92 results about "Oxytetracycline Hydrochloride" patented technology

The invention provides a piglet milk powder capable of completely replacing sow milk, comprising the following components: 25-98wt% of dried whole milk, 0-70wt% of defatted milk powder, 0-13wt% of dried egg powder, 0-30wt% of mixed powder of emulsified plant fat and lactose, 0-5wt% of whey powder, 0.5-2.0wt% of lactocin powder, 0.3wt% of probiotics preparation, 0.2-1.0wt% of acidulant, 0.15-0.3wt% of trace elements pre-mix material, 0.25-1.0g / kg of piglet vitamin pre-mix material, 50-300mg / kg of vitamin C, 800-2000mg / kg of choline chloride, 10-50mg / kg of colistine sulfate, and 30-80mg / kg of oxycycline; and the rest is flavoring additive and preservative.

The invention discloses swine eperythrozoonosis-resisting compound long-acting oxytetracycline injection, which comprises the following components in part by mass: oxytetracycline hydrochloride (or alkaloids thereof), roxarsone, acetaminophen, glycerol formal, polyvinylpyrrolidone K12, polyvinylpyrrolidone K17, polyethylene glycol 200, polyethylene glycol 400, magnesium chloride, sodium formaldehyde sulphoxylate, monoethanol amine and water for injection. Due to the compatibility of the oxytetracycline hydrochloride (or the alkaloids thereof), the roxarsone and the acetaminophen and synergistic action of each medicament component, the injection treats both symptoms and root causes of swine eperythrozoonosis so as to fulfill the aim of quick and effective treatment.

The invention provides a method for preparing oxytetracycline hydrochloride. In the method, oxytetracycline is used as an initiative raw material, hydrochloric acid and methanol are used as co-solvents, and active carbon is used for decolorizing. A finished product is obtained by salt formation under the action of dry HCL, dynamical stirring, cooling and crystallization, crushing and screening of a wet product and airflow drying. The oxytetracycline hydrochloride prepared by the preparation method accords with the standards of Chinese Pharmacopoeia, United States Pharmacopeia, British Pharmacopoeia and European Pharmacopoeia, the methanol residue is superior to ICH requirement, and the yield reaches over 95.5 percent.

The invention discloses a compound pesticide for preventing and controlling liberobacter asiaticum and a preparation method thereof. According to objective requirements of prevention and control of liberobacter asiaticum, ZhongShengmycin and oxytetracycline hydrochloride are used as sterilization pesticides, salicylic acid is used as an anti-disease regulation agent and alpha-naphthalene acetic acid is used as a rooting accelerant; the materials are reasonably blended, and pesticide application is carried out by adopting a trunk infusion method, so that the advantages of the agents are complementary to each other; and the compound pesticide has the properties of high efficiency, low toxin, safety, economy and multiple functions, and can be used for preventing and controlling liberobacter asiaticum very well.

The invention discloses a compound composition containing methanesulphonyl myclobutanil and an antibiotics bactericide and a preparation. The compound composition consists of the methanesulphonyl myclobutanil and the antibiotics bactericide, wherein the weight ratio of the methanesulphonyl myclobutanil to the antibiotics bactericide is (100:1)-(1:30), and preferably (30:1)-(1:10); the antibiotics bactericide is selected from any one of kasugamycin, streptomycin sulfate, validamycin, polyoxin, tetramycin, blasticidin, antifungalmycine, ningnanmycin, cytosintetidemycin and oxytetracycline hydrochloride. The compound composition and the preparation provided by the invention have a remarkable synergistic interaction effect in comparison with single dosage, and are capable of effectively controlling the bacterial diseases and / or fungal diseases such as cucumber bacterial angular leaf spot, tobacco bacterial wilt and rice blast so as to improve the control effect, reduce the dosage of the pesticides, reduce the control cost and be more widely to sterilize.

The invention belongs to the technical field of medicine preparation, and relates to an oxytetracycline hydrochloride effervescent tablet for dairy cattle and a preparation method thereof. The effervescent tablet comprises the following compositions in percentage by weight: 15-40 percent of oxytetracycline hydrochloride, 10-30 percent of tartaric acid, 15-45 percent of sodium bicarbonate, 1-15 percent of polyvinylpyrrolidone, 1-10 percent of polyethylene glycol 6000, 1-30 percent of anhydrous glucose, and 0.01-3 percent of magnesium stearate. The preparation method comprises the following steps: raw material preprocessing-mixing-preparation of soft material-granulation-drying-granular straightening-tabletting. The oxytetracycline hydrochloride effervescent tablet for dairy cattle has the advantages of being convenient to carry and use, good in effect, strong in stability and the like.

The invention provides a preparation method of oxytetracycline hydrochloride. Oxytetracycline dihyclorate serves as a starting material, is sequentially subjected to alcohol dissolution and acid alcohol dissolution procedures and activated carbon decoloration treatment and cooling crystallization procedures and is dried to obtain finished oxytetracycline hydrochloride; in the alcohol dissolution procedure, the mass-to-volume ratio of oxytetracycline to alcoholic solution is 1:(7-9); and in the acid alcohol dissolution procedure, the mass-to-volume ratio of the oxytetracycline to acid alcohol solution is 1: (0.077-0.13). The oxytetracycline hydrochloride prepared by the method is large in size, good in flowability, high in observent density, low in energy consumption in a production process and low in cost; and because ethyl alcohol serves as crystallization solvent, the oxytetracycline hydrochloride is non-toxic and harmless, and does not pollute environments.

The invention relates to a compound preparation for treating diseases caused by poultry sensitive bacteria and a preparation method thereof. The compound preparation is a long-acting injectable suspension prepared from florfenicol and occrycetin as main medicines and comprises 2.0-20.0% (W / V) of florfenicol, 5.0-30.0% (W / V) of occrycetin, 0.05-0.40% (W / V) of antioxidant, 1-10% (W / V) of antiallergic factor synergist, 0.01-0.04% (W / V) of complexing agent, 0.01-15% (W / V) of suspending agent, 1.0-10.0% (W / V) of flocculating agent, 0.01-0.5% (W / V) of preservative and 60-100% (W / V) of water for injection. The liquid medicine of the invention has stable performance and can effectively overcome the defects of instable performance, easy color change, precipitation and failure and the like of injections. The compound preparation has small irritativeness, low cost and simple process and can prolong the residence time of medicine in body and increase the bioavailability of the medicine. The compound preparation can be used for preventing and treating infectious diseases caused by poultry sensitive bacteria, such as pasteurellosis, colibacillosis, salmonellosis, contagious pleuropneumonia, mycoplasmlpneumonia of swine, acute respiratory infection and the like.

The invention discloses a method for producing large-grain oxytetracycline hydrochloride. The method comprises the steps of dissolving, activated carbon decolorization treatment, crystallization and drying; and during batch operation, a mother liquor generated in the previous process is added to a filtrate in the crystallization step and the mother liquor generated in the crystallization step is further used in the next process. According to the method for producing the large-grain oxytetracycline hydrochloride, 1-3 times of mother liquor (produced from the previous round) is added to the filtrate before acid-adding salt formation on the basis of not changing the original technological process, so that an oxytetracycline hydrochloride crude drug which is good in mobility and high in bulk density and meets the requirements of customers can be produced while the yield of the oxytetracycline hydrochloride is effectively increased; and the oxytetracycline hydrochloride crude drug has good practicability.

The invention relates to a production process of oxytetracycline dihydrate hydrochloride, in particular to a process for preparing oxytetracycline dihydrate hydrochloride by the steps of salifying and crystallizing through using oxytetracycline as the raw material and isopropanol-normal butanol as crystallized solvent and adding chlorine hydride-normal butanol. Four production processes of oxytetracycline dihydrate hydrochloride are provided both here and abroad, and oxytetracycline hydrochloride obtained by the four prior production processes has low apparent density and poor fluidity either, or low yield and high cost. The oxytetracycline hydrochloride obtained by the production process of oxytetracycline dihydrate hydrochloride, which is provided by the invention, has high apparent density, good fluidity and high yield.

The invention discloses a preparation method of large-grain occrycetin, comprising the following steps of: adding hydrochloric acid to purified water; adding terramycin under stirring; adding methanol after compete dissolution, uniformly stirring, and filtering to obtain filter liquor; adding a high-concentration aqueous salt solution containing chloridions to the filter liquor under stirring, and also adding the hydrochloric acid and a small quantity of seed crystals; standing, and crystallizing to separate out an occrycetin crystallized wet product; and drying through a vacuum dryer to obtain the large-grain occrycetin. In the invention, an aqueous methanol solution is used as a solvent because the methanol not only has low price but also is easy to recover, the harm on personnel and anenvironment is reduced because the methanol has little volatilization loss at room temperature, short crystallization time and energy saving are achieved by standing and crystallizing at normal temperature; and the produdct has good flowability, good water solubility and alcohol solubility, high yield coefficient reaching more than 81 percent, terramycin consumption reduction and low cost.

The invention relates to a method for recovering oxytetracycline from an oxytetracycline hydrochloride waste liquid. The method comprises the steps of: slowly neutralizing hydrogen chloride in a waste liquid of oxytetracycline hydrochloride preparation, carrying out pressure filtration, distilling the filtrate under reduced pressure to recover methanol, distilling a residual liquid, adding purified water, adjusting the acidity with hydrochloric acid, then adding diluted sulfuric acid or water-soluble sulfate and acid sulfate to remove calcium ions in the solution, then adding potassium ferrocyanide and zinc sulfate to remove iron and other impurities, carrying out plate-frame separation, adjusting the acidity of the filtrate to precipitate oxytetracycline crystals, centrifugally separating, and drying under reduced pressure in vacuum to obtain oxytetracycline. The method has the advantages that the recovered oxytetracycline has high yield and good quality, normal recovery of methanol is not influenced, the used materials are low in price and consumption, and the recovery cost is low; most of added materials are converted into solid waste residues, which are easy to treat; after oxytetracycline is recovered from the waste liquid, the total amount of pollutants in the waste liquid is reduced; the process is simple and the operation is convenient; and compared with the original production process, only a small amount of simple equipment is increased.

The invention discloses a long-acting compound terramycin injection for animals. Each 1000 ml of long-acting compound terramycin injection contains 190-250g of occrycetin, 400-450g of alpha-pyrrolidone, 300-350ml of N,N-dimethyl formamide, 35-50g of nicotinamide, 35-50g of sodium salicylate, 100-130g of magnesium chloride, 100-130g of hydroxymethanesulfinic acid sodium hydrosulfite and 4-7g of disodium edetate dehydrate. A pH conditioning agent adjusts the pH value to 8.0-9.0; injecting water is used to perform calibration until the constant volume is 1000 ml; the pH conditioning agent is ethanol amine. According to the long-acting compound terramycin injection for animals, the chelating temperature is low and within 30-60 DEG C, products is high in chelating degree and steady in quality, and can still keep the standard amber within 2-year period of validity; an extended agent is added, so that drug function is good and the acting time is long; the drug function keeps for 72 hours after the drug in a normal dosage is administrated, so that the inconvenience of repeated drug administration is solved, and thus the long-acting function is played.

The invention discloses an oil injection containing antibacterial agents / solid polyethylene glycol drug-loading particles. The oil injection is prepared by consisting of the drug-loading particles through antibacterial agents and solid polyethylene glycol and suspending the drug-loading particles in an oil medium. The antibacterial agents comprise enrofloxacin, danofloxacin mesylate, Marbofloxacin, mequindox, tilmicosin, tylosin, oxytetracycline hydrochloride, ceftiofur hydrochloride, cefquinome sulfate, lincomycin hydrochloride, florfenicol, erythrocin and doxycycline hydrochloride; preferentially the polyethylene glycol with the molecular weight of more than 6000 is used for preparing the preparation; more preferentially, any one of isopropyl myristate, soybean oil for injection, corn oil and tea-seed oil is used for preparing the preparation. Hydroxypropyl methyl cellulose or high-substituted hydroxy propyl cellulose can be added into the preparation.

The invention discloses a compound occrycetin, dried alum and borneol effervescent tablet and a preparation method thereof. The compound occrycetin, dried alum and borneol effervescent tablet is characterized in that the dried alum has the functions of astringing self, stopping bleeding, promoting tissue regeneration and detoxifying, the borneol has the functions of eliminating swelling, relivingpain and detoxifying, and the dried alum and borneol are combined with the occrycetin, so as to enhance the detoxifying function of the compound occrycetin, dried alum and borneol effervescent tablet,relieve the injury to wounds by toxin, reduce the pain caused by the inflammation diminishing function of the occrycetin in the treatment process, and reach the effects of healing up sore, promotingtissue regeneration, and accelerating restoration of uterus. Because of the particular effervescent disintegrating drug-release characteristic, the compound occrycetin, dried alum and borneol effervescent tablet is especially suitable for the local administration of vagina and uterus, the contact area of drug with the inflammation part is effectively increased, and the concentration of drug at thelocal part is increased; compared with the common occrycetin local preparation, the antibacterial effect is obviously improved.

The invention discloses a preparation method for oxytetracycline hydrochloride. The preparation method comprises the following steps: (A) dissolving 20-30 Kg of anhydrous calcium chloride into 750-900 L of methanol solvent, adding 4-6 Kg of diatomaceous earth to facilitate filtration at the same time, stirring, and filtering a methanol solution to obtain a methanol-calcium chloride solution; (B) adding 5-8 L of high-purity hydrochloric acid into the methanol-calcium chloride solution, uniformly stirring, then adding 150-180 Kgof oxytetracycline dihyclorate, fully stirring for dissolution, adding 45-70 L of high-purity hydrochloric acid, and performing cooling crystallization to obtain oxytetracycline hydrochloride crystals; (C) placing the oxytetracycline hydrochloride crystals into a centrifuge, leaching the oxytetracycline hydrochloride crystals for four times with 200 L of methanol, performing centrifugation for 50 minutes after leaching, discharging, and performing fluidized drying, and after drying, cooling and discharging to obtain a oxytetracycline hydrochloride finished product. According to the preparation method, the oxytetracycline hydrochloride yield can be stabilized to be about 94 percent.

The invention discloses a method for preparing long-acting terramycin injection by utilizing carbamide and sodium bisulfite in a combined way. The long-acting terramycin injection comprises the following raw materials in parts by weight: 10-15 parts of tetramycin hydrochloride, 4-5 parts of magnesium chloride, 2-3 parts of carbamide, 0.5-0.8 part of sodium thiosulfate, 4-6 parts of ethanolamine, 1-1.5 parts of sodium bisulfite, 50-60 parts of alpha-pyrrolidone, 0.01-0.03 part of disodium EDTA and 100-150 parts of water for injection. Compared with the prior art, the long-acting terramycin injection disclosed by the invention has the advantages of high bioavailability, good curative effect, quick effect, definite curative effect and stability in quality and can keep higher biological activity for a longer time and sufficiently keep the stability of a product; the preparation method disclosed by the invention has the advantages of easiness for operation of product preparation, low cost and industrialized large-scale production.

The present invention provides a young pigeon feed which consists of the following components in parts by mass: corn 40-45 parts, wheat 10-15 parts, millet 5-8 parts, mung beans 1-2 parts, soybeans 1-2 parts, sorghum 1-2 parts, brown rice 1-2 parts, protein powder 1-2 parts, glucose 1-2 parts, baking powder 0.5-0.8 part, fructus cannabis 0.5-0.8 parts, astragalus membranaceus 0.1-0.2 part, lysine 0.3-0.5 part, methionine 0.4-0.6 part, oxytetracycline hydrochloride 0.1-0.2 part, safflower fruits 0.8-1.2 parts, compound vitamins 0.03-0.05 part and egg shells 0.2-0.4 part.. The young pigeon feed can provide all the nutrients needed for the growth of young pigeons, the young pigeons do not show any sign of indigestion after being fed, grow and gain weight rapidly, and have low morbidity.

The invention discloses a method for recycling oxytetracycline hydrochloride from oxytetracycline hydrochloride crystallization mother liquid. The method comprises the following steps: (1) adjusting the pH value of oxytetracycline hydrochloride mother liquid, and filtering to remove insoluble impurities; (2) separating treated filtrate by virtue of an ultrafiltration system so as to obtain a concentrated solution rich in oxytetracycline hydrochloride and an alcohol solution containing a small amount of calcium salt, and recycling methanol from the alcohol solution; (3) carrying out alkalization crystallization on the concentrated solution obtained through ultrafiltration, adding an alkalization reagent during alkalization so as to adjust the pH value, and recycling oxytetracycline, wherein the recycling rate of oxytetracycline reaches 93%-96%; and (4) adding recycled oxytetracycline into absolute methanol which is 5 times of volume dose of oxytetracycline, adding a small amount of calcium chloride to aid dissolving, filtering, adding hydrochloric acid methanol, and crystallizing, so as to obtain oxytetracycline hydrochloride. According to the method, inorganic salt, namely calcium salt, is filtered and separated by virtue of a membrane, the concentrated solution is subjected to alkalization crystallization to generate oxytetracycline, oxytetracycline is refined by virtue of hydrochloric acid ethanol so as to generate oxytetracycline hydrochloride, and the content of obtained oxytetracycline hydrochloride reaches 96%.

The invention discloses a drug and method for preventing and treating jujube witches broom. The drug is prepared from the following ingredients, in parts by weight: 400-600 parts of vaseline, 100-300parts of wool fat, 200-400 parts of oxytetracycline hydrochloride, 1-10 parts of urea, 1-10 parts of monopotassium phosphate, 1-3 parts of ferrous sulfate and 1-10 parts of animal protein amino acid.The method comprises the steps that old skin is peeled off from the phloem of a tree trunk till the white part is exposed, the white part is evenly coated with the drug; and the drug can be applied tothe tree body which is not curative through one-time therapy. The method is reasonable in design, and the drug is convenient to use and low in cost, can effectively cure jujube witches broom, and hasthe outstanding ecological, economic and social benefits.

The invention discloses a detection method for malachite green in aquatic products. The detection method comprises experiment steps of preparing a magnetic molecularly imprinted polymer, establishinga method based on an aptamer and ferroferric oxide mimic enzyme catalysis and the like. According to the detection method, firstly, a dopamine polymerization method is used for preparing a malachite green (MG) magnetic molecularly imprinted polymer (MG-MMIPs); trace MG in a sample is adsorbed by utilizing the MG-MMIPs, so that the aims of enriching a target object and removing a complicated mediumare realized; then after enriched MG is desorbed, a detection method of the aptamer and ferroferric oxide mimic enzyme catalysis is used for detecting. The method has the sensitivity of 5 nmol L<-1>and the lowest detection limit reaches 3.6 nmol L<-1>. A specific experiment aiming at two structural analogues (including brilliant green and crystal violet) of MG and other bacteriostatic drugs (including sulfaguanidine, sulphanilamide, oxytetracycline hydrochloride and chloramphenicol) shows that the method has good selectivity in MG detection.

The present invention provides a pigeon health-care sand which consists of the following components in parts by mass: 45-50 parts of oyster shell tablets, 8-10 parts of medium sand, 6-8 parts of yellow mud, 1.4-1.8 parts of stone grains, 0.5-0.8 part of calcium bicarbonate, 0.2-0.3 part of calcium hydrogen phosphate, 0.1-0.3 part of alum, 1.2-1.5 parts of vermiculite, 0.8-1.2 parts of cattle bone meal, 2-4 parts of matured plaster, 1-2 parts of red iron oxide, 0.1-0.3 part of sodium selenite, 3-5 parts of edible salt, 1.2-1.6 parts of charcoal, 0.1-0.3 part of oxytetracycline hydrochloride, 0.2-0.3 part of yeast powder, 0.7-0.9 part of gentiana scabra, 1.2-1.6 parts of liquorice, 0.5-0.8 part of methionine, 0.2-0.4 part of lysine, 0.01-0.02 part of compound vitamin, and 0.2-0.4 part of egg shells. The pigeon health-care sand is rich in nutrition, and can improve pigeon egg production and enhance disease resistance.

The newborn squab feed disclosed by the invention is prepared from the following raw materials in parts by weight: 280-320 parts of corn flour, 580-620 parts of chicken feed, 18-22 parts of fish meal, 2.0-2.4 parts of methionine, and 2.8 parts of lysine ‑3.2 parts, 8‑12 parts of salt, 2.8‑3.2 parts of oxytetracycline hydrochloride, 10‑30 parts of egg white, 400‑500 parts of multivitamins, 10‑30 parts of andrographis powder, 20‑40 parts of licorice powder, multivitamins 5-10 parts, 1-1.3 parts of iron oxide red, 20-30 parts of bone meal, 10-15 parts of shell powder; the newborn pigeon feed of the present invention feeds 0-7 days old newborn pigeons, and has the following characteristics: 1. Because the feed is nutritious, comprehensive and easy to digest, newborn pigeons are healthy and rarely get sick; 2. The feed return rate is high, and the meat-to-feed ratio can reach 1:1, which greatly improves the economic value of farmers; 3. New Raw pigeons are not fed with the pigeon milk of the hens, which shortens the laying cycle of the hens.

The present invention provides a pigeon health-care sand which consists of the following components in parts by mass: 45-50 parts of oyster shell tablets, 12-15 parts of medium sand, 6-8 parts of red earth, 0.2-0.3 part of calcium bicarbonate, 0.2-0.4 part of alum, 1.2-1.5 parts of vermiculite, 0.5-0.8 part of sucrose, 0.8-1.2 parts of cattle bone meal, 0.5-0.8 parts of matured plaster, 2-4 parts of limestone, 1-2 parts of ferrum dioxide, 0.1-0.3 part of sodium selenite, 2-4 parts of edible salt, 1.2-1.6 parts of charcoal, 0.1-0.3 part of oxytetracycline hydrochloride, 0.7-0.9 part of gentiana scabra, 1.4-1.8 parts of liquorice, 0.5-0.8 part of methionine, 0.2-0.4 part of cystine, 0.01-0.02 part of compound vitamin, and 0.3-0.5 part of egg shells. Each component is pulverized, mixed uniformly and dried. The pigeon health-care sand can improve pigeon egg production.

The invention discloses a porous boron nitride loaded iron nano material as well as a preparation method and application thereof. The preparation method of the porous boron nitride loaded iron nano material comprises the following steps: preparing porous boron nitride by taking melamine and boric acid as raw materials, and carrying out a reaction with Fe(NO3)3.9 H2O to prepare the novel porous boron nitride loaded iron nano material which contains an iron base with high catalytic capability and has the characteristics of large specific surface area and multiple pores. The porous boron nitrideloaded iron nano material has efficient catalytic activity on sodium persulfate and can catalytically generate a large number of SO<4-> free radicals to remove oxytetracycline hydrochloride, so that the porous boron nitride loaded iron nano-material has the advantages of high catalytic activity, recyclability, avoidance of secondary pollution, wider pH application range, low energy consumption, high efficiency and the like when applied to treatment of wastewater containing oxytetracycline.

The invention discloses a method for preparing a nutrient fertilizer for Celosia plumose. The nutrient fertilizer for the Celosia plumose comprises the following components in percentage by weight: 14 to 18 percent of dried excrement, 4 to 6 percent of dried chicken manure, 2 to 4 percent of dried rabbit manure, 12 to 16 percent of soybean cake meal, 18 to 20 percent of bone meal, 1 to 3 percent of zinc phosphate fertilizer, 10 to 12 percent of bran, 10 to 12 percent of corn stalk, 8 to 10 percent of corn meal, 2 to 6 percent of yellow sand, 0.2 to 0.4 percent of carbendazim, 0.2 to 0.4 percent of chlorothalonil, 0.1 to 0.3 percent of oxytetracycline hydrochloride, 0.1 to 3 percent of DuPont methomyl and 4 to 6 percent of epoxy resin. The method comprises the following steps of: stirring all the components into a stirrer for 180 minutes; taking the components out and crushing the components in a 2 percent particle crusher; taking the components out and pouring the components into a fermenting tank to stack, and covering and compacting the components with thick plastic cloth; and forming the nutrient fertilizer in a mold box with the height of 20 centimeters, the width of 15 centimeters and the length of 30 centimeters into nutrient fertilizer blocks so as to obtain the qualified nutrient fertilizer for the Celosia plumose.

The invention discloses a preparation method of occrycetin, which belongs to the technical field of oxytetracycline preparation. The preparation method comprises the following steps of mixing prepared modified emulsion with prepared thyme monoterpene glycoside extracts, polyvinyl alcohol and phenol, dropwise adding a sodium hydroxide solution, heating in water bath, filtering and drying, so as to obtain adsorption microspheres which are adsorbed into prepared occrycetin dispersion liquid, spirally evaporating, then mixing with deionized water, heating in water bath in a stirring state, filtering, and spirally evaporating filtrate so as to be dry and obtain the occrycetin. Examples show that the preparation method has the advantages of low cost and simple, convenient process and no damage to personnel and environment in the whole operating process, the prepared product has the advantages of compact internal structure, difficulty in breaking, good flowability and water solubility, no residual methanol and good quality, and the yield can be stabilized to 95 to 98%.

The invention belongs to the field of environmental materials, and concretely relates to a preparation method and an application of a BiVO4@carbon nanodot composite photocatalytic material. Sodium lignosulfonate, bismuth nitrate pentahydrate and ammonium metavanadate are used as raw materials, the sodium lignosulfonate is added during the hydrothermal synthesis of BiVO4, and the sodium lignosulfonate controls the morphology growth of the BiVO4 in the reaction process, and is carbonized at a high temperature under a high pressure to obtain to nanodots so as to obtain the BiVO4@carbon nanodot composite material with a carbon nanodot wrapped BiVO4particle structure. The preparation process is simple and convenient, and the BiVO4@carbon nanodot composite photocatalytic material has a better oxytetracycline hydrochloride-degrading effect than the pure phase BiVO4 material, and has a great application prospect in degradation of antibiotic wastewater. The biomaterial is used as a carbon source, so the development and utilization of the biomaterial are broadened.

The invention provides a pesticide composition containing Dufulin and an antibiotic bactericide, and a bactericide thereof. The pesticide composition contains Dufulin and the antibiotic bactericide, wherein a weight ratio of Dufulin to the antibiotic bactericide is 60:1-1:80. The antibiotic bactericide is one of kasugamycin, zhongshengmycin, streptomycin sulfate, validamycin, polyoxin, tetramycin, blasticidin S, antimycin, cytosinpeptidemycin and oxytetracycline hydrochloride. The pesticide composition and the bactericide can be processed to prepare a wettable powder, a water dispersible granule, an emulsion in water, a micro-emulsion, a seed treatment dry powder, a suspension, a suspension seed coating agent, an ultralow-volume liquid or a granule. The pesticide composition and the bactericide are mainly used for controlling plant diseases, and have the advantages of substantial control effect, long persistent period, safety to crops, and obvious synergistic effects.