44 results about "Tendon grafting" patented technology

Devices formed of or including biocompatible polyhydroxyalkanoates are provided with controlled degradation rates, preferably less than one year under physiological conditions. Preferred devices include sutures, suture fasteners, meniscus repair devices, rivets, tacks, staples, screws (including interference screws), bone plates and bone plating systems, surgical mesh, repair patches, slings, cardiovascular patches, orthopedic pins (including bone filling augmentation material), adhesion barriers, stents, guided tissue repair / regeneration devices, articular cartilage repair devices, nerve guides, tendon repair devices, atrial septal defect repair devices, pericardial patches, bulking and filling agents, vein valves, bone marrow scaffolds, meniscus regeneration devices, ligament and tendon grafts, ocular cell implants, spinal fusion cages, skin substitutes, dural substitutes, bone graft substitutes, bone dowels, wound dressings, and hemostats. The polyhydroxyalkanoates can contain additives, be formed of mixtures of monomers or include pendant groups or modifications in their backbones, or can be chemically modified, all to alter the degradation rates. The polyhydroxyalkanoate compositions also provide favorable mechanical properties, biocompatibility, and degradation times within desirable time frames under physiological conditions.

Devices formed of or including biocompatible polyhydroxyalkanoates are provided with controlled degradation rates, preferably less than one year under physiological conditions. Preferred devices include sutures, suture fasteners, meniscus repair devices, rivets, tacks, staples, screws (including interference screws), bone plates and bone plating systems, surgical mesh, repair patches, slings, cardiovascular patches, orthopedic pins (including bone filling augmentation material), adhesion barriers, stents, guided tissue repair / regeneration devices, articular cartilage repair devices, nerve guides, tendon repair devices, atrial septal defect repair devices, pericardial patches, bulking and filling agents, vein valves, bone marrow scaffolds, meniscus regeneration devices, ligament and tendon grafts, ocular cell implants, spinal fusion cages, skin substitutes, dural substitutes, bone graft substitutes, bone dowels, wound dressings, and hemostats. The polyhydroxyalkanoates can contain additives, be formed of mixtures of monomers or include pendant groups or modifications in their backbones, or can be chemically modified, all to alter the degradation rates. The polyhydroxyalkanoate compositions also provide favorable mechanical properties, biocompatibility, and degradation times within desirable time frames under physiological conditions.

A bioabsorbable implantable device for replacing sutures in construction of a composite graft in ligament replacement surgery. In certain embodiments the device has a female component and a male component where the female component receives and secures the male component. In other embodiments the components of the device are in the shape of a rivet or a staple. The bioabsorbable implantable devices can be used for securing tendon grafts to bone blocks and for holding together the fibers of the tendon graft when the bone-tendon-bone graft is inserted into a patient during surgery. The bioabsorbable implantable device may also be part of a package for use in surgery. The package includes a sterile container for holding at least a graft that is of a predetermined length and width. The package may also include bone blocks. The package is marked as to the graft size including the width and the length of the graft. The graft and the bone blocks may be autogenous, allogenic or constructed from man-made materials.

A surgical drill for providing holes at an angle for use in repair and replacement of the ACL is disclosed, generally comprising a drill guide having a head that is angularly adjustable with respect to a body, a flexible guide pin and a flexible drill. The adjustable head of the drill guide allows a surgeon to drill a hole in the femur at an angle to a tunnel provided in the tibia. Because the surgeon can access the femur via the hole in the tibia, the surgical drill of the present invention obviates the need for a second hole in the tissue and also makes placement of femur hole more precise for securement of the ligament or tendon graft within the hole.

A method for anchoring autologous or artificial tendon grafts in bone is provided. In one embodiment, the method includes affixing a stabilizing element in bone; and placing the stem of an insertion element therein. A tendon graft may be secured to the insertion element either before or after its placement in the stabilizing element. Two such anchors may be linked with one or multiple grafts, in either a two-ply or four-ply arrangement.

The present invention relates generally to methods for preparing a dual tendon bundle that is useful as a replacement ligament or tendon graft for, for example, anterior cruciate ligament (ACL) reconstruction. More particularly, the dual tendon bundle prepared according to the present invention has a functional cross section diameter and / or a minimum length that meets or exceeds the standard requirements for replacement ligament or tendon grafts. The present invention further relates to the dual tendon bundle prepared by the disclosed methods and packages comprising the same. Methods of using the dual tendon bundle prepared according to the present invention by providing the dual tendon bundle thus obtained for implanting into a patient in need thereof are also provided.

An anchor assembly for autologous or artificial tendon grafts comprises an insertion element and a stabilizing element. The insertion element has a stem and a head containing an aperture large enough to receive a graft. The stabilizing element is adapted to be embedded in bone, and comprises a sleeve with a cavity arranged to receive and hold the insertion element stem. In use, the stabilizing element is affixed in the bone, and the stem of the insertion element is placed therein. A tendon graft may be secured to the insertion element either before or after its placement in the stabilizing element. Two such anchors may be linked with one or multiple grafts, in either a two-ply or four-ply arrangement.

An expanding plug for tendon fixation features a two-part system in which an expansion pin fits inside a fixation sleeve. The fixation sleeve is configured to expand diametrically to achieve interference fixation of a graft tendon inside of a bone tunnel. Fixation sleeve expansion is urged by a two-step engagement of the expansion pin. The tendon graft is assembled to the expanding bolt and situated within a bone tunnel. Passing suture is used to pull a joint-line end of the expansion pin into the tunnel to partially expand the fixation sleeve at the joint-line end. Pulling a graft end of the expansion pin toward the joint line expands the fixation sleeve to place the expanding plug in the fully deployed configuration.

An expanding plug for tendon fixation features a two-part system in which an expansion pin fits inside a fixation sleeve. The fixation sleeve is configured to expand diametrically to achieve interference fixation of a graft tendon inside of a bone tunnel. Fixation sleeve expansion is urged by a two-step engagement of the expansion pin. The tendon graft is assembled to the expanding bolt and situated within a bone tunnel. Passing suture is used to pull a joint-line end of the expansion pin into the tunnel to partially expand the fixation sleeve at the joint-line end. Pulling a graft end of the expansion pin toward the joint line expands the fixation sleeve to place the expanding plug in the fully deployed configuration.

Methods of generating and expanding proliferative, multipotent connective tissue progenitor cells from adult stem cells are provided. Also provided are methods of generating functional tendon grafts in vitro and bone, cartilage and connective tissues in vivo using the isolated cell preparation of connective tissue progenitor cells.

A surgical drill for providing holes at an angle for use in repair and replacement of the ACL is disclosed, generally comprising a drill guide having a head that is angularly adjustable with respect to a body, a flexible guide pin and a flexible drill. The adjustable head of the drill guide allows a surgeon to drill a hole in the femur at an angle to a tunnel provided in the tibia. Because the surgeon can access the femur via the hole in the tibia, the surgical drill of the present invention obviates the need for a second hole in the tissue and also makes placement of femur hole more precise for securement of the ligament or tendon graft within the hole.

A device serves for blocking a tendon graft in a drilled hole. An element is connected to said tendon graft which can be expanded radially. The element has a cylindrical body which is divided by an oblique cut into two wedge-shaped bodies initially connected to one another via a predetermined break point.

Techniques and reconstruction systems for ligament repair and fixation. A bone tendon graft is prepared by folding the bone block over a suspensory fixation device (for example, a knotless suture construct such as a knotless, adjustable, self-cinching suture loop / button construct, a suture, crosspin, or screw, etc.). A flexible strand is then used to suture the bone plug to the tendon so that the overall graft is shortened significantly and the suspensory fixation device is securely attached. The technique does not require passage of the suspensory fixation device through the bone block which makes the graft passage easier since the graft is pulled from the tip. The technique also allows shortening of the overall graft.

The invention discloses an organ engineering tendon graft which comprises (a) biodegradable materials which can be accepted in pharmacy; (b) seed cells which can be inoculated to the biodegradable materials, and the seed cells are selected from the following groups: (i) fibroblasts, (ii) adipose-derived cells, or (iii) the mixture of the dermal fibroblasts and the adipose-derived cells with the ratio of 1:10000 to 10000:1. The graft is gotten from the cultivation of a complex of the seed cells and the biodegradable materials in a bioreactor, and the complex is obtained through the mixing of the seed cells and the biodegradable materials which can be accepted in pharmacy. The graft can be used for restoring the tendon defect.

A fixing tool used in a ligament reconstruction operation includes a fixing member having a main body part provided with a through-hole and two spike parts which can be stricken into the bone and a fixing screw. The fixing screw includes a shaft part having a self-tap portion and a male screw portion, a head part, and a lumen. The fixing screw can be screwed into the bone plug in a state where a guide pin pierced into the bone plug penetrates the lumen of the fixing screw and a pulling member mounted to the bone plug and extended from the bone tunnel is being pulled. The fixing screw can adjust a tensile force of the tendon graft by adjusting the amount of screwing of the fixing screw into the bone plug after the head part of the fixing screw contacts the fixing member.

A fixation device for securing a transplant in a bone tunnel, having a strap with a plurality of protrusions disposed along its length, a fastening member with an aperture therein for passing the strap, and a connection element disposed at a distal end of the strap for engaging a transplant is provided. The fixation device is configured such that, when the distal side of the fastening member lies substantially flush against an outer surface of the bone, a longitudinal axis of the aperture is substantially parallel to a longitudinal axis of the bone tunnel. A method for securing a transplant in a bone tunnel using the aforementioned fixation device is also provided.

A tapered tendon graft anchor employed during a tendon graft reconstruction surgical procedure. The anchor of the invention comprises a “hair-pin” configuration formed of a loop and two opposing leafs. Each of the leafs include inwardly extending teeth in facing alignment with each other. The outer surfaces of the leafs are tapered to a frustro-conical shape. A harvested tendon with a bone block at one end is positioned with a cavity defined by the loop of the “hair pin” configuration with the tendon positioned between the inwardly extending teeth of the leafs. When the anchor is positioned within a hole in the bone of the joint whose ligament is to be reconstructed, the tendon is tightly grasped by the anchor to securely anchor the tendon in the hole allowing the bone block to be grafted within the hole.

The invention discloses a segmented and gradient functional tendon sleeve implanting device and a preparation method thereof. The preparation method includes the steps: (1) firstly, a three-dimensional bracket structure containing a bone tunnel part and a joint cavity part and having a porous hollow cylindrical structure shape is prepared through an electrostatic spinning or textile weaving method; (2) surface modification is conducted on wefts of the joint cavity part through a physical or chemical method, and surface modification comprises protein and small molecular compound modification; (3) gradient modification is conducted on the bone tunnel part through a physical or chemical method, and gradient modification comprises bone material, protein and small molecular compound modification; and (4) a needle threading marker hole is reserved in the outer surface of the bone tunnel part, a traction line is arranged, and thus the segmented and gradient functional tendon sleeve implantingdevice is obtained. The segmented and gradient functional tendon sleeve implanting device can achieve a promoting enhancement effect on clinical ACL repair through autograft tendon and allogenic tendon grafts and artificial grafts and ligament regeneration and tendon-bone healing of other ligament and tendon injuries, and provide mechanical protection without forming of stress shielding.

The present invention provides a tissue engineering tendon graft. It includes: (a). pharmaceutically-acceptable bio-degradable material.; (b) seed cell, said seed cell can be inoculated in the described bio-degradable material and is selected from (i) fibroblast; and (ii), mixture of fibroblast and tendon cell and / or bone marrow matrix stem cell according to the ratio of 1:10-10000:1; and (c) bio-membrane, the exterior of said bio-degradable material is covered with said bio-membrane. Said invented graft can beused for effectively curing musculotendinous defect. Said invention also provides its preparation and application.

Methods of generating and expanding proliferative, multipotent connective tissue progenitor cells from embryonic stem cells and embryoid bodies are provided. Also provided are methods of generating functional tendon grafts in vitro and bone, cartilage and connective tissues in vivo using the isolated cell preparation of connective tissue progenitor cells.

A fixing tool used in a ligament reconstruction operation to fix a tendon graft having a bone plug can be inserted into a bone tunnel formed at a bone. The fixing tool includes a fixing member having a main body part provided with a through-hole and two spike parts which extend almost parallelly and can be stricken into the bone and a fixing screw including a shaft part having a self-tap portion and a male screw portion, a head part, and a lumen. The fixing screw can be screwed into the bone plug in a state where a guide pin pierced into the bone plug is penetrated through the lumen of the fixing screw and a pulling member mounted to the bone plug and extended from the bone tunnel is being pulled. The fixing screw can be adjusted a tensile force of the tendon graft by adjusting an amount of screwing of the fixing screw into the bone plug after the head part of the fixing screw contacts to the fixing member.

The present invention relates to a device for the interfacial augmentation of tissue grafts for the purpose of tendon and ligament reconstruction. The inventive device works both as a delivery vessel for osteoconductive and osteoinductive factors and as a scaffold to stimulate and support bone ingrowth and comprises a tubular composite silk sheath, said tubular composite silk sheath comprising: a backbone consisting of a tubular silk mesh, and a carrier material consisting of a porous silk sponge, wherein said tubular silk mesh consists of degummed silk fibroin fibers, wherein said porous silk sponge comprises silk fibroin fibers and hydroxyapatite particles and said tubular silk mesh and said porous silk sponge form a composite material. The present invention is also directed to a method for the manufacturing of such augmentation devices, a method for fixation of the thus fabricated tissue interface augmentation devices onto ligament or tendon grafts, a method for applying such devices for ligament and / or tendon reconstruction to tendon grafts, as well as their application in ligament and tendon reconstruction.

The present invention relates generally to methods for preparing a dual tendon bundle that is useful as a replacement ligament or tendon graft for, for example, anterior cruciate ligament (ACL) reconstruction. More particularly, the dual tendon bundle prepared according to the present invention has a functional cross section diameter and / or a minimum length that meets or exceeds the standard requirements for replacement ligament or tendon grafts. The present invention further relates to the dual tendon bundle prepared by the disclosed methods and packages comprising the same. Methods of using the dual tendon bundle prepared according to the present invention by providing the dual tendon bundle thus obtained for implanting into a patient in need thereof are also provided.

The invention relates to a polyurethane bone-tendon graft biomaterial and method of making the bone-tendon graft biomaterial. The biomaterial has a gradient of mechanical properties through photocrosslinking such that a first end of the biomaterial is crosslinked at a higher degree than a second end, and the first end of the biomaterial has mechanical properties of bone and the second end of the biomaterial has mechanical properties of tendon.

A tendon graft stripping device for use in removing the muscle attachments to a tendon while the tendon is being prepared for use as a graft during ligament and tendon reconstruction surgery is disclosed. The muscle stripping device is made from a metal or plastic block having multiple slots therein. The multiple slots, which are of various diameters and have a circular or rectangular shape, are inter-connected by much smaller grooves to allow the passage of a tendon to be stripped through the different diameter size slots.

The invention discloses a quick repair method for continuous collapse of an RC framework structure. The invention relates to a repair method for the continuous collapse of the RC framework structure, and aims to solve the problems of large economic losses and long reconstruction cycle caused by the situation that when buildings are continuously collapsed, the whole structure needs to be dismantled. The method is realized through the following steps: I, building supporting systems each of which consists of a jack, a supporting pier and a steel base plate; II, supporting the bottoms of damaged columns and the bottoms of damaged beams with the built steel base plates; III, jacking up a collapsed structure to the elevation of a structure which is not collapsed; IV, supporting the bottom of each layer of the damaged beams above the damaged columns with the steel base plates; V, striking concrete at the region of the end part of a damaged beam till the concrete is crushed; VI, straightening a reinforcing bar which is not cracked in the damaged beam, and transecting a cracked reinforcing bar; VII, repairing the cracked reinforcing bar according to a tendon grafting method; VIII, bundling hoop tendons, supporting molds, casting grouting materials, and dismantling molds; IX, repairing the damaged columns; X, removing supporting piers, the jacks, the base plates, and the like under the damaged beams. The method disclosed by the invention is applied to the field of the continuous collapse of the RC framework structure.

The present invention relates to a device for the interfacial augmentation of tissue grafts for the purpose of tendon and ligament reconstruction. The inventive device works both as a delivery vessel for osteoconductive and osteoinductive factors and as a scaffold to stimulate and support bone ingrowth and comprises a tubular composite silk sheath, said tubular composite silk sheath comprising: a backbone consisting of a tubular silk mesh, and a carrier material consisting of a porous silk sponge, wherein said tubular silk mesh consists of degummed silk fibroin fibers, wherein said porous silk sponge comprises silk fibroin fibers and hydroxyapatite particles and said tubular silk mesh and said porous silk sponge form a composite material. The present invention is also directed to a method for the manufacturing of such augmentation devices, a method for fixation of the thus fabricated tissue interface augmentation devices onto ligament or tendon grafts, a method for applying such devices for ligament and / or tendon reconstruction to tendon grafts, as well as their application in ligament and tendon reconstruction.