181results about How to "Good antifungal activity" patented technology

An anti-fungal composition, including: (a) an extract of botanical materials, the botanical materials including material from Echinacea species, and Propolis, which is a material derived from the hives of bees; and (b) an essential oil. The compositions of the present invention have been shown to have unexpectedly prolonged anti-fungal activity, as well as having anti-bacterial and anti-inflammatory activities. Preferably, the essential oil includes at least one oil selected from the group consisting of tea-tree oil, thyme oil and lavander oil. Also preferably, the herbal extract includes a mixture of Calendula, poke root, Echinacea and Propolis extract.

The invention discloses a water soluble triazole compound and a synthesis method thereof. The water soluble triazole compound has a structure as shown in Formula Ia, Formula Ib, Formula Ic or Formula Id, wherein R1 is a group in Formula II. The compound of the invention is formed by adding a new group on the structural basis of a broad-spectrum, high-efficiency antifungal compound discovered in the present clinical application and new drug development process to increase the water solubility and reduce the toxicity, is a derivate of the triazole antifungal drug, and has the characteristics of broad antifungal spectrum, high antifungal activity, good safety and the like.

Antimycotic compositions comprising a rhamnolipid component and related methods of use.

The present subject matter relates to a preservative or antimicrobial compositions which comprise low concentrations of botanical extracts, in synergistic combinations with alkanediols in a solvent system, optionally with fruit acids. Additionally, the present subject matter relates to a preservative or antimicrobial compositions which comprise a silver compound, an essential oil or individual constituent, one or more zinc salts, and one or more alkanediol. The compositions of the application may be used in personal care products including wound care products or in veterinary use. Preferably, the compositions of the application have little or no human-detectable fragrance.

The present invention provides a low-cost, efficient method for producing a glycolipid biosurfactant, in particular, lactonic sophorose lipids. This method is characterized by culturing a microorganism capable of producing the biosurfactant under limited oxygen supply. The present invention enables preferential production of lactonic sophorose lipids and facilitates recovery of the lactonic sophorose lipids in a solid form. Further, the present invention enables production of high purity acidic sophorose lipids by hydrolyzing high purity lactonic sophorose lipids produced by the above method. The present invention also provides lactonic sophorose lipids that possess strong antibacterial and antifungal activities, and an antibacterial and / or antifungal agent containing the sophorose lipids.

An antifungal fragrance composition containing as its active ingredients: (a) at least one type of fragrance component selected from the group consisting of an aliphatic or aromatic aldehyde having 5 to 16 carbon atoms and an aliphatic or aromatic alcohol having 5 to 16 carbon atoms, and (b) at least one type of compound different from component (a) and selected from the group consisting of an aliphatic or aromatic aldehyde, an aliphatic or aromatic alcohol, acetal and ester that produces synergistic antifungal effects in the presence of said fragrance component (a). The present antifungal fragrance composition demonstrates antifungal activity by adding a small amount of oils and fragrant chemical products that have a minimal effect on the scent of the fragrance composition.

The present invention provides an agglutinant protein obtained by separating plant astragalus root and purifying its extract and its preparation method. In the concrete, said invention uses the astragalus root as raw material, and utilizes ammonium sulfate with different saturations to make fractional precipitation and multistep ion exchange column chromatography so as to obtain astragalus agglutinant protein which can be used for blood agglutination and has the obvious antifungal action.

The present invention provides a novel dominant selectable marker system in yeast that is based on an aminoglycoside, nourseothricin (NST). This compound possesses a powerful antifungal activity against Candida albicans and S. cerevisiae. The invention provides a cognate drug resistance marker for use in gene transformation and disruption experimentation in Candida albicans and Saccharomyces cerevisiae. In particular, the invention presents: 1) direct utility for gene manipulations in both clinically and experimentally relevant strains regardless of genotype and without affecting growth rate, or hyphal formation; and 2) applicability to antifungal drug discovery, including target validation and various forms of drug screening assays.

Self-preserved, multi-dose ophthalmic compositions containing tobramycin are described. The compositions do not contain a conventional antimicrobial preservative, such as benzalkonium chloride. Rather, the compositions are self-preserved as a result of the inherent antimicrobial activity of tobramycin. The compositions preferably also contain either boric acid or, more preferably, a borate / polyol complex selected from the group consisting of borate / propylene glycol, borate / glycerol, and combinations thereof.

Disclosed is a pharmaceutical composition containing a pharmaceutically effective amount of 4-hydroxy-5-methoxy-4-[2-methyl-3-(methyl-2-butenyl)-2-oxiranyl]-1-oxaspiro[2,5]octan-6-one, which is capable of preventing or treating seborrhea caused by a fungus, Pityrosporum ovale.

The invention provides extracts and preparations based on the species Tulbaghia violacea (Harv.) (wild garlic), which elicits a significant antimicrobial, preferably antifungal activity in vitro and in vivo, even under field and glasshouse conditions. Moreover, these extracts deriving from the soil parts as well as of the aerial parts of the plant elicit a significant bio-stimulatory activity, expressed, above all, by an increased growth metabolism supporting seed growth. Furthermore, combined extracts or preparations from Tulbaghia violacea and species of the genus Agapanthus show a higher antifungal and bio-stimulatory efficacy as compared to the extracts or preparations of the single species, indicating that synergism is participated in the involved biological processes.

The invention provides a glycopeptide antifungal compound and a pharmaceutically acceptable salt thereof, a preparation method and application thereof, and a pharmaceutical composition containing the active component. The glycopeptide antifungal compound has a general structural formula shown as below; n equals to 1, 2 or 3; and R represents monosaccharide or disaccharide, wherein the monosaccharide is glucose, galactose, xylose, rhamnose, mannose, ribose, glucosamine or acetyl glucosamine, and the disaccharide is maltose or lactose. Compared with existing clinical antifungal drugs, the compound provided by the invention has advantages of high efficiency, low toxicity and broad antibacterial spectrum, etc.; therefore, the compound can be applied to preparation of antifungal drugs. The preparation method provided by the invention successfully introduce different glycosyls onto primary amino group of Caspofungin, and has advantages of simple process and high yield.

Disclosed is a formulation and method for the treatment of fungal infections of the nail (onychomycosis) utilizing a topical composition comprising zinc pyrithione, a solubilizer for the zinc pyrithione, a film former, and a volatile solvent. The formulation is preferably in the form of a lacquer. The composition containing the metal pyrithione complex is topically applied to the infected nail preferably as a nail polish or lacquer which may be applied with a dropper, swab or the like to the afflicted nail surface. The treatment can be done at least two times a day, with a course of treatment lasting from several weeks to several months or until a cure is effected or a significant reduction of the infection is achieved.

A pharmaceutical composition containing one or more antifungal agents selected from an arylamidine derivative represented by the general formula:(wherein R1 represents an amidino group that may be substituted with a hydroxyl group that may be protected with an acyl group, an amidino group that may be substituted with an alkoxy group that may be substituted, or an amidino group that may be substituted with an aralkyloxy group that may be substituted; R2 and R3 identically or differently represent a hydrogen atom or a halogen atom) or a salt thereof, an azole antifungal agent, a polyene antifungal agent, a candin antifungal agent and a fluoropyrimidine antifungal agent has a strong antifungal activity and is useful for the treatment of fungal infection. A method for using them in combination is useful as an excellent therapeutic method for fungal infection. A pharmaceutical composition containing the arylamidine derivative represented by the above general formula or a salt thereof and an immunosuppressant has a strong antifungal activity and is useful for the treatment of fungal infection and a skin disease such as atopic dermatitis. A method for using them in combination is useful as an excellent therapeutic method for fungal infection and a skin disease such as atopic dermatitis.

The invention relates to the technical field of medicine, and provides substituted tricyclo-quinone compounds and pharmaceutically acceptable salts thereof. The structural general formula of the substituted aromatic tetracyclic compounds is disclosed in the specification. The invention also provides a preparation method of the compounds and application of the compounds in preparation of antifungal drugs.

The invention discloses a high-efficiency and low-toxicity pimaricin derivative, of which the molecular formula is C33H49NO11, and the chemical structural formula is as shown in the specification. The high-efficiency and low-toxicity pimaricin derivative is obtained from a genetically engineered strain streptomyces chattanoogensis QZ01 zymophyte body as a raw material by bacterial treatment, organic reagent extraction, reverse phase chromatographic column chromatography and high-performance liquid chromatography. The compound disclosed by the invention is stable in structure, good in activity and low in toxicity, can be used as an antifungal drug and a food preservative, and has a good clinical application prospect and economic value.

The invention relates to the technical field of medicines and particularly relates to pseudolarix acid derivatives with the structure shown in a formula (1) (the detailed definitions of all groups are shown in the specification). The compounds have favorable activity for various tumor cells such as human lung cancer, colon cancer, breast cancer and the like; besides, the compounds show better antifungal activity. The invention also discloses a composition and preparation method of the pseudolarix acid derivatives as well as the application of the seudolarix acid derivatives in preparation of antitumor medicaments, antifungal medicaments or anti-angiogenesis medicaments.

Disclosed herein is a novel antifungal compound, derivatives that are used to treat fungal infections. In a specific embodiment, the compound is a small molecule. In a specific embodiment, the compound described herein inhibits yeast to hypha transition under robust hyphal inducing conditions at lower concentration of the molecule. Also disclosed is a composition comprising the antifungal compound. In a specific embodiment, the composition is a pharmaceutical composition. Also disclosed is a method of treating and / or preventing fungal infection using the disclosed compound. The disclosed compound exhibits antifungal activity against wide range of fungal species at slightly higher concentrations. Antifungal compound disclosed herein is used as anti-biofilm agent against fungal infections.

The present invention relates to polyene macrolide derivatives according to the formula:wherein M is a macrocyclic lactone ring; N is a polyene sugar, substituted or unsubstituted; X is independently selected from O, S, N or NH; R is independently selected from an alkyl, cycloalkyl, heterocycloalkyl aryl, heteroaryl, arylalkyl, and heteroaryalkyl group; and i is an integer from 1 to 3, with the condition that it has a negative charge or the zwitterions character is restored; or a pharmaceutically acceptable salt thereof useful as antibiotics.

The invention relates to the technical field of pharmaceuticals, and provides a substituted aryl tetracyclic antifungal compound and pharmaceutically acceptable salts. The substituted aryl tetracyclic antifungal compound is as shown in a structural formula of the description. The invention further provides a preparation method of the compound and an application of the compound in preparing antifungal medicaments.

The invention discloses a tricyclic isoxazole derivative, belongs to the technical field of medicines, and provides a compound with a general formula (1) as shown in the specification, a geometrical isomer of the compound or pharmaceutically acceptable salt, hydrates, solvates and prodrugs of the compound and preparation methods of the salt, the hydrates, the solvates and the prodrugs. The compound has good antifungal activity for various superficial and deep fungi and the advantages of high efficiency, low toxicity, wide antifungal spectrum and the like as compared with existing clinically-applied antifungal drugs, and the compound can be used for preparing antifungal drugs.

The invention relates to a natural antibacterial polyphenol compound, a preparation method thereof and application of the natural antibacterial polyphenol compound to electronic cigarettes, and belongs to the technical field of phytochemistry. The structural formula of the compound is shown as a formula (I), wherein the formula (I) is shown in the description. The compound is separated from barks of periploca sepium Bunge for the first time and determined to be the polyphenol compound through a nuclear magnetic resonance and mass spectrometry method, and the specific structure of the compound is characterized. The compound shows good inhibitory activity against bacteria such as phytophthora parasitica, fusarium asiaticum and alternaria alternata and good antifungal activity and has good application prospects. Meanwhile, the compound is used in electronic cigarette liquid, can have a good antibacterial effect, prolong the shelf life of the electronic cigarette liquid and reduce the excessive sweetness in the smoking process and is easy to apply and popularize.

The invention belongs to the technical field of medicaments and provides a substituted benzothiazole compound and a pharmaceutically acceptable salt thereof. The structural formula of the substituted benzothiazole compound is as shown in formula I, wherein in formula I, R is a substituted naphthalene ring or a substituted aromatic heterocycle. The invention also provides the applications of the substituted benzothiazole compound and the pharmaceutically acceptable salt thereof to the preparation of medicaments for resisting fungi, tumors, viruses, high blood pressure and thrombus and topoisomerase inhibitors.

The invention discloses a beta-tetrahydro-carboline antifungal compound and a pharmaceutically acceptable salt thereof. The structure of the compound is shown as the general formula I, wherein n is 1to 3; R1 is hydrogen or monosubstituted acetylene or polysubstituted acetylene in any optional position on the benzene ring, X is O or NH, R2 is substituted or unsubstituted aliphatic or aromatic ring; or X is NR3, R2 and R3 are individually lower alkyl and substituted or unsubstituted aliphatic or aromatic ring; or X is N, R2 and X composes substituted or unsubstituted heterocycloalkyl. The invention also discloses a preparation method of the compound and the application of the compound in preparation of antifungal drugs. The compound has the characteristic of well antifungal activity, the result of partial compound is better than that of the control drug fluconazole, and the compound can be utilized to prepare antifungal drugs. The experiment result also show that the combined usage of the partial compound and fluconazole has good synergistic effect to clinically isolated fluconazole-resistant candida albicans.

The present invention relates to a novel triazole alcohol compound. The triazole alcohol compound has a following chemical structural formula as shown in a chemical structure in the specification, wherein X is CH=CH or O; R is selected from alkyl, halogen, alkoxy or nitryl. The invention has the advantages that: the compound has good antifungal activity for various superficial and deep fungi, has the advantages of high efficiency, low toxicity and wide antifungal spectrum compared with conventional clinical applied antifungal drugs, and can be used in the preparation of antifungal drugs. The compound is simple in the preparation method, high in yield, and good in antifungal effect, and a novel compound is provided for the preparation of antifungal drugs.

The invention discloses a bacillus BH072 (Bacillus sp.BH072) and a method for preparing antibacterial peptide iturin A through culturing the strain bacillus BH072 (Bacillus sp.BH072). According to the invention, iturin A is generated by adopting a fermentation method, 6%-7% inoculum size of bacillus BH072 (Bacillus sp.BH072) is taken from a seed culture medium to be inoculated to a fermentation culture medium to culture for 60 hours at the culture temperature of 29-30 DEG C at the pH of 6.4-6.5 at the rotation speed of 150rpm, and purification and extraction are carried out. The bacillus BH072 (Bacillus sp.BH072) disclosed by the invention has an obvious bactericidal effect on phytopathogens such as Aspergillus niger, Fusarium oxysporum, Botrytis cinerea and pythium, has broad-spectrum antibacterial property; through the optimization of fermentation conditions, the utilization rate of the strain is improved, a reference is provided for other similar tests; the iturin A separated from fermentation liquor by adopting an effective separation method has strong antifungal activity; after identification and yield optimization, the yield of the iturin A is 52.21mg / ml and is higher than that of reported strain iturin A; and the iturin A is suitable for large-scale industrial production after development.

The invention relates to the technical field of the marine chemical industry engineering, and concretely relates to a chitosan quaternary ammonium salt containing triazole, and a preparation method and an application thereof. The chitosan quaternary ammonium salt containing triazole is represented by formula (1); and in the general formula, the average value of n is 20-3000, and R is aliphatic hydrocarbon or aromatic hydrocarbon. The above substance obtained in the invention has good fungus inhibition activity, and can be widely used in the biological field, the medicinal field, the food field, the chemical industry field and the like.

The invention discloses a low-toxicity pimaricin derivate. A molecular formula of the low-toxicity pimaricin derivative is C33H49NO10 and the chemical structural formula is shown in the specification. The low-toxicity pimaricin derivative is obtained by performing production strain (Streptomyces chattanoogensis QZ02) construction, fermentation and culture of mutant strain QZ02, thallus treatment, organic reagent extraction, reversed phase column chromatography and high performance liquid chromatography separation. The compound has the advantages of stable structure, high activity and extremely low toxicity, and can be used as an antifungal drug and a food antiseptic; therefore, the low-toxicity pimaricin derivative has good application prospect.