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40 results about "Pulmonary tb" patented technology
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Application of mycobacterium tuberculosis proteins in preparation of products used for diagnosis of latent tuberculosis infection
The invention provides 13 mycobacterium tuberculosis proteins in development and / or designing of products capable of discrimination, diagnosis, auxiliary diagnosis, screening and / or auxiliary screening of latent tuberculosis infection. The invention further provides protein chips prepared from 13 mycobacterium tuberculosis protein antigens. The protein chips prepared in the invention are used for detecting the levels of IgG antibodies respectively corresponding to the 13 protein antigens in serum of a patient with latent tuberculosis infection and of a normal person, and detection results of the antibodies respectively corresponding to the three protein are analyzed together so as to determine whether an examined person suffers from latent tuberculosis infection; detection results show that optimal operating points of the protein chips provided by the invention in auxiliary diagnosis of latent tuberculosis infection have specificity of 89.4% and sensitivity of 80.6%, both higher than indexes of diagnosis of latent tuberculosis infection in the prior art.
Owner:广东希格生物科技有限公司
Traditional Chinese medicine for treating pulmonary tuberculosis
InactiveCN102048989AUnique combinationAdjustment functionAntibacterial agentsPlant ingredientsBletilla striataBloodstained sputum
The invention relates to a traditional Chinese medicine for treating pulmonary tuberculosis, which belongs to the field of medicines. The invention aims to provide the traditional Chinese medicine for treating pulmonary tuberculosis, which adopts the theory of traditional Chinese medicine and has the effects of nourishing Yin and moistening lung, regulating functions of an organism, relieving cough and reducing sputum and the like. In the invention, the prepared traditional Chinese medicine comprises the following active ingredients: dwarf lilyturf tuber, root of straight ladybell, lily, bulbus fritilariae, manyflower solomonseal rhizome, yam, sessile stemona root, bletilla and platycodon root. The traditional Chinese medicine has unique compatibility, can regulate the overall functions of the organism, has the effects of nourishing Yin and moistening lung and relieving cough and reducing sputum, has the effective rate of 83.33 percent and is used for treating pulmonary tuberculosis and yin deficiency of lungs. The traditional chinese medicine provided by the invention is used for treating symptoms containing tussiculation, night sweat, feverish palms and soles, sputum with blood streaks or blood sports, chest ache, dry mouth and lips, shortness of cough, coughing with little viscous sputum, red cheek, dry skin, red tongue and shortage of the production of body fluid, thready pulse or weak or intermittent pulse and the like.
Owner:JILIN ACAD OF TRADITIONAL CHINESE MEDICINE
Kit for detecting active pulmonary tuberculosis
ActiveCN103045723AEarly Detection ImprovesEarly detection to improve the early diagnosis of active tuberculosisMicrobiological testing/measurementMicroorganism based processesSerum mirnaPulmonary tb
The invention provides a diagnostic kit for detecting active pulmonary tuberculosis. The kit consists of an RNA extract buffer solution, a specific serum miRNA composition for the active pulmonary tuberculosis, internal reference reverse transcription primers, polymerase chain reaction (PCR) primers and a fluorescent quantitative reverse transcription-polymerase chain reaction (RT-PCR) reaction solution, wherein the specific serum miRNA composition for the active pulmonary tuberculosis consists of four differential expression serum miRNAs, namely hsa-miR-29c, hsa-miR-22, hsa-miR-320b and hsa-miR-101. By using the specific serum miRNAs composition for the active pulmonary tuberculosis to detect the active pulmonary tuberculosis on the serum miRNAs level, the sensitivity is 90.2 percent, and the specificity is 75.0 percent; and the kit has early-stage diagnostic value for the active pulmonary tuberculosis, and can realize early warning and early diagnosis of the active pulmonary tuberculosis.
Owner:ZHEJIANG UNIV
Serum miRNA combination-based pulmonary tuberculosis therapeutic effect evaluation kit and applications thereof
InactiveCN106884052AReliable resultsStrong specificityMicrobiological testing/measurementRNA extractionCurative effect
The invention discloses a serum miRNA combination-based pulmonary tuberculosis therapeutic effect evaluation kit and applications thereof. The kit comprises an RNA extraction buffering solution, a Poly (A)-containing reaction solution, a reverse transcription reaction solution, a serum miRNA upstream primer combination, an internal reference upstream primer, a universal downstream primer and a fluorescent quantitation RT-PCR reaction solution, wherein the serum miRNA upstream primer combination comprises four differentially expressed serum miRNA: hsa-miR-21-5p, hsa-miR-92a-3p, hsa-miR-125a-5p and hsa-miR-148b-3p, the sequences of which are respectively SEQ ID NO:1, SEQ ID NO:2, SEQ ID NO:3 and SEQ ID NO:4; the internal reference is hsa-miR-16, the sequence of which is SEQ ID NO:5. The detection sensitivity of the kit on treatment of pulmonary tuberculosis is 65.38%, and the specificity is 80.77%, so that the specificity is strong and the sensitivity is high, and the kit has higher accuracy, and is simple and convenient to operate, high in efficiency, small in specimen state limit, and superior to the sputum culture currently clinically adopted, thus providing a new evaluation method for the evaluation on the therapeutic efficacy of pulmonary tuberculosis.
Owner:李继承
Pulmonary tuberculosis intelligent recognition method and system with image symptom interpretation
ActiveCN110969613AReliable Activity JudgmentReliable inner relationshipImage enhancementImage analysisX-rayImaging study
The embodiment of the invention provides a pulmonary tuberculosis intelligent recognition method and system with image symptom interpretation. The pulmonary tuberculosis intelligent recognition methodcomprises the steps: preprocessing an X ray chest radiograph so as to be converted into a vector diagram; carrying out abnormal region identification to obtain a classification result of whether a suspected focus exists or not; judging whether a suspected focus is identified in the abnormal area or not; performing classification correction processing to obtain a conditional probability of the suspected lesion; judging whether a suspected focus caused by pulmonary tuberculosis exists in the abnormal area or not; processing a suspected area corresponding to the suspected focus on an original image to obtain a sub-image vector diagram; explaining that the abnormal region has image characterization significance to obtain characterization description to judge whether the abnormal region has pulmonary tuberculosis or not; and based on the eigenimage description, carrying out pulmonary tuberculosis activity discrimination. According to the embodiment of the invention, the internal relation between the image symptom features in the chest radiography can be effectively obtained, and the judgment logic of iconography can be better met compared with the judgment made only based on the image,and the recognition precision and efficiency can be greatly improved.
Owner:PERCEPTION VISION MEDICAL TECH CO LTD +1
Medicament for treating pulmonary tuberculosis by combined chemotherapy with traditional Chinese medicine Fuying and preparation method
InactiveCN102784339AGood curative effectHave a double effectAntibacterial agentsOrganic active ingredientsBletilla striataIsoniazid
The invention relates to a medicament for treating pulmonary tuberculosis by combined chemotherapy with traditional Chinese medicine Fuying and a preparation method; in the medicament, a traditional Chinese medicine of Fuying No. I comprises gecko, donkey-hide gelatin, stemona, adenophora stricta, radix ophiopogonis, prunella vulgaris, radix scrophulariae, fritillaria thun-bergli, cortex lycii radicis, bletilla striata, picrorhiza scrophulariiflora pennell, rehmanniae radix, and anemarrhena, and is mainly used for expelling evil and nourishing yang; a traditional Chinese medicine of Fuying No. II comprises codonopsis pilosula, Chinese yam, poria cocos, schisandra chinensis, radix rehmanniae preparata, angelica, caulis spatholobi, gentrin knotweed, bighead atractylodes rhizome, and radix astragali, and is mainly used for strengthening the body resistance and nourishing body; western medicines participating the combined chemotherapy comprise: streptomycin injections, isoniazid tablets, rifampin, and pyrazinamide capsules; during the combined chemotherapy with the medicines, not only stable therapeutic effect on pulmonary tuberculosis is realized, but also nourishing treatment effect on patients with hepatopathy is realized; during preparation, geckoes are grinded into fine powder, and fried with donkey-hide gelatin; then the other medicines are cleaned, dried, pulverized, and grinded into fine powder; the fine powder is sieved by a No. 6 sieve to obtain a pulvis; the pulvis is packaged into bags to obtain the Fuying No. I. During the preparation of the Fuying No. II, the medicines are also selected, cleaned, pulverized, and grinded into fine powder; the fine powder is sieved by a No. 6 sieve to obtain a pulvis; the pulvis is packaged into bags to obtain the Fuying No. II. During treatment, the traditional Chinese medicine Fuying is combined with western medicines for administration.
Owner:辛焰
Sputum treating liquid for detecting Mycobacterium tuberculosis
InactiveCN105274185AComplete formEasy to useMicrobiological testing/measurementMicroorganism based processesBoronic acidEthanol
A sputum treating liquid for inspecting standard films of Mycobacterium tuberculosis in sputum comprises ethyl alcohol, isopropyl alcohol, boric acid, disodium EDTA, SDS, a mucus dissolving agent and distilled water and is capable of dissolving phlegm, deactivating pathogenic bacteria such as Mycobacterium tuberculosis as well as viruses in sputum, preventing corrosion and splitting exfoliative cells in sputum. Applied with simple centrifugal operation, the sputum treatment with the sputum treating liquid enables 8 to 10 spits of sputum to be treated at a time, and even sputum left for 24 hours, the treatment quantity of sputum is increased, standard operation is achieved through a standard automatic film-making technique, the operation is simple and easy, detection sensitivity is improved, detection is accurate and reliable, and the sputum treating liquid is suitable for the general investigation of tuberculosis high-risk groups, screening of rural tuberculosis and clinical diagnosis of tuberculosis.
Owner:NANJING BANGBO BIOTECH CO LTD
Anticonsumption preparation and its new preparation method
A composite Chinese medicine in the form of dripping pill and soft capsule for treating infiltrative pulmonary tuberculosis and blood-stained sputum, and its preparing process are disclosed.
Owner:FUKANGREN BIO PHARMA
Dry powder inhalant capable of preventing mycobacterium tuberculosis from transmitting through respiratory tract
InactiveCN103110633AEasy accessStop transmissionAntibacterial agentsOrganic active ingredientsIsoniazidMicrosphere
The invention relates to a dry powder inhalant capable of preventing mycobacterium tuberculosis from transmitting through respiratory tract, and is capable of effectively solving a medical problem that mycobacterium tuberculosis infects pulmonary tuberculosis through the respiratory tract. The method comprises the following steps of: preparing the dry powder inhalant from 9.9-80% of an isoniazide sustained release microsphere, 19.9-90% of a rifampicin sustained release microsphere and 0.1-5% of a flow aid by weight percent, uniformly mixing the isoniazide sustained release microsphere, the rifampicin sustained release microsphere and the flow aid, packaging in gelatin or plastic capsules or aluminum-plastic bubble caps, or packaging in a multi-dosage dry powder inhalation device in the form of a reservoir, so as to obtain the dry powder inhalant. The dry powder inhalant disclosed by the invention is scientific and rational in formula, easy to produce and manufacture, good in use effect, and favorable for the powder to enter into pulmonary alveoli; the medicine is transmitted to and absorbed by the pulmonary alveoli to effectively kill and inhibit mycobacterium tuberculosis in trachea, bronchia and alveoli secretion of the respiratory tract, so as to reduce the quantity of floating droplets of patients of pulmonary tuberculosis removed in the surrounding environment, and to block the transmission of the mycobacterium tuberculosis in the public environment; and therefore, the dry powder inhalant has an important meaning for preventing the pulmonary tuberculosis.
Owner:ZHENGZHOU UNIV
Protein markers assisting diagnosis of severe secondary pulmonary tuberculosis
The invention discloses protein markers assisting diagnosis of severe secondary pulmonary tuberculosis. The invention provides applications of a product for detecting SOD1 protein, a product for detecting S100A9 protein, a product for detecting ORM2 protein and a product for detecting IL1F6 protein in preparation of a kit used for assisting diagnosis of severe secondary pulmonary tuberculosis. The four protein markers (S100A9, ORM2, IL1F6 and SOD1) assisting diagnosis of the severe secondary pulmonary tuberculosis are found, and a model for assisting diagnosis of the severe secondary pulmonary tuberculosis by utilizing the four protein markers is built. The protein markers provide basis for further explanation of developing and aggravating mechanisms of the secondary pulmonary tuberculosis, provide a novel method and novel indexes for disease development, aggravation early warning, and forecast evaluation, lays a foundation for reasonable treatment and cure of the severe secondary pulmonary tuberculosis, and provides technical supports for reducing the death rate of pulmonary tuberculosis.
Owner:BEIJING CHEST HOSPITAL CAPITAL MEDICAL UNIV
One group of nucleic acid aptamers capable of specifically identifying Beijing genotypes tuberculosis bacterial strain antigen and application of nucleic acid aptamers
ActiveCN104450724AHigh affinityStrong specificityMaterial analysisDNA/RNA fragmentationAptamerAntigen
Owner:武汉顺可达生物科技有限公司
Pulmonary tuberculosis sampler
PendingCN111721587AEasy to move up and downConvenient automatic insertionWithdrawing sample devicesChemicalsEngineeringPulmonary tb
The invention discloses a pulmonary tuberculosis sampler, which comprises a supporting column, an electric telescopic rod, a cleaning box and a positive and negative motor, wherein a top cover is fixedly mounted above the supporting column, a sampling needle tube is connected to the middle of the upper part of the top cover, a piston rod is connected to the inner side of the sampling needle tube,a groove is formed in the lower portion of the left side of the piston rod, an electric telescopic rod is fixedly installed on the left side of the top cover, a sliding groove is formed in the inner surface of the supporting column, a rotating rod is rotatably connected to the bottom of the supporting column, and a connecting block is welded to the inner side of the cleaning box. According to thepulmonary tuberculosis sampler, the positive and negative motor can drive the rotating gear to be meshed with tooth blocks on the surface of the sampling needle tube, so that the sampling needle tubecan conveniently move up and down on the surface of the top cover, the sampler can be conveniently and automatically inserted into a cup for containing pathogen sputum of pulmonary tuberculosis, and the rod body of the sampler can conveniently extend upwards and conveniently drive the piston rod to move upwards for sampling operation by matching with the electric telescopic rod.
Owner:岑良
Breathing machine for internal medicine-tuberculosis
The invention discloses a breathing machine for internal medicine-tuberculosis. The breathing machine includes a disinfecting box; the top end of the disinfecting box is provided with an installationmouth; a filtering plate is slidingly installed in the installation mouth; the top end of the filtering plate extends to the external of the disinfecting box and is fixedly connected to a baffle plate; the top end of the baffle plate is fixedly connected to a pulling handle; the side, away from the installation mouth, on the top end of the disinfecting box is fixedly connected to a water adding port; a sealing cover is installed on the water adding port in a threaded manner; one side of the disinfecting box is respectively and fixedly connected to an air outlet pipe and a water outlet pipe; and the water outlet pipe is located under the air outlet pipe. The breathing machine is reasonable in structure and significant in beneficial effect, and has double disinfection effects; the tuberculosis viruses left on the disinfecting box and the filtering plate can be completely killed, so that the spreading of the viruses can be effectively isolated; the filtering plate can be conveniently taken out, so that the convenient replacing of the filtering plate can be realized; and a catheter can be conveniently stored in a catheter storage box, so that the dragging of the catheter due to the excessive long catheter can be effectively prevented from causing the twining and damaging of the catheter.
Owner:曹雪松
Classification device based on lipid biomarkers and application
PendingCN112185462AReduce physical injuryBiostatisticsHybridisationLipid biomarkerHematological test
The invention discloses a classification device based on lipid biomarkers and application. Specifically, the classification device based on lipid biomarkers comprises a data acquisition module configured to acquire a feature data set of a patient; a model matching module configured to inquire a classification model library and determine a matched classification model according to the medication characteristics, wherein the classification model is obtained by training a preset classification algorithm according to expression quantities of lipid biomarkers in blood of different types of patients; and a patient classification module configured to obtain a classification result of the patient for pulmonary tuberculosis according to the classification model and the expression quantities of thelipid biomarkers in the blood. According to the technical scheme, harm to the body of a patient is low, the device can be suitable for early screening of pulmonary tuberculosis and evaluation of whether pulmonary tuberculosis is cured or not, and a new and objective classification scheme is provided for early screening diagnosis and curative effect evaluation of pulmonary tuberculosis.
Owner:李继承
Antibacterial and anti-inflammatory medical gel and preparation method thereof
PendingCN114425098AImprove antibacterial and anti-inflammatory functionsHigh medical valueBandagesBiotechnologyDisease
The invention belongs to the technical field of medical dressings, and particularly relates to antibacterial and anti-inflammatory medical gel and a preparation method thereof.The medical gel is prepared from, by weight, 45-65 parts of deionized water, 20-30 parts of hydroxymethyl chitosan, 15-25 parts of polyvinyl alcohol, 10-15 parts of calcium alginate, 0-12 parts of glycerin, 8-10 parts of emulsifier, 3-6 parts of preservative and 8-12 parts of traditional Chinese medicine additive; wherein the traditional Chinese medicine additive is prepared from the following raw materials in parts by weight: 4-6 parts of honeysuckle flowers and 4-6 parts of hibiscus syriacus roots; honeysuckle flowers have the effects of resisting pathogenic microorganisms, resisting toxicity, diminishing inflammation, promoting the phagocytic function of inflammatory cells and the like in pharmacology, hibiscus syriacus roots are sweet in taste and cool in nature, return to lung, kidney and large intestine meridians, have the effects of clearing away heat and toxic materials and eliminating carbuncle swelling and can be used for treating diseases such as intestinal wind, dysentery, pulmonary abscess, intestinal abscess, haemorrhoids swelling and pain, leukorrheal reddish discharge, mange and pulmonary tuberculosis. The antibacterial and anti-inflammatory functions of the gel can be greatly improved, and the medical value of the gel is improved.
Owner:褚二喜
Pulmonary tuberculosis risk assessment method and system based on exhaled gas mass spectrum detection
PendingCN114324549AIncreased sensitivityImprove featuresMaterial analysis by electric/magnetic meansCharacter and pattern recognitionPulmonary tbIntensive care medicine
The invention discloses a pulmonary tuberculosis risk assessment method and system based on exhaled gas mass spectrum detection. The method comprises the following steps: collecting an exhaled gas sample of a target population; detecting each exhaled gas sample through mass spectrometric detection equipment, and outputting an original spectrogram; performing calibration processing on the original spectrogram to obtain a standard spectrogram; dividing the standard spectrogram into a training set and a verification set according to a preset proportion; extracting the relative abundance of the volatile organic compound of each molecular weight under the determined molecular weight precision as a mass spectrum characteristic; constructing a spectrogram classification model; training for multiple times, and selecting the spectrogram classification model with the optimal AUC as a pulmonary tuberculosis detection model; and collecting expired gas of a to-be-detected person, and inputting the expired gas into the pulmonary tuberculosis detection model after mass spectrometric detection to obtain a pulmonary tuberculosis risk assessment result. The kit has good sensitivity and specificity in pulmonary tuberculosis diagnosis, and has the advantages of low detection limit, high resolution, high sensitivity, high detection speed and the like.
Owner:SHENZHEN BREATHA BIOTECHNOLOGY CO LTD
Traditional Chinese medicine composition for treating dog tuberculosis and preparation method of traditional Chinese medicine composition
InactiveCN104906543ALow side effectsLower resistanceAntibacterial agentsAluminium/calcium/magnesium active ingredientsPinelliaBottle
The invention relates to a traditional Chinese medicine composition for treating dog tuberculosis. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 10-20 parts of platycodon grandiflorum, 11-20 parts of semen lepidii, 10-20 parts of Chinese-date, 12-20 parts of ephedra, 10-13 parts of gypsum, 10-20 parts of pinellia ternate and 10-14 parts of fresh ginger. The traditional Chinese medicine composition can be water aqua. The preparation method comprises the following preparation steps: (1) weighing various traditional Chinese medicines according to the formula ratio, and feeding to an extraction tank; (2) adding 5-15fold water to the extraction tank, and boiling twice and 2-12 hours each time; (3) filtering and merging filtrate of twice; (4) carrying out vacuum concentration at 30-80 DEG C until the volume is 10%-50% of original volume; and (5) filtering, deslagging and filling each bottle with100-200ml of liquid to obtain a finished product. The composition has the efficacies of relieving cough and asthma, eliminating phlegm, promoting circulation of qi, invigorating the spleen and replenishing qi; the traditional Chinese medicine composition provided by the invention is capable of treating exterior and interior of the dog tuberculosis, and is significant in curative effect; and the recovery rate can reach 90%.
Owner:GREAT BIOLOGY PHARMA TIANJIN
Respirator for pulmonary tuberculosis patients
The invention discloses a respirator for pulmonary tuberculosis patients. The respirator comprises a breathing mask, a processor and a corrugated pipe, wherein the breathing mask is provided with an air inlet and an air outlet, and a first activated carbon filter layer is arranged in the air inlet and used for filtering inhaled air; the processor comprises a shell and an ultrasonic nebulizer, the shell is provided with an atomization cavity and an exhaust cavity; the ultrasonic nebulizer is arranged in the atomization cavity and used for atomizing disinfectant in the atomization cavity to form atomized liquid medicine; atomization spray holes are formed between the exhaust cavity and the atomization cavity, and the atomized liquid medicine is sprayed into the exhaust cavity through the atomization spray holes; and one end of the corrugated pipe is connected to the air outlet, and the other end of the corrugated pipe is connected to the exhaust cavity, so that air exhausted from the air outlet is exhausted after being disinfected by the atomized liquid medicine in the exhaust cavity. The respirator for pulmonary tuberculosis patients provided by the embodiment of the invention can be used for performing disinfection and sterilization on exhaled air, and the infection risk can be greatly reduced.
Owner:THE THIRD PEOPLES HOSPITAL OF SHENZHEN
Traditional Chinese medicine for treating tuberculosis
InactiveCN105617196AImprove immunitySignificant effectAntibacterial agentsDispersion deliveryMedicinal herbsLiver and kidney
The invention relates to the field of traditional Chinese medicine, in particular to traditional Chinese medicine for treating tuberculosis. Each dose of the traditional Chinese medicine for treating tuberculosis comprises the following medicinal herbs: 25 g of lily, 25 g of ainsliaea fragrans Champ., 25 g of radix stemonae, 25 g of bletilla, 25 g of humulus japonicus, 25 g of lucid asparagus, 15 g of cortex lycii radicis, 15 g of dwarf lilyturf turber, 30 g of heartleaf houttuynia herb, 30 g of siegesbeckia glabrescens makino, 25 g of petelot habenaria, 25 g of walnut kernel, 10 g of ginkgo, 15 g of osbeckia opipara, 10 g of longspur epimedium, 30 g of semen coicis, 25 g of alpinia japonica, 25 g of ceylon cynoglossum, 30 g of cirsium japonicum, 20 g of bistort, 50 g of cynoglossumfurcatum Wall., 15 g of Chinese arbor-vitae branches, 30 g of pilea notata and 30 g of liquorice. The traditional Chinese medicine for treating tuberculosis adopts the various traditional Chinese medicines to condition lungs, has the efficacies of nourishing yin, moistening lung, suppressing cough, reducing phlegm, cooling blood, stopping bleeding, removing blood stasis to regenerate tissues, regulating the flow of qi, relieving pain, benefiting a liver and kidneys, resisting bacterium, tonifying deficiency, and enhancing immunity, not only can resist tuberculosis from the source, but also can protect the lever, has obvious effects in treating symptoms such as cough, expectoration, hemoptysis and chest pain of tuberculosis, is free of toxic and side effects, and high in safety, and can treat both symptoms and root causes.
Owner:AFFILIATED YONGCHUAN HOSPITAL OF CHONGQING MEDICAL UNIV
Application of CD4+T lymphocyte characteristic protein to identification of latent tuberculosis infection and active tuberculosis
The invention discloses application of CD4+T lymphocyte characteristic protein to identification of active tuberculosis and latent tuberculosis infection (LTBI). The invention provides application ofa substance for detecting an expression quantity of integrin beta-3 and / or integrin-linked kinase to preparation of a product for distinguishing or identifying or assisting to distinguish or identifya patient with the active tuberculosis and a latent tuberculosis infection infected person. The invention finds out that integrin beta-3 and integrin-linked kinase protein can distinguish an LTBI patient and an initially-treated active tuberculosis patient, and novel diagnostic standards are provided for diagnosing the LTBI patient and the initially-treated active tuberculosis patient.
Owner:BEIJING CHEST HOSPITAL CAPITAL MEDICAL UNIV
Pharmaceutical composition suitable for primary treatment of extra-short-range treatment of smear-positive pulmonary tuberculosis
InactiveCN112294822AShorten treatment timeImprove absorption rateAntibacterial agentsOrganic active ingredientsPyrazineChemotherapy combinations
The invention discloses a pharmaceutical composition suitable for primary treatment of extra-short-range treatment of smear-positive pulmonary tuberculosis. The invention provides the pharmaceutical composition for treating primary treatment of smeared-positive pulmonary tuberculosis. The pharmaceutical composition is composed of levofloxacin, isoniazid, rifampicin, pyrazinamide and ethambutol. The pharmaceutical composition provided by the invention can be used for completing the primary treatment of the smeared-positive pulmonary tuberculosis through chemotherapy for four and a half months with a shorter range and higher efficiency, and compared with a standard six-month chemotherapy regimen, the pharmaceutical composition has the characteristic of high focus absorptivity, under the condition of ensuring a higher sputum culture negative conversion rate, a lower adverse reaction rate, a higher cure rate and a lower recurrence rate. According to the present invention, the treatment time of the primary treatment of the smeared-positive pulmonary tuberculosis can be shortened, and the pharmaceutical composition has important significance for reducing the prevalence and propagation oftuberculosis.
Owner:BEIJING CHEST HOSPITAL CAPITAL MEDICAL UNIV +1
Traditional Chinese medicine for treating pulmonary tuberculosis
InactiveCN102048989BUnique combinationAdjustment functionAntibacterial agentsPlant ingredientsBletilla striataBloodstained sputum
Owner:JILIN ACAD OF TRADITIONAL CHINESE MEDICINE
A set of peripheral blood gene markers for noninvasive diagnosis of active pulmonary tuberculosis
ActiveCN107523626BEasy to detectImprove accuracyMicrobiological testing/measurementDNA/RNA fragmentationDiseasePulmonary tb
The invention discloses a group of peripheral blood gene markers for noninvasive diagnosis of active pulmonary tuberculosis, and primers are designed according to the group of peripheral blood gene markers, and the designed primers can be used for noninvasive diagnosis of active pulmonary tuberculosis. The invention can effectively distinguish tuberculosis patients from normal people, tuberculosis patients from other lung disease groups, tuberculosis patients from potential tuberculosis-infected individuals, and can be used as an indicator for detecting anti-tuberculosis curative effect. The detection is convenient, non-invasive, highly accurate and specific Strong, good stability, suitable for promotion and use.
Owner:顾万君 +1
Medicinal composition for treating pulmonary tuberculosis, and preparation method and use thereof
InactiveCN105381355ASignificant effectNo side effectsAntibacterial agentsOrganic active ingredientsFritillaria cirrhosaTreatment effect
The invention discloses a medicinal composition for treating pulmonary tuberculosis, and a preparation method and a use thereof. The medicinal composition is prepared from Radix Glehniae, Radix Stemonae, Anemone chinensis, Radix Ranunculi Ternati, Common Boxwood, Cortex Lycii, centipedes, Fagopyrum cymosum, Orange Sugarmustard, Metaplexis japonica (Thunb.) Makino, Human Placenta, Veronica peregrina L., Fritillaria cirrhosa, deerhorn glue, turtle shell, Hibiscus trionum, Poria cocos, Meconopsis punicea, oyster, tingli seed and pork lung extract; the pork lung extract is one or more of phosphatidylcholine, dipalmitoylphosphatidylcholine, phosphatidylethanolamine, phosphatidylserine, phosphatidylinositol and sphingomyelin; and the effective component of Common Boxwood is cycloprotobuxinamin. The medicinal composition adopting traditional Chinese medicine and western medicine combination has the efficacies of moistening lung and relieving coughs, clearing heat and eliminating inflammation, cooling blood and stopping bleeding, and eliminating swelling and relieving pains, and has the advantages of substantial pulmonary tuberculosis treatment effect, safety, reliability, no toxic or side effects, short treatment course, fast effectiveness, low cost, and reaching of the purpose of simultaneous treatment of principal and subordinate symptoms.
Owner:吴申龙
A kind of traditional Chinese medicine prescription and its application in the preparation of pulmonary tuberculosis auxiliary medicine
ActiveCN108498745BAbnormal liver functionPromotion of overcastAntibacterial agentsDispersion deliveryBiotechnologyAngelica Sinensis Root
The invention discloses a prescription of a traditional Chinese medicine and application of the prescription in preparation of a pulmonary tuberculosis assistance medicine. The traditional Chinese medicine is prepared from a main medicinal component including the following ingredients in parts by weight: 30-45 parts of schisandra chinensis, 30-40 parts of lily, 25-30 parts of angelica sinensis and25-30 parts of poria cocos, and an auxiliary medicinal component including the following ingredients in parts by weight: 20-25 parts of Chinese yam, 15-20 parts of Jordan almonds, 10-15 parts of Chinese wolfberry fruits, 12-15 parts of radix salviae miltiorrhizae, 10-15 parts of radix stemonae and 8-10 parts of rhizoma atractylodis macrocephalae. After the prescription of the traditional Chinesemedicine is used for 2 months, the effective rate for converting sputum bacteria to negative is 93.33 percent, the effective rate of focus is 77.78 percent, the effective rate of imageological changeis 84.44 percent, which are remarkably higher than those of a control group (P is more than 0.05) without the prescription. The traditional Chinese medicine can assist an antituberculous scheme to remarkably improve the pulmonary tuberculosis resistance, and can achieve the effects of promoting sputum bacterial to be converted to negative, promoting focus absorption and closing the hole, so that the clinical symptom can be improved.
Owner:PEOPLES HOSPITAL OF XINJIANG UYGUR AUTONOMOUS REGION +1
A traditional Chinese medicine for invigorating spleen and dehumidification and preparation method thereof
ActiveCN105435084BGood reliefGood gastrointestinal responseDispersion deliveryDigestive systemFurred tongueAntituberculosis drug
The invention provides traditional Chinese medicine having the effects of invigorating spleen and removing damp and a preparation method thereof. The traditional Chinese medicine is prepared from the following components in parts by weight: 10-30 parts of dangshen, 10-30 parts of astragalus, 5-25 parts of bighead atractylodes rhizome, 5-25 parts of poria cocos, 5-25 parts of apricot kernel, 5-25 parts of pinellia tuber, 1-20 parts of dried orange peel, 5-25 parts of sessile stemona root, 5-25 parts of amomum fruit, 5-25 parts of bitter orange, 5-25 parts of baikal skullcap root and 1-20 parts of liquoric root. The traditional Chinese medicine having the effects of invigorating spleen and removing damp provided by the invention comprises a plurality of Chinese medicinal active components, has the effects of invigorating spleen, tonifying Qi, regulating the middle warmer and the like, has good relieving effects on the common symptoms of cough, expectoration, tiredness, muscle emaciation, poor appetite, tongue coating, weak pulse and the like of retreated pulmonary tuberculosis patients, and has a good relieving effect on a gastrointestinal reaction occurring after taking of anti-tubercular agents. The preparation method of the traditional Chinese medicine having the effects of invigorating spleen and removing damp provided by the invention has the advantages of convenience, simpleness, easiness for operation and the like, and is suitable for batch production and wide application.
Owner:叶庆
Uses of hsa-mirna-423-5p and hsa-mirna-423-5p inhibitors
ActiveCN108866177BReduced scavengingClearance pick-upAntibacterial agentsMicrobiological testing/measurementResistant tuberculosisPharmacology
The invention discloses the use of hsa-miRNA-423-5p in the preparation of an autophagy maturation inhibitor, and the use of the hsa-miRNA-423-5p inhibitor in the preparation of a drug for treating tuberculosis. The expression level of hsa-miRNA-423-5p provided by the present invention in the serum of tuberculosis patients is significantly higher than that of healthy controls, and it is confirmed that when hsa-miRNA-423-5p is highly expressed, it can lead to obvious autophagy maturation blocking phenomenon; hsa When the expression of ‑miRNA‑423‑5p is inhibited, the phenomenon of autophagy maturation inhibition is relieved. Therefore, hsa‑miRNA‑423‑5p can be used as a good target for the treatment of tuberculosis. Moreover, hsa-miRNA-423-5p is a small molecule that exists by itself, so it is superior to chemical drugs in terms of side effects, and will not cause drug-resistant tuberculosis due to repeated medication.
Owner:李继承
Detection kit for phthisis mitochondria-derived small RNA (Ribonucleic Acid)
PendingCN114540518AImprove stabilityImprove featuresMicrobiological testing/measurementAgainst vector-borne diseasesPulmonary tbSmall RNA
The invention discloses a pulmonary tuberculosis mitochondria-derived small RNA (Ribonucleic Acid) detection kit. The pulmonary tuberculosis mitochondria-derived small RNA detection kit is characterized by comprising a pair of reverse transcription primers and detection primers corresponding to up-regulation of the expression ratio of mitochondria-derived small RNA and 6 pairs of down-regulation of the expression ratio of mitochondria-derived small RNA. The invention provides a specific expression profile of a mitochondrial-derived small RNA (mdsRNA) ratio in peripheral blood of a pulmonary tuberculosis patient, and a reverse transcription primer, a detection primer, a detection kit and a diagnosis model of the specific expression profile, and provides support for early discovery and early treatment of clinical pulmonary tuberculosis.
Owner:LIUZHOU WORKERS HOSPITAL
Serum metabolism marker related to pulmonary tuberculosis and application thereof
The invention discloses a serum metabolism marker related to pulmonary tuberculosis and application of the serum metabolism marker related to the pulmonary tuberculosis, and the serum metabolism marker related to the pulmonary tuberculosis comprises at least one of 3-oxopalmitic acid, akebia stem saponin, thiolithocholic acid, 2-decyl furan, (decahydro-4, 8, 8-trimethyl-1, 4-methylene azulene-9-subunit) methanol, D-(+)-camphor and 2-methylamino adenosine, and the serum metabolism marker related to the pulmonary tuberculosis comprises at least one of 3-oxopalmitic acid, akebia stem saponin, thiolithocholic acid, 2-decyl furan, (decahydro-4, 8, 8-trimethyl-1, 4-methylene azulene-9-subunit) methanol, D-(+)-camphor and 2-methylamino adenosine. According to the application, the serum metabolism marker is used for preparing a detection reagent or applied to detection related to pulmonary tuberculosis. The serum metabolism marker is suitable for detection related to pulmonary tuberculosis, the accuracy of the detection result is high, and the detection efficiency can be improved.
Owner:广东省结核病控制中心
Excrement metabolite and detection system for detecting active pulmonary tuberculosis
The invention discloses an excrement metabolite and detection system for detecting active pulmonary tuberculosis. The excrement metabolite is selected from 13 kinds of differential metabolites. The detection system is based on an excrement LC-MS metabonomics technology, LC-MS detection is carried out on excrement of a to-be-detected patient, the relative expression quantities of 13 different metabolites are obtained respectively, and then whether the to-be-detected patient is an active pulmonary tuberculosis patient or not is judged according to the relative expression quantities of the metabolites. Compared with the traditional method, the method provided by the invention has the advantages of non-invasion, simple sample treatment, no damage to the sample, small sample injection amount, good repeatability, low cost and the like.
Owner:广东省结核病控制中心
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