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253 results about "Oviduct" patented technology
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The passageway from the ovaries to the outside of the body is known as the oviduct. In female mammals this passageway is also known as the uterine tube or Fallopian tube. The eggs travel along the oviduct. These eggs will either be fertilized by sperm to become a zygote, or will degenerate in the body. Normally, these are paired structures, but in birds and some cartilaginous fishes, one or the other side fails to develop (together with the corresponding ovary), and only one functional oviduct is found.
Methods for the culture of human embryonic stem cells on human feeder cells
InactiveUS7432104B2Artificial cell constructsMammal material medical ingredientsBone Marrow Stromal CellCell culture media
Methods and cell culture medium for the generation of human pluripotent embryonic stem cells are disclosed. Human embryonic stem cells are cultured with human granulosa feeder cells, muscle cells, Fallopian ductal epithelial cells, bone marrow stromal cells, and skin fibroblasts and the embryonic stem cells maintain their pluripotent phenotype. The human pluripotent embryonic stem cells can be cultured without feeder cells, and in the presence of supplemental growth factors. The human pluripotent embryonic stem cells can be alternatively cultured with conditioned medium obtained from a cell culture capable of maintaining human embryonic stem cells in a pluripotent state, wherein the cell culture is a human granulosa cell culture.
Owner:VIACYTE INC
Combination medicine for curing the hoary hair
InactiveCN101284121AAmphibian material medical ingredientsDermatological disorderTherapeutic effectSesame seed
A Chinese medicinal composition for treating alopecia and leukotrichia contains thirty Chinese traditional medicines such as fineleaf schizonepeta herb, divaricate saposhnikovia root, ginger, rehmannia root, tree peony bark, red peony root, kuhseng, densefruit pittany root-bark, tuckahoe, oriental waterplantain tuber, belvedere fruit, danshen root, ginseng, safflower, jujube, fleece-flower root, mulberry fruit, angelica, drynaria, desertliving cistanche, prepared rehmannia root, solomonseal rhizome, eucommia, black sesame seed, black soyhean, chinese caterpillar fungus, forest frog oviduct, etc. Oral administration in combination with external application of the composition is adopted so that medicine factor directly acts on dermal layer of scalp for activating hair follicle cell regeneration, adjusting sebum secretion, improving scalp metabolism, supplementing nutrition required by hair, holding hair, blackening hair and caring hair.
Owner:范广伦
Glycosylation in avians
Transgenic avians which produce proteins in their oviduct tissue having modified oligosaccharide structures and methods of making such avians are disclosed herein. The invention also includes the modified proteins produced in the transgenic birds.
Owner:ALEXION PHARMA INC
Method and device for use in the diagnosis of inflammatory states in the urogenital tract
PCT No. PCT / SE97 / 00610 Sec. 371 Date Dec. 8, 1998 Sec. 102(e) Date Dec. 8, 1998 PCT Filed Apr. 11, 1997 PCT Pub. No. WO97 / 37587 PCT Pub. Date Oct. 16, 1997Device and method for collecting endogenous gaseous nitric oxide (NO), in the urogenital tract, for example in the urinary tract and in the uterus and oviducts. According to one embodiment, a NO permeable, liquid impermeable inflatable body (16) is positioned in the urethra (5) surrounded by the prostate gland (17), whereby an additional inflatable body (4) positioned in the bladder (2) serves to seal off the bladder from the urethra and helps in the positioning of the device. The present invention further relates to a method and a system for use in the diagnosis of inflammatory states in said organs.
Owner:AEROCRINE AB
Tissue specific expression of exogenous proteins in transgenic chickens
InactiveUS20030172387A1Improve concentrationEasy to collectEgg immunoglobulinsVectorsGerm layerExogenous DNA
Transgenes encoding exogenous proteins are stably integrated into embryonic stem cells and are present in the somatic tissue of transgenic or chimeric birds. The transgenes encode exogenous proteins and are expressed in any of endodermal, ectodermal, mesodermal, or extra embryonic tissue. Tissue specificity is provided by selecting the content of the transgene accordingly. Transgenic birds whose genome is comprised of trangene derived exogenous DNA express exogenous proteins with tissue specificity, and specifically express exogenous proteins in the tubular gland cells of the oviduct to concentrate exogenous proteins in egg white..
Owner:SYNAGEVA BIOPHARMA CORP
Transgenic avians with an ovomucoid gene expression control region linked to a nucleotide sequence encoding a heterologous polypeptide
The present invention provides novel isolated nucleic acids that comprise an avian nucleic acid sequence comprising a ovomucoid gene expression control region. The ovomucoid promoter region of the present invention will allow expression of an operably linked heterologous nucleic acid insert in a transfected avian cell such as, for example, an oviduct cell. The isolated avian ovomucoid of the present invention may be operably linked with a selected nucleic acid insert, wherein the nucleic acid insert encodes a polypeptide desired to be expressed in a transfected cell. The recombinant DNA of the present invention may further comprise a polyadenylation signal sequence. The present invention further includes expression vectors comprising an isolated avian ovomucoid gene expression control region of the present invention, and transfected cells and transgenic avians comprising the expression vectors.
Owner:SYNAGEVA BIOPHARMA CORP
Tissue specific expression of antibodies in chickens
InactiveUS20060191026A1Improve concentrationEasy to collectEgg immunoglobulinsFermentationTissue specificTransgene
Transgenes encoding exogenous antibodies are stably integrated into donor cells and are present in the somatic tissue of chimeric birds. The transgenes encode exogenous antibodies and are preferably expressed in the oviduct for collection in the egg. Tissue specificity is provided by selecting the content of the transgene accordingly. Birds whose genome is comprised of trangene-derived exogenous antibody-encoding DNA express exogenous antibodies having desirable chemical properties with increased therapeutic utility compared to antibodies derived from bacterial expression systems.
Owner:SYNAGEVA BIOPHARMA CORP
Ovomucoid promoters and methods of use
The present invention provides novel isolated nucleic acids that comprise an avian nucleic acid sequence comprising a ovomucoid gene expression control region. The ovomucoid promoter region of the present invention will allow expression of an operably linked heterologous nucleic acid insert in a transfected avian cell such as, for example, an oviduct cell. The isolated avian ovomucoid of the present invention may be operably linked with a selected nucleic acid insert, wherein the nucleic acid insert encodes a polypeptide desired to be expressed in a transfected cell. The recombinant DNA of the present invention may further comprise a polyadenylation signal sequence. The present invention further includes expression vectors comprising an isolated avian ovomucoid gene expression control region of the present invention, and transfected cells and transgenic avians comprising the expression vectors.
Owner:SYNAGEVA BIOPHARMA CORP
Medicine for treating woman sterility
InactiveCN1565516ASignificant effect in treating infertilitySmall side effectsUnknown materialsSexual disorderEndometriumOviduct
Owner:沈观印 +1
Avians expressing heterologous protein
InactiveUS7534929B2Altered phenotypeEfficient expressionAnimal cellsVectorsFowlNucleic acid sequencing
Owner:SYNAGEVA BIOPHARMA CORP +1
Chinese medicinal preparation for treating female sterility caused by salpingemphraxis
ActiveCN101569673ABlock validHigh cure rateUnknown materialsSexual disorderDiseaseIntestinal structure
The invention relates to a preparation for treating female sterility, in particular to a Chinese medicinal preparation for treating female sterility caused by salpingemphraxis. The Chinese medicinal preparation mainly adopts Chinese medicines by certain weight portion, such as pangolin, pseudo-ginseng, frankincense, safflower, hemlock parsley, peach kernel, rhizoma zedoariae and the like, to play the functions of sterilizing and diminishing inflammation, eliminating stasis to resolve swelling, circulating blood and dissipating stagnation, regulating the menstruation and dispersing ruffian, removing retention and circulating vital energy, dredging and lubricating the intestines on salpinx chronic inflammation, conglutination, hydrops and obstructive obstruction. Compared with the traditional treatment method, the Chinese medicinal prepration has the advantages of treating both principal and secondary aspect of disease without any pain or side effect on a patient with accurate healing efficacy on clinical tests, and significantly improving the cure rate and pregnancy rate after healing.
Owner:樊成华
Tissue specific expression of exogenous proteins in transgenic chickens
InactiveUS20060053504A1High expressionFacilitates concentration and collectionEgg immunoglobulinsVectorsGerm layerSomatic cell
Transgenes encoding exogenous proteins are stably integrated into embryonic stem cells and are present in the somatic tissue of transgenic or chimeric birds. The transgenes encode exogenous proteins and are expressed in any of endodermal, ectodermal, mesodermal, or extra embryonic tissue. Tissue specificity is provided by selecting the content of the transgene accordingly. Transgenic birds whose genome is comprised of trangene derived exogenous DNA express exogenous proteins with tissue specificity, and specifically express exogenous proteins in the tubular gland cells of the oviduct to concentrate exogenous proteins in egg white.
Owner:SYNAGEVA BIOPHARMA CORP
Tissue Specific Expression of Exogenous Proteins in Transgenic Chickens
InactiveUS20090165155A1Improve concentrationEasy to collectAnimal cellsEgg immunoglobulinsExogenous DNASomatic cell
Transgenes encoding exogenous proteins are stably integrated into embryonic stem cells and are present in the somatic tissue of transgenic or chimeric birds. The transgenes encode exogenous proteins and are expressed in any of endodermal, ectodermal, mesodermal, or extra embryonic tissue. Tissue specificity is provided by selecting the content of the transgene accordingly. Transgenic birds whose genome is comprised of trangene derived exogenous DNA express exogenous proteins with tissue specificity, and specifically express exogenous proteins in the tubular gland cells of the oviduct to concentrate exogenous proteins in egg white.
Owner:SYNAGEVA BIOPHARMA CORP
Transgenic avians and protein production
InactiveUS20050188431A1Altered phenotypeEfficient expressionAnimal cellsVectorsFowlNucleic acid sequencing
This invention provides vectors and methods for the stable introduction of exogenous nucleic acid sequences into the genome of avians in order to express the exogenous sequences to alter the phenotype of the avians or to produce desired proteins. In particular, transgenic avians are produced which express exogenous sequences in their oviducts and which deposit exogenous proteins into their eggs. Avian eggs that contain exogenous proteins are encompassed by this invention. The instant invention further provides novel forms of interferon and erythropoietin which are efficiently expressed in the oviduct of transgenic avians and deposited into avian eggs.
Owner:SYNAGEVA BIOPHARMA CORP +1
Preparation method and application of tissue slice for observing temporal-spatial distribution of early embryo development in vivo
InactiveCN102944456AObservation continuityEasy to observe continuityPreparing sample for investigationCooking & bakingFluorescence
The invention discloses a preparation method and an application of a tissue slice for observing temporal-spatial distribution of early embryo development in vivo. The preparation method comprises the following steps that 4% paraformaldehyde fixing, upward gradient ethanol dehydration, wax dipping, embedding, serial section, baking, dewaxing and downward gradient ethanol rehydration are performed in sequence on oviducts or uterine tissues which contain mice embryos in every period, and finally, after haematoxylin-eosin staining is performed on the tissues in the slice, neutral gum is used for sealing the slice, or after immunofluorescence histochemical staining is performed on the slice, a fluorescence resistant quenching sealing agent is used for sealing the slice. The tissue slice disclosed by the invention can be used for manufacturing a map of early mice embryo development and detecting the expression of Crb3 in the mice embryos in every period of development in vivo. The preparation method has the advantages that positions of all organs in the embryos can be relatively fixed, so that the position change of embryo cells in a genital tract and the continuity of embryo development can be conveniently observed, the structure is clear, and the tissue slice is convenient to store.
Owner:NORTHWEST A & F UNIV
Chinese medicinal composition for beauty treatment and face nursing, and preparation method thereof
ActiveCN101401878AAccelerated agingAbundant resourcesAmphibian material medical ingredientsAerosol deliverySide effectMagnesium stearate
The invention discloses a traditional Chinese medicine composition for beautifying skin. The effective components of the composition consists of the following raw medicines in daily dosage: 2 to 8 grams of ginseng, 3 to 6 grams of angelica, 3 to 9 grams of red sage roots, 100 to 700 milligrams of forest frog oviducts and 145 to 900 milligrams of grape seed extract. The medicine composition can be added with microcrystalline cellulose or magnesium stearate as auxiliary materials to prepare tablets, or be added with stearic acid, glyceryl monostearate, hydrogenerated polyisobutene, olive oil, methyl glucose sesquistearate, glycerin, azone, ethyl nipagin ester and distilled water as the auxiliary materials to prepare cream. The composition has the advantages of high product safety performance, no toxic or side effect, speckle removal, wrinkling resistance, skin aging improvement, good skin beautifying efficacies, and stable and reliable product quality. In addition, the composition is rich in resources of the raw medicines, scientific and reasonable in formulation and simple in preparation process, and meets the requirements of industrial production.
Owner:东方药林药业有限公司
Oviduct recanalization therapeutic catheter with air bag and capable of automatically being fixed
InactiveCN103239794ASimple structureEasy to disassembleBalloon catheterObstetrical instrumentsOuter CannulaSalpingostomy
The invention discloses an oviduct recanalization therapeutic catheter with an air bag and capable of automatically being fixed. The oviduct recanalization therapeutic catheter comprises a taper-shaped fixator, an outer sleeve positioned behind the taper-shaped fixator, a main catheter penetrating through the taper-shaped fixator and the main sleeve and a detachable inner-layer oviduct catheter mounted in the main catheter. The oviduct recanalization therapeutic catheter is simple in structure, has multiple using methods and can be applied to multiple therapeutic methods. When the oviduct recanalization therapeutic catheter is used, traumas to patients' uterine necks caused by multiple catheter inserting during therapeutic processes are effectively avoided, clinical operation difficulty is greatly reduced, and meanwhile, therapeutic costs and expenses are saved.
Owner:江门市富美尔环保电子科技有限公司
Cell lines and methods for producing proteins
The methods of the present invention involve the manipulation and / or propagation of oviduct tumor cells derived from either wild-type or transgenic avians.
Owner:SYNAGEVA BIOPHARMA CORP
Chinese herbal medicine containing feed for laying hens
InactiveCN106036015AMeeting nutritional needsQuality improvementFood processingAnimal feeding stuffDiseasePatrinia
The invention provides a Chinese herbal medicine containing feed for laying hens. The feed contains the following raw materials in parts by weight: 50-80 parts of corn flour, 20-30 parts of rice flour, 15-25 parts of millet flour, 10-20 parts of pumpkin flour, 40-60 parts of sweet potato flour, 50-70 parts of bean cake meal, 80-90 parts of rapeseed cake meal, 90-120 parts of rice bran, 25-40 parts of highland barley powder, 35-50 parts of fish meal, 20-40 parts of bone meal, 10-18 parts of conch powder, 35-60 parts of calcium hydrogen phosphate, 60-80 parts of rock flour, 20-30 parts of common salt, 40-50 parts of sodium bicarbonate, 5-15 parts of compound trace elements, 4-10 parts of multivitamins, 10-25 parts of amino acids, 5-8 parts of taraxacum mongolicum, 8-15 parts of folium artemisiae argyi, 12-20 parts of crataegus pinnatifida, 5-15 parts of Chinese angelica, 5-20 parts of whiteflower patrinia herb and 5-10 parts of fructus liquidambaris. The feed for the laying hens is rich in nutrition, contains Chinese herbal medicine ingredients and is green and environmentally friendly, so that the laying hens can be far away from diseases, oviducts of the laying hens can be unobstructed, eggs are high in quality and large in number, and thus nutritional requirements of people can be met.
Owner:TAICANG XINHUA GRAIN PRODN SPECIALIZED COOP
Traditional Chinese medicine compound pharmaceutical composition used for laying fowls and preparation method and application thereof
ActiveCN101744923APromote dissolutionPromote absorptionAnimal feeding stuffSexual disorderSalvia miltiorrhizaSide effect
Owner:BEIJING DABEINONG ANIMAL HEALTH TECH +1
Animal model with male reproductive disorders, as well as preparation method and application thereof
InactiveCN103361336ADoes not affect normal developmentDoes not affect hormone levelsMicrobiological testing/measurementRecombinant DNA-technologyUterusMature sperm
The invention provides an animal model with male reproductive disorders of a non-human mammalian animal, as well as a preparation method and application of the animal model, and further identifies the functions of a Prss37 gene and a protein. The Prss37 gene of the animal model is inactivated, thereby affecting the appearance of ADAM3 in mature sperms produced by the animal model, indirectly affecting the combination of the sperms-zona pellucida and the migration of the sperms from the uterus to the oviduct and resulting in the serious male reproductive disorders. The model, the Prss37 gene and the protein thereof can be used for screening ADAM3 ripening accelerators, as well as sterility infertility treatment agents or contraceptive medicaments.
Owner:上海南方模式生物研究中心 +1
Poultry semen diluent for maintaining sperm motility and prolonging insemination time
InactiveCN103609552APrevention of salpingitisReduce the ratioDead animal preservationSodium acetateBiology
The invention discloses poultry semen diluent for maintaining the sperm motility and prolonging the insemination time. Every 1000ml of diluent comprises the following components: 0.5g to 1.4g of magnesium chloride, 1g to 1.3g of potassium citrate, 8g to 10g of sodium acetate, 10g to 20g of fructose, 10g to 25g of sodium glutamate, 1g to 5g of multi-vitamin and water. The poultry semen diluent has the beneficial effects that the insemination time can be prolonged, the number of the raised breeder cocks can be reduced, the stress on a breeder hen caused by the artificial insemination can be alleviated, the egg laying rate can be improved, the fertility rate can be increased, the incidence probability of the oviduct inflammatory can be reduced, and the quality of the chicks can be improved.
Owner:ANHUI WUXING FOOD
Medicine composition capable of improving sleep quality and preparation method of medicine composition as well as application of medicine composition
InactiveCN104069335ANo side effectsSleep longerNervous disorderUnknown materialsSide effectTraditional medicine
The invention belongs to the field of traditional Chinese medicine, and particularly relates to a medicine composition capable of improving sleep quality and a preparation method of the medicine composition as well as an application of the medicine composition. The medicine composition comprises the following constituents in parts by weight: 0.1 part to 0.3 part of a forest frog's oviduct, 3 parts to 10 parts of spina date seed, 1 part to 5 parts of polygala tenuifolia, 1 part to 5 parts of poria cocos, and 0.5 part to 3 parts of artichoke; the preparation method comprises the following steps: weighting the spina date seed, the polygala tenuifolia, the poria cocos, forest frog's oviduct powder and artichoke powder; extracting the spina date seed, the polygala tenuifolia and the poria cocos in water; concentrating the filtrate acquired in the last step into an extract; drying the extract to acquire extracting powder; mixing the extracting powder with the forest frog's oviduct powder and the artichoke powder uniformly to acquire the medicine composition capable of improving the sleep quality. The medicine composition is used for preparing the medicine capable of improving and curing the sleep quality or health food. The medicine composition does not have any side effect. Therefore, the medicine composition is suitable for people for a wide range.
Owner:天津百药汇电子商务有限公司
Diagnosis of gynecological neoplasms by detecting the levels of oviduct-specific glycoprotein
The present invention provides a method for detecting cancer in a patient. A sample from the patient is provided, and the level of oviduct-specific glycoprotein (OGP) in the sample is determined and compared to a control sample. Increased levels of OGP in the sample as compared to the control indicates that the patient has cancer. In one aspect, the cancer is a gynecological cancer, such as ovarian cancer. Kits for conducting the methods of the invention are also provided.
Owner:THE UNIV OF BRITISH COLUMBIA
Traditional Chinese medicine composition for curing oviduct obstruction
InactiveCN103330920AImplement blockingGood curative effectSexual disorderPlant ingredientsMyrrhAngelica Sinensis Root
The invention relates to a traditional Chinese medicine composition for curing oviduct obstruction. The traditional Chinese medicine composition is prepared from the following raw materials in part by weight: 15-25 parts of radix salviae miltiorrhizae, 10-20 parts of motherwort, 10-20 parts of beautiful sweetgum fruit, 10-20 parts of cuscuta chinensis, 10-20 parts of achyranthes bidentata, 7-13 parts of radix curcumae, 7-13 parts of radix paeoniae rubra, 7-13 parts of ligusticum wallichii, 7-13 parts of rhizoma sparganii, 7-13 parts of zedoary, 7-13 parts of laminaria, 7-13 parts of spina gleditsiae, 7-13 parts of trogopterus dung, 7-13 parts of rhizoma cyperi, 7-13 parts of folium artemisiae argyi, 7-13 parts of angelica sinensis, 7-13 parts of rheum officinale, 7-13 parts of radix paeoniae alba, 7-13 parts of herba epimedii, 7-13 parts of cowherb seeds, 3-9 parts of peach kernels, 3-9 parts of myrrh, 2-4 parts of pericarpium citri reticulatae, 2-4 parts of asarum, 2-4 parts of cantharides and 2-4 parts of carthamus tinctorius. The traditional Chinese medicine composition has the advantages of stable curative effect, short curative time and simple preparation method.
Owner:韩乃枝
Chinese medicament for treating extrauterine pregnancy
InactiveCN101732670ASignificant decompositionSignificantly absorbentSexual disorderPlant ingredientsPatriniaPregnancy
Owner:黄毅
Preparation method for microecologics for laying hen feeds and application of microecologics
InactiveCN103518980BGrowth inhibitionStimulate immune responseAnimal feeding stuffSodium bicarbonateSolubility
The invention discloses a preparation method for microecologics for laying hen feeds and application of the microecologics. The microecologics is prepared by uniformly mixing living microcapsules bacterium powder with selenium carrageenan, zinc methionine and auxiliary materials through a spray drying technology, wherein living microcapsules bacterium powder is obtained by uniformly mixing lactobacillus plantarum and bacillus subtilis strains with an aqueous solution containing pectin, tween-80, glycerinum, mannitol, trehalose and sodium bicarbonate after the lactobacillus plantarum and the bacillus subtilis strains are subjected to enrichment culture. The microecologics can be stored under a normal-temperature condition and is high in enteric solubility and biological adhesive. On the basis of normal daily ration, the laying hens are also fed with the microecologics, so that the anti-oxidization capability of organ bodies of laying hens can be improved; therefore, the damage degree of fallopian tubes of the laying hens in the later period of laying is reduced, excessive release of inflammatory factors in tissues can be suppressed, and the injury caused by inflammatory reaction can be alleviated; the activity and the completeness of organ tissues and cells can be guaranteed, the organ health is retained, and the productivity is improved.
Owner:NANJING AGRICULTURAL UNIVERSITY
Kidney-warming yang-supporting medicine composition and preparation method thereof
ActiveCN102895478APlay the role of warming the kidney and supporting yangConvenient treatmentComponent separationDigestive systemPenisStalactite
The invention relates to a kidney-warming yang-supporting medicine composition and a preparation method thereof. An active component of the medicine composition is prepared from, by weight: 10-15 parts of ginseng, 4-18 parts of Chinese magnoliavine fruit, 100-450 parts of epimedium, 10-15 parts of Mongolian milkvetch root, 10-15 parts of spine date seed, 10-15 parts of dan-shen root, 60-225 parts of raw rehmannia root, 10-45parts of hairy antler pilose antler, 0.5-3 parts of forest frog's oviduct, 10-15 parts of tubular stalactite, 10-120 parts of tuber onion seed, 60-225 parts of common cnidium fruit, 10-135 parts of common fenugreek seed, 0.5-3 parts of deer penis and testes, 10-75 parts of ox penis and testes, 10-45 parts of dog penis and testes, 10-15 parts of sea horse, 10-15 parts of large dried shrimp, 1-7.5 parts of borneol, and 100-450 parts of tussah silkworm chrysalis. As a result of pharmaceutical effect experiments, the medicine composition and the formula provided by the invention assists in substantially treating kidney-yang deficiency syndrome. The effect of the medicine composition is better than compositions not provided by the invention.
Owner:吉林省银诺克药业有限公司
Method for preparing soft tissue decellular matrix through supercritical fluid technology
InactiveCN107164298AIncrease the diffusion coefficientMass transfer speedBiological preparation purgeMuscle tissueBlood Vessel Tissue
The present invention discloses a preparation method of a soft tissue decellular matrix, and relates to the technical field of clinical medicine, biomedical medicine and regenerative medicine. According to the present invention, the natural soft tissue decellular matrix is prepared by using a supercritical fluid technology, wherein the natural soft tissue comprises small intestine tissue, blood vessel tissue, muscle tissue, heart tissue, valve tissue, lung tissue, spleen tissue, kidney tissue, liver tissue, stomach tissue, gallbladder tissue, fat tissue, cartilage tissue, trachea tissue, esophagus tissue, bladder tissue, ureter tissue, oviduct tissue, or uterus tissue. According to the present invention, with the preparation method, the damage on the soft tissue matrix component is low, and the obtained soft tissue decellular matrix has advantages of low immunogenicity and good biocompatibility.
Owner:GUANGZHOU SUN SHING BIOTECH CO LTD
Method for producing transgenic pigs through overexpression HOXA10 genes
InactiveCN104531763ASimple and fast operationImprove efficiencyFermentationVector-based foreign material introductionMolecular identificationEmbryo transfer
The invention belongs to the technical field of pig transgenosis and particularly relates to a method for producing transgenic pigs through overexpression HOXA10 genes. The method is characterized in that constructed HOXA10 gene expression carriers are subjected to lipofection and sulfate (G418) screening to obtain HOXA10 transgenic cell lines with stable expression; the HOXA10 transgenic cell lines are transplanted into denucleated pig oocytes with HOXA10 transgenic pig fibroblasts as nuclear donors through an artificial nuclear transplantation method to form reconstructed embryos; the reconstructed embryos are transplanted into a receptor sow oviduct, and after a sow gives birth to the HOXA10 transgenic pigs and molecular identification is conducted, masculine HOXA10 transgenic pigs are screened out. The transgenic pigs obtained through the method provide materials for research about the mechanism of improving the reproductive capacity through the HOXA10 genes and provide an animal model for revealing other functions of the HOXA10 genes.
Owner:HUAZHONG AGRI UNIV
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