The invention relates to a preparation method of 
ropivacaine mesylate injection packed by a soda-
lime glass 
bottle, which comprises the following 
processing steps of ingredient preparation, liquor preparation, soda-
lime glass 
bottle and rubber plug cleaning, filling, capping, sterilization, lamp test, labeling, packing and finished 
product inspection. The injection is subject to a 
filtration sterilization 
processing step once and a flowing 
steam sterilization processing step once, wherein microorganisms larger than 0.22 microns in liquid 
medicine are removed by a filter method, microorganismssmaller than 0.22 microns are killed by flowing 
steam sterilization, and insoluble particles in the liquid 
medicine are removed during 
filtration sterilization simultaneously, thereby greatly reducingthe occurrence of phlebitis; and the invention is packed by the soda-
lime glass 
bottle which has the advantages of 
heat resistance, acid and alkali resistance, large strength, and the like, thereby ensuring the stability of the 
medicine. Clinic comparison tests show that the 
ropivacaine mesylate injection packed by a soda-lime glass bottle has the advantages of quicker effect, long action time, reliable 
anesthetic effect, small 
toxicity to heart, separate blocking pf sensory and motor nerves, and the like, thereby being suitable for 
anesthesia in surgeries and postoperative analgesia.