45 results about "Tissue pressure" patented technology

A tissue press and method for shaping or compressing a piece of tissue comprises first and second members movable relative to each other. A first forming element of a predetermined shape is selectively engageable on the first member. A second forming element of predetermined shape is selectively engageable on the second member. The first and second forming elements are positionable on opposite sides of the piece of tissue. The first and second members are relatively movable between a first spaced apart condition and a second condition in which the piece of tissue is held between the first and second forming elements. Means are preferably provided for monitoring and controlling the amount of pressure applied to the piece of tissue, in order to maintain the tissue in a viable living condition. Means may also be provided for draining off fluid from compressed tissue, so that the tissue can be implanted in a compressed state and imbibe fluid from the host site. A retainer, which may be expandable, can be used to maintain the tissue graft in a compressed condition.

Provided is a durable tissue pH / pCO2 and / or tissue oxygen sensitive probe of sufficient strength to withstand direct tissue pressures in vivo, the probe comprising one or more sensor chambers within a biocompatible, gas-permeable membrane containing together in a single chamber, or in separate chambers, respectively, a pH sensitive fluorophor from which pCO2 level(s) are calculated when the fluorophor is excited and the resulting fluorescence is measured and / or an oxygen sensitive phosphor solution producing oxygen quenchable phosphorescence when excited. Further provided is a tissue pH / pCO2 and / or tissue oxygen detection and measurement system comprising the probe, and methods for use of the probe and the system to directly, rapidly and accurately measure tissue pH / pCO2 and / or tissue oxygen levels in a patient without reliance on blood vessels or fluid protection of the probe.

The invention relates to an intelligent instrument for measuring the tissue thickness. The intelligent instrument comprises a button cell type intelligent thickness measuring clip or an external power supply type intelligent thickness measuring clip, a linear incision anastomat or a manual thickness measuring instrument or an automatic thickness measuring instrument, and a staple anvil. The button cell type intelligent thickness measuring clip comprises an outer shell, a pressing key, waterproof soft glass, an integrated circuit board and a bottom cover. The waterproof soft glass is arranged between the pressing key and the integrated circuit board and covers the surface of the pressing key. A button cell, a power module, a display module, a tissue pressure intensity measuring module, a tissue thickness measuring module, a control module and a wireless transmission module are mounted on the back face of the integrated circuit board. An eddy-current transducer and a pressure sensor are mounted on the front face of the integrated circuit board. The button cell type intelligent thickness measuring clip is matched with a wireless transmission device. The intelligent instrument for measuring the tissue thickness has the advantages that the tissue thickness can be measured in a quantitative mode, tissue thickness measurement is accurate, corresponding anastomotic staple cartridges can be selected conveniently, and the success rate of anastomotic surgery is increased.

The present invention is directed to therapeutic compounds, treatment methods, and kits affecting the NCCa-ATP channel of neural tissue, including neurons, glia and blood vessels within the nervous system, and methods of using same. The NCCa-ATP channel is newly expressed in neural tissue following injury such as ischemia, and is regulated by the sulfonylurea receptor SUR1, being inhibited by sulfonylurea compounds, e.g., glibenclamide and tolbutamide, and opened by diazoxide. Antagonists of the NCCa-ATP channel, including SUR1 antagonists, are useful in the prevention, diminution, and treatment of injured or diseased neural tissue, including astrocytes, neurons and capillary endothelial cells, that is due to ischemia, tissue trauma, brain swelling and increased tissue pressure, or other forms of brain or spinal cord disease or injury. Agonists of the NCCa-ATP channel may be are useful in the treatment neural tissue where damage or destruction of the tissue, such as a gliotic capsule, is desired.

The invention relates to an intelligent instrument for measuring the tissue thickness. The intelligent instrument comprises a button cell type intelligent thickness measuring clip or an external power supply type intelligent thickness measuring clip, a linear incision anastomat or a manual thickness measuring instrument or an automatic thickness measuring instrument, and a staple anvil. The button cell type intelligent thickness measuring clip comprises an outer shell, a pressing key, waterproof soft glass, an integrated circuit board and a bottom cover. The waterproof soft glass is arranged between the pressing key and the integrated circuit board and covers the surface of the pressing key. A button cell, a power module, a display module, a tissue pressure intensity measuring module, a tissue thickness measuring module, a control module and a wireless transmission module are mounted on the back face of the integrated circuit board. An eddy-current transducer and a pressure sensor are mounted on the front face of the integrated circuit board. The button cell type intelligent thickness measuring clip is matched with a wireless transmission device. The intelligent instrument for measuring the tissue thickness has the advantages that the tissue thickness can be measured in a quantitative mode, tissue thickness measurement is accurate, corresponding anastomotic staple cartridges can be selected conveniently, and the success rate of anastomotic surgery is increased.

The present invention is directed to a combination of therapeutic compounds and treatment methods and kits using the combination. In particular, one of the combination affects the NCca-ATP channel of neural tissue, including neurons, glia and blood vessels within the nervous system. Exemplary SUR1 and / or TRPM4 antagonists that inhibit the NCca-ATP channel may be employed in the combination. The combination therapy also employs one or more of a non-selective cation channel blocker and / or an antagonist of VEFG, NOS, MMP, or thrombin. Exemplary indications for the combination therapy includes the prevention, diminution, and / or treatment of injured or diseased neural tissue, including astrocytes, neurons and capillary endothelial cells, that is due to ischemia, tissue trauma, brain swelling and increased tissue pressure, or other forms of brain or spinal cord disease or injury, for example. In other embodiments, there are methods and compositions directed to antagonists of TRPM4, including at least for therapeutic treatment of traumatic brain injury, cerebral ischemia, central nervous system (CNS) damage, peripheral nervous system (PNS) damage, cerebral hypoxia, or edema, for example.

A pressure monitoring method and system for warning a patient or caregiver that soft tissue pressure has exceeded some predetermined level that over time would necessitate moving the patient to minimize or prevent soft tissue damage. The method and system entail the use of a pressure-sensitive pad assembly adapted to be applied to a surface of the patient's body and generate electrical outputs corresponding to soft tissue pressure sensed at the surface. The system monitors the electrical outputs over a preselected time period and generates a cumulative output signal based on the electrical outputs and corresponding to whether or not the soft tissue pressure has exceeded a predetermined pressure level during the preselected time period. The system generates audible and visual warnings if the cumulative output signal exceeds a predetermined cumulative threshold until the soft tissue pressure drops below the predetermined pressure level.

Provided is a durable oxygen sensitive probe of sufficient strength to withstand direct tissue pressures in vivo, the probe comprising a sensor chamber within a biocompatible, gas-permeable membrane containing an oxygen sensitive analyte solution producing oxygen quenchable phosphorescence when excited. Further provided is a tissue oxygen detection and measurement system comprising the probe, and methods for use of the probe and the system to directly, rapidly and accurately measure tissue oxygen levels in a patient without reliance on blood vessels or fluid protection of the probe.

A tissue press for shaping or compressing a piece of tissue comprises first and second members movable relative to each other. A first forming element of a predetermined shape is selectively engageable on the first member. A second forming element of predetermined shape is selectively engageable on the second member. The first and second forming elements are positionable on opposite sides of the piece of tissue. The first and second members are relatively movable between a first spaced apart condition and a second condition in which the piece of tissue is held between the first and second forming elements. Means are preferably provided for monitoring and controlling the amount of pressure applied to the piece of tissue, in order to maintain the tissue in a viable living condition. Means may also be provided for draining off fluid from compressed tissue, so that the tissue can be implanted in a compressed state and imbibe fluid from the host site. A retainer, which may be expandable, can be used to maintain the tissue graft in a compressed condition.

An apparatus adapted to position a functional device tip, such as a sensor, in a body site having both fluid and non-fluid tissue components, in a manner that substantially mitigates the impingement of non-fluid tissue impingement on the device tip. One such apparatus can be used to both remove fluid from a tissue site, such as a site exhibiting tissue swelling, and to determine tissue pressure, using a single catheter. An apparatus can provide a pressure sensor that is adapted to be positioned and used within the tissue site itself, without substantial impingement by non-fluid tissue, and optionally also provides the ability to concurrently remove and / or deliver fluids or components thereof to or from the tissue site.

A tissue press for shaping or compressing a piece of tissue comprises first and second members movable relative to each other. A first forming element of a predetermined shape is selectively engageable on the first member. A second forming element of predetermined shape is selectively engageable on the second member. The first and second forming elements are positionable on opposite sides of the piece of tissue. The first and second members are relatively movable between a first spaced apart condition and a second condition in which the piece of tissue is held between the first and second forming elements. Means are preferably provided for monitoring and controlling the amount of pressure applied to the piece of tissue, in order to maintain the tissue in a viable living condition. Means may also be provided for draining off fluid from compressed tissue, so that the tissue can be implanted in a compressed state and imbibe fluid from the host site. A retainer, which may be expandable, can be used to maintain the tissue graft in a compressed condition.

The present invention provides a medical support pillow and method for supporting a patient in the lateral position while maintaining an open airway. The Lateral Airway Support Pillow includes a chest support, a shoulder recess, a head support, and a posterior bolster. The orientation of these components support the patient in the lateral position, with the spine and airway in a straight position, thus eliminating possible airway obstruction. One embodiment of the invention contains a head support with a posterior recess and a neck support which provides for straightening the neck and airway and aligning the oral, pharyngeal, and laryngeal axes of the airway. Other embodiments position and elevate the patient in such a manner to treat or prevent soft tissue pressure injury, gastroesophageal reflux, congestive heart failure, or sleep apnea.

An electric intelligent surgical anastomat comprises an electric intelligent drive component and a replaceable suture execution component, the electric intelligent drive component is arranged in a gun type outer shell, a power supply switch, a nail abutting seat opening switch and a nail abutting seat closing switch are arranged on the outer shell, and a master control circuit board, a gearbox, a nail abutting seat opening / closing motor and a percussion motor are arranged in the outer shell. Surgical suturing instruments and other products of the same series are automatically and intelligently controlled, compared with the existing mechanical surgical suturing instruments, the electric intelligent surgical anastomat is more convenient to operate, doctors can operate the anastomat and complete operations without learning, precise control of tissue pressure and suture nail forming is adopted, bleeding and leakage due to the fact that the mechanical surgical suturing instruments are used improperly are effectively prevented from happening to an anastomotic stoma, and the operational quality of the mechanical surgical suturing instruments is improved. Operation quality and safety is improved, and the operation of users is more convenient.

The present invention provides a medical support pillow and method for supporting a patient in the lateral position while maintaining an open airway. The lateral airway support pillow includes a chest support, a shoulder recess, a head support and a posterior bolster. The orientation of these components support the patient in the lateral position, with the spine and airway in a straight position, thus eliminating possible airway obstruction. One embodiment of the invention contains a head support with a posterior recess and a neck support which provides for straightening of the neck and airway and aligning the oral, pharyngeal, and laryngeal axes of the airway. Other embodiments position and elevate the patient in such a manner to treat or prevent soft tissue pressure injury, gastroesophageal reflux, congestive heart failure, or sleep apnea.

The present invention is directed to therapeutic compositions targeting the NCCa-ATP channel of an astrocyte, neuron or capillary endothelial cell and methods of using same. More specifically, agonists and antagonists of the NCCa-ATP channel are contemplated. The therapeutic compositions are used to treat cancer, more specifically, a metastatic brain tumor, wherein a tumor-brain barrier is present. Such treatments are contemplated in combination with conventional anti-cancer therapies. Alternatively, the compositions are used to prevent cell death and to treat cerebral edema that result from ischemia, due to interruption of blood flow, to tissue trauma or to increased tissue pressure.

Described is a method and system providing therapeutic positive airway pressure to a particular area of patient's airways. The system may include a flow generator and a processing arrangement. The flow generator supplies an airflow to an airway of the patient. The processing arrangement is connected to the flow generator to control a supply pressure at which the airflow is generated by the flow generator. The processing arrangement continuously adjusts the supply pressure to maintain a pressure in a predetermined portion of the patient's airway substantially constant. The predetermined portion of the patient's airway includes a collapsible portion of an upper airway of the patient. The processing arrangement also controls the supply pressure to maintain the pressure in the collapsible portion of the patient's airway at a value at least as great as a tissue pressure below which the collapsible portion collapses.

The invention relates to a medical care auxiliary appliance, in particular to bedsore-proof early warning device. The bedsore-proof early warning device is provided with a pressure sensitive element, a tissue hypoxia degree monitoring device, a data processing unit and an alarm unit. When in use, the pressure sensitive element is attached to a bedsore-susceptible part to monitor the pressure of the part, and the tissue hypoxia degree is monitored by an instrument, thereby the actual hypoxia degree of the tissue at the pressed part of a patient can be mastered in time. When the local tissue pressure of an individual exceeds a certain range and lasts for a certain time, and the oxygen partial pressure of the tissue is lowered and possible to cause ischemic hurt, the bedsore-proof warning device warns to prompt the medical personnel and caregiver to be on guard that the patient is in the risk of suffering bedsore and take measures in time such as turning over the body of the patient to prevent bedsore. The bedsore-proof early warning device greatly lowers the workload of the nursing personnel and reduces the pain of the seriously ill patients.

Wound bandaging / dressing foam structure including a low rebound, temperature-conforming, acceleration-rate-sensitive cushioning expanse applicable to wound-proximate-associated anatomical tissue to apply a predetermined expanse of substantially uniform, non-blood-flow-occluding pressure, accompanied by adjacent, included lateral extremities of this expanse which apply a gradually declining-to-zero anatomical-tissue pressure.

The present invention is directed to therapeutic compounds, treatment methods, and kits affecting the NCCa-ATP channel of neural tissue, including neurons, glia and blood vessels within the nervous system, and methods of using same. The NCCa-ATP channel is newly expressed in neural tissue following injury such as ischemia, and is regulated by the sulfonylurea receptor SUR1, being inhibited by sulfonylurea compounds, e.g., glibenclamide and tolbutamide, and opened by diazoxide. Antagonists of the NCCa-ATP channel, including SUR1 antagonists, are useful in the prevention, diminution, and treatment of injured or diseased neural tissue, including astrocytes, neurons and capillary endothelial cells, that is due to ischemia, tissue trauma, brain swelling and increased tissue pressure, or other forms of brain or spinal cord disease or injury. Agonists of the NCCa-ATP channel may be are useful in the treatment neural tissue where damage or destruction of the tissue, such as a gliotic capsule, is desired.

The invention discloses a human body knee joint soft tissue pressure and track measurement system. The human body knee joint soft tissue pressure and track measurement system includes a measurement device and a display device; and the measurement device and the display device are in a communication connection. The measurement device includes a housing, a switch, a circuit board, a battery pack, and a thin film sensor; the switch, the battery pack and the thin film sensor are electrically connected to the circuit board; the circuit board and the battery pack are arranged outside the housing; the housing is provided with stress surfaces and the switch; the thin film sensor is arranged on the stress surfaces; the stress surfaces are half-moon-shaped inner concave arc stress surfaces; the housing is provided with a vertical column; the number of the stress surfaces is two, and the stress surfaces are symmetrically arranged at two sides of the vertical column; the circuit board is welded with a microprocessor and a blue-tooth module; and the microprocessor is electrically connected to the blue-tooth module.

A compression device for exerting pressure on an arm, shoulder, and / or trunk of a patient in need thereof (for example, a patient with hyperalgia or recovering from surgery in which the lymphatic system is affected), including an arm compression hose, a shoulder part for exerting pressure on the shoulder and trunk area, and a band-shaped fastening means for positioning the shoulder part and exerting pressure on the shoulder part. The arm compression hose exerts a pressure that decreases from a maximum pressure at the wrist or hand to a minimum pressure near the shoulder end of the arm, where the minimum pressure is approximately 70% of the maximum pressure. One or more lining pockets can be constructed on the inner lining of the compression device, where each lining pocket can hold one or more compression pads to increase tissue pressure in one or more body areas in need thereof. The compression pads each can have a shape that approximately conforms to the shape of the body part to which it is applied. The shoulder part can also have a shape that approximately conforms to the contour of the shoulder / trunk area to which it is applied. In addition, compression pants can be prepared with lining pockets for receiving compression pads. In one embodiment, compression pants include one or more donut-shaped pads or equivalents thereof that are placed in one or more lining pockets, each of which surrounds one or more osteoma openings.

Described is a method and system providing therapeutic positive airway pressure to a particular area of patient's airways. The system may include a flow generator and a processing arrangement. The flow generator supplies an airflow to an airway of the patient. The processing arrangement is connected to the flow generator to control a supply pressure at which the airflow is generated by the flow generator. The processing arrangement continuously adjusts the supply pressure to maintain a pressure in a predetermined portion of the patent's airway substantially constant. The predetermined portion of the patient's airway includes a collapsible portion of an upper airway of the patient. The processing arrangement also controls the supply pressure to maintain the pressure in the collapsible portion of the patient's airway at a value at least as great as a tissue pressure below which the collapsible portion collapses.

Systems and methods for accessing, stabilizing and sealing a device attached to a tissue surface comprising a tissue attaching device having an outer base ring defining an opening therethrough and a distally projecting tissue attachment element. The systems variously utilize annular sealing flanges distally attached to the outer base ring outside or inside the tissue attachment element to create a fluid tight seal. The systems variously utilize coils with regions of differing pitch to create sealing tissue pressure. Methods for installing an apical attaching device with a transapical port into a patient, comprising assessing the patient's viability for installation of the apical attaching device by determining an Index of Tissue Elasticity (ITE).

The invention provides a knee joint soft tissue pressure measuring device, measuring system and measuring method for a human knee joint replacement operation, can solve the problem of balance of internal pressure and external pressure of a knee joint during a knee joint replacement operation, and provides a reference for the osteotomy amount at a femoral part and the implantation size of prosthesis. The device has the advantages of simple structure, low cost and high universality. The measurement precision and sensitivity are high, operation is simple, display information is rich, operation ofa doctor can be greatly facilitated, and the operation time is saved, so that clinical operation efficiency is improved, the bleeding amount of a patient and injury to the patient caused by the operation can be obviously reduced,.

Provided is a durable oxygen sensitive probe of sufficient strength to withstand direct tissue pressures in vivo, the probe comprising a sensor chamber within a biocompatible, gas-permeable membrane containing an oxygen sensitive analyte solution producing oxygen quenchable phosphorescence when excited. Further provided is a tissue oxygen detection and measurement system comprising the probe, and methods for use of the probe and the system to directly, rapidly and accurately measure tissue oxygen levels in a patient without reliance on blood vessels or fluid protection of the probe.

An improved shunt valve for the control of hydrocephalus provides for physiological atmospherically-referenced siphon control that is not adversely affected by overlying tissue. The valve includes one or more porous outer anti-fouling membranes to protect the flow control membranes from external mechanical tissue pressure, while permitting free movement of the flow control moveable membranes and permitting positive inlet pressure to regulate flow through the improved fluid shunt valve of the invention. The porous membranes are configured to prevent tissue ingrowth into the membranes pores while allowing adequate fluid flow across so as not to inhibit movement of the movable membrane.

The invention relates to a medical care auxiliary appliance, in particular to bedsore-proof early warning device. The bedsore-proof early warning device is provided with a pressure sensitive element, a tissue hypoxia degree monitoring device, a data processing unit and an alarm unit. When in use, the pressure sensitive element is attached to a bedsore-susceptible part to monitor the pressure of the part, and the tissue hypoxia degree is monitored by an instrument, thereby the actual hypoxia degree of the tissue at the pressed part of a patient can be mastered in time. When the local tissue pressure of an individual exceeds a certain range and lasts for a certain time, and the oxygen partial pressure of the tissue is lowered and possible to cause ischemic hurt, the bedsore-proof warning device warns to prompt the medical personnel and caregiver to be on guard that the patient is in the risk of suffering bedsore and take measures in time such as turning over the body of the patient to prevent bedsore. The bedsore-proof early warning device greatly lowers the workload of the nursing personnel and reduces the pain of the seriously ill patients.

The invention relates to a pressure injury monitoring and feedback device and feedback regulation system, and belongs to the technical field of monitoring devices. Pressure acquisition assemblies and a transmission assembly are arranged in a flexible shell of the device; the pressure acquisition assemblies are connected with a control assembly; the pressure acquisition assemblies are used for acquiring contact pressure information of a target part; the transmission assembly is used for receiving and sending the contact pressure information; and the control assembly receives the contact pressure information of the target part, thereby calculating the internal stress, corresponding to the contact pressure information, of deep tissue, and an early warning is given out when a pressure injury threshold value of the target part is reached. According to the device, by measuring the contact pressure information of the external surface, the internal stress of the deep tissue corresponding to the contact pressure information is predicted, and monitoring of the pressure injury of the deep tissue is realized, so that the early warning is given out at the early stage of the pressure injury for intervention to effectively prevent the pressure injury, and the device is convenient and quick.

An improved shunt valve for the control of hydrocephalus provides for physiological atmospherically-referenced siphon control that is not adversely affected by overlying tissue. The valve includes one or more porous outer anti-fouling membranes to protect the flow control membranes from external mechanical tissue pressure, while permitting free movement of the flow control moveable membranes and permitting positive inlet pressure to regulate flow through the improved fluid shunt valve of the invention. The porous membranes are configured to prevent tissue ingrowth into the membranes pores while allowing adequate fluid flow across so as not to inhibit movement of the movable membrane.

The invention relates to a pressure quenching method of a high-hardness 5Cr13MoV wearable liner and belongs to the field of machine manufacturing. The method disclosed by the invention comprises the following steps: (1) air cooling 0.3% of PAG quenching agent, water cooling a convex surface, and carrying out multi-element cooling and quenching based on air cooling; (2) wherein the working surface of the wearable liner is a grid base plate of which the uniform thickness of the convex surface is 5mm, carrying out pressure quenching on a press machine according to a reversible deformation principle to counteract quenching deformation during quenching; after charging a work-piece, preheating before heating. A slow cooling mode is used in a high-temperature section and a low-temperature section, so as to reduce the quenching thermal stress and tissue pressure. The steel which is very sensitive to a 5Cr13MoV quenching crack is fully pre-cooled in air before being quenched, and cooled by using an ideal micro-deformation hardening agent 0.3% PAG in the quenching process. Thus, deformation and crack can be reduced, and the hardness also can be improved.