The invention discloses a 
tilapia mossambica streptococcicosis resistant traditional Chinese herbal 
medicine preparation and a preparation process thereof. The traditional Chinese herbal 
medicine preparation is prepared from the following raw materials in parts by weight: 10-25 parts of 
scutellaria baicalensis, 10-25 parts of fructus 
forsythia, 10-25 parts of 
rheum officinale and 10-25 parts of 
dioscorea bulbifer. The preparation process comprises the following steps: weighing the 
raw material medicines according to formula weights, adding 
distilled water which is 20 times the total weight ofthe 
raw material medicines, and performing water bath for three times at 100 DEG C, and concentrating, thereby obtaining the traditional Chinese herbal 
medicine preparation, wherein the water bath lasts for one hour each time, and the 
alcohol precipitation concentration is 60%. The traditional Chinese herbal medicine preparation has the functions of clearing heat and removing toxins, preventing 
bacteria and preventing stress as well as regulating body 
immunity, the 
disease resistance of 
tilapia mossambica can be effectively improved, moreover the traditional Chinese herbal medicine preparationis low in medicine residue, medicine residue standard exceeding can be avoided, and 
drug resistance of 
pathogenic bacteria can be avoided; and besides, by adopting the preparation process disclosed by the invention, the contents of effective components of the 
tilapia mossambica streptococcicosis resistant traditional Chinese herbal medicine preparation can be effectively increased, so that the medicinal effect can be improved, the preparation process is simple, and the cost can be lowered.