48 results about "Vascular body" patented technology

A time-varying modulating signal is used as a plethysmography signal, rather than a time-varying detected optical power. The time-varying detected optical power is used (e.g., in a feedback loop) to adjust the source intensity. Light is transmitted from a light source, wherein an intensity of the transmitted light is based on a light control signal. A portion of the light transmitted from the light source is received at a light detector, the portion having an associated detected light intensity. A feedback signal is produced based the portion of light received at the light detector, the feedback signal indicative of the detected light intensity. The feedback signal is compared to a reference signal to produce a comparison signal. The light control signal is then adjusted based on the comparison signal, wherein at least one of the comparison signal and the light control signal is representative of volume changes in blood vessels.

The present invention relates to a catheter system useful in treating lower extremity arterial chronic total occlusion (CTO). More particularly, the catheter system includes a first catheter having a first lumen extending therethrough, and a second catheter having a second lumen extending therethrough. The second catheter includes an engaging mechanism, such as an inflatable balloon, for engaging at least a portion of the first catheter such that a guide wire can be fed from the first lumen of the first catheter to the second lumen of the second catheter. In use, the first catheter is advanced to a treatment site through a vascular body from a downstream side of the treatment site. The second catheter is also advanced to the treatment site through the vascular body from an upstream side of the treatment site. The second catheter is engaged with the first catheter within the vascular body. The guide wire is then fed from the first catheter into the second catheter. Thereafter, the first and second catheters are removed from the vascular body, thereby leaving the guide wire extending through the treatment site. The guide wire is used to advance a treatment balloon to the treatment site for treating a CTO condition existing therein.

A method and system for analyzing tubular structures, such as vascular bodies, with respect to their geometrical properties and mechanical loading conditions is disclosed. To this end, geometrical and structural models of vascular bodies are generated from standard sets of image data. The method or system works automatically and the tubular structure is analyzed within clinical relevant times by users without engineering background. Most critical in that sense is the integration of novel volume meshing and 3D segmentation techniques. The derived geometrical and structural models distinguish between structural relevant types of tissue, e.g., for abdominal aortic aneurysms the vessel wall and the intra-luminal thrombus are considered separately. The structural investigation of the vascular body is based on a detailed nonlinear Finite Element analysis. Here, the derived geometrical model, in-vivo boundary / loading conditions and finite deformation constitutive descriptions of the vascular tissues render the structural biomechanical problem. Different visualization concepts are provided and allow an efficient and detailed investigation of the derived geometrical and mechanical data. In addition, this information is pooled and statistical properties, derived from it, can be used to analyze vascular bodies of interest.

The present invention provides compositions and methods for treating or preventing diseases associated with vascular and non-vascular body passageways, the method comprising the step of delivering to a body passageway a therapeutic agent delivered locally through a polymer matrix from an implanted stent or other structure.

A system for the treatment of lower extremity arterial chronic total occlusion (CTO) incorporates remote access of the guide-wire, at least one specifically shaped catheter, and a wire-capture dilation balloon catheter. A capture balloon catheter serves to capture the wire used to traverse the CTO. The capture balloon has a lumen with two axial openings and a radial opening. The capture balloon enters the vascular body from a first opening along a first guide-wire until the balloon is adjacent the CTO. A second guide-wire is advanced from a second opening in the vascular body that is located on an opposite side of the CTO. After the first guide-wire is removed, the second guide-wire is advanced through the funnel-shaped opening in the balloon, then through the radial opening of the lumen and through the lumen so as to advance out of the first opening of the vascular body. A conventional treatment balloon can then be advanced on the second guide-wire to the CTO for treatment.

The invention discloses a blood collection tube uncovering and covering all-in-one machine and a blood collection tube rack of the blood collection tube uncovering and covering all-in-one machine. In operation, blood collection tube bodies and blood collection tube caps of vacuum blood collection tubes are respectively clamped through a blood collection tube body clamping device and a blood collection tube cap clamping device, wherein the blood collection tube body clamping device controls the separation of a plurality of abreast gripper components through a first motor, and therefore the vacuum blood collection tubes can be placed in the gripper components, and the closing of the gripper components is controlled to guarantee that the blood collection tube bodies of the vacuum blood collection tubes are stably clamped; and meanwhile, the blood collection tube cap clamping device controls a third worm gear and third worm component to work through a third motor so as to achieve the opening and closing of the blood collection tube caps of the vacuum blood collection tubes. Through the structural design, the blood collection tube uncovering and covering all-in-one machine and the blood collection tube rack of the blood collection tube uncovering and covering all-in-one machine can reduce biohazards, improve safety production capability, reduce manpower cost, improve labor efficiency, promote the automation, the informatization and the intelligentization levels of medical laboratories, reduce resource cost, and improve work efficiency.

The invention discloses a method for the individualized noninvasive calculation of the blood flow of coronary artery branches of a patient in a maximal congestion state, and relates to the field of biomechanics and hemodynamics. The method comprises the steps of obtaining physiological parameters, such as myocardial mass, heart rate and blood pressure, of the patient clinically; establishing a mathematical model for calculating the blood flow of coronary arteries in the maximum congestion state on the basis of an allometric growth rule; reconstructing a three-dimensional geometric model of thecoronary arteries on the basis of coronary artery CT images of the patient, measuring the vessel sizes and diameters of the coronary artery branches, and then obtaining the diversion ratio of each branch on the basis of the vessel sizes of the branches and the Poiseuille's law; combining the blood flow of the coronary arteries of the patient and the diversion ratio of each branch to obtain the blood flow of each coronary artery branch through calculation. By means of the method, the individualized blood flow of each coronary artery branch of the patient is calculated in a noninvasive mode, and more accurate boundary conditions can be provided for blood flow simulation of the coronary arteries.

The invention features methods for detecting the hydration state or vascular volume of a subject using a device capable of nuclear magnetic resonance (NMR) measurement. The methods involve exposing a portion of a tissue of the subject in vivo to a magnetic field and RF pulse from the device to excite hydrogen nuclei of water within the tissue portion, and measuring a relaxation parameter of the hydrogen nuclei in the tissue portion, the relaxation parameter being a quantitative measure of the hydration state or vascular volume of the subject as a whole. The invention also features devices and computer-readable storage media for per forming the methods of the invention.

A method of treating a target site within a vascular channel of the body uses a catheter assembly having proximal and distal occluders which are positioned in occluding states at positions proximal and distal of a target site to define an occluded region therebetween. An agent is injected into the region. An intervention is performed at the target site while the vessel is occluded and the agent is in the region. The catheter assembly is removed from the channel. Intervention may include expanding a balloon within a temporary stent structure against the channel, collapsing balloon and then removing the collapsed balloon and stent structure from the channel. A balloon stent assembly comprises a catheter assembly, a temporary stent surrounding a balloon, the temporary stent placeable in a contracted state by the catheter assembly and in an expanded state by inflation of the balloon.

A balloon catheter for treating, preventing, or reducing the recurrence of a stricture and / or cancer, or for treating benign prostatic hyperplasia (BPH), in a non-vascular body lumen is disclosed. The ballon catheter comprises: an elongated balloon; a coating layer overlying an exterior surface of the balloon, wherein the coating layer includes one or more water-soluble additives and an initial drug load of a therapeutic agent; and a length-control mechanism (600) which stretches and elongates the balloon during deflation, giving the balloon a smaller cross-sectional deflated profile for tracking through the body lumen and for removal after treatment.

The invention discloses a method for establishing an intracranial vessel simulation three-dimensional stenosis model based on transfer learning. The method comprises the following steps: acquiring a bright blood image group and an enhanced black blood image group of an intracranial vessel; preprocessing each bright blood image and the corresponding enhanced black blood image to obtain a first bright blood image and a first black blood image; performing image registration by using mutual information based on Gaussian distribution sampling and a registration method of an image pyramid; groupingthe registered bright blood images to obtain MIP images in all directions; obtaining a two-dimensional blood vessel segmentation image based on the MIP image and the fundus blood vessel image; performing back projection synthesis on the two-dimensional blood vessel segmentation image to obtain first three-dimensional blood vessel body data, and obtaining an intracranial blood vessel simulation three-dimensional model by utilizing the second three-dimensional blood vessel body data; and for each section of blood vessel in the model, obtaining a numerical value of a target parameter representingthe stenosis degree of the section of blood vessel, and marking the intracranial blood vessel simulation three-dimensional model by utilizing the numerical value of the target parameter to obtain a simulated three-dimensional intracranial blood vessel stenosis analysis model.

The invention provides a composite aortic arch reconstruction system and a using method thereof. The system comprises a quadrifurcation vascular prosthesis and a cross arch covered stent; the vascularprosthesis comprises a vascular body, an arch upper branch communicated with the vascular body and a perfusion branch, the arch upper branch is sequentially divided into an anonyma branch, a left common carotid branch and a left collarbone lower branch, and blood vessel lumina are communicated with each other. The cross arch covered stent comprises an inner layer metal stent and an outer layer vascular cover, and conical and preflex designs which more conform to the physiological structure of an aorta of a human body are adopted. When an aortic arch surgery is carried out, deep hypothermic circulatory arrest can be avoided by means of the system to reduce the difficulties of vascular anatomy and vascular anastomosis, shorten the surgical operating time and improve the success rate of thesurgery.

Various embodiments disclosed relate to drug-coated balloon catheters for treating, preventing, or reducing the recurrence of a stricture and / or cancer, or for treating benign prostatic hyperplasia (BPH), in a non-vascular body lumen and methods of using the same. A drug-coated balloon catheter for delivering a therapeutic agent to a target site of a body lumen stricture includes an elongated balloon having a main diameter. The balloon catheter includes a coating layer overlying an exterior surface of the balloon. The coating layer includes one or more water-soluble additives and an initial drug load of a therapeutic agent. In some embodiments, the balloon catheter includes a length-control mechanism which stretches and elongates the balloon when it is in a deflated state, giving the balloon a smaller cross-sectional deflated profile for tracking through the body lumen and for removal after treatment.

The invention discloses a coating having an endothelium bionic function and a preparation method of the coating. The coating is applied to surface modification of cardiovascular implants and blood contact materials; and a carboxyl disulfide bond containing compound, which has nitric oxide catalytic activity, and heparin are immobilized on the surface of the coating rich in amino. The functional coating shows an endothelium-like bionic function; the coating not only offers an excellent anti-coagulation property but also integrates excellent functions of inhibiting proliferation of smooth muscle cells and promoting growth of endothelial cells; and the coating can be widely applied to surface treatment of such medical apparatuses as vascular stents, artificial blood vessels, extracorporeal circulation catheters, central venous catheters and the like.

The present invention provides compositions and methods for treating or preventing diseases associated with vascular and non-vascular body passageways, the method comprising the step of delivering to a body passageway a therapeutic agent delivered locally through a polymer matrix from an implanted stent or other structure.

The invention relates to a blood vessel reconstruction method and device based on a dynamic perfusion image, equipment and a medium. The method comprises the following steps: screening a first blood vessel voxel belonging to an input artery and a second blood vessel voxel belonging to an output vein from each blood vessel voxel of a dynamic perfusion image; respectively generating an artery input curve and a vein output curve based on the contrast agent concentration change curves of the first blood vessel voxels and the second blood vessel voxels; determining a starting time when the contrast agent begins to reach the input artery based on the artery input curve, and determining a deadline based on an intersection point of the artery input curve and the vein output curve, so as to determine an artery time interval; determining the average contrast agent concentration of each vascular voxel in the artery time interval to generate a concentration distribution three-dimensional diagram; segmenting the concentration distribution three-dimensional image to obtain a candidate blood vessel voxel segmentation image, and reconstructing a three-dimensional artery blood vessel image after removing blood vessel voxels of which the peak reaching time is outside the artery time interval from the candidate blood vessel voxel segmentation image. According to the scheme, limitation can be avoided.

The invention discloses a method for quickly establishing an intracranial blood vessel simulation three-dimensional model based on transfer learning. The method comprises the following steps: collecting a bright blood image group and an enhanced black blood image group of an intracranial blood vessel part; preprocessing each bright blood image and the corresponding enhanced black blood image to obtain a first bright blood image and a first black blood image; performing image registration on the first bright blood image by using mutual information based on Gaussian distribution sampling and a registration method of an image pyramid; utilizing a maximum intensity projection method to obtain MIP images in all directions from the registered bright blood image groups; taking the MIP image as atarget domain, taking the fundus blood vessel image as a source domain, and obtaining a two-dimensional blood vessel segmentation image by using a transfer learning method; performing back projectionsynthesis on the two-dimensional blood vessel segmentation images in the three directions to obtain first three-dimensional blood vessel body data; and obtaining an intracranial blood vessel simulation three-dimensional model by utilizing the second three-dimensional blood vessel body data corresponding to the registered bright blood image group. According to the method, the whole state of the intracranial blood vessel can be simply, conveniently, quickly and visually obtained clinically.

A method of monitoring a blood pressure includes: emitting a laser to a blood vessel in a body part; detecting, from the body part, laser speckles caused by scattering of the emitted laser; obtaining a bio-signal indicating a change in a volume of the blood vessel by using the detected laser speckles; and estimating a blood pressure based on the obtained bio-signal.

The present invention provides a system for assessing the severity and stage of PAD including at least one sensor that measures skin perfusion pressure; a knowledge base that provides data on lower extremity angiosomes; and a processing device in operable communication with the sensor and the knowledge base, the processing device that outputs a visual representation of at least one of the lower extremity angiosomes that guides the sensor in the mapping of a testing site relative to a target vessel where the skin perfusion pressure measurement will be taken.

The invention discloses an in-vitro stress culture device for a blood vessel, a culture system and a culture method. The device is characterized in that two sides of a culture tank are coaxially provided with connecting pieces in which first fixed parts are coaxially arranged, fasteners are coaxially fixed outside the connecting pieces and are internally and coaxially provided with second fixed parts, and the first fixed parts and the second fixed parts are internally, respectively and coaxially provided with a third through hole and a fourth through hole; sealing rings are arranged between the first fixed parts and the second fixed parts; blood vessel connecting pipes extend into the culture tank after passing through the fourth through holes, the sealing rings and the third through holes. The device is capable of improving the coaxiality of the blood vessel and the blood vessel connecting pipes and good in sealing performance. A surge flask in the system is formed into a loop together with the in-vitro stress culture device for the blood vessel through an input pipeline and an output pipeline; the input pipeline is provided with a constant flow pump and a flow sensor, and the output pipeline is provided with a pressure sensor; a gas regulating valve, the constant flow pump, the flow sensor and the pressure sensor are respectively connected with a PC (personal computer). The system and the culture method can be used for precisely controlling the pressure and flow in a culture process and improving the reliability of a culture result.

The invention discloses a method for establishing an intracranial vessel simulation three-dimensional stenosis model based on transfer learning. The method comprises the following steps: acquiring a bright blood image group and an enhanced black blood image group of an intracranial vessel; performing image registration by using a registration method based on mutual information and an image pyramidto obtain a registered bright blood image group; utilizing the registered bright blood image group to obtain an MIP image in each direction; obtaining a two-dimensional blood vessel segmentation image based on the MIP image as a target domain and a fundus blood vessel image; synthesizing the two-dimensional blood vessel segmentation images in the three directions by using a back projection methodto obtain first three-dimensional blood vessel body data; obtaining an intracranial blood vessel simulation three-dimensional model by utilizing the second three-dimensional blood vessel body data corresponding to the registered bright blood image group; and for each section of blood vessel in the model, obtaining a numerical value of a target parameter representing the stenosis degree of the section of blood vessel, and marking the intracranial blood vessel simulation three-dimensional model by utilizing the numerical value of the target parameter to obtain a simulated three-dimensional intracranial vessel stenosis analysis model.

The present disclosure relates to a device configured to move within a body cavity, such as the gastrointestinal tract, in particular, the small intestine, and methods of using the device. The presently disclosed device may be self-driving, and the articulation of a tip of the device may be controlled and fine tuned. The presently disclosed device may be used in a variety of body cavities such as a vascular body lumen, a digestive body lumen, a respiratory body lumen, or a urinary body lumen, for example, for endoscopic purposes, for delivering a substance into the body cavity, for removing a substance or tissue from the body cavity, for capturing an image of the body cavity, and / or for performing an operation of a tissue or organ using the device.

The invention belongs to the field of biomedical engineering, provides a blood vessel culture experiment cavity device capable of being repeatedly sterilized at high temperature, uses a blood vessel connecting tube with adjustable length and a convenient blood vessel mounting device, and provides an experiment cavity device capable of realizing blood vessel in-vitro simulation culture and being used for simulating blood flow stimulation on blood vessels. The blood vessel is assembled through an external fixing device, so that the blood vessel is convenient to assemble and easy to implement, and the pollution risk during operation is reduced; meanwhile, the blood vessel is placed into the blood vessel culture cavity in a pressing-in mode.

The invention features methods for detecting the hydration state or vascular volume of a subject using a device capable of nuclear magnetic resonance (NMR) measurement. The methods involve exposing a portion of a tissue of the subject in vivo to a magnetic field and RF pulse from the device to excite hydrogen nuclei of water within the tissue portion, and measuring a relaxation parameter of the hydrogen nuclei in the tissue portion, the relaxation parameter being a quantitative measure of the hydration state or vascular volume of the subject as a whole. The invention also features devices and computer-readable storage media for performing the methods of the invention.

The invention discloses a quality testing method dynamic test phantom simulating cardiovascular motion for quality evaluation of CT imaging, and its control principle and quality testing method. The dynamic test phantom includes: a control system, an electric cylinder unit, a piston pump unit, a fluid circuit unit and a cardiovascular phantom; the control system includes a control box and a control PC, wherein the control box includes a PLC control system and an electrocardiogram generator, and the PLC control system is connected with the control PC and the electrocardiogram generator respectively; the electric cylinder unit includes an electric cylinder drive unit and an electric cylinder transmission unit, wherein the electric cylinder drive unit is connected with the PLC control system, and the electric cylinder transmission unit is connected with the electric cylinder drive unit; the piston pump unit is connected with the electric cylinder transmission unit; the fluid circuit unit includes a fluid confluence module and fluid pipelines, which are connected with the piston pump unit and the cardiovascular phantom respectively; and the cardiovascular phantom includes a ventricular phantom, coronary artery phantoms and a water tank. The dynamic test phantom according to the invention can simulate ventricular strokes and multiple motion phases, and has standard models of normal heart rate, arrhythmis, coronary artery stenosis, etc.

Many medical procedures involve the implantation of an element in a vascular body. Current imaging techniques allow the positioning of such expandable elements to be checked, before and after implantation, using contrast bursts into the blood from a pigtail catheter. When the implantation of the medical device needs to be performed quickly, the pigtail catheter is pulled back briskly. This process is prone to error, because at the point of implantation, a medical professional has many other factors to consider, as well as the withdrawal of the catheter. If an implantable device traps the pigtail catheter during or after expansion, undesirable results can occur, such as having to pull sharply on the catheter to remove it, and in the process, disrupting the newly implanted device. This application discusses a technique for automatically generating a region of implantation around a medical device prior to and during implantation. If a second medical device, such as a pigtail catheter, strays into the area, an alarm can be generated to warn a medical professional to withdraw the catheter, before deployment continues.

The invention discloses an experiment simulation device for cardiovascular diseases. The device comprises a combined box body, bases, a tray, a PC controller, a transparent cover cylinder, a cardiovascular phantom and a liquid storage box, the left base and the right base are installed at the bottom end of the interior of the combined box body, and fences are symmetrically arranged on the two sides of the top end of the tray; the PC controller and the transparent cover cylinder are arranged on the left side and the right side of the interior of the combined box body correspondingly, the cardiovascular phantom is arranged in the transparent cover cylinder, the liquid storage box is fixed to the center of the interior of the combined box body, and the output end of a water pump communicateswith a plurality of liquid supply pipes; and the bottom of the cardiovascular phantom is correspondingly communicated with a plurality of return pipes. An experiment simulation instrument is providedwith a packaging protection structure convenient to open and close, rotating adjustment and fixing are convenient, the display effect of the experiment simulation device is improved, the functions ofautomatic control and visual display are achieved, and therefore the cardiovascular disease experiment simulation effect is improved.