85results about How to "Amphipathic" patented technology

The invention discloses a method for preparing Pickering emulsion by utilizing modified nano-crystalline cellulose. The method comprises the following steps: 1) taking the nano-crystalline cellulose modified with an amphiphilic segmented copolymer and grinding into powder, thereby acquiring the amphiphilic segmented copolymer modified nano-crystalline cellulose powder; 2) dispersing the amphiphilic segmented copolymer modified nano-crystalline cellulose powder acquired in the step 1) into deionized water, thereby forming modified nano-crystalline cellulose dispersion liquid; and 3) weighting an oily solvent, adding into the modified nano-crystalline cellulose dispersion liquid acquired in the step 2), and mixing and emulsifying, thereby forming stable Pickering emulsion. The method for preparing the Pickering emulsion by utilizing the modified nano-crystalline cellulose has the characteristics of less CNC dosage and low application cost.

The invention discloses a preparation method of a multifunctional oil-water separation material based on graphene oxide nanobelts, wherein the preparation method includes following steps: (1) cutting functionalized graphene oxide nanobelts in an oxidizing manner; and (2) preparing a graphene oxide nanobelt porous thin film through a vacuum-suction filtering method. The porous screen multifunctional oil-water separation thin film is 38 + / - 2 cm<2> in area and is 5-200 nm in pore size. The multifunctional oil-water separation material screen film can simultaneously perform oil-water separation and heavy metal adsorption to a mixture containing oil and water and heavy metal ions and the like components which are insoluble to each other. The integrated water-purifying renewable film has very important significance on protecting environment and maintaining ecologic system balance.

The invention relates to the preparation and applications of RGD-fatty amine series compound as tumor targeting vector material, and the compound has a structure as the right formula.

The invention discloses a magnetic nanoparticle / macromolecular Janus microparticle and a preparation method and application thereof. The method comprises the following steps: (1) respectively charging a dispersion phase and a continuous phase into different passages in a micro-fluidic chip, finally mixing the dispersion phase with the continuous phase, and obtaining a single-emulsion-drop system on the other end of the micro-fluidic chip, wherein the dispersion phase is prepared from magnetic nanoparticles, a macromolecular polymer and an organic solvent, and the continuous phase is an aqueous solution of a surface active agent; (2) standing the single-emulsion-drop system obtained in the step (1) at room temperature, then standing in a magnetic field, after the standing is completed, heating to remove the organic solvent in the system, and washing with water. The method is novel, simple in process, common in equipment, good in operability and powerful in functions. The obtained microparticle is good in single monodispersion and has magnetism; and other functional materials can be added, so that integration of multiple functions of the material is realized.

The invention discloses a conjugate of fatty aminoacyl alexan, preparation and application in anti-tumor thereof. The invention also discloses a pharmacosome of the conjugate of fatty aminoacyl alexan, preparation thereof, and its applicant in anti-tumor and preparation of target medicine material of microemulsion, lipid medicine carrier. In comparison with alexan, the inventive conjugate of fatty aminoacyl alexan has a strong transmembrane ability, high bioavailability, long halflife, and amphipathic nature. It is demonstrated that the inventive compound and pharmacosome have great anti-tumor activity.

The invention discloses a graphene modified polyurethane insulation board including first cement fireproof cloth, a graphene modified polyurethane insulation layer and second cement fireproof cloth which are arranged from top to bottom; the graphene modified polyurethane insulation layer comprises the following components in parts by weight: 900-1100 parts of a white material, 1350-1650 parts of a black material, 4.5-5.5 parts of a flame retardant, 225-275 parts of a graphite powder, and 4.5-5.5 parts of graphene. The invention provides the graphene modified polyurethane insulation board and a production method thereof, and aims to solve the problem that a conventional prepared polyurethane insulation board cannot be good in both insulation properties and flame retardant properties.

The invention discloses a magnetic fluorescent bifunctional nano biological probe and a preparation method thereof. The invention is characterized by preparing magnetic fluorescent bifunctional nanoparticles which can be used a nano biological probe, wherein each nanoparticle is in a core-shell spherical structure, and the nanoparticles are prepared from hydrophobic superparamagnetic nanoparticles as the core layer and a fluorescent amphipathic polymer as the shell layer by a nano emulsion process. After entering cells, the composite magnetic fluorescent nanoparticles can be used for imaging analysis on the cells respectively by a fluorescence process and a magnetic resonance imaging process. The magnetic fluorescent nano probe disclosed by the invention has high sensitivity and stability, greatly enhances the sensitivity and accuracy of cell imaging, reduces the emergence of false positive and false negative in cell diagnosis and analysis, and can be well used for diagnosing various diseases, such as tumor cells, cancer cells and the like.

The invention relates to a binder with a three-dimensional network structure and a preparation method and an application thereof. The binder is formed by cross-linking a low-molecular-weight polyurethane prepolymer by taking high-molecular-weight polyacrylic acid and high-molecular-weight polyurethane as chain-shaped brackets. The binder has the cohesiveness of polyacrylic acid and the high elasticity of polyurethane, and can firmly bind an active material and a conductive agent together. In the charging and discharging process, the active material expands and contracts, and the binder can expand and contract along with the expansion and contraction of the active material. Thus, the structural stability of an electrode material can be well maintained, the electrode does not come off in thecharging and discharging process, and the cycling stability and the rate capability can be improved.

The invention provides a preparation method of a graphene oxide and nanosized silica composite filler reinforced binder for dentistry. The method comprises the following steps: preparing a graphene oxide and nanosized silica composite; performing surface modification for graphene oxide and nanosized silica; compositing graphene oxide and nanosized silica with the binder to obtain the binder for dentistry. The binder for dentistry is relatively high in binding strength; a graphene oxide and nanosized silica composite filler can be dispersed well in the binder; in addition, the modified composite filler is amphiphilic and can permeate dentin well while being applied to the binder for dentistry, so that the binding strength with the dentin is improved. The graphene oxide and nanosized silica composite filler produced in the preparation process can be applied to modification of other reins or macromolecules.

The invention relates to an amphiphilic fluorinated acrylate penta-block copolymer and a preparation method thereof. The technical characteristics are that a name is amphiphilic fluorinated acrylate penta-block copolymer, namely poly-fluorinated acrylate-b-polymethacrylate-b-polyethylene glycol-b-polymethacrylate-b-poly-fluorinated acrylate. A synthetic method uses a bromine-terminated polyethylene glycol as a macro-molecule initiator and uses a one-pan way to gradually charge, that is performs an atom transfer radical polymerization reaction of the macro-molecule initiator with methacrylate, and after the reaction ends, directly adds the fluorinated acrylate to obtain the amphiphilic fluorinated acrylate penta-block copolymer through the atom transfer radical polymerization reaction. The copolymer and the preparation method have advantages of mild reaction condition, simple operation, reduced steps, high product yield, reduced cost, clear product structure and narrow molecular weight distribution, can save time and raw materials, and has potential application in fields of LCD, aerospace coating, photoconductive material, nano-carbon material, pharmaceutical carriers, etc.

The invention relates to a preparation method of TEMPO-containing (4-oxo-2,2,6,6-tetramethylpiperidinooxy containing) block polymer, comprising the specific steps: preparing macromolecular initiator PEG-Br by bromination of polyethylene glycol PEG, using 2,2,6,6-tetramethylpiperidide-4-methylacrylate TMPM as a monomer, acquiring block polymer PEG-PTMPM by means of ARGET ATRP (activator regenerated by electron transfer and atom transfer radical polymerization), and oxidizing via 3-chloroperoxybenzoic acid to obtain TEMPO-containing block polymer PEG-PTMA. In a NaClO water-oil oxidation system, benzyl alcohol is selectively catalytically oxidized by PEG-PTMA, good selective catalytic oxidation is presented, and catalytic performance still remains good after 5 times of recycling is available. The TEMPO-containing block polymer is high in TEMPO supporting capacity, simple in synthetic process and good in catalytic performance.

The invention relates to a protein grafted copolymer. Protein is taken as a substrate, polymer side chains are grafted and polymerized on main chains of the protein, and the copolymer contains about 14.0%-94.0% by mass of the protein and about 6%-86% by mass of the polymer side chains. The invention relates to a preparation method and an application of the protein grafted copolymer.

The invention belongs to the technical field of green catalysis, and particularly relates to a method for catalyzing an aqueous-phase Heck reaction in the presence of palladium nano particle supported amphipathic carbon spheres. The method is characterized in that the palladium nano particle supported carbon sphere catalyst (Pd / PHCSs) is synthesized in situ by adopting carbon spheres (PHCSs), which are synthesized in a hydrothermal method, as a carrier, PdCl2 as a precursor and ethanol as a solvent and a reduction agent. The catalyst can be applied to the aqueous-phase Heck reaction and is high in catalytic activity; moreover, the synthesis process of the catalyst is simple, and the catalyst is recyclable and is free of environment pollution.

The invention provides a polymer material, which is represented by the formula I and contains cholic acid, and a preparation method thereof. The invention further provides a liposome, which takes phosphatide and cholesterol as the carriers and is modified by the polymer material represented by the formula I. Drugs are coated in the phosphatide bi-molecule layer. The provided liposome has double functions of active targeting and passive targeting; and furthermore, the preparation method is simple and practical and can be applied to massive production. The in-vivo experiment results show that the liposome has a strong targeting performance on livers and thus has a good application prospect.

The invention discloses a rainwash resistant pesticide adjuvant composition and application thereof. The rainwash resistant pesticide adjuvant composition comprises, by weight, 1-10% of polysaccharide, 5-20% of polyquaternium, 10-40% of alkyl-polyoxyethylene ester, 10-20% of emulsifier and the balance being solvents. The pesticide adjuvant can be used as a spray additive of herbicides, has excellent hydrophilcity, and has good rainwash resistance function to the herbicides, especially the water-soluble herbicides.

The invention discloses an amphiphilic derivative of oil acylated chitosan oligosaccharide guanidine grafted polyethyleneimine and a preparation method thereof. The amphiphilic derivative takes low molecular weight polyethyleneimine and chitosan oligosaccharide as a low cytotoxicity template, and then introduces guanidyl and lipophilic segment-oleoyl. The derivative takes the chitosan oligosaccharide as a base, so that non-toxicity and high bioactivity can be endowed to the derivative; nuclear localization ability, high transfection efficiency and lower cytotoxicity can be endowed to the derivative by introducing the guanidyl; and through the introduction of the lipophilic segment, the derivative can have amphipathy, so that the derivative is easier to take in by cells.

The invention provides a measurement method of the pore size distribution characteristic of oil-bearing dense sandstone, belongs to the field of geology, and particularly relates to the field of dense sandstone. Octamethyl cyclotetrasiloxane is taken as probe liquid, the nano-scaled pore of the oil-bearing dense sandstone can be completely and quantitatively depicted, and the characterization precision of the pore size distribution numerical value of the oil-bearing dense sandstone is improved. The measurement method comprises the following the following steps: performing pretreatment on an oil-bearing dense sandstone sample; testing an oil-bearing dense sandstone original sample through a nuclear magnetic resonance freezing-thawing method; testing a saturated sample through the nuclear magnetic resonance freezing-thawing method for oil-bearing dense sandstone original sample saturated octamethyl cyclotetrasiloxane; and computing the pore size distribution of the oil-bearing dense sandstone through data of the oil-bearing dense sandstone original sample and the oil-bearing dense sandstone saturated sample.

The invention discloses a preparation method of nano zirconium carbide modified paraffin phase change microcapsules. The method comprises the following steps: performing hydrophobic modification treatment on zirconium carbide, and dispersing the hydrophobic modified zirconium carbide into water to obtain a hydrophobic modified nano zirconium carbide-water dispersion liquid; mixing paraffin, an emulsifying agent, the hydrophobic modified nano zirconium carbide-water dispersion liquid and a dispersant, and performing emulsification treatment to prepare a zirconium carbide / paraffin Pickering emulsion; and mixing the zirconium carbide / paraffin Pickering emulsion and a melamine-urea-formaldehyde prepolymer, and performing curing treatment. According to the method provided by the invention, in the nano zirconium carbide modified paraffin phase change microcapsules prepared by the method, the nano zirconium carbide is used as a reinforcing material and present in a wall material of the microcapsules, so that the thermal conductivity and photothermal conversion performance of the paraffin phase change microcapsules are significantly improved.

The invention discloses a polymer drag reducer for oil and gas exploitation. The polymer drag reducer comprises a drag reduction component, a film forming component and microcrystalline wax, the preparation process of the polymer drag reducer for oil and gas exploitation comprises the following steps: 1, preparing the drag reduction component; 2, preparing the film forming component; and 3, weighing the drag reduction component and the film forming component, heating the film forming component and the drag reduction component to be molten, stirring and mixing, drying to constant weight to obtain a first component, heating the microcrystalline wax to be completely dissolved, soaking the first component into the dissolved microcrystalline wax, taking out, quickly adding into deionized water,and airing to obtain the polymer drag reducer for oil and gas exploitation. The drag reducer synthesized in the invention is easily soluble in water and has a good drag reduction effect.

The invention discloses a preparation method for a polyhydroxy functional POSS hybrid material. The preparation method is characterized by the following steps: adding reactants, namely, polyethylene glycol derivative PEG (C=CH2) containing unsaturated carbon-carbon double bond at one end, olefinic organism (RHC=CH2), octa-sulfydryl POSS and dissolvent into a reactor; adding radical initiator afterthe added reactants dissolve and uniformly disperse; reacting for 40min-4h under the nitrogen shielding condition at 30-80 DEG C or under an ultraviolet light condition, thereby acquiring the POSS hybrid material; removing the remained radical initiator and unreacted reactants, and drying, thereby acquiring the polyhydroxy functional POSS hybrid material. The preparation method disclosed by the invention has the advantages of simplicity in operation, easily acquired reaction materials, fast reaction and mild reaction condition. The polyhydroxy functional POSS hybrid material prepared according to the invention has the advantages of high biocompatibility, controllable hydrophily and hydrophobicity, controllable form under condensed state, multifunctional reaction group and the like.

The invention provides a high-polymer material with cholic acid, a method for preparing the high-polymer material and liposome. The high-polymer material is shown as a formula I. Phospholipid and cholesterol are used as carriers for the liposome, the liposome is modified by the high-polymer material shown as the formula I, and medicines are entrapped in bi-molecular layers of the phospholipid. Thehigh-polymer material, the method and the liposome have the advantages that an active targeting effect and a passive targeting effect can be realized by the liposome; the method is simple and practical, amplification production can be facilitated, the high-polymer material and the liposome are high in targeting capacity for livers as shown in in-vivo experiments, and accordingly the high-polymermaterial, the method and the liposome have excellent application prospects.

The invention relates to a preparation method of a biomass cement grinding aid, and belongs to the technical field of cement grinding aid. The preparation method comprises following steps: pine bark and bagasse are taken as raw materials, are crushed, and are subjected to steam explosion so as to obtain an explosion product; the explosion product is mixed with cellulase, pectase, and protease forenzymatic hydrolysis so as to obtain an enzymatic hydrolysis product; the enzymatic hydrolysis product is subjected to acid treatment, oxidation, and alkali treatment reaction respectively so as to obtain a reaction filtered residue; and at last, the reaction filtered residue is mixed with sodium sulfite for reaction, and vacuum freeze-drying is carried out so as to obtain the biomass cement grinding aid. The biomass cement grinding aid is excellent in grinding aid effect, and promising in application prospect.

The invention provides an electrodeposition preparation method of a light-crosslinking bio-based coating. The preparation method comprises the following steps: preparing micellar particles and compound self-assembly micelles particles of coating functional factors from amphiphilic ionic biological macromolecules containing photosensitive groups in a self-assembly manner; forming a film on a medical metal surface by using a potentiostatic electrodeposition technology; carrying out crosslinking on the micellar particles by ultraviolet irradiation crosslinking reaction, so as to obtain a medical biological coating material based on a self-assembly micellar film. The method is simple and convenient to operate, mild in condition and wide in application range.

The invention discloses a photochemical preparation method of amphiphilic silver nanometer granules, which uses water as a solvent, an amphiphilic macromolecule thiomichler's ketone photo initiator asa reducing agent and a stabilizing agent and silver nitrate as a raw material, and the materials are simply mixed and form silver nanometer granules with uniform granular size distribution under ultraviolet light irradiation. The silver nanometer granules prepared by the invention have amphiphilic property and can be dissolved into various polarity and non-polarity solvents. The whole preparationprocess has simplicity and environmental protection.

The invention relates to the preparation of a modified chitosan drug carrying microsphere. Firstly, hymecromone is modified to obtain a hydrophobic group, the modified hymecromone is then used for modifying chitosan into an amphipathic chitosan which has a hydrophilic chain and a hydrophobic chain at the same time, an antibacterial agent is then added, and the chitosan drug carrying microsphere is produced by adopting a self-assembly method. The method has a simple preparation technology and moderate reaction conditions, and is lower in cost, and the prepared modified chitosan has amphipathy, the antibacterial agent is added, the drug carrying microsphere can be self assembled without adding a crosslinking agent, so the cytotoxicity is avoided. Moreover, the added antibacterial agent is the natural biological extract, so beneficial fungi and normal cells in the human body can be prevented from being damaged.

The invention relates to an ibuprofen end group-containing polyethylene glycol medicine macromonomer and a synthesis method thereof, belonging to the technical field of pharmaceutical chemistry and synthesis thereof. The macromonomer is white powder, is soluble in N,N-dimethylformamide, methylene dichloride, chloroform, dioxane, dimethyl sulfoxide, distilled water or phosphoric acid PBS buffer solution, is not soluble in petroleum ether or aether, and has a structure as shown in the specification, wherein n is an integral number in a interval of 45-224. Under the catalysis condition, polyethylene glycol reacts with ibuprofen acyl chloride to synthesize the crude macromonomer, and then the crude macromonomer is purified to obtain the finished macromonomer, wherein the raw material ibuprofen acyl chloride is synthesized by referencing the known literatures. The macromonomer has the advantages of long half-life period, good water-solubility, little dosage, low toxicity and small thrill on intestines and stomach, contains degradable ester bonds, and is especially suitable for being used as an active component of ibuprofen slow-release drugs.

The invention belongs to the field of preparation of organic / inorganic nano-composite microspheres, and particularly relates to a preparation method of polymer / ZnO / SiO2 nano-composite microspheres. The preparation method includes the steps that firstly, vinyl monomers and organic siloxane are copolymerized through a miniemulsion polymerization method to prepare polymer microspheres carrying active silicon hydroxyl on the surfaces; then, an organic amine alkali source acts with active silicon hydroxyl on the surfaces of the polymer microspheres to generate nano-ZnO on the surfaces of the polymer microspheres in situ, and polymer / ZnO nano-composite microspheres are prepared; finally, the polymer / ZnO / SiO2 nano-composite microspheres are prepared in situ with a sol-gel method under the induced nucleation effect of nano-ZnO particles on the surfaces of the polymer microspheres. The obtained polymer / ZnO / SiO2 nano-composite microspheres are controllable in particle size and morphology, and solve the problems that nano-ZnO particles are prone to agglomeration and poor in dispersity; the nano-composite microspheres can be applied to the fields of paint, adhesives, ink, plastic, rubber, fibers and the like as multifunctional filler, and can bring excellent mechanical performance, ultraviolet resistance, antistatic performance, durability and the like to the materials.

The invention discloses amphiphilic calcite type calcium carbonate. A polyoxyethylene polyoxypropylene-ether diblock copolymer (F127) serves as a soft template agent, calcium chloride as a calcium source is added into a sodium carbonate solution, the obtained calcium carbonate crystals are in a regular hexagon shape, the side length is 2.5-3 micrometers, all calcium carbonate crystals are evenly dispersed, and the amphiphilic calcite type calcium carbonate which is good in regularity, oleophylic and hydrophilic is obtained. The preparation method includes the following steps of 1, preparationof the solution, 2, addition of the template agent and 3, preparation of amphiphilic calcite type calcium carbonate. As an electronic packaging material, the calcium carbonate is fully mixed with epoxy resin (E44) and a curing agent for curing, and a heat-conductive reinforced electronic packaging material with the thermal diffusivity of 0.0024-0.0080 is obtained. The amphiphilic calcite type calcium carbonate has the advantages that calcium carbonate crystals are of calcite type, dispersion is uniform, the size is regular and 2.5-3 micrometers, the calcium carbonate has amphipathicity, an in-situ polymerization method is used, the preparation process is simple, the cost of the template agent is low, and the production cost is cheap.

The invention discloses a preparation method of octanoic acid starch ester and application of octanoic acid starch ester in pesticide microcapsules. The invention belongs to the technical field of preparation and application of natural polymer materials. The octanoic acid starch ester is prepared by adopting starch as a raw material, adding an auxiliary agent and an octanoic acid esterification agent and adopting a mechanical activation solid-phase technology, and the substitution degree of the octanoic acid starch ester is more than 0.25. The obtained octanoic acid starch ester is applied asa wall material to the field of pesticide microcapsules, and the embedding rate of the obtained pesticide microcapsules exceeds 88.6%. The octanoic acid starch ester is prepared by adopting a mechanical activation solid-phase technology, the method is simple, the obtained material has the characteristics of good film-forming property and low viscosity, the defects of high viscosity, poor fluidityand low solid content of traditional starch can be overcome, and the octanoic acid starch ester is applied to the field of pesticide microcapsules, is green and environment-friendly and plays a role in sustained and controlled release, so that the pesticide utilization rate is increased.