474 results about "Lesion site" patented technology

A stent graft for deploying a stent graft at a lesion site is provided. The stent graft comprises a tubular graft and a support stent, at least a portion of which lies within the tubular graft. The graft has a proximal end and a distal end. The support stent has a proximal end and a distal end, and comprises at least one wire forming a first helical wire portion having a first translational direction about an axis of the support stent and a second helical wire portion having a second translational direction about the axis opposite the first translational direction. When the support stent is in a compressed delivery configuration, the support stent has a first length, and when the support stent is in an expanded deployed configuration, the support stent has a second length which is less than the first length. When in the delivery configuration, the support stent is attached to the graft only at or near the proximal end of the graft.

A delivery system for deploying a stent graft at a lesion site is provided. The delivery system comprises a wire lumen and a support stent slidably positioned about the wire lumen. The support stent is expandable from a compressed delivery configuration to an expanded configuration. An inner sheath is retractably positioned about the support stent with the support stent in the delivery configuration. An anchor stent is slidably positioned about the inner sheath. A tubular graft proximal end is coupled to the anchor stent and deployable with the anchor stent from a compressed delivery configuration to a deployed configuration. An outer sheath is retractably positioned about the anchor stent and the graft in the compressed delivery configuration.

A bifurcated or straight intravascular folded tubular member is deliverable percutaneously or by small cutdown to the site of a vascular lesion. Its inserted state has a smaller nondeployed diameter and a shorter nondeployed length. The intravascular tubular member has a folded tubular section that is unfolded following insertion into the blood vessel. The length of the intravascular folded tubular member is sized in situ to the length of the vessel lesion without error associated with diagnostic estimation of lesion length. The folded tubular member is self-expandable or balloon-expandable to a larger deployed diameter following delivery to the lesion site. An attachment anchor can be positioned at the inlet or outlet ends of the intravascular folded tubular member to prevent leakage between the tubular member and the native vessel lumen and to prevent migration of the tubular member. The attachment anchor has a short axial length to provide a more focal line of attachment to the vessel wall. Such attachment is valuable in attaching to a short aortic neck in the treatment of abdominal aortic aneurysm. The attachment anchor can have barbs which are held in a protected conformation during insertion of the tubular member and are released upon deployment of the attachment anchor. The intravascular tubular member can be formed of woven multifilament polymeric strands with metallic strands interwoven along with them. Double weaving is incorporated to prevent leakage at crossover points.

A thin-walled sheath is placed over a balloon having an antirestenotic drug placed on the balloon of a balloon dilatation catheter. The sheath protects the drug from dissolution into the blood and allows improved delivery to the lesion site. A rolling action of the sheath prevents the drug from loss due to shearing motion. The sheath can also provide a protected surface for carrying the drug and providing exposure to the lesion site for delivery of the drug. The sheath can also serve as a delivery sheath for providing delivery of a stent via a single catheter introduction for drug delivery and stent delivery.

The present invention provides wound dressings, optionally surgically implantable, containing biodegradable, polymers and hydrogels having allogenic or autologous precursor cells, such as stem cells and progenitor cells dispersed within. Alternatively, the wound dressings can have conditioned medium obtained from the precursor cells dispersed within. The wound dressings promote tissue restoration processes at a site of application or implantation. Additional bioactive agents can also be dispersed within the polymer / hydrogel matrix, which can be formulated to biodegrade at a controlled rate by adjusting the composition. Methods are also provided for using such biodegradable wound dressings as a delivery device or carrier for the precursor cells, conditioned medium and bioactive agents, or as coatings on implantable medical devices, to promote tissue restoration at a lesion site.

In a disease case DB, disease case images are classified by disorder and registered. In a feature quantity DB, a feature quantity (second feature quantity) of each disease case image classified by disorder is registered. A server compares a feature quantity (first feature quantity) of a lesion site included in a diagnosis target image, with the second feature quantity on a disorder-by-disorder basis, retrieves representative disease case images based on a comparison result from the disease case DB on a disorder-by-disorder basis, and provides a user with retrieved representative disease case images. Therefore, the user can obtain disease case images useful for determining a disorder or statistical information and the like regarding the disorder during image diagnosis based on the diagnosis target image.

A system for treating a lesion site of a patient is disclosed. The system includes a cannula having a lumen, a conduit in communication with said lumen, an introducer stylet removably disposed within said cannula, a resecting device selectively insertable within said cannula, and an adjuvant treatment device selectively insertable within said cannula.

The invention relates an amphiphilic polysaccharide-anti-tumor medicament conjugate capable of releasing medicines specifically at a lesion site of a living body, as well as a preparation method and application of a medicinal composition of the amphiphilic polysaccharide-anti-tumor medicament conjugate. In the conjugates, hydrophobic anti-tumor medicaments are introduced into a polysaccharide skeleton through a connecting arm which contains a disulfide bond, so that the polysaccharide-anti-tumor medicament conjugate has amphipathic characteristics and can be self-assembled into nano-micelles; the nano-micelles can load anti-tumor medicaments additionally and also can be directly used as conjugate pre-drug micelles. The amphiphilic polysaccharide-anti-tumor medicament conjugate is mainly characterized in that 1) after the nano-micelles reach the lesion site, the disulfide bond connecting arm of the conjugate can be specifically degraded by high-concentration reducing substances in lesion cells, so that the micelles are depolymerized and the medicament is released quickly, and therefore, the treatment effect is improved; 2) the anti-tumor medicament is chemically conjugated and physically coated to achieve a common treatment effect. The polysaccharide conjugate and the medicinal composition thereof can be used for injection, oral administration or external use administration; the anti-tumor activity can be improved remarkably; new ideas are provided for the development of anti-tumor medicaments.

A method for treating a lesion of an animal, the animal having at least one vessel that carries blood to the lesion, comprising locating the vessel, administering a composition comprising a photodynamic agent, applying energy to the vessel to photocoagulate the vessel and thereby reduce the rate at which the treatment composition exits said lesion and applying energy to said lesion, of a type and an amount sufficient to excite the photodynamic agent, causing the lesion to undergo photodynamic therapy. Preferably, a dye that is both a fluorescent dye and a radiation absorbing dye, such as indocyanine green dye, is added to the treatment composition to allow (a) confirmation of the presence of the treatment composition in the lesion to be detected by fluorescent angiography and (b) the rate of blow flow to be reduced in the blood vessel feeding the lesion using dye enhanced photocoagulation.

The invention discloses an image omics based lesion tissue auxiliary prognosis system and method. The method comprises the steps of extracting image data of lesion parts with an automatic or manual segmentation method from a big-data-volume patient image database; according to segmentation results of lesion part images, extracting image phenotypic characteristics of each lesion part, and finishing feature extraction of image data of all lesion parts in the patient image database; and based on characteristic data and clinical information data of each lesion part, performing training data set and test data set classification on the data in the patient image database, performing pathologic analysis, clinical stage analysis, gene mutation prediction and survival time prediction of the lesion parts in the training data set with a computer automatic identification method, and performing verification in the test data set. The method is capable of performing qualitative and quantitative prediction analysis on a specific individual and providing credible prediction and analysis results.

The invention discloses a colposcopy image-based cervical cancer detection method, device and terminal equipment and a computer readable storage medium. The method comprises the following steps of: ina bidirectional convolutional neural network-based cervical cancer detection model, positioning and extracting a cervical opening position of an obtained colposcopy image so as to generate an ROI image comprising a cervical cancer disease area; extracting a cutting edge of the ROI image through a bidirectional convolutional neural network so as to generate a cut image; and carrying out cancer grade classification on the cut image through a classification convolutional neural network so as to output a cervical cancer lesion grade and then rapidly and correctly obtain a cervical cancer detection result. According to the method, doctors that are lack of experiences can be helped to rapidly judge diseased regions, discover atypical diseased regions and judge the disease degrees and sampling regions, so that help and auxo-action are provided for discovering cervical cancer and precancerous lesions.

A system for treating a lesion site of a patient is disclosed. The system includes a cannula having a lumen, a conduit in communication with said lumen, an introducer stylet removably disposed within said cannula, a resecting device selectively insertable within said cannula, and an adjuvant treatment device selectively insertable within said cannula.

The present invention provides methods and compositions for sequentially and separately reducing infection and / or inflammation and regenerating tissue at a lesion site, by contacting the lesion site with a biodegradable scaffold that first delivers one or more agents at the lesion site to reduce infection and / or inflammation and then delivers one or more agents to regenerate tissue at the lesion site after inflammation is reduced.

The invention discloses a magnetic resonance imaging nanometer drug carrier, and a nanometer drug loading system and a preparation method thereof. The magnetic resonance imaging nanometer drug carrieris a triblock polymer nanoparticle, wherein the triblock polymer is PLGA-PEI-PEG, and has active groups on the surface, and the active groups comprise amino, hydroxyl and carboxyl. According to the present invention, the drug carrier can efficiently load a nuclear magnetic resonance imaging drug and an antitumor drug to make the antitumor drug specifically reach the tumor lesion site, such that the nuclear magnetic resonance positioning of the superparamagnetic ferroferric oxide nanoparticle at the tumor region can be achieved while the high-selectivity and low-toxicity treatment effect can be achieved, and the disadvantages of poor selectivity, strong toxic-side effect, easy drug-resistance generation and the like of the traditional cytotoxic drugs can be overcome; and the preparation method is simple and is easy to perform, the prepared triblock polymer nanoparticle can be stably stored in the aqueous solution so as to be easily stored, and various functional groups exist on the surface of the particle, such that the prepared triblock polymer nanoparticle can be easily subjected to surface modification or surface functionalization.

A multiple imaging system for precisely determining the position of lesion in human body is composed of the first imaging system, the second imaging system, a guide track, a bed body and its base, the bed board, and a regulation mechanism consisting of another guide track, regulatable base, auxiliary supporter, and displacement sensor.

The present invention provides methods for making, delivering and using formulations that combine a therapeutically active agent(s) (such as for example a Rho antagonist(s)) and a flowable carrier component capable of forming a therapeutically acceptable matrix in vivo (such as for example tissue adhesives), to injured nerves to promote repair and regeneration and regrowth of injured (mammalian) neuronal cells, e.g. for facilitating axon growth at a desired lesion site. Preferred active agents are known Rho antagonists such as for example C3, chimeric C3 proteins, etc. or substances selected from among known trans-4-amino(alkyl)-1-pyridylcarbamoylcyclohexane compounds or Rho kinase inhibitors. The system for example may deliver an antagonist(s) in a tissue adhesive such as, for example, a fibrin glue or a collagen gel to create a delivery matrix in situ. A kit and methods of stimulating neuronal regeneration are also included.

A blood vessel embolization method includes inserting a balloon catheter into a blood vessel of a human or an animal having a lesion site and disposing a balloon of the balloon catheter at a portion located at a proximal side of the blood vessel and in a neighborhood of the lesion site thereof; shutting off a blood flow in the blood vessel by expanding the balloon; discharging a glucose solution from a distal end of the balloon catheter in a state in which the blood flow in the blood vessel is shut off; discharging a cyanoacrylate-based embolization substance-containing liquid from the distal end of the balloon catheter after the glucose solution injection step; hardening an embolization substance by maintaining a blood flow shut-off state of the blood vessel after the embolization substance injection step; and removing the balloon catheter from the blood vessel after the embolization substance-hardening step.

The invention relates to a Chinese medicinal composition and a preparation process thereof, in particular to a method for preparing medicinal composition capsules for treating dysmenorrheal and a preparation process. The medicinal composition capsules are prepared from the following medicinal ingredients: prepared rehmannia root, Chinese angelica, Szechuan lovage rhizome, white paeony root, largehead atractylodes rhizome, Indian buead, honey-fried liquoric root, red paeony root, peach seed, safflower, yanhusuo, trogopterus dung, combined spicebush root, nutgrass galingale rhizome, tree peony bark, bupleurum, bitter orange, tangerine peel, zedoary, dragon's blood, prepared tuber of multiflower knotweed, medcinal evodia fruit, pinellia tuber and dried ginger through compatibility; and the preparation method comprises the following steps of: drying all medicines at low temperature, mixing, crushing, stirring medicinal powder uniformly, putting into a capsule filler, and filling according to the filling capacity of each capsule of between 0.6 and 0.8 gram. The medicinal composition capsules are a pure Chinese medicinal formula and prevent the harm of western medicine to human bodies, and the medicines can reach the lesion site of infection directly; and clinical application is safe, but pregnant women and patients who do not suffer from qi depression to blood stasis are forbidden, and patients who suffer from discomfort in gastrointestinal excess-heat should be used with caution.

The invention discloses a double-frequency focused ultrasound system. The double-frequency focused ultrasound system comprises an ultrasound transducer component which is provided with a first ultrasound transducer and a second ultrasound transducer, a first power amplifier which is connected with the first ultrasound transducer, a first signal generator which is connected with the first power amplifier, a second power amplifier which is connected with the second ultrasound transducer, a second signal generator which is connected with the second power amplifier, a plurality of signal receiving devices which are contacted with human skin, and a signal analysis device which is connected with a plurality of signal receiving devices, wherein the first ultrasound transducer and the second ultrasound transducer are confocal. By using the principle that the beat frequency is produced by the difference frequency interference, low-frequency vibration with a good mechanical effect is generated in a target area by utilizing two high-frequency sound waves with high space directivity, the mechanical stimulation of tissues and organs is realized, the mechanical stimulation and the tissue ablation are combined through double-frequency focused ultrasound, so that the diagnosis and treatment of lesion sites through the mechanical stimulation are realized.

The invention relates to an externally-applied traditional Chinese medicine for treating arthritis, which comprises the following components in part by weight: 1 to 3 parts of common monkshood mother root, 1 to 3 parts of kusnezoff monkshood root, 4 to 8 parts of angelica dahurica, 4 to 6 parts of incised notopterygium rhizome, 3 to 7 parts of pubescent angelica root, 1 to 3 parts of manchurian wildginger, 2 to 4 parts of szechuan lovage rhizome, 2 to 4 parts of cassia twig, 0.5 to 0.9 part of clematis root, 0.4 to 0.8 part of common clubmoss herb and 0.3 to 0.7 part of garden balsam stem. A preparation method comprises the following steps of: mixing the components according to the ratio, decocting in water, filtering dregs of decoction and extracting solution for three times, and mixing the obtained liquid medicine for three times uniformly for later use. Before each time of use, the externally-applied traditional Chinese medicine is heated, and after being fumed by the heated externally-applied traditional Chinese medicine, painful joints are immersed and washed for at least twice in a day. The externally-applied traditional Chinese medicine has wide raw material sources and scientific and reasonable formula, can act on a lesion site directly, can be widely used for treating rheumatic arthritis, osteoarthritis and rheumatoid arthritis, and has the characteristics of simple using method, no toxic or side effect and obvious effect.

The invention relates to a multifunctional balloon dilatation catheter. The multifunctional balloon dilatation catheter comprises an inner catheter body, an outer catheter and a dilatation balloon, wherein a wire guide channel is formed in the inner catheter body, the outer catheter body and the inner catheter body are coaxially arranged, and the dilatation balloon is fixed to the outer catheter body. The multifunctional balloon dilatation catheter further comprises plugging balloons fixed to the outer catheter body, the plugging balloons and the dilatation balloon are arranged at intervals, a low-pressure transmitting channel, a high-pressure transmitting channel and a sucking channel are formed between the outer catheter body and the inner catheter body in the radial direction, and the outlet ends of the low-pressure transmitting channel, the high-pressure transmitting channel, the sucking channel and the wire guide channel are provided with Ruhr connectors respectively. By means of the multifunctional balloon dilatation catheter, small plaque falling from a lesion site is trapped in closed space formed by the plugging balloons, the dilatation balloon and the blood vessel wall and pumped away in time while balloon dilatation is carried out in a PCI operation; in the operation process, balloon dilatation and thrombus aspiration are completed at a time under the condition that devices are not needed to be replaced, the number of times of medical instrument exchange in the body of a patient is decreased, and therefore complications caused by blood injures of the patient are reduced.

The invention discloses a device and a method for testing the flowing property of a blood flow at a lesion site where a blood vessel stent is implanted, which are used for testing the influences of the stent on the blood flow after the stent is implanted into a blood vessel. The method mainly comprises the measurement of wall shearing stress and the observation of fluid disturbance, wherein the wall shearing stress is measured by an electrochemical process, and the disturbance of the fluid is observed by using a camera. The device comprises a water tank and a peristaltic pump, wherein the outlet of the peristaltic pump passes through a buffer tank, a one-way regulating valve, a flow meter, a pressure transmitter and a test section in turn, the outlet of the test section is connected with the inlet of the water tank by a pipe and thus, a closed circulating system is formed. A light source is arranged on one side of the test section, and a camera which is connected with a computer is arranged on the other side of the test section. The pressure of the circulating system can be regulated by a pressurizing device connected with the water tank, the flow in the test section is regulated by the one-way regulating valve and the peristaltic pump, and the flow pressure transmitter and the flow meter are connected with the computer respectively.

The invention belongs to the fields of image processing and pattern recognition, and relates to a simulated surgery planning method based on medical images. The method comprises the following steps: a changeable curve is generated in the three-dimensional space; a plurality of operation points are arranged on the curve; the curve is controlled and adjusted by the operation points; additional operation points can be arranged on the curve, or the operation points on the curve can be reduced; and according to the planned curve, the cutting angle of a scalpel is calculated, and the scalpel is arranged reasonably, so that cutting processes in future operations can be facilitated. Compared with the prior medical image processing system, the invention creatively introduces a simulated surgery planning system which performs virtual surgery path planning to lesion sites on the basis of three-dimensional CT imaging, so that the invention is of critical importance and use value to being proficient at operative procedures and reducing operative risks.

Systems, catheter and methods for treating Atrial Fibrillation (AF) are provided, which are configured to illuminate a heart tissue having a lesion site; obtain a mitochondrial nicotinamide adenine dinucleotide hydrogen (NADH) fluorescence intensity from the illuminated heart tissue along a first line across the lesion site; create a 2-dimensional (2D) map of the depth of the lesion site along the first line based on the NADH fluorescence intensity; and determine a depth of the lesion site at a selected point along the first line from the 2D map, wherein a lower NADH fluorescence intensity corresponds to a greater depth in the lesion site and a higher NADH fluorescence intensity corresponds to an unablated tissue. The process may be repeated to create a 3 dimensional map of the depth of the lesion.

The present invention provides a tumor-targeted nuclear magnetic resonance / fluorescence dual-mode imaging contrast agent, preparation and applications thereof. According to the present invention, the contrast agent is nanometer micro-particles formed by self-assembling a nuclear magnetic resonance amphiphilic molecule, a near-infrared fluorescent dye amphiphilic molecule and a tumor targeting amphiphilic molecule in a solution, can stably exists under a physiological pH value condition, can be specifically accumulated at a tumor site in a targeting manner, can significantly enhance the intensity of the MRI signal and the near-infrared fluorescence signal at a tumor lesion site, can improve the specificity and the sensitivity of nuclear magnetic resonance imaging and near infrared fluorescence imaging scanning, and is expected to be adopted as the contrast agent for fluorescence guidance during tumor resection surgeries and postoperative nuclear magnetic resonance monitoring.

The invention relates to a construction method of a stomach cancer image recognition model based on artificial intelligence. The image recognition model can accurately recognize a lesion site in a stomach cancer image.

Provided is a surgical system for NOTES by which surgical invasion can be reduced. A surgical system for NOTES comprising a circular anastomosis device (1) wherein an anvil part (3) attached to a guide electrical wire (100) is connected to a main body (2) to be inserted into body tract and then inserted into a body tract (T) from a natural orifice (Ma) and, after cutting off a lesion site (T3) inthe body tract with a pair of linear cutters (558, 559) of a linear cutter / stapler (500) having been inserted from a body cavity (Mb), the cut ends are anastomosed together for the repair.

The present application provides a method and an apparatus for segmenting a three-dimensional medical image. The method comprises: acquiring an original three-dimensional medical image of a lesion site; from the original three-dimensional medical image, selecting a region of interest so as to construct a mesh model of the region of interest; calculating distance field information and a shape index feature of the mesh model; segmenting the mesh model according to the distance field information; calculating a mixture cost value of each point in a segmented mesh model according to the distance field information, the shape index feature and a gray cost statistical value of each point; determining a segmentation path according to the mixture cost value of each point; and segmenting target tissue from the region of interest according to the segmentation path. With adoption of the method for segmenting a three-dimensional medical image provided by the present disclosure, diseased tissue in the original three-dimensional medical image can be accurately positioned and segmented, thereby improving the accuracy of three-dimensional medical image segmentation.

The invention discloses a monolayer molybdenum disulfide-cobalt ferrite nanocomposite material and a preparation method and application thereof, and particularly relates to the field of novel nanocomposite materials. The monolayer molybdenum disulfide-cobalt ferrite nanocomposite material consists of molybdenum disulfide nanonanosheets and cobalt ferrite nanoparticles, wherein the surfaces of the molybdenum disulfide nanonanosheets are uniformly modified by the cobalt ferrite nanoparticles; the molybdenum disulfide nanonanosheets adopt layered stripping structures. The cobalt ferrite nanoparticles are assembled on the surfaces of the molybdenum disulfide nanonanosheets through a reaction in which amino groups and carboxyl groups form amide bonds; the preparation method has the advantages of low energy consumption, low cost and high yield; the obtained composite material can be used as a magnetic resonance imaging contrast agent and a controllable medicine carrier at the same time; under the guidance of a magnetic field, a medicine can reach and be enriched on a lesion site so as to achieve intelligent medicine release and real-time therapeutic effect assessment under the guidance of magnetic resonance imaging; through change of the relative contents of molybdenum disulfide and cobalt ferrite in the composite material, controllable adjustment of the magnetic resonance imaging effect and the medicine loading capacity can be achieved.