4657 results about "Antibacterial activity" patented technology

A luer fitting is disclosed. The luer fitting includes a body having a first end and a second end, wherein the first end comprises an antibacterial component disposed therewith. The luer fitting is connected over a catheter that has been primed with a locking solution. The antibacterial component is fluidly engaged with the locking solution such that the antibacterial component diffuses through the locking solution. A method of reducing antibacterial activity in a catheter utilizing the fitting is also disclosed.

Plastic films, fibers and articles are provided long-term antimicrobial activity with a combination of certain phenolic and inorganic antimicrobial agents. The plastic films, fibers and articles with antimicrobial activity exhibit superior resistance to discoloration, may be processed at high temperature, and maintain physical properties upon weathering, especially upon exposure to ultraviolet radiation.

A topical spray or foam, methods of making the formulation, and methods of use thereof, has been developed. In one preferred embodiment, the composition includes one or more active agents and exhibits both antibacterial activity and antifungal activity. Excipients such as chemical disinfectants, anti-pruritic agents to minimize itching, and skin protective compounds may be added. The composition may be formulated to be dispensed as a spray or foam and the spray or foam may be administered either by a hand pump or by an aerosolizing propellant. A second single phase formulation has also been developed. The formulation comprises a first drug which is water soluble or hydrophilic and a second drug which is lipid soluble or hydrophobic, wherein at least one of the drugs is bound to an ion-exchange resin. The use of binding resins, such as ion-exchange resins, allows drugs with incompatible solvent requirements to be prepared in a single-phase formulation.

A method for enhancing, by at least 10 fold, the antibacterial activity of an antisense oligonucleotide composed of morpholino subunits linked by phosphorus-containing intersubunit linkages. The method includes one or both of: conjugating an arginine-rich carrier to a 3′ or 5′ end of the oligonucleotide and modifying the oligonucleotide to contain 20%-50% intersubunit linkages that are positively charged at physiological pH. Also disclosed is an antisense oligonucleotide having enhanced antibacterial activity by virtue of one or both modifications.

Durable non-electrically conductive metal treatments (such as coatings or finishes) for yarns and textile fabrics. Such treatments preferably comprise silver and / or silver ions; however, other metals, such as zinc, iron, copper, nickel, cobalt, aluminum, gold, manganese, magnesium, and the like, may also be present or alternatively utilized. Such a treatment provides, as one example, an antimicrobial fiber and / or textile fabric which remains on the surface and does not permit electrical conductivity over the surface. The treatment is extremely durable on such substrates; after a substantial number of standard launderings and dryings, the treatment does not wear away in any appreciable amount and thus the substrate retains its antimicrobial activity (or other property). The method of adherence to the target yarn and / or fabric may be performed any number of ways, most preferably through the utilization of a binder system or through a transfer method from a donor fabric to a target textile fabric in the presence of moisture and upon exposure to heat. The particular methods of adherence, as well as the treated textile fabrics and individual fibers are also encompassed within this invention.

20,23-disubstituted mycaminosyltylonolide derivatives and use of the same in the field of the prophylaxis and treatment of pasteurellosis are disclosed. The di-substituents are peperidino optionally substituted with one or two methyl groups. The derivatives have selective antibacterial activity against Pasteurella.

The invention discloses a porous graphene loaded cerium nano composite antibacterial agent which is compounded from porous graphene and cerium, wherein nano cerium is deposited on a porous graphene layer; the particle size of the nano cerium is within 5-20nm; the specific surface area of the porous graphene is 350-450m<2> / g; the conductivity of the porous graphene is 20-60S.m<-1>; and the weightlessness of the porous graphene within 900 DEG C is 4-6wt%. The invention further discloses a preparation method of the porous graphene loaded cerium nano composite antibacterial agent. The method comprises the preparation of the porous graphene and the preparation of the porous graphene loaded cerium. The porous graphene loaded cerium has longer antimicrobial activity, can improve the security and reduce the use cost, and has wide prospects in industrial applications.

A method of treating eczema in a human or other mammal in need thereof comprising administering systemically to said human or other mammal a tetracycline compound in an amount that is effective to treat eczema, but has substantially no antibacterial activity.

A method for enhancing, by at least 10 fold, the antibacterial activity of an antisense oligonucleotide composed of morpholino subunits linked by phosphorus-containing intersubunit linkages. The method includes one or both of: conjugating an arginine-rich carrier to a 3′ or 5′ end of the oligonucleotide and modifying the oligonucleotide to contain 20%-50% intersubunit linkages that are positively charged at physiological pH. Also disclosed is an antisense oligonucleotide having enhanced antibacterial activity by virtue of one or both modifications.

Novel protected cyclopeptide intermediates are prepared from polymyxin B are used to synthesize new peptide antibiotics. Intermediates are readily derivatized and deprotected to provide new families of antibiotics, which have potent anti-bacterial activity against gram-negative bacteria; but also are useful and potent against gram-positive bacteria.

The invention discloses a bacillus belleus GT11 and application thereof. The bacillus belleus CT11 is collected at China General Microbiological Culture Collection Center on December 13th, 2016; the collection number is CGMCC No.13446; the bacillus belleus CT11 can be prepared into water agent, wettable powder or coating material and can be used for preventing and controlling the root rot diseases of pseudo-ginseng and plukenetia volubilis and Chinese cabbage clubroot. The invention provides an efficient, nontoxic, safe, non-residual and conveniently used biological agent for preventing and controlling the diseases such as root rot and clubroot; the effective active ingredient is bacillus belleus CT11 strain; the strain can generate the secondary metabolite antimicrobial active matter, is capable of degrading the cell wall of pathogenic bacteria and has an excellent growth-promoting effect for the crops, such as, plukenetia volubilis, pseudo-ginseng and Chinese cabbage; besides, the bacillus belleus CT11 has a better antibacterial effect for pseudo-ginseng phytophthora sojae, pseudo-ginseng fusarium solani, plukenetia volubilis gray mold, paddy bacterial mycosphaerella, and the like.

A nano-class mesoporous Ag-carried antibacterial agent used for detergent, cosmetics, water treating, textile, etc contains inorganic oxide as carrier with orderly mesopore structure and Ag as active antibacterial component. Its advantages are large specific surface area, broad spectrum, high effect and durability, and no damage to people.

A novel cephem compound of the formula:wherein R1 is a phosphono group or a group convertible to a phosphono group; R2 is a hydrogen atom or a group having a linkage through a carbon atom; each of Q and X is a nitrogen atom or CH; Y is S, O or CH2; n is 0 or 1; one of R3 and R4 is a pyridinium group which may be substituted and the other is a hydrogen atom or hydrocarbon group which may be substituted, or R3 and R4 taken together may form a quaternalized nitrogen-containing heterocyclic ring which may be substituted, or its ester or its salt, which has a superior anti-bacterial activity, stability, absorbability, etc., a production thereof and a pharmaceutical composition containing it, is provided.

The subject invention pertains to materials and methods for the prevention and treatment of gastrointestinal diseases, including inflammatory bowel diseases such as Crohn's disease and ulcerative colitis. Therapeutic compositions of the invention include compositions that can neutralize hydrogen peroxide, such as reducing agents and oxidizing agents. In one embodiment, a therapeutic composition of the invention comprises a reducing agent such as sodium thiosulfate. Therapeutic compositions of the invention can optionally include compounds with antibacterial activity, compositions that inhibit bacterial adherence to cells and tissue, compositions that inhibits epithelial lipid peroxidation, compositions that add viscosity to a solution, compositions that inhibit most cells, and / or compositions that help to seal or repair tight junctions between cells of the colonic epithelium of the gastrointestinal tract. Methods of the invention include administration of compounds or compositions of the invention. In one embodiment, compounds or compositions of the invention are rectally instilled in a patient.

The present invention provides novel sulfone and sulfoxide substituted heterocyclic urea compounds having useful antibacterial activity. Use of these compounds as pharmaceutical compositions and methods of production are provided.

Plastic films, fibers and articles are provided long-term antimicrobial activity with a combination of certain phenolic and inorganic antimicrobial agents. The plastic films, fibers and articles with antimicrobial activity exhibit superior resistance to discoloration, may be processed at high temperature, and maintain physical properties upon weathering, especially upon exposure to ultraviolet radiation.

The utility model discloses an inorganic composite antimicrobial with zinc - rare earth and a preparation method and applications thereof. The antimicrobial uses natural or chemosynthetic ion exchange material as the carrier, and loads the double active centre of the zinc ions and the rare earth ions by an ion exchange method, wherein, the content of the zinc ions is 6.0 to 8.0wt%, the content of the rare earth ions is 2.0 to 4.0wt%. The antimicrobial exchanges the zinc ions and the rare earth ions into the carrier by means of a liquidoid or a solidoid ion exchange, and then the inorganic composite antimicrobial is prepared after a post treatment. Because having a double antimicrobial active centre of the zinc ions and the rare earth ions which can generate a synergistic effect, the antimicrobial has the advantages of broad antimicrobial spectrum, higher antimicrobial efficiency, good thermal stability and photostability, steady color and low cost; the antimicrobial is an ideal substitute for the silver-loaded inorganic antimicrobial, and can be added in plastic, rubber, fiber, paints, adhesive, paper or ceramic and other material for preparing antimicrobial functional material and products.

The invention provides multifunctional viscose. The multifunctional viscose comprises viscose, graphene and nano-silver, wherein nano-silver is loaded to a graphene slice layer in situ. The invention further provides a preparation method of the multifunctional viscose. The preparation method is characterized by comprising the following steps: (a) dispersing graphene in a water solution, so as to obtain a graphene dispersion liquid; (b) dissolving silver salt into the graphene dispersion liquid, adding a reducing agent, and carrying out reduction reaction, so as to obtain nano-silver-loaded graphene dispersion liquid; and (c) uniformly mixing the nano-silver-loaded graphene dispersion liquid with viscose liquid, and carrying out spinning, so as to obtain the multifunctional viscose. An experimental result shows that compared with viscose which is not added with nano-silver-loaded graphene, the multifunctional viscose has the advantages that the far infrared temperature increase performance is increased by not less than 100%, the ultraviolet protecting coefficient is increased by not less than 70%, and the antibacterial activity reaches 99.9% and is increased by not less than 100%.

An antibacterial antisense conjugate and method of using the same for treating a bacterial infection in a mammalian host are disclosed. The conjugate includes an antisense oligonucleotide conjugated to a carrier peptide that significantly enhances the antibacterial activity of the oligonucleotide. The antisense oligonucleotide contains 10-20 nucleotide bases and has a targeting nucleic acid sequence complementary to a target sequence containing or within 10 bases, in a downstream direction, of the translational start codon of a bacterial mRNA that encodes a bacterial protein essential for bacterial replication, where the compound binds to a target mRNA with a Tm of between 50° to 60° C. The carrier peptide is an arginine-rich peptide containing between 6 and 12 amino acids.

A process for preparing the antibacterial activated carbon fibres containing nano silver particles includes preparing the activated carbon fibres by using phosphoric acid as activator, and dipping for adsorbing the silver particles by said fibres. It can kill all the Escherichia coli and staphylococlus aureus in water. Its advantages are less consumption, and high, fost and durable antibacterial effect.

The present invention relates to a lysin protein originated from bacteriophage, more precisely a lysin protein comprising the amino acid sequence represented by SEQ. ID. NO: 2 which has no harm to human and animals comprising eukaryotic cells owing to its specificity to bacteria and has broad antibacterial activity, and a pharmaceutical composition for the prevention and treatment of infectious disease caused by bacteria comprising the said lysin protein as an active ingredient.

The invention relates to a Bacillus subtilis T-500. The Bacillus subtilis T-500 has been preserved in CGMCC (China General Microbiological Culture Collection), and the preservation number is CGMCC NO:6058. The Bacillus subtilis T-500 can be used as a biological pesticide for preventing and treating multiple plant diseases, and can also be used as a biological fertilizer for promoting the yield increase of crops. The Bacillus subtilis T-500 has higher antibacterial activity on Magnaporthe oryzae, Pellicularia sasakii, Xanthomonas oryzae, Ustilaginoidea virens, Xanthomonas oryzae pv. oryzicola, Fusarium graminearum, Aspergillus flavus, Aspergillus niger and other pathogenic bacteria, and has better prevention and control effects on diseases caused by the pathogenic bacteria. The Bacillus subtilis T-500 can prevent and treat rice leaf diseases when being diluted 200-500 times on the leaves of rice, can prevent and treat bakanae diseases of rice after seed soaking, and can prevent and treat soil-borne diseases of vegetables and the like after root irrigation.

The invention discloses a preparation method of water-soluble chitosan / polyvinyl alcohol composite films capable of being used as biological package materials. Water-soluble chitosan and polyvinyl alcohol are respectively dissolved in deionized water, the solution is subjected to mixing casting for forming films, then, the films are soaked into one kind of solution or several kinds of mixed solution from glutaraldehyde solution, borax solution, epichlorohydrin, glyoxal and sodium tripolyphosphate to be subjected to crosslinking for 40 to 60 minutes, peeling and natural drying or baking are carried out, and the water-soluble chitosan / polyvinyl alcohol composite films are obtained. The composite films have good antibacterial activity, biocompatibility and biodegradability, in addition, special gas blocking performance and excellent mechanical performance are realized, and the composite films have the advantages of chitosan and the polyvinyl alcohol. In addition, the production cost is low, the preparation process is simple, the production efficiency is high, and the environment is friendly.

A method of treating shingles in a human in need thereof. The method comprises administering a tetracycline compound in an amount that is effective to treat shingles, but has substantially no antibacterial activity.

An antimicrobial composition and more particularly a germicidal spray for sanitizing and disinfecting surfaces including leather, wood, metal, plastic and fabric, comprises a mixture of essential oils capable of being dissolved or dispersed by a solvent in a water carrier, oils and an ionizing agent such as Blue Stone ions which speeds up the antimicrobial activity of the essential oils. The product of the invention is completely natural and non-toxic to adults and children even if swallowed.

The present invention relates to antifungal and antibacterial activity of processed Morinda citrifolia products, as well as from various fractions of extracts from these processed products and the Morinda citrifolia L. plant, and related methods to determine mean inhibitory concentrations. In particular, the present invention relates to ethanol, methanol and ethyl acetate extracts from Morinda citrifolia L. and their inhibitory activities on common fungi and bacteria and the identification of mean inhibitory concentrations.

The present invention provides novel amide and sulfonamide substituted heterocyclic urea compounds having useful antibacterial activity. Use of these compounds as pharmaceutical compositions and method of their production are also provided.

The invention discloses a preparation method and applications of wild jujube endophytic bacillus amyloliquefaciens new strain SZ23 and fermentation broth. The bacillus amyloliquefaciens new strain SZ23 is preserved at China General Microbiological Culture Collection Center on July, 25th, 2014, and preservation number is CGMCC No.9481. Morphological characteristics, physiological and biochemical indexes, and 16S rDNA sequencing results of bacillus amyloliquefaciens new strain SZ23 are detailedly disclosed by the invention. It is shown by bacteriostasis experiments that, the fermentation broth of bacillus amyloliquefaciens new strain SZ23 possesses excellent bacteriostatic activity on alternaria kikuchiana, fusarium oxyspirum F sp niveum, fusarium oxysporum Schl.f.sp vasinfectum(Atk.)Snyd.& Hans, alternaria solani, fusarium wilt of cucumber, cotton rhizoctonia solani kuhn, fusarium graminearum schw, and botrytis cirerea Pers et Tris; bacteriostasis rate ranges from 55.6% to 92.2%; and it is confirmed that wild jujube endophytic bacillus amyloliquefaciens new strain SZ23 possesses excellent broad-spectrum antibacterial activity. It is confirmed by practical experiments that control rate of the fermentation broth of new strain SZ23 on alternaria kikuchiana is more than 75%.

The present invention provides peppermint composite cellulose fibers, which contain 1-12 wt% of a peppermint extract component and 0.5-3 wt% of peppermint odor essential oil slow-release microcapsules, wherein the dry breaking strength of the fibers is 1.0-3.0 cN / dtex, the wet breaking strength of the fibers is 0.8-1.6 cN / dtex, the dry elongation at break is 16-24%, the residual sulfur content is less than or equal to 18 mg / 100 g, the antibacterial activity logarithm value is more than 2.0, and the bactericidal activity logarithm value is more than 0. The peppermint composite cellulose fiber preparation method comprises: peppermint extract adding liquid preparation, degenerated viscose glue preparing, peppermint blending viscose glue preparing, spinning and post-treating, and filament drafting and post-treating so as to obtain the peppermint composite cellulose fibers. The peppermint composite cellulose fibers of the present invention have characteristics of good wearability, textile processability, antibacterial function, bacterial inhibition function, lasting and fresh peppermint aroma, lasting odor, good textile processing performance, and significant antibacterial function.

The present invention relates to an antimicrobial composition comprising an isothiazolinone, such as 1,2-benzisothiazolin-3-one, and a zinc compound selected from zinc salts, zinc oxides, zinc hydroxides or combinations thereof. Useful zinc salts include for example, oxides, sulfates, chlorides, and combinations thereof. In use, the zinc from the zinc compound enhances the antimicrobial activity to the isothiazolin-containing composition. This enhancement permits achieving the desired antimicrobial activity at a lower usage rate than is achieved using the isothiazolinone in the absence of the zinc compound. The antimicrobial composition can also contain co-biocides, such as pyrithiones, including zinc pyrithione or copper pyrithione.