31results about How to "Convenient IV" patented technology

The invention provides a paramagnetic metal complex functionalized fluorogold nano-cluster magnetic resonance and fluorescence imaging contrast agent. The invention relates to the field of magnetic resonance imaging and fluorescence imaging contrast agents. With the contrast agent provided by the invention, problems of existing contrast agents of low relaxation efficiency, high toxicity, low tissue organ selectivity and fast in-vivo metabolism can be solved. According to the invention, ethylenediaminetetraacetic acid (EDTA) or diethylene triaminepentaacetic acid (DTPA) are connected to folic-acid-modified bovine serum albumin fluorogold nano-clusters through amide bonds; and EDTA or DTPA is respectively coordinated with paramagnetic metal ions, such that the complex is obtained. With the contrast agent provided by the invention, the relaxation efficiency can reach 23.7mM<-1>*s<-1>. The contrast agent has an advantage of low toxicity. According to the invention, high spatial resolution of magnetic resonance imaging and high sensitivity of fluorescence imaging are combined. Therefore, the contrast agent provided by the invention can be used in magnetic resonance imaging and fluorescence imaging.

The invention discloses an experimental visual rat tail vein fixator comprising a base, wherein the base is provided with a fixed block and a regulating rod; one end of the regulating rod is movably connected with the fixed block or base, and the other end of the regulating rod is provided with a tail supporting frame; the distance between the tail supporting frame and the fixed block can be regulated through regulating the regulating rod; the top of the tail supporting frame is provided with a chute; a horizontally-irradiating yellow fluorescent lamp is embedded in the side wall of the chute; the fixed block is provided with a first fixed groove; the fixed block is provided with a pressing block which can be opened or closed relative to the fixed block so as to press or release a rat tail. The experimental visual rat tail vein fixator also has the advantages of simple and compact structure, low manufacturing cost as well as simplicity and convenience in use.

The invention provides a paramagnetic metal complex and a synthetic method and application thereof. The paramagnetic metal complex is an arabinogalactan-modified 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacethyl paramagnetic metal complex. A magnetic resonance imaging contrast agent prepared from the paramagnetic metal complex has high stability, water solubility and relaxation rate and is targeted to liver and kidney, so that targeted imaging is realized, and the imaging contrast and definition are improved. The paramagnetic metal complex has a good effect on raising the early diagnosis levels of diseases of liver and kidney organs, is about 2 times the relaxation rate of dotarem, has very long targeted radiography imaging time, can be easily prepared into a solution with required concentration for intravenous injection, is suitable for sterilizing and disinfecting with a hot pressing method, can be selectively identified by an asialoglycoprotein receptor on a liver parenchyma surface, and has high selectivity on livers of human beings or other mammals.

The invention discloses a portable anesthesia device for an anesthesia department, and relates to the technical field of anesthesia devices. The portable anesthesia device comprises an outer frame, ahorizontal plate is fixedly connected on the right side of the outer frame, an infusion device is fixedly connected at the top of the horizontal plate, a side plate is fixedly connected on the left side of the outer frame, an oxygen infusion device is fixedly connected at the top of the side plate, and a working table is fixedly connected at the top of the outer frame. According to the portable anesthesia device, anesthesia drugs are conveniently and intravenously injected into a patient, the patient is narcotized, the height of an injection frame can be adjusted according to requirements, theportable anesthesia device is simple to operate and convenient to use, so that the patient more smoothly breathes, the stability of a body function of the patient is ensured, vibration applied to thedevice is reduced, the stability of the device is improved, accidents are prevented, a narcotizing process is conveniently controlled by medical staff, body information of the patient is convenientlyobserved by the medical staff, and unforeseen circumstances are prevented.

The invention provides a diamino polyethylene glycol modified paramagnetic metal complex magnetic resonance imaging contrast agent, and aims at solving the problems of low relaxation rate, high toxicity and large dosage of a contrast agent in the prior art. The contrast agent is prepared by the following steps: reacting 1,4,7,10-tetrazacyclododecane-1,4,7,10-tetraacetic acid compound with diaminopolyethylene glycol with different molecular weights; preparing a macromolecular ligand through an amidation reaction; and forming a paramagnetic metal complex with paramagnetic metal elements Sc, Ti, V, Mn, Cu, Mo, Ru, Fe or positive trivalent or divalent ion of lanthanide rare-earth elements. The contrast agent has the advantages of high stability, water solubility, relaxation rate and small dosage.

A contrast medium for the magnetic resonance (or X-ray CT) imaging of liver with high selectivity and low poison is prepared from the acid byanhydride of EDTA and DTPA and russianolive gum through reaction and then matching with the 2- or 3- valence ions of paramagnetic metal (Mn or Fe) or La- system RE element to obtain a russianolive gum modified paramagnetic metal match.

An injection of water-soluble 17-allylamino-17-demethoxy geldanamycin (17-AAG) for treating multiple kinds of cancers is prepared from 17-AAG and polyethanediol for increasing the solubility of 17-AAG in water.

The invention discloses an aspartate-leucine copolymer modified paramagnetism metal complex as well as a preparation method and application thereof, belongs to the technical field of contrast agents, and solves the technical problems in the prior art that a magnetic resonance contrast agent is lower in targeting and high in dosage so as to further improve the relaxation efficiency, imaging contrast ratio, definition and sensitivity of the contrast agent. The structural formula of the metal complex is shown in the formula I (refer to the description), wherein z is an integer ranging from 1 to 1000, x is an integer ranging from 1 to 1000, y is an integer ranging from 1 to 1000, and M<m+> refers to paramagnetism metal ions. The metal complex can be used as a magnetic resonance imaging contrast agent which has excellent stability, water-solubility and relaxation efficiency, also has excellent targeting to a liver, and is higher in imaging contrast ratio and definition; the dosage lower limit of the metal complex is only 0.001 mmol / kg.

The invention relates to a heating and pressurizing infusion set, and relating to an infusion set. The invention aims to solve the problem that in the process of intravenous guttae, a medicine bottle can not be hung without an infusion support, and the problem that during the intravenous injection, the temperature of the liquid medicine is the storage temperature which is always lower than the temperature of human body in frigid climate, thus during the liquid medicine is injected, negative effect on the patient is always generated because of the undercooling liquid medicine, and the problem that during the transfusion, the patients need to sit and lie down, which influences the movement. The outer wall of the packet body of the invention is provided with a heating metal wire interface connected with heating metal wire; one end of wire is connected with a circuit board; the other end of the wire is connected with an air pump; the outlet of the air pump is connected with the inlet of an air bag; the outlet of the air bag is connected with the interface for inserting the medicine bottle; the air bag, the interface for inserting medicine bottle and the air pump are all arranged in the bottom of the packet; and the bottom of the packet is provided with the outlet of an infusion tube. The invention can achieve zero error output, can be repeatedly used, saves resources, and can transfuse at hospital, at home or in the way.

The invention discloses a mouse tail vein injection fixing tube, which comprises a base, a bracket, a fixing platform and a fixing tube body, the top of the base is fixedly connected with the bottom of the bracket by bolts, and the top of the bracket is provided with a The fixed table top, the fixed pipe body is placed on one side of the top of the fixed table, wherein, one side of the fixed pipe body is provided with a pipe cover, and the pipe cover is set in a threaded structure together with the fixed pipe body The side is fixedly connected, the middle part of the tube cover is provided with through hole 1, and the bottom of the fixed tube body is provided with several through holes 2, and the fixed tube body is fixedly connected with one side of the fixed table through several adhesive tapes , several fixing columns are arranged on the other side of the top of the fixing platform and on the side away from the fixing tube body. Beneficial effects: the work efficiency is improved, the operation is convenient, and the reservation and adjustment of the fixed position of the mouse tail are greatly facilitated.

The invention relates to a magnetic resonance image contrast agent which uses arabinogalactan as carrier, wherein its production comprises that: using ethylenediamine tetra acetic acid, diethylene triamine pentacetic acid N-butanimide active ester, ethylenediamine tetra acetic acid, or the anhydrides of diethylene triamine pentacetic, via one short connecting arm to react with amination arabinogalactan; forming amido bond to connect ethylenediamine tetra acetic acid or diethylene triamine pentacetic acid to the arabinogalactan, to match magnetic metal ion as manganese, iron or lanthanide rare-earth element, to obtain complex. The invention has significant liver selectivity and low cute toxin. And the inventive contrast agent can be used in magnetic resonance diagnosis, X-ray CT or Y-flashimaging diagnosis.

The invention discloses a pneumatic device for intravenous infusion, relates to a pneumatic device and aims to solve the problems that the conventional intravenous infusion needs an infusion bottle bracket for hanging an infusion bottle, which is inconvenient for a patient who needs to move. A spring and a plug are arranged inside a spring seat; an opening baffle sheet is fixed at the outermost end of the spring seat; and a sealing gasket is fixed on the inner side of the opening baffle sheet and is matched with the plug. A cylinder is fixed on a base; an overhead valve is fixed on the base inside the cylinder; a plastic gasket base is fixed on an outer wall of the overhead valve; a plastic gasket is arranged on the plastic gasket base; one end of an air outlet adapter is communicated with the overhead valve; internal threads are formed on an inner wall of the cylinder; and the internal threads of the cylinder are matched with external threads of a tank body. The pneumatic device has the inflation pressure of 0.6 to 1 MPa and the inflation capacity of 500 to 600 cubic centimeters, can be used for 2,000ml of liquid medicine for intravenous infusion, and has the advantages of convenient carrying, high safety, easy disinfection and convenient replacement.

The invention discloses an operation table for tail vein injection of mice in batches, which includes a work table and 3-8 operation units, and the operation unit includes a rotating shaft one, a rotating arm one, a rotating shaft two, a rotating arm two, and a rotating shaft 3. The mouse fixing device and heating switch, the first rotating arm can rotate 360 ​​degrees along the horizontal plane and 180 degrees along the vertical plane, the second rotating arm can rotate 180 degrees along the vertical plane, the mouse fixing device can rotate 180 degrees along the vertical plane, The mouse fixing device is provided with a heating device and a heat-conducting material, and also includes a control circuit, and the control circuit controls the opening or closing of the heating device through a heating switch. The mouse fixing device includes a base plate and a mouse cage. By setting a long groove on the base plate and covering the mouse body in the mouse cage, the tail of the mouse is exposed, and a pressing plate and a fixing belt are set to completely secure the tail of the mouse. fix it up. The console has a simple structure and is easy to operate, and the mice are immobilized and injected in batches to form an assembly line operation and improve efficiency.

The invention relates to a palonosetron hydrochloride injection and a preparation method thereof. The palonosetron hydrochloride injection is characterized by comprising palonosetron and an osmotic pressure regulator. The preparation is simple in formulation and process, and the quality is stable and easy to control; moreover, the preparation can be applied to direct intravenous drip administration; clinical application is convenient, administration compliance is high, and the safety is high.

The invention relates to a paramagnetic metal complex modified by an aspartic acid-leucine copolymer as well as a preparation method and an application of the paramagnetic metal complex, and is used for solving the technical problems of low biodegradability, low liver targeting property, immunity defects and the like of the existing liver-type macromolecular contrast agent. The paramagnetic metal complex is formed by taking the aspartic acid-leucine copolymer as a carrier, wherein annular 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid ligands are connected on side chains of the carrier. A magnetic resonance imaging contrast agent prepared from the paramagnetic metal complex provided by the invention has the characteristics of a corresponding polyamine multi-carboxy complex, so that the magnetic resonance imaging contrast agent is good in stability, water solubility and relaxation rate, and simultaneously has the targeting property to the liver so as to realize the targeted imaging to improve the imaging contrast ratio and the imaging definition. Thus, the magnetic resonance imaging contrast agent has a good effect for improving the early-stage diagnosis level of diseases of the liver organs.

The invention provides a paramagnetism metal complex magnetic resonance imaging contrast agent containing asparaginic acid-glucan and a preparation method of the contrast agent, to solve the problem that in the prior art the contrast agent is low in relaxation rate. According to the contrast agent, the glucan is used as a carrier; asparaginic acid is connected with 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA), and is further subjected to coordination with the paramagnetism metal ions in a mole ratio of 1:1 so as to obtain the complex. According to the preparation method of the paramagnetism metal complex magnetic resonance imaging contrast agent containing the asparaginic acid-glucan, the contrast agent with relatively higher relaxation efficiency is obtained by controlling the dosage ratio of reaction raw materials, the pH value of solution, the reaction temperature and the reaction time. The contrast agent can be used for magnetic resonance imaging; after the contrast agent imaging is accomplished, the asparaginic acid carried in the contrast agent has protection function on hearts, and therefore the contrast agent is an imaging contrast agent with double functions.

The invention provides a practical patient garment. The practical patient garment with two sleeves is mandarin, zippers with double sliders are arranged on the two sleeves and at the 2 / 3 cutting and sewing positions on front pieces of the patient garment, and a pull ring is arranged at each of sleeve ends and front piece ends when each zipper is zipped up. Another two zippers with double sliders are arranged on the outer sides of two sleeve elbows, and two pull rings are arranged at two ends of each zipper respectively when each zipper is zipped up. The practical patient garment is simple to manufacture as the zippers with the double sliders are arranged on the two sleeves and at the 2 / 3 cutting and sewing positions on the front pieces of the patient garment without adding processing processes. Besides, the practical patient garment can bring convenience to patients and is convenient for nurses to perform intravenous injection for the patients.

The invention provides a paramagnetic metal complex using an aspartic acid-isoleucine copolymer as a carrier, a preparation method of the paramagnetic metal complex and a magnetic resonance imaging contrast agent, and belongs to the field of the magnetic resonance imaging contrast agent, in order to solve the technical problems of a contrast agent in the prior art which is relatively low in liver identification, short in imaging time and not high in relaxivity. The complex takes the aspartic acid-isoleucine copolymer as a carrier and is connected with a ring-shaped 1,4,7,10-tetraazacycl ododecane-1,4,7,10-tetraacetic acid ligand on a side chain of the carrier, and the structure of the complex is as shown in formula (I). The invention also provides a preparation method of the paramagnetic metal complex using the aspartic acid-isoleucine copolymer as a carrier. The invention also provides a magnetic resonance imaging contrast agent which is prepared from the paramagnetic metal complex using the aspartic acid-isoleucine copolymer as a carrier. The contrast agent disclosed by the invention has good selectivity for livers of human bodies or other mammals.

A three-dimensional positioning fixing frame for a hillock hemorrhage biological experiment effectively solves the problem that a mouse absorbs medicine slowly after the mouse is injected with the medicine and comprises a box body, a bottom plate is fixedly connected to the interior of the box body, a rotating shell is arranged on the upper side of the bottom plate, an operation plate is arranged in the rotating shell, and a power rod is arranged on the upper side of the bottom plate. A rotating frame is arranged on the lower side of the power rod, a driving plate is arranged on the left side of the rotating frame, a first runway cavity is formed in the left side of a rotating shell, a second runway cavity is formed in the right side of the rotating shell, a cover plate is arranged on the upper side of the rotating shell, first fixing plates are fixedly connected to the front side and the rear side of the rotating shell, and second fixing plates are arranged on the front side and the rear side of the rotating shell. By means of the design, the function of driving an experimental mouse to move so as to accelerate blood circulation is effectively added, the purposes of fixing the mouse and conducting intravenous injection on the tail are achieved, and the problem that an experimental site is not easy to clean after an experiment is conducted is solved.

The invention provides a Ce6 derivative, its nano-preparation, its preparation method and application. The Ce6 derivative, which is named TCe6, has a structural formula as shown in the following formula. In the present invention, TCe6 and CHC are co-assembled to construct TCe6 / CHC NPs, which solves the problems of insufficient oxygen and low efficiency in PDT, and realizes efficient photodynamic therapy. .

The invention provides a paramagnetism metal complex magnetic resonance imaging contrast agent containing asparaginic acid-glucan and a preparation method of the contrast agent, to solve the problem that in the prior art the contrast agent is low in relaxation rate. According to the contrast agent, the glucan is used as a carrier; asparaginic acid is connected with 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA), and is further subjected to coordination with the paramagnetism metal ions in a mole ratio of 1:1 so as to obtain the complex. According to the preparation method of the paramagnetism metal complex magnetic resonance imaging contrast agent containing the asparaginic acid-glucan, the contrast agent with relatively higher relaxation efficiency is obtained by controlling the dosage ratio of reaction raw materials, the pH value of solution, the reaction temperature and the reaction time. The contrast agent can be used for magnetic resonance imaging; after the contrast agent imaging is accomplished, the asparaginic acid carried in the contrast agent has protection function on hearts, and therefore the contrast agent is an imaging contrast agent with double functions.

A contrast medium for the magnetic resonance (or X-ray CT) imaging of liver with high selectivity and low poison is prepared from the acid byanhydride of EDTA and DTPA and russianolive gum through reaction and then matching with the 2- or 3- valence ions of paramagnetic metal (Mn or Fe) or La- system RE element to obtain a russianolive gum modified paramagnetic metal match.

The invention provides a paramagnetic metal complex and a synthetic method and application thereof. The paramagnetic metal complex is an arabinogalactan-modified 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacethyl paramagnetic metal complex. A magnetic resonance imaging contrast agent prepared from the paramagnetic metal complex has high stability, water solubility and relaxation rate and is targeted to liver and kidney, so that targeted imaging is realized, and the imaging contrast and definition are improved. The paramagnetic metal complex has a good effect on raising the early diagnosis levels of diseases of liver and kidney organs, is about 2 times the relaxation rate of dotarem, has very long targeted radiography imaging time, can be easily prepared into a solution with required concentration for intravenous injection, is suitable for sterilizing and disinfecting with a hot pressing method, can be selectively identified by an asialoglycoprotein receptor on a liver parenchyma surface, and has high selectivity on livers of human beings or other mammals.