481 results about "Sarcosine" patented technology

A shortened process for producing a solution containing substantially purified capsular polysaccharides from a cellular Streptococcus pneumoniae lysate broth is described. Ultrafiltering and diafiltering a clarified S. pneumoniae lysate followed by pH adjustment to less than 4.5, preferably about 3.5, precipitated at least 98% of the protein in the solution without seriously affecting polysaccharide yield. Furthermore, following ultrafiltration and diafiltration and acidification to a pH of less than 4.5, filtration using activated carbon precipitated at least 90% of remaining protein without seriously affecting polysaccharide yield. Exemplary, non-limiting S. pneumoniae serotypes that can be purified using the shortened process of the invention are 1, 4, 5, 6A, 6B, 7F, 9V, 14, 18C, 19A, 19F, and 23F. In one embodiment, the Streptococcus pneumoniae cells are lysed using deoxycholate sodium (DOC), while in another embodiment the lytic agent is a non-animal derived lytic agent such as N-lauryl sarcosine sodium (NLS).

A high throughput screening and isolation system identifies rare enhancer mixtures from a candidate pool of penetration enhancer combinations. The combinations are screened for high penetration but low irritation potential using a unique data mining method to find new potent and safe chemical penetration enhancer combinations. The members of a library of chemical penetration enhancer combinations are screened with a high throughput device to identify “hot spots”, particular combinations that show higher chemical penetration enhancement compared to neighboring compositions. The irritation potentials of the hot spot combinations are measured to identify combinations that also show low irritation potential. A active component, such as a drug, is then combined with the combination in a formulation which is tested for the ability of the drug to penetrate into or through skin. It is then assessed whether the formulation can deliver the quantity of drug required, and animal tests are conducted to confirm in vivo the ability of the chemical penetration enhancer combinations to facilitate transport of sufficient active molecules across the skin to achieve therapeutic levels of the active molecule in the animal's blood. The invention provides specific unique and rare mixtures of chemical penetration enhancers that enhance skin permeability to hydrophilic macromolecules by more than 50-fold without inducing skin irritation, such as combinations of sodium laurel ether sulfate and 1-phenyl piperazine, and combinations of N-lauryl sarcosine and Span 20 / sorbitan monolaurate.

A composition is disclosed herein comprising from about 0.001% to about 0.4% cyclosporin A, castor oil, and a surfactant selected from the group consisting of alcohol ethoxylates, alcohols, alkyl glycosides, alkyl polyglycosides, alkylphenol ethoxylates, amine oxides, block polymers, carboxylated alcohol or alkylphenol ethoxylates, carboxylic acids / fatty acids, cellulose derivatives, ethoxylated alcohols, ethoxylated alkylphenols, ethoxylated aryl phenols, ethoxylated fatty acids, ethoxylated fatty acids, ethoxylated fatty esters and oils, fatty alcohols, fatty esters, glycol esters, lanolin-based derivatives, lecithin and lecithin derivatives, lignin and lignin derivatives, methyl esters, monoglycerides and derivatives , phosphalipids, polyacrylic acids, polyethylene glycols, polyethylene oxide-polypropylene oxide copolymers, polyethylene oxides, polymeric surfactants, polypropylene oxides, propoxylated alcohols, propoxylated alkyl phenols, propoxylated fatty acids, protein-based surfactants, sarcosine derivatives, silicone-based surfactants, sorbitan derivatives, stearates, sucrose and glucose esters and derivatives, and combinations thereof.

The instant invention relates to a lubricant composition stabilized against the deleterious effects of heat and oxygen. The composition comprises a hydrotreated or hydrodewaxed oil and an effective antioxidant stabilizing amount of a mixture of a phenolic antioxidant; an N,N-disubstituted aminomethyl-1,2,4-triazole; an aromatic amine antioxidant; an alkyl phenoxy alkanoic acid; and an N-acyl sarcosine derivative. Optionally, further additives are added to the subject lubricant compositions.

A method and related compositions, including the use of N-acyl derivatives of sarcosine, provide for the delivery of bioactive agents through tissue surfaces such as the skin. The method and composition are particularly well suited for hydrophobic active agents such as serotonin (5HT3) receptor antagonists (e.g., ondansetron), antipsychotic agents (e.g., risperidone), benzodiazepines (e.g., flumazenil), and progestins (e.g., levonorgestrel).

Compositions of the formulae (I), (II) and (III); where R1, R2 and R3 are residues of amino acids such as, but not limited to, valine, sarcosine, leucine, glutamine, tryptophan, tyrosine, alanine and 4(4-aminophenyl)butyric acid or combination thereof, and salts thereof. Methods of preparation of these compositions and methods of treating any disease condition responsive to THC comprising administration of at least one these compositions in a pharmaceutically acceptable carrier using a pharmaceutically acceptable formulation.

A composition is disclosed herein comprising from about 0.001% to about 0.4% cyclosporin A, castor oil, and a surfactant selected from the group consisting of alcohol ethoxylates, alcohols, alkyl glycosides, alkyl polyglycosides, alkylphenol ethoxylates, amine oxides, block polymers, carboxylated alcohol or alkylphenol ethoxylates, carboxylic acids / fatty acids, cellulose derivatives, ethoxylated alcohols, ethoxylated alkylphenols, ethoxylated aryl phenols, ethoxylated fatty acids, ethoxylated fatty acids, ethoxylated fatty esters and oils, fatty alcohols, fatty esters, glycol esters, lanolin-based derivatives, lecithin and lecithin derivatives, lignin and lignin derivatives, methyl esters, monoglycerides and derivatives, phosphalipids, polyacrylic acids, polyethylene glycols, polyethylene oxide-polypropylene oxide copolymers, polyethylene oxides, polymeric surfactants, polypropylene oxides, propoxylated alcohols, propoxylated alkyl phenols, propoxylated fatty acids, protein-based surfactants, sarcosine derivatives, silicone-based surfactants, sorbitan derivatives, stearates, sucrose and glucose esters and derivatives, and combinations thereof.

There is provided a coated powder having a high skin care effect and a high anti-aging effect. The powder which can be used in cosmetics is coated with a mixture (lipoamino acid composition) comprising N-acyl derivatives (also including the form of a salt) of (1) at least one amino acid selected from proline and hydroxyproline, (2) at least one amino acid selected from alanine, glycine and sarcosine and (3) at least one amino acid selected from aspartic acid and glutamic acid, and at least one selected from fatty acids (and / or metal salts thereof) having a carbon number of at least 12 and at most 22.

A composition is disclosed herein comprising from about 0.001% to about 0.4% cyclosporin A, castor oil, and a surfactant selected from the group consisting of alcohol ethoxylates, alcohols, alkyl glycosides, alkyl polyglycosides, alkylphenol ethoxylates, amine oxides, block polymers, carboxylated alcohol or alkylphenol ethoxylates, carboxylic adds / fatty acids, cellulose derivatives, ethoxylated alcohols, ethoxylated alkylphenols, ethoxylated aryl phenols, ethoxylated fatty acids, ethoxylated fatty acids, ethoxylated fatty esters and oils, fatty alcohols, fatty esters, glycol esters, lanolin-based derivatives, lecithin and lecithin derivatives, lignin and lignin derivatives, methyl esters, monoglycerides and derivatives, phosphalipids, polyacrylic acids, polyethylene glycols, polyethylene oxide-polypropylene oxide copolymers, polyethylene oxides, polymeric surfactants, polypropylene oxides, propoxylated alcohols, propoxylated alkyl phenols, propoxylated fatty acids, protein-based surfactants, sarcosine derivatives, silicone-based surfactants, sorbitan derivatives, stearates, sucrose and glucose esters and derivatives, and combinations thereof.

The sarcosine compounds used as a corrosion inhibitor according to the present invention include sarcosine and salt compounds thereof. The corrosion inhibitor is used in chemical mechanical polishing compositions or post CMP clean agents, which forms a protective film on the surface of a work piece to prevent the work piece from corrosion in chemical mechanical polishing, and thus common residue defect on the surface of a work piece due to the use of a conventional corrosion inhibitor (e.g. benzotriazole (BTA)) can be improved or the surface of a work piece can be protected from corrosion in post-CMP cleaning.

The invention relates to an emulsified metal antirusting agent and a preparation method thereof. The antirusting agent comprises the components by weight percentage of 2-2.5% of dicarboxylic acid, 6-6.5% of triethanolamine, 1-1.5% of monoethanolamine, 5-6.5% of synthesized borate, 8-10% of dodecenylbutadioic acid, 4.5-6% of octadecane oeoyl sarcosine acid, 0.1% of benzotriazole and 66.9-73.4% of water. The preparation method comprises the following steps of: firstly preparing a water-base antirusting agent; subsequently adding the octadecane oeoyl sarcosine acid, the synthesized borate and thedodecenylbutadioic acid in a reaction kettle; and mixing the solution, thus obtaining the emulsified antirust product. The method utilizes the strong adsorption function between the antirusting agentand the metal, displaces the residual oil dirt out of the surface of the metal, leads the surface of the metal to be adsorbed by a hydrophobic protective film; no oil dirt is remained on the surfaceof the metal that is processed by the antirusting agent, and the surface of the metal is not easy to be polluted by the dust; the antirusting agent can be used directly; furthermore, the components contains no nitrite, thus being safe and environment-friendly for use.

The present invention relates to one kind of efficient whitening toothpaste and its making process. The efficient whitening toothpaste is compounded with nanometer silica 30-40 wt%, natural glycerin 10-15 wt%, sorbitol 18-30 wt%, methylol cellulose 0.5-1.2 wt%, hydroxyethyl cellulose 0.1-0.3 wt%, sodium lauryl sarcosine 1.5-2.5 wt%, complex enzyme 0.01-0.1 wt%, whitening particle 1.5-5 wt%, EDTA-2Na 0.1-0.3 wt%, zinc citrate 0.5-3.5 wt%, propolis 0.3-0.8 wt%, strontium chloride 0.5-0.8 wt%, saccharin sodium 0.2-0.3 wt%, D-panthenol 0.8-1.0 wt%, perfume 0.8-1.2 wt%, and deionized water for the rest. Based on the formation cause of tooth yellow, dental plaque, tartar, tea dirt and cigarette dirt, four cleaning and whitening components are selected to produce synergistic whitening effect without damage to enamel.

The invention provides oil-control anti-hair-loss liquid shampoo and belongs to the technical field of washing and cosmetic products.The oil-control anti-hair-loss liquid shampoo comprises, by percent content, 15-20% of sodium lauryl polyoxyethylene ether sulfate, 5-10% of cocoamidopropyl betaine, 5-10% of sodium lauroyl sarcosine, 1-3% of cocamidopropyl DEA, 1-2% of cocamidopropyl MEA, 1-5% of isopropanol, 1-5% of glossy privet fruit extract, 1-5% of prepared rehmannia roots, 1-5% of ginger extract, 1-5% of cacumen biotae extract, 0.5-1.5% of thickener, 0.1% of bactericide, 0.1% of citric acid and the balance water, wherein the percent content of all components sums up to 100%.According to the oil-control anti-hair-loss liquid shampoo, through mutual compatibility and the synergistic effect of all the components, the oil-control and anti-hair-loss effects can be achieved, oil control time is effectively prolonged, hair can maintain clean and cool for a long time, and thereby the effect of preventing alopecia seborrhoeica is achieved.

The embodiments provide Compound KC-7, N-1-[(S)-2-(oxycodone-6-enol-carbonyl-methyl-amino)-2-carbonyl-sarcosine-ethyl amine]-arginine-glycine-acetate, or acceptable salts, solvates, and hydrates thereof. The present disclosure also provides compositions, and their methods of use, where the \compositions comprise a prodrug, Compound KC-7, that provides controlled release of oxycodone. Such compositions can optionally provide a trypsin inhibitor that interacts with the enzyme that mediates the controlled release of oxycodone from the prodrug so as to attenuate enzymatic cleavage of the prodrug.

The invention relates to the technical field of auxiliary manufacturing in the fiber processing technology, in particular to finish for nylon FDY and a preparation method. The finish for nylon FDY comprises the following components: 55-60% of isooctyl stearate, 5-7% of scouring agents, 5-7% of oleic acid, 8-10% of coconut oil diethanolamine, 5-7% of hydrogenated castor oil polyoxyethylene ether, 5-7% of fatty alcohol polyoxyethylene ether 4, 1-2% of oleic acid sarcosine, 0.5-1% of hypophosphorous acid, 1-1.5% of potassium hydroxide and 5-7% of wetting agent. The preparation method comprises the process steps of mixing, stirring and testing. The finish for nylon FDY has good thermal stability, is less in volatilization and free of coking and has low coefficient of dynamic friction in the drawing stage and good cohesion.

The invention provides biodegradable micro-lubricating oil. The biodegradable micro-lubricating oil is characterized by comprising fatty acyl sarcosine with the mass percent content being 5-10%, wherein the fatty acyl sarcosine is prepared from carboxylic acid and sarcosine through acylation reaction. The biodegradable micro-lubricating oil provided by the invention has good biodegradability, and good extreme pressure antiwear property and lubricating property, and is used by matching with a micro-lubricating device; the usage amount can be reduced to below 5% of the original amount; good lubricating and cooling effects are achieved; and the biodegradable micro-lubricating oil has significant benefits of energy conservation and emission reduction, and environmental protection.

A shortened process for producing a solution containing substantially purified capsular polysaccharides from a cellular Streptococcus pneumoniae lysate broth is described. Ultrafiltering and diafiltering a clarified S. pneumoniae lysate followed by pH adjustment to less than 4.5, preferably about 3.5, precipitated at least 98% of the protein in the solution without seriously affecting polysaccharide yield. Furthermore, following ultrafiltration and diafiltration and acidification to a pH of less than 4.5, filtration using activated carbon precipitated at least 90% of remaining protein without seriously affecting polysaccharide yield. Exemplary, non-limiting S. pneumoniae serotypes that can be purified using the shortened process of the invention are 1, 4, 5, 6A, 6B, 7F, 9V, 14, 18C, 19A, 19F, and 23F. In one embodiment, the Streptococcus pneumoniae cells are lysed using deoxycholate sodium (DOC), while in another embodiment the lytic agent is a non-animal derived lytic agent such as N-lauryl sarcosine sodium (NLS).

The invention belongs to the field of daily chemical products and specifically relates to a low-stimulation hair-cleaning compound. The low-stimulation hair-cleaning compound contains 5.0-40.0% of surface active agents, 0.5-2% of wetting agents, 0.05-0.1% of chelating agents, 0.1-0.6% of preservatives, 0.2-0.8% of thickening agents, 0.05-0.1% of anti-sensitization agents, less than or equal to 1%of essences, and the balance of water. The surface active agents are selected from at least one of cocamidopropyl betaine, alkyl glycoside, sodium lauroyl sarcosine and polyoxyethylene (80) triol laurate. The low-stimulation hair-cleaning compound does not contain the traditional strong-stimulation surface active agents; the new amino acid surface active agents and the amphoteric surface active agents are adopted; and the low-stimulation hair-cleaning compound is a hair-cleaning compound which has the advantages that the foaming property is excellent, the cleaning capacity is moderate, the excessive degreasing is avoided, the hair is free from being dry and unsmooth, and the hair-cleaning compound does not contain any cation and silicone oil, is deposition-free, does not generate residuesand is mild and stimulation-free.

An acid treatment composition is provided including a corrosion inhibitor and an optional corrosion inhibitor intensifier in an acidic solution. More specifically, the composition includes an anionic surfactant. Methods for treating wells with these acid treatment compositions are also provided that help control corrosion of the steel used in the wells during the acid treatment.

A composition is disclosed herein comprising from about 0.001% to about 0.4% cyclosporin A, castor oil, and a surfactant selected from the group consisting of alcohol ethoxylates, alcohols, alkyl glycosides, alkyl polyglycosides, alkylphenol ethoxylates, amine oxides, block polymers, carboxylated alcohol or alkylphenol ethoxylates, carboxylic acids / fatty acids, cellulose derivatives, ethoxylated alcohols, ethoxylated alkylphenols, ethoxylated aryl phenols, ethoxylated fatty acids, ethoxylated fatty acids, ethoxylated fatty esters and oils, fatty alcohols, fatty esters, glycol esters, lanolin-based derivatives, lecithin and lecithin derivatives, lignin and lignin derivatives, methyl esters, monoglycerides and derivatives, phosphalipids, polyacrylic acids, polyethylene glycols, polyethylene oxide-polypropylene oxide copolymers, polyethylene oxides, polymeric surfactants, polypropylene oxides, propoxylated alcohols, propoxylated alkyl phenols, propoxylated fatty acids, protein-based surfactants, sarcosine derivatives, silicone-based surfactants, sorbitan derivatives, stearates, sucrose and glucose esters and derivatives, and combinations thereof.

Disclosed is a rust-preventive oil composition with a kinetic viscosity of 20 to 100mm2 / s at 40 DEG C that contains: (A) as a base oil, at least one type of oil chosen from among mineral oils and synthetic oils; (B) 0.1 to 10% by mass of water based on the total amount of the composition; and (C) one or more particular rust-preventive additives chosen from a group comprising sarcosine compounds, nonionic surfactants, sulfonate, ester, amine, carboxylic acid, fatty acid amine salts, carboxylate, paraffin wax, oxidized wax salt, and boron compounds. The rust-preventive oil composition is effective in preventing rust development over the long term on metallic components such as steel sheets, bearings, steel balls, and guide rails, even when rust-causing factors that adhere onto such objects, such as when these components are assembled with bare hands, remain.

It has been discovered that certain combinations compounds are excellent penetration enhancers and, as such, can be incorporated in a topical formulation to facilitate administration of active agents. The increased penetration enhancement can also lead to a reduction in the total concentration of skin irritants in the formulation. There is described herein a topical formulation comprising (i) at least one active agent; (ii) a first compound, and (iii) a second compound, wherein the first compound and second compound are different, and each is selected from the group consisting of N-lauroyl sarcosine, sodium octyl sulfate, methyl laurate, isopropyl myristate, oleic acid, glyceryl oleate and sodium lauryl sulfoacetate.

A cell permeabilization and stabilization reagent and method of use are disclosed. The reagent contains a N-acyl sarcosine or a salt thereof, a pH adjusting agent to adjust pH of the reagent in a range from about 4 to about 6; and an aqueous medium; the reagent having a low ionic strength defined by a conductivity of less than 9.0 mS / cm. The reagent further contains bovine serum albumin and glycerol. The reagent may further include an alkyl sulfate surfactant. Upon incubating the cells with the reagent, the reagent permeates the cellular membrane to allow penetration of an intracellular marker, causes intracellular protein aggregation within the cellular membrane, while preserves a cellular constituent for binding with a cellular marker for subsequent analysis by flow cytometry.

The invention discloses anti-dandruff shampoo with an effect of improving the microbial flora on the scalp skin. The anti-dandruff shampoo is prepared from the following raw materials: water, polydimethylsiloxane, glycol stearate, sodium lauroyl sarcosine, polyquaternium-10, cetostearyl alcohol, ammonium chloride, vaccinium uliginosum berry extract, celery seed extract, silk hydrolysate, zinc pyrithione, piroctone olamine, EDTA disodium, surfactant, preservatie, artemisinin and rosemary water. The invention further discloses a preparation process of the shampoo. The shampoo can be used for improving the microbial environment of the scalp skin and improving the resistance of the scalp skin and can achieve the effect of effectively removing dandruff and preventing dandruff reoccurrence.

The invention relates to green antibacterial efficient cleanser essence and a preparation method thereof, and belongs to the technical field of detergents in daily-use chemical industries. The green antibacterial efficient cleanser essence comprises the following components by weight: 5-10 parts of tea saponin, 0.2-0.5 part of nano-silver, 0.5-1 part of a natural substance extractive, 15-25 parts of lauryl sodium sulfate, 5-10 parts of sodium lauroyl sarcosine, 5-10 parts of ethylene diamine tetraacetic acid, 1.2-1.8 parts of citric acid, 1.2-1.8 parts of sodium citrate, 0.5-1 part of refined salt, 0.5-1 part of sodium benzoate, 0.5-1 part of AES, and 30-40 parts of water. The preparation method comprises the following steps: using lauryl sodium sulfate, sodium lauroyl sarcosine, the ethylene diamine tetraacetic acid and the water according to the proportion and mixing uniformly, putting ethylene diamine tetraacetic acid into the water and stirring uniformly, then adding the citric acid, sodium citrate, the refined salt, and sodium benzoate into the water slowly while stirring at the temperature of 35-40 DEG C until a product is sticky, finally, adding tea saponin, the nano-silver, the natural substance extractive, and the AES and stirring at the temperature of 40-45 DEG C for 8-10 h to obtain a finished product. Compared with conventional cleanser essence, the green antibacterial efficient cleanser essence has high dirt-removing power, little residual, nontoxicity and an antibacterial effect.

The invention relates to an oil control and acne removal composition and an application thereof. The oil control and acne removal composition comprises, by weight, 2-25 parts of water-soluble polyurethane, 5-25 parts of kaolin, 1-5 parts of titanium dioxide, 3-10 parts of dipropylene glycol, 0.1-1 part of zinc pyrrolidone carboxylate and 1-5 parts of an anti-acne active substance. A polyurethane-containing mud film is produced by adopting the aqueous polyurethane as a film forming component and selecting the dipropylene glycol as a film forming assistant, the kaolin controls oil through externally adsorbing the oil, and octanoylglycine, sarcosine, Cinnamomum zeylanicum bark extract and zinc salt of strong acid of pyrrolidone can inhibit the oil secretion through inhibiting 5alpha-reductase, so the composition can effectively inhibit acne propionibacteria of acne skins and effectively restore acnes on oily skins.

The invention relates to a multifunctional organic rust inhibitor prepared by reaction of an organic acid and a hydroxyl compound, the molar ratio of organic acid to hydroxyl compound is 1:1-1:2.5; the organic acid is an arbitrary proportion mixture of one or more than two substance of lauric acid, palmitic acid, stearic acid, benzoic acid, p-tert-butyl benzoic acid, lauroyl sarcosine and oleoyl sarcosine, the hydroxyl compound is an arbitrary proportion mixture of one or more than two substance of n-butyl alcohol, lauryl alcohol, ethanolamine, diethanolamine, triethanolamine, N-methyldiethanolamine, N, N-dimethylethanolamine, and 2-amino-2-methyl-1 - propanol. The multifunctional organic rust inhibitor can protect steel bar and concrete from erosion of chloride and sulfate and other corrosion mediums, plays a dual role of concrete self protection and steel bar corrosion protection, greatly improves the service life of a reinforced concrete structure, and is simple in synthesis process and easy to implement.

The invention relates to a micron acicular-structure N-methyl-2-phenyl-3,4-fullerenylpyrrolidine, and a preparation method and application thereof. The fullerene C60, benzaldehyde and sarcosine are used as raw materials to prepare the N-methyl-2-phenyl-3,4-fullerenylpyrrolidine and N-methyl-2-phenyl-3,4-fullerenylpyrrolidine in a micron acicular structure; and the micron acicular-structure N-methyl-2-phenyl-3,4-fullerenylpyrrolidine is used as a support to prepare the catalyst for preparing p-aminophenol from nitrobenzene by catalytic hydrogenation. The product prepared by the technique has the advantages of high yield and high purity; and the prepared catalyst has the advantages of high activity and long service life.

The embodiment of the invention discloses a method for detecting sarcosine, which comprises the following steps: providing a capillary tube for capillary electrophoresis-electrochemiluminescence detection; adding a background buffer solution and pyridine ruthenium derivants into a capillary electrophoresis-electrochemiluminescence detection device; injecting a running buffer solution into the capillary tube, and under the condition that the running buffer solution is filled in the capillary tube, injecting a sample solution into the capillary tube; and applying voltages to the two ends of thecapillary tube to perform the capillary electrophoresis-electrochemiluminescence detection. In the method, the pyridine ruthenium derivants are selected as luminous reagents, and preferably, bipyridine ruthenium with high flexibility and high stability is utilized, so the highly-efficient and quick detection of the sarcosine is realized through simple apparatuses; and compared with gas chromatography-mass spectrometry, the method has the advantage of relatively low cost.

The present invention belongs to the field of daily chemicals, and relates to a shampoo composition. An amino acid shampoo composition enhancing conditioning effect comprises the following raw materials: a non-sulfate anionic surfactant; an amphoteric surfactant; a cationic polysaccharide polymer derivative; an anti dandruff agent; a suspending agent; a non-volatile conditioner; and the balance ofpure water, wherein the non-sulfate anionic surfactant at least comprises one or two of N-fatty acyl alanine salt and N-fatty acyl sarcosine salt, and also comprises one or two of fatty acyl methyl taurine salt, fatty alcohol ether sulfosuccinate. Through reasonable construction of composition architecture, synergic effects of the raw materials, and limitation of key parameters of the raw materials, the composition can achieve high consistency and stability, brings a good conditioning effect, and can carry a lot of effective particle deposition, and after many times of cleaning, less siliconeoil deposit is felt.