of which the number average molecular weight is 1,000-30,000; and the amino acid-N-inner carboxylic acid anhydride is preferably gamma-benzyl-L-glutamate-N-inner carboxylic acid anhydride or gamma-benzyl-L-aspartate-N-inner carboxylic acid anhydride. The grafted copolymer has a simple preparation process, high biocompatibility and wide application prospect in the field of biological medical materials, and is provided with a photo-crosslinking group.

The invention provides poly(gamma-propynyl-L-glutamate) block copolymer. The block copolymer contains a block A shown in the formula (I) and a block B shown in the formula (II). The poly(gamma-propynyl-L-glutamate) block copolymer is AB block copolymer, wherein the number average molecular weight of the block A is 550-10000, the number average molecular weight of the block B is 800-20000, and the weight percentage of the block B to the block copolymer is 25%-75%. The invention also provides a preparation method of the poly(gamma-propynyl-L-glutamate) block copolymer and poly(gamma-propynyl-L-glutamate) block copolymer hydrogel. Compared with the prior art, the block copolymer provided by the invention contains propynyl, thus the application range of the block copolymer can be expanded.

The invention provides a novel hair washing / caring / nourishing composition. The novel hair washing / caring / nourishing composition is composed of three parts, namely a liquid shampoo, a hair conditioner and a hair nourishing essence, wherein the liquid shampoo is prepared from 20-60% of glycerol, 1-5% of lauramide MEA, 15-25% of lauroyl glutamate, 0.2-1% of guar gum hydroxypropyl trimethyl ammonium chloride, 0.3-1% of essence and 20-50% of water; the hair conditioner is prepared from 30-70% of glycerol, 3-8% of octadecanol, 0.5-2% of guar gum hydroxypropyl trimethyl ammonium chloride, 1-3% of behentrimonium chloride and 20-60% of water; the hair nourishing essence is prepared from 30-85% of jojoba oil, 3-25% of squalane, 5-40% of caprylin / capric glycerate, 0.5-5% of egg oil, 1-10% of curcuma oil, and 1-10% of camellia oil. According to the novel hair washing / caring / nourishing composition, the three parts, namely the liquid shampoo, the hair conditioner and the hair nourishing essence, are matched with each other to achieve a synergic effect; the composition has the characteristics of mild and non-irritating properties, rich foam, high compatibility, hair nourishing and caring, no preservative and the like.

The invention relates to acne removing cream and a method for preparing the same. The acne removing cream comprises, by weight, steareth-2, lauroyl glutamate, steareth-21, cetyl alcohol, glyceryl stearate, dimethicone, isomerization cetane, capric triglyceride, isopalmitic acid ethylhexyl acrylate, vitamin E, bisabolol, propylene glycol, dipotassium glycyrrhizinate, butanediol, hexamidine (hydroxyethanesulphonic acid) dibasic, EDTA (ethylene diamine tetraacetic acid)-disodium, water, matrine, preservatives, asiaticoside, pH (potential of hydrogen) regulators and thickeners. The acne removing cream and the method have the advantages that various raw materials are mixed with one another, and accordingly facial skin cleaning and care effects can be realized; pimple, acne, papule, pustule and the like on the faces of users can be effectively removed.

The invention relates to a soap ammonia type facial cleansing product and a preparation method thereof. The product comprises an amino acid surfactant, a soap-based surfactant, an auxiliary surfactant, an auxiliary agent and a solvent, wherein the amino acid surfactant is at least one selected from potassium cocoyl glycinate, sodium cocoyl glycinate, sodium lauroyl sarcosine, TEA-cocoyl alaninate,sodium cocoyl glutamate, TEA-lauroyl glutamate, sodium lauroyl glutamate and sodium palmitoleyl glutamate; the soap-based surfactant is at least one selected from potassium cocoate, potassium laurate, potassium myristate, potassium palmitate and potassium stearate; and the auxiliary surfactant is at least one selected from sodium lauroamphoacetate, lauryl hydroxyl sulphobetaine, cocamidopropyl betaine, lauryl glucoside, decyl glucoside, cocamidopropyl betaine, cocamide, dodecyl dimethyl betaine and palm kernelamide. The cleaning agent has the characteristics of low irritation, high cleaning efficiency, rich foam and good use feeling.

The invention belongs to the technical field of daily care products and discloses a moisturizing and repairing composition and an epidermis biomimetic membrane liquid crystal complex constructed therefrom. The core components of the moisturizing and repairing composition and the epidermis biomimetic membrane liquid crystal complex include ceramide, phytosphingosine, cholesterol, lauryl glutamate, squalane, myristyl alcohol, cetostearyl alcohol, arginine, glycine and hydroxyproline. In the invention, by means of combination of various raw materials and through a layered liquid crystal forming mechanism, the special epidermis biomimetic membrane is developed, by which a lamellar liquid crystal body, which likes a keratinocyte intercellular lipid layer, can be formed, so that an effect of protecting skin and improving skin can be achieved.

The present invention relates to: a composition for transdermal delivery, comprising 1) a nanoemulsion comprising an active ingredient, saturated lecithin, phytosteryl / behenyl / octyldodecyl lauroyl glutamate, a polyol, and water, and 2) a modified layered double hydroxide; and a preparation method therefor.

The invention discloses a polyethylene glycol block polypeptide molecular brush. The polyethylene glycol block polypeptide molecular brush has a structure as shown in a formula (1) in the specification, and comprises a main chain and a side chain, wherein the main chain is a two-block polymer composed of polyethylene glycol and polypeptide; the side chain is an alkoxy ether dendrimer. The preparation method comprises the following steps: preparing gamma-chloroethyl-L-glutamate from chlorohydrin and L-glutamic acid, and initiating the ring opening polymerization of alpha-amino acid-N-carboxyanhydride by use of amino polyethylene glycol monomethyl ether to obtain polyethylene glycol-b-poly(gamma-chloroethyl-L-glutamate; grafting the alkoxy ether dendrimer to the polypeptide chain by virtue of azidation and click reaction, thereby preparing the polyethylene glycol block polypeptide molecular brush. The invention also discloses a hydrogel containing alpha-cyclodextrin and the polyethylene glycol block polypeptide molecular brush. The hydrogel is prepared by mixing and stirring the molecular brush and the alpha-cyclodextrin in water and then performing ultrasonic and standing treatment. The hydrogel has unique structure andmorphology and excellent biocompatibility, and has wide application prospect in the fields of functional materials, cell culture medias, medicine carrier and the like.

The invention discloses an activated fluorescent latex microsphere for a 25-hydroxyvitamin D3 fluorescent immunochromatographic detection card and the detection card. The preparation method of the activated fluorescent latex microsphere comprises the following steps: 1) adding a surfactant into a buffer solution with pH of 8 to 10 and adding dimethylformamide, N, N'-dicyclohexylcarbodiimide and N-hydroxysuccinimide into the solution, and 2) taking a dispersion liquid of fluorescent latex microspheres with amido groups on the surfaces, adjusting pH of the dispersion liquid to 8-10 through a buffer solution, adding the dispersion liquid into the mixture obtained in the step 1), carrying out stirring for a reaction, then carrying out centrifugation after the reaction, and removing the supernatant so that the surface-activated fluorescent latex microspheres are obtained. The surfactant contains polyethylene glycol monolaurate, dodecyl benzene sulfonate and lauroyl glutamate according to a weight ratio of 2-10: 0.5-2: 3-7.

The present invention provides a liquid emulsion cosmetic which does not increase contents of oil and glycerin and has excellent moisturizing performance. Specifically, a liquid cosmetic which is an emulsion cosmetic, is characterized by containing isostearate phytosterol, phytosterol / octyldodecyl lauroyl glutamate, hydrogenated lecithin and oil agent in oil phase.

The invention discloses a preparation method of N-lauroyl-glutamate sodium, which comprises the following steps: I. performing condensation reaction to lauric acid and glutamic acid in a solvent; II. performing acidifying skimming reaction to the material obtained in the step I, to obtain an N-lauroyl-glutamic acid mixed solution; III. performing solvent removal reaction to the N-lauroyl-glutamic acid by a rotary scraper thin-film evaporation method; and IV. performing neutralization reaction to the N-lauroyl-glutamic acid, to obtain N-lauroyl-glutamate sodium. The solvent of N-lauroyl-glutamic acid mixed solution is removed by adopting the rotary scraper thin-film evaporation method, so that the energy consumption is small, the production efficiency is high, the product N-lauroyl-glutamate sodium has the advantages of being shallow in color and low in acetone residuals.

The invention relates to a method for preparing aluminum oxide. The method is characterized by comprising the following steps of: dissolving aluminum oxide solid in 0.1-0.5mol / L lauroyl sodium glutamate aqueous liquor to obtain 1-5mol / L aluminum chloride liquor; adding ammonia water or mixed liquor of ammonia water and organic amine into the aluminum chloride liquor, and adjusting pH value to 7-8 so as to obtain Al<3+>:OH<-> in the liquid; standing the liquor for 3-5hours at 20-50 DEG C by lauroyl glutamate ions, wherein the molar ratio is 1: (0.05-3): (1.5-7.5); crystallizing the liquor after standing in a reaction kettle at 100-140 DEG C for 24-96hours; and filtering and washing the crystallizing liquid and roasting in a muffle furnace at 500-700 DEG C for 4-6 hours to obtain solid aluminum oxide. The specific surface area of gamma-aluminum oxide can reach 240-400<m2> / g.

The invention provides a facial cleanser without irritation to eyes and a preparation method thereof. The facial cleanser comprises the following components in percentage by mass: 20-30% of lauroyl glutamate, 0-10% of betaine, 1-5% of acrylic acid (ester) / C10-30 alkanol acrylate crosslinked polymer, 5-15% of cocoyl potassium glycinate, 0.1-1% of potassium hydroxide, 0-0.3% of a preservative, 0.1-3% of oat (AVENA SATIVA) beta-glucan, 10-20% of glycerol, 0-0.3% of essence and the balance of water. The facial cleanser without irritation to the eyes does not irritate the eyes in the using process.

The invention pertains to a polyglutamate microballoon sphere with an active surface and a preparation method thereof. A compound with functional groups such as chlorine, nitrine, triple bond, double bond and the like at one end and hydroxide radical at the other end, poly benzyl glutamate and the like are adopted to conduct ester exchange reaction to obtain a copolymer of glutamate with a part of lateral chain activated and then the polyglutamate microballoon sphere with the surface containing functional groups is obtained by an emulsification method. The particle size of the polyglutamate microballoon sphere prepared by the method is 0.5 Mu m to 10 Mu m and the functional group content thereof is 0 percent to 100 percent (with respect to the number of the polyglutamate repetitive units); wherein, the number-average molecular weight of the polyglutamate is 5 thousand to 20 thousand and the hydrolysis degree is less than 1 percent (with respect to the number of the polyglutamate). The prepared polyglutamate microballoon sphere can be applied to biomedical material fields like medicament carriers, sorbing material, separation and purification of base materials, long-range markers, diagnostic medium and the like.

A method for synthesizing theanine comprises the following steps of: (1) suspending glutamic acid in C1-6 alcohol, performing a catalytic reaction under acidic condition, neutralizing to neutral by the use of an organic base, followed by centrifugation to obtain glutamic acid-5-ester; (2) suspending glutamic acid-5-ester in C1-4 alcohol, adding ethylamine for a reaction to obtain a theanine ethylamine solution; recovering ethylamine and ethanol by the use of the theanine ethylamine solution, followed by pressure reduction, condensation and crystallization, separating and collecting crystals; (3) dissolving the crystals in water, followed by refining and filtering, adding edible alcohol for crystallization, separating and collecting crystals to obtain theanine. High-purity L-theanine and D-theanine can be obtained by the adoption of the synthesis method provided by the invention. The corresponding isomer of the prepared theanine is less than 0.02%. The contents of two structures contained in the obtained high-purity DL-theanine are similar. In addition, the production technology of theanine is simple and short; the whole reaction process is carried out in normal pressure; in comparison with synthesis methods which require pressure, the synthesis method provided by the invention is safer and more environment-friendly to life and environment, is simple in operation, results in high yield, requires low cost, and has no high requirement on equipment.

The invention discloses repairing cream. The cream is prepared by mixing deionized water, glycerin, betaine, 1,3-propanediol, a polyacrylate cross-linked polymer-6, plant squalane, phytosteryl / octyldodecyl lauroyl glutamate, poly(dimethylsiloxane), an Olea europaea fruit unsaponifiable matter, octadecyl 3-hydroxy-11-oxoolean-12-en-29-oate, tocopheryl acetate, natto gum, ectoine, 1,2-pentanediol, fucose, carboxymethyl chitosan, a shaddock fruit extract product, ceramide 3, 3-[2-(ethylhexyl)oxyl]-1,2-propandiol, and other components. Glucocorticoids and antibiotics are not contained, the productcan be used for gradually alleviating and improving symptoms of eczematoid dermatitis excited by glucocorticoid without recurrence, the product can adjust function of macrophage and neurotransmitter,inhibit inactivation of Na+ / K+-ATPase induced by hormone, reverse dryness, tightness, pruritus, papule, redness and other disorder skin problems in a short time, and mitigate pain of patients.

The present invention provides a liquid crystal transdermal absorption promoter and a preparation method thereof, and uses of the liquid crystal transdermal absorption promoter in anti-aging cosmetics, wherein the liquid crystal transdermal absorption promoter comprises, by weight, 1-20 parts of phytosterol / octyldodecyl lauroyl glutamate, 1-20 parts of arachidyl glucoside, 1-30 parts of Isononyl Isononanoate, 1-30 parts of cetearyl alcohol, 1-30 parts of shea butter, 1-50 parts of butanediol, and 50-90 parts of water. According to the present invention, the polypeptide anti-aging cosmetic prepared through the transdermal absorption promoter is the oil-in-water cosmetic, and has characteristics of good stability, good affinity to skin, mild skin feeling, refreshing and no irritation; and the skin clinical trial results show that the composition can effectively promote the transdermal absorption of the active polypeptide in the anti-aging cosmetic, and can promote the active polypeptideto well provide the skin care effects of significantly facial wrinkle reducing, smooth and firm skin restoring and skin gloss and transparency enhancing.

The invention discloses a composition with a skin barrier repair function as well as a preparation method and application thereof. The composition comprises the following raw materials in percentage by mass as follows: 0.1-3% of hydrogenated lecithin, 0.1-5% of phytosterol / octyl dodecyl lauroyl glutamate, 0.1-5% of a artichoke leaf extract, 0.1-5% of a saccharide isomer, 0.1-10% of a ceramide composition, 0.05-5% of polyquaternary ammonium salt-51, 0.05-0.3% of xanthan gum, 0.1-2.0% of a preservative and the balance water. The composition can alleviate various external irritation and harm, canquickly recover the moisture content of inured and dry skin, and has a barrier repair function of repairing skin cuticles. The barrier effect composition and essence thereof show excellent effects ofresisting photoaging, inhibiting loss of epidermis moisture, keeping the content of skin moisture, repairing the skin barrier function, improving the size of skin pores, improving inflammatory skin and repairing injured skin.

The invention discloses polypeptide anti-wrinkle firming eye cream and a preparation process thereof. The polypeptide anti-wrinkle firming eye cream comprises the following components in percentage bymass: a material A, a material B, a material C, a material D and 0-1% of polypeptide, wherein the material A comprises, in percentage by mass, 40-50% of deionized water, 4-8% of butanediol, 3-6% of glycerol, 0-0.1% of p-hydroxyacetophenone, 0-0.5% of sodium polyacrylate and 0-0.5% of EDTA disodium salt; the material B comprises, in percentage by mass, 5-10% of squalane, 2-4% of docosyl alcohol, 2-4% of polyglycerol-3 methyl glucose distearate, 2-4% of polydimethylsiloxane, 1-3% of diisostearyl malate, 1-3% of meadowfoam seed oil, 0-1% of stearic acid, 0-1% of an emulsifier and 0.5%-3.5% of emollient; and the material C comprises, in percentage by mass, 1-3% of phytosterol / behenyl alcohol / octyldecyl lauroyl glutamate, 1-3% of 1,2-pentanediol and 0-1% of a thickening agent. The polypeptideraw material is added into the eye cream, so wrinkles can be effectively removed and resisted, and better wrinkle removing and wrinkle resisting effects are obtained after continuous use of the eye cream.

The invention discloses a dermal composition containing radix Nostoc extract, comprising radix nostoc extract and phytosterol / octyl dodecyl lauryl glutamate. A Chinese medicinal composition contain radix Nostoc extract can replenish skin nutrition, repair skin damage barrier, maintain skin moisture content, improve skin elasticity, improve cheek gloss, make skin look more transparent and vigorous,and improve common problems of sensitive skin such as tension, dryness, itching, peeling and that like. The invention also provides a preparation method of the Nostoc spp. Extract.

The invention provides chloroethyl alcohol functional poly (L-glutamic acid) homopolymer and random copolymer and a preparation method and an application thereof. The synthetic process of the polymer comprises the following steps: by using primary amine as the initiator, synthesizing chloroethyl alcohol functional poly (L-glutamic acid) homopolymer through the ring opening reaction of Gamma-2- chloroethane-L-glutamate-N-carboxyl acid anhydride, and obtaining chloroethyl alcohol functional poly (L-glutamic acid) random copolymer through the ring opening reaction of Gamma-2- chloroethane-L-glutamate-N-carboxyl acid anhydride with Gamma-2- benzyl-L-glutamate-N-carboxyl acid anhydride and the elimination of benzyl alcohol protection. Chloroethyl alcohol functional poly (L-glutamic acid) homopolymer and random copolymer can trigger the polymerization of methacrylate monomer through atom transfer radical polymerization reaction, so as to obtain poly (L-glutamic acid) with a temperature and pH sensitivity. The material synthesized by using the method can be used as the carrier material for controlled release of medicines, gene therapy and tissue engineering.

The present invention relates to the technical field of proteins, in particular to a recombinant fibronectin-human-like collagen anti-aging composition and a preparation method thereof. The composition comprises the following components in parts by weight: 1-5 parts of an emulsifier I, 0.1-1 part of an emulsifier II, 1-3 parts of cetostearyl alcohol, 0.5-2 parts of shea butter, 1-5 parts of simmondsia chinensis seed oil, 1-5 parts of hydrogenated polyisobutene, 1-5 parts of isononyl isononanoate, 1-5 parts of Acticire, 0.1-1 part of phytosterol / octyldodecanol lauroyl glutamate, 0.1-1 part of tocopherol acetate and 0.1-0.5 parts of a recombinant fibronectin-human-like collagen concentrated solution. Fine wrinkles are smoothed by taking a recombinant fibronectin-human-like collagen raw material with the high safety and the good anti-aging effect as a main functional agent, and supplementing various small molecular peptides. Sodium polyglutamate and glucan as the moisturizing components fully moisturize the skin based on the aging resistance to make the skin glossy, exquisite and elastic.

The invention provides an amino acid soap. The amino acid soap is prepared from, by weight, 0.002-0.2 part of benzene azole sulfonate derivatives, 0.002-0.2 part of tri(tetramethyl hydroxyperidiol)citrate, 30-60 parts of N-acylamino acid, 15-30 parts of arginine, 3-10 parts of triethanolamine, 2-20 parts of strong base, 10-30 parts of moisturizing agent and 0.2-10 parts of skin modifier. The N-acylamino acid is selected from one or more of lauroyl glutamate, coconut oil acyl glutamate, tetradecanoyl glutamate, stearoyl glutamate, palmitoyl glutamate and cocamidopropyl propionic acid. According to the amino acid soap, the specific benzene azole sulfonate derivatives and tri(tetramethyl hydroxyperidiol)citrate are selected and added in the amino acid soap and have synergetic effects, so that the amino acid soap can more effectively resist discoloration caused by ultraviolet radiation, oxidation and other factors.

The invention provides a moisturizing cosmetic. The moisturizing cosmetic is prepared from 2% to 13% of phytosteryl isostearate, 1% to 10% of phytosterol / octyldodecanol lauroyl glutamate, 2% to 3% of sorbitan monostearate, 6% to 15% of hydrogenated lecithin, 10% to 20% of evening primrose seed oil, 3% to 6% of salvia officinalis, 40% to 75% of squalane and the balance natural dew. By means of the moisturizing cosmetic, water of skin cells can be supplemented, the skin becomes soft, fine, smooth, moist and limber accordingly, internal heat can be further removed, and the moisturizing cosmetic is resistant to bacteria to a certain degree.

The invention relates to a foaming agent, specifically to an ether alcohol composite foaming agent. The ether alcohol composite foaming agent comprises the following preparation raw materials in percentages by weight: 5 to 20% of an ether alcohol surfactant, 1 to 8% of an amino acid surfactant, 0.1 to 1% of a reinforcing agent, 0.01 to 1% of a stabilizing agent and 70 to 93.89% of water, wherein the ether alcohol surfactant is one or more selected from the group consisting of n-alcohol ethoxylate and iso-alcohol ethoxylate; the amino acid surfactant is one or more selected from the group consisting of lauroyl glutamate, cocoyl alaninate, myristic glutamate, cocoyl glycinate and cocoyl alaninate; the reinforcing agent is one or more selected from the group consisting of lauryl sulfate, dodecyl benzene sulfonate and dodecyl sulfonate; and the stabilizing agent is one or more selected from the group consisting of polyacrylamide, gelatin, hydroxypropyl methyl cellulose and xanthan gum.

Poly(α-amino acid) which contain: (A) a glutamic acid γ-ester unit represented by formula (I): and (B) one or more kinds of units selected from a glutamic acid γ-ester unit represented by formula (II), an alanine unit, a phenylalanine unit and an Nε-benzyloxycarbonyllysine unit, represented by formula (III), and a glutamic acid γ-ester unit represented by formula (IV) can be dissolved in various solvents and are useful for preparing piezoelectric elements which exhibit superior piezoelectricity.

The invention discloses a long-lasting moisturizing lipstick and a preparation method thereof. The long-lasting moisturizing lipstick is prepared from bis-diglycerol polyacyladipate-2, cetyl ethyl hexanoate, tridecyl trimellitate, diisostearyl malate, polymethyl methacrylate, ozocerite, polyethylene, ethylhexyl palmitate, microcrystalline wax, hydrogenated castor oil dipolylinoleate, stearyl polydimethylsiloxane, an antioxidant, phytosterol / octyldodecanol lauroyl glutamate, jojoba seed oil, meadowfoam seed oil, a preservative, a moisturizing conditioner, a dispersing agent, a coloring agent and the like. The long-lasting moisturizing lipstick provided by the invention not only can endow the lip skin with natural color, but also has the advantage of difficulty in makeup removal; through thesynergistic effect of the raw materials, the lipstick has the effects of moistening and moisturizing; the lipstick is easy to spread and make up, and the makeup effect is uniform; and in addition, the preparation process is simple, and industrial production is easy.

The invention relates to a di-glutamate derivative and a preparation method and application in the preparation of pemetrexed thereof. The glutamate derivative is used as a key intermediate for preparing pemetrexed. The method has simple treatment after reaction and high product purity, and facilitates the industrialized production.