34 results about "Octyl cyanoacrylate" patented technology

A medical adhesive for adhering skin and hemostasis of viscera is prepared from at least two organic compounds chosen from alpha-ethyl cyanoacrylate, alpha-ethoxyethyl cyanoacrylate, alpha-butyl cyanoacrylate and alpha-octyl cyanoacrylate through proportional mixing.

The invention discloses a medical adhesive and a preparation method thereof. The medical adhesive comprises the following raw materials in parts by weight: 80-90 parts of alpha-cyanoacrylate, 5.5-10 parts of plasticizer, 4-8 parts of tackifier, 0.5-2 parts of stabilizer and 0.05-0.1 part of polymerization inhibitor, wherein the plasticizer is prepared by mixing dibutyl phthalate and dioctyl phthalate in a ratio of parts by weight of (20-30):(70-80), the tackifier is polymethyl methacrylate, the stabilizer is p-toluenesulfonic acid, and the polymerization inhibitor is hydroquinone. The medical adhesive provided by the invention has the advantages that the medical adhesive is convenient to use, is quickly cured, has high bonding strength, low heat release during bonding and low skin irritation, does not have toxic or side effects on human bodies and avoids whitening.

The present invention relates to a cyanoacrylate-based bio-adhesive composition, and aims to provide a cyanoacrylate-based bio-adhesive composition having an excellent biodegradability and anti-bacterial effect. The present invention provides a cyanoacrylate-based bio-adhesive composition having an enhanced biodegradability by using, as a thickening agent, poly octyl cyanoacrylate generated as a byproduct when preparing octyl cyanoacrylate, and having an excellent anti-bacterial effect by using 3,5-diiodo-4-pyridone-1-acetic acid as an anion stabilizer.

Cyanoacrylate adhesive compositions comprise a mixture of two cyanoacrylate monomers, including 2-octyl cyanoacrylate and n-butyl cyanoacrylate. The monomers are stabilized and sterilized by irradiation, and do not substantially increase in viscosity after sterilization or after two years of shelf storage. These compositions have anti-microbial properties, and may be used to close wounds as well as secure catheters inserted into the body in place.

The invention belongs to the technical field of manufacturing of an animal specimen and discloses a manufacturing method for fish, bird, mammalia and skeleton specimen. The method mainly comprises the steps of manufacturing specimen precursor, filling prosthesis, solidifying and forming, and sealing externally; utilizing alpha-octyl 2-cyanoacrylate or / and alpha-n-butyl cyanoacrylate matching prosthesis to form the specimen precursor; and utilizing alpha-octyl 2-cyanoacrylate or / and alpha-n-butyl cyanoacrylate to solidify, form and externally seal the specimen precursor after being formed. According to the technical scheme provided by the invention, the difficulty in preparing the animal specimen is reduced, the manufacturing cost of the specimen is also reduced, and meanwhile, the quality and storage effect of the specimen are increased on the basis of ensuring the manufacturing health of the specimen. The technical scheme provided by the invention has commercial popularizing value and significance.

The invention provides a quick-acting hemostatic yarn for promoting wound healing and a preparation method and application thereof. The quick-acting hemostatic yarn is prepared from the following components by weight: 35-60 parts of sodium carboxymethyl cellulose, 30-50 parts of polyurethane elastomer, 5-20 parts of alpha-N-octyl cyanoacrylate, 10-30 parts of chitosan, 10-20 parts of methyl p-hydroxybenzoate, 15-25 parts of propyl p-hydroxybenzoate and 5-10 parts of xanthan gum. The chitosan is a mixture of lauroyl sulfuric acid deacetylated chitosan and carboxymethyl chitosan. The quick-acting hemostatic yarn has better hemostatic effect and bacteriostasis rate, can further provide a suitable moist recovery environment for wounds, and has no allergic reaction to skin.

The invention relates to an acid-soluble pressure-bearing plugging agent for drilling fluid and a preparation method. The acid-soluble pressure-bearing plugging agent contains a friction material, a bridging material, a filler material, iron tailing sand, volcanic ash powder, woody activated carbon powder, nano calcium-zinc phosphate, paraffin, polyalcohol fatty acid ester, titanium white, red clay, alginic acid, dimethyl diallyl ammonium chloride, polyvinyl acetate, glyceryl monostearate, a glued stone cementing material, copper oxide, Dibenzyl disulfide, alpha-n-octyl-cyanoacrylate, sodium caseinate, steel slag, white carbon black, dolomite powder, manganese dioxide, diatomite, dibutyl phthalate, polyvinyl alcohol, tert-butylhydroquinone, phthalic anhydride and H2O. According to the acid-soluble pressure-bearing plugging agent for the drilling fluid and the preparation method, by using the preparation method, the defects in the prior art that on-site operating methods are tedious, operating requirements are strict, plugging performance is often poor due to invasion of surrounding solid-state particulate matters, a plugging framework is damaged, and a motor shaft or rotating shaft is subjected to expanding and contracting under the action of stress of the shaft during rotating due to infirm connection are avoided.

The invention belongs to the technical field of biomedical materials, particularly relates to a medical adhesive material capable of rapidly stopping bleeding, and further discloses a preparation method of the medical adhesive material. According to the medical adhesive material disclosed by the invention, alpha-n-butyl cyanoacrylate and alpha-n-octyl cyanoacrylate are used as a mixed medical adhesive matrix, and a hemostatic material namely carboxymethyl chitosan is swelled and modified in a manner that CO2 supercritical fluid carries selected ionic liquid, so that the bleeding stopping performance of the carboxymethyl chitosan is effectively improved, the bleeding stopping performance of the whole medical adhesive material is greatly improved, and rapid bleeding stopping is achieved.

A polymer conetwork formed from the polymerization reaction of octyl-cyanoacrylate and a tri-telechelic star polymer comprising polyisobutylene terminated with cyanoacrylate groups (Ø(PIB-CA)3), wherein the ratio of octyl cyanoacrylate to Ø(PIB-CA)3 is from about 10:1 to about 40:1.

The disclosure relates to a suture manufactured using poly octyl cyanoacrylate, and a method for manufacturing same. The disclosure provides a method for manufacturing a suture, and a suture prepared using the method, the method comprising: a step for preparing octyl cyanoacetate by reacting cyanoacetic acid and octane alcohol by 1:1 equivalence ratio under the existence of a solvent; a step for reacting the octyl cyanoacetate and paraformaldehyde by 1:1 equivalence ratio under the existence of a solvent; a step for isolating and refining octyl cyanoacrylate after removing the solvent when the reaction is completed; a step for collecting poly octyl cyanoacrylate from the byproduct left from refining octyl cyanoacrylate; and a step for manufacturing a suture by a braid process after manufacturing a thread by melt spinning and extrusion molding the collected poly octyl cyanoacrylate.

The invention discloses a wood modifier which comprises the following substances in part by weight: 26 parts of sodium carboxymethylcellulose, 3 parts of Arabic gum, 4 parts of octyl-2-cyanoacrylate, 37 parts of ethanol, 1 part of an ammonium polyphosphate-zinc borate composite flame retardant, 0.2 part of citric acid, 19 parts of water, 0.07 part of benzoic acid, 13 parts of polylactic-co-glycolic acid, and 0.03 part of benzalkonium chloride, wherein the pH value of sodium carboxymethylcellulose is 4.5; ammonium polyphosphate is twice of zinc borate in weight, the degree of polymerization of ammonium polyphosphate is 23-25, the phosphorus content of ammonium polyphosphate is 30%, and the nitrogen content of ammonium polyphosphate is 16%; and the molecular weight of polylactic-co-glycolic acid is 6,000-8,000. The wood modifier, prepared according to the preparation method, is high in wood dimensional stability, high in decay resistance and low in water absorption swelling rate.

A nail glue composition contains Beta-methoxyethyl cyanoacrylate, octyl cyanoacrylate, and polymethyl methacrylate. The nail glue composition is substantially odorless and has increased softness.

The invention relates to a preparation method of a medical adhesive with high antibacterial performance. The method is characterized by comprising the following steps: step one, adding sodium alginate, lignin, tannic acid and a stabilizer into sterile water according to parts by weight, heating to 100 DEG C, stirring and dissolving for 150 minutes, and cooling to room temperature to obtain an aqueous solution A; step two, adding poly(alpha-isobutylcyanoacrylate-alpha-octylcyanoacrylate), polyurethane and polyisoprene into seabuckthorn seed oil according to parts by weight, heating to 80 DEG C,stirring for 75 minutes, and cooling to room temperature to obtain a seabuckthorn seed oil solution B; step three, uniformly mixing the aqueous solution A with the seabuckthorn seed oil solution B, adding highly-effective antimicrobial components and a formaldehyde inhibitor according to parts by weight, and stirring for 4 hours; and step four, filtering, sterilizing, split charging, sealing andpackaging the product obtained in the step three to obtain the medical adhesive with high antibacterial performance.

The invention discloses a medical adhesive and a preparation method thereof. The medical adhesive comprises the following raw materials in parts by weight: 80-90 parts of alpha-cyanoacrylate, 5.5-10 parts of plasticizer, 4-8 parts of tackifier, 0.5-2 parts of stabilizer and 0.05-0.1 part of polymerization inhibitor, wherein the plasticizer is prepared by mixing dibutyl phthalate and dioctyl phthalate in a ratio of parts by weight of (20-30):(70-80), the tackifier is polymethyl methacrylate, the stabilizer is p-toluenesulfonic acid, and the polymerization inhibitor is hydroquinone. The medical adhesive provided by the invention has the advantages that the medical adhesive is convenient to use, is quickly cured, has high bonding strength, low heat release during bonding and low skin irritation, does not have toxic or side effects on human bodies and avoids whitening.

The invention relates to a medical sealing adhesive as well as a preparation method and application thereof. The medical sealing adhesive is prepared from an alpha-octyl cyanoacrylate monomer and a thickening agent, wherein the thickening agent is an alpha-octyl cyanoacrylate polymer. The preparation method comprises the following steps: carrying out ultraviolet irradiation crosslinking on an alpha-octyl cyanoacrylate monomer to obtain an alpha-octyl cyanoacrylate polymer; carrying out ball milling on an alpha-octyl cyanoacrylate polymer; and packaging the alpha-octyl cyanoacrylate polymer andan alpha-octyl cyanoacrylate monomer in a container protected by inert gas, and carrying out moist heat sterilization to obtain the medical sealing adhesive finished product. The medical sealing adhesive can be used as an ocular surface sealing adhesive or a fundus sealing adhesive.

The invention provides a self-lubricating ultrasonic sound conducting pad and a preparation method thereof. The preparation method of the self-lubricating ultrasonic sound conducting pad comprises the following steps: coating a first surface of a viscous hydrogel layer with an adhesive; an adhesive is smeared on the second surface of the smooth hydrogel layer; bonding the first surface of the viscous hydrogel layer coated with the adhesive with the second surface of the slippery hydrogel layer coated with the adhesive to obtain the self-lubricating ultrasonic sound guide pad; wherein the adhesive comprises an adhesive and a dispersion, the adhesive comprises any one or a combination of more of polyurethane, 2-ethylhexyl acrylate, methyl cyanoacrylate, octyl cyanoacrylate or ethyl cyanoacrylate, and the dispersion comprises an alkene alkane organic matter.

The invention belongs to the technical field of biomedical materials, in particular to an anti-inflammatory medical glue material for rapid hemostasis, and further discloses a preparation method thereof. The medical adhesive material of the present invention uses α-n-butyl cyanoacrylate and α-n-octyl cyanoacrylate as a mixed medical adhesive matrix, and is mixed with CO 2 The supercritical fluid carries selected ionic liquids and anti-inflammatory active ingredients to swell and modify the hemostatic material carboxymethyl chitosan, which not only effectively improves the hemostatic performance of carboxymethyl chitosan, but also makes the whole medical adhesive material hemostatic The performance is greatly improved, and rapid hemostasis is realized, and the medical glue has better antibacterial performance, and can be applied to more clinical occasions.

The biological antibacterial film-forming liquid medical dressing comprises a film-forming material, a bactericide and an organic solvent, the liquid medical dressing further comprises dopamine-graphene oxide. The film-forming material is selected from a combination of nitrocellulose and alpha-cyanoacrylate octyl ester. In addition, the invention further discloses a preparation method of the biological antibacterial film-forming liquid medical dressing. Compared with the prior art, the biological antibacterial film-forming liquid medical dressing is better in air permeability and better in antibacterial property.

The invention discloses a preparation method of a medical adhesive with efficient anti-inflammation and bleeding-stopping functions. The medical adhesive is characterized by containing the following components in parts by weight: 20-25 parts of alpha-octyl cyanoacrylate, 25-35 parts of alpha-isoctyl cyanoacrylate, 2-6 parts of polyvinyl acetate, 12-20 parts of an efficient anti-inflammation component, 13-23 parts of an efficient bleeding-stopping component, 3-6 parts of a cell activator MG-60, 8-10 parts of allantoin, 1 part of hydrolyzed wheat proteins, 1 part of a stabilizer, 150-220 parts of a compound anti-inflammation fruit oil component and 200 parts of sterile water. By particularly selecting multiple extracts with the anti-inflammation and bleeding-stopping functions and adding twoefficient anti-inflammation components and one efficient bleeding-stopping component, the integral anti-inflammation and bleeding-stopping effects of the medical adhesive are improved, and the medical adhesive is high in bonding strength, short in bleeding-stopping time and accordant with clinical application requirements on medical adhesives.

A polymer conetwork formed from the polymerization reaction of octyl-cyanoacrylate and a tri-telechelic star polymer comprising poiyisobutyiene terminated with cyanoacrylate groups (O(PIB-CA)3), wherein the ratio of octyl cyanoacrylate to O(PIB-CA)3 is from about 10: 1 to about 40: 1.

Nanoparticles comprising biologically active peptides and poly(octylcyanoacrylate) as well as related subject matter is disclosed.

The invention discloses a medical adhesive with efficient anti-inflammation and hemostasis functions. The medical adhesive is characterized by comprising, by weight, 20-25 parts of alpha-N-octyl cyanoacrylate, 25-35 parts of alpha-isooctyl cyanoacrylate, 2-6 parts of polyvinyl acetate, 12-20 parts of efficient anti-inflammation components, 13-23 parts of efficient hemostasis components, 3-6 partsof cell activators MG-60, 8-10 parts of allantoin, 1 part of hydrolyzed wheat protein, 1 part of stabilizers, 150-220 parts of compound anti-inflammatory fruit oil components and 200 parts of sterilewater. The medical adhesive particularly selects various extracts with the anti-inflammation and hemostasis functions, two efficient anti-inflammation components and one efficient hemostasis componentare added, so that overall anti-inflammation and hemostasis effects are improved, and the medical adhesive is high in bonding strength and short in hemostasis time and meets application requirementsof clinical medical adhesives.

The invention belongs to the technical field of biomedical materials, particularly relates to an anti-inflammatory rapid hemostatic medical adhesive material, and further discloses a preparation method thereof. According to the medical adhesive material disclosed by the invention, alpha-n-butyl cyanoacrylate and alpha-n-octyl cyanoacrylate are used as a mixed medical adhesive matrix, and a hemostatic material carboxymethyl chitosan is swelled and modified in a manner that a CO2 supercritical fluid carries selected ionic liquid and anti-inflammatory active ingredients, so that the hemostatic performance of the carboxymethyl chitosan is effectively improved, the hemostatic performance of the whole medical adhesive material is greatly improved, rapid hemostasis is achieved, and a medical adhesive has relatively good antibacterial performance and can be suitable for more clinical occasions.

The invention discloses a medical adhesive with efficient anti-inflammation and hemostasis functions. The medical adhesive is characterized by comprising, by weight, 20-25 parts of alpha-N-octyl cyanoacrylate, 25-35 parts of alpha-isooctyl cyanoacrylate, 2-6 parts of polyvinyl acetate, 12-20 parts of efficient anti-inflammation components, 13-23 parts of efficient hemostasis components, 3-6 partsof cell activators MG-60, 8-10 parts of allantoin, 1 part of hydrolyzed wheat protein, 1 part of stabilizers, 150-220 parts of compound anti-inflammatory fruit oil components and 200 parts of sterilewater. The medical adhesive particularly selects various extracts with the anti-inflammation and hemostasis functions, two efficient anti-inflammation components and one efficient hemostasis componentare added, so that overall anti-inflammation and hemostasis effects are improved, and the medical adhesive is high in bonding strength and short in hemostasis time and meets application requirementsof clinical medical adhesives.

The invention discloses a wood modifier which comprises the following substances in part by weight: 26 parts of sodium carboxymethylcellulose, 3 parts of Arabic gum, 4 parts of octyl-2-cyanoacrylate, 37 parts of ethanol, 1 part of an ammonium polyphosphate-zinc borate composite flame retardant, 0.2 part of citric acid, 19 parts of water, 0.07 part of benzoic acid, 13 parts of polylactic-co-glycolic acid, and 0.03 part of benzalkonium chloride, wherein the pH value of sodium carboxymethylcellulose is 4.5; ammonium polyphosphate is twice of zinc borate in weight, the degree of polymerization of ammonium polyphosphate is 23-25, the phosphorus content of ammonium polyphosphate is 30%, and the nitrogen content of ammonium polyphosphate is 16%; and the molecular weight of polylactic-co-glycolic acid is 6,000-8,000. The wood modifier, prepared according to the preparation method, is high in wood dimensional stability, high in decay resistance and low in water absorption swelling rate.

The invention relates to a high antimicrobial property medical binder. The high antimicrobial property medical binder is prepared from the following components in parts by weight: 45-55 parts of poly(alpha-isobutylcyanoacrylate-alpha-octyl cyanoacrylate), 24-36 parts of efficient antimicrobial components, 2-5 parts of polyurethane, 20-25 parts of polyisoprene, 2-4 parts of sodium alginate, 3-6 parts of xylogen, 7-10 parts of gallotannic acid, 1 part of a stabilizer, 1 part of a formaldehyde inhibitor, 150-200 parts of seabuckthorn seed oil and 180 parts of sterile water. Three antimicrobial components are specially added to the medical binder, so the medical binder is high in antibacterial rate, high in binding strength, good in biocompatibility, and high in overall curative ratio, and complies with the application requirements to the medical binder clinically.

An embolisation agent is a mixture of n-butyl cyanoacrylate and octyl cyanoacrylate having CPS ratios between 1-1000 cps. The invention is particularly related to a medical method and medical device used in treatments which enable to obturate, superficial varicosity, Pake and hemorrhoids with embolisation. By means of the device and method subject to the invention the progression of varicose veins, Pake and internal and external hemorrhoids can be stopped, obturated or clogged.

The invention relates to a method for synthesizing n-octyl α-cyanoacrylate, comprising the following steps: taking paraformaldehyde and n-octyl cyanoacetate as raw materials and petroleum ether as a reaction medium; Condensation reaction at ~84°C to obtain a reaction mixture containing n-octyl α-cyanoacrylate polymer; after the reaction is completed, recover the petroleum ether in the reaction mixture, then add a polymerization inhibitor, and carry out cracking and distillation under reduced pressure to obtain α-n-octyl cyanoacrylate crude monomer; the crude n-octyl cyanoacrylate monomer is purified to obtain fine n-octyl cyanoacrylate. The method has high reaction efficiency, high product yield, strong safety and less harm to operators.