664results about How to "Increase irritation" patented technology

Short deoxyribonucleic acid molecules that are partially single-stranded, dumbbell-shaped, and covalently closed, which contain one or more unmethylated cytosine guanosine motif (CpG motif) and exhibit immunomodifying effects. Such molecules can be used for immunostimulation applications in humans or vertebrates.

Short deoxyribonucleic acid molecules that are partially single-stranded, dumbbell-shaped, and covalently closed, which contain one or more unmethylated cytosine guanosine motif (CpG motif) and exhibit immunomodifying effects. Such molecules can be used for immunostimulation applications in humans or vertebrates.

The invention belongs to the field of daily chemical goods, and discloses a transparent beauty treatment soap composition. The transparent beauty treatment soap composition includes 5.0-40.0% of aliphatic acid, 0.0-11.2% of an alkali, 1.0-15.0% of an amino acid surfactant, 40.0-70.0% of a crystallization aid, and the balance water; the pH value of the transparent beauty treatment soap composition is 8.0-11.0, and the neutralization of the aliphatic acid and the alkali is 90-100%; and the crystallization aid comprises at least one of alcohols, carbohydrates, and PEG hydrogenation oil and fat. The transparent beauty treatment soap composition which appropriately selects the amino acid surfactant has a very good foaming characteristic, a very good mildness and a very good moistening feeling, greatly improves the foam and the skin feeling and irradiation after washing of a transparent beauty treatment soap using the composition, and allows the transparent beauty treatment soap to have the advantages of very good foaming characteristic, very good mildness, and non-dry and non-tightening good skin feelings after washing.

4,4-difluoro-1,2,3,4-tetrahydro-5H-1-benzazepine derivatives, which have excellent arginine vasopressin V2 activity and are useful for a drug for the treatment of central diabetes insipidus and / or nocturia.

A compound of the formula:wherein Ar is an aromatic ring assembly group which may be substituted or a fused aromatic group which may be substituted; X is (i) a bond, (ii) -S-, -SO- or -SO2-, (iii) C1-6 alkylene, C2-6 alkenylene or C2-6 alkynylene, etc., (iv) -CO-O- or (v) -(CH2)p-X1-, -(CH2)p-X1- (CH2)q-, -(CH2)r-CO-X1-, -SO2-NR8- or -(CH2)r-SO2-NR8- wherein X1 is O or NR8, R8 is H, a hydrocarbon group which may be substituted or an acyl, p is 0 to 5, q is 1 to 5, p+q is 1 to 5, and r is 1 to 4; Y is a divalent C1-6 aliphatic hydrocarbon group optionally containing O or S, which may be substituted; R1 and R2 each is H or a lower alkyl which may be substituted, or R1 and R2 form a N-containing heterocyclic ring which may be substituted; Ring A is a benzene ring which may be further substituted; and Ring B is a 4- to 8-membered ring which may be further substituted, or a salt thereof has the effect of inhibiting amyloid-beta protein production and / or secretion and is useful as a pharmaceutical composition for preventing and / or treating the neurodegenerative disease, etc.

The invention relates to dynamic emulation cinema analog equipment which comprises a screen, a projector assembly and viewer seats arranged into an array, wherein the viewer seats are hung on a cantilever, and the cantilever is connected with a lifting arm; the lifting arm is arranged on a base, and the base can rotate to drive the lifting arm to rotate together; the lifting arms lifts up and down to drive the cantilever to lift up and down; and the cantilever moves up and down to drive the viewer seats to move up and down together. In operation, viewers enter the seat array to sit from the ground, and at the moment, the seat array is back on to the screen; because the seats are back on to the screen at the moment, the viewers cannot feel the screen completely, thus the viewers cannot conscious of seeing a film sensuously, thereby the sense of reality of the back scene is greatly increased; after the viewers sit down, the seat array is lifted; and after the seat array is lifted to an appointed height, the seat array is rotated to dead against the screen so as to ensure that the viewers enter the scene of the film.

When a user sets water power using a water power adjustment switch in a remote control device, a controller controls the period of pressure fluctuations, the width of pressure fluctuations, and the central pressure of the discharge pressure of a pump on the basis of a signal transmitted by radio from the remote control device. When the user sets the divergent angle of washing water using a washing area adjustment switch in the remote control device, the controller controls the divergent angle of the washing water sprayed from a posterior nozzle on the basis of the signal transmitted by radio from the remote control device. Consequently, the washing water supplied to a side surface of a cylindrical swirl chamber from a first flow path in the posterior nozzle is sprayed from a spray hole as dispersed spiral flow, and the washing water supplied to a lower part of the cylindrical swirl chamber from a second flow path in the posterior nozzle is sprayed from the spray hole as linear flow.

A multifunctional sonic treating techinque for increasing the yield of plant and improving its quality and its sound wave generator are disclosed. The pulse modulated sound waves and sweep-frequency sound waves, which have strong force energy and information actions, are emitted toward the plant to promote the sequential activity of mass, energy and information, resulting in high yield and quality.

This invention discloses a sort of method that it uses the light-sensitive lacquer hot-melt method to prepare the roundness heave biologic micro-electrode array. It uses the light-sensitive lacquer technique to prepare the heave cylindrical light-sensitive lacquer, and it adopts the hot-melt circumfluence light-sensitive lacquer to form the roundness salient point. A bed of polymer which is covered in the underlay is used for the protecting material of the bottom of the device, and the presented in figures forms the metal electrode point and the lead, and then that it covers the polymer to be the protecting material of the top of the device. The presented in figures reveals the electrode point and the weld point, and it gets the needed roundness heave smooth micro-electrode array. The cost of the invention is low, also the technical process is simple, and it has the upper irritant effect. It is used for the preparation of the biologic micro-electrode array which has the nerve-cell stimulation of the retina prosthesis and so on.

An injectable composition comprises a benzimidazole compound having an antiulcer action and a strong alkali (e.g., an alkali metal hydroxide such as sodium hydroxide) in a proportion of about 1 equivalent of the latter relative to 1 mol of the former, and is substantially free from a nonaqueous solvent. The injectable composition may comprise N-methylglucamine, and a saccharide (such as mannitol). The injectable composition may be a freeze-dried preparation. The freeze-dried preparation is dissolvable in or dilutive with a distilled water for injection or an infusion solution without a nonaqueous solvent. The injectable composition is useful as an antiulcer agent.

The invention discloses a passivator and preparing method of electrolytic metal Mn surface, which comprises the following parts: 70-80 percent silicate, 0.1-0.2 percent cosolvent, 0.3-0.5 percent inhibitor, 0.05-0.1 percent accelerant and water. The invention improves the operational environment for workers, which solves the problem of serious pollution of electrolytic Mn factory.

The invention discloses a method for improving the quality of cabo, comprising the following steps: dissolving microbial enzymes in a citric acid solution, uniformly spraying the completely dissolved enzyme solution on the cabo, treating the cabo sprayed with enzyme solution under constant temperature and humidity, and drying, etc. The invention uses the microbial enzyme technique to strengthen the fermentation treatment of the cabo, which reduces the wood flavor of the cabo, improves the irritation caused by undesirable substances such as cellulose. The improved cabo facilitates the process of the subsequent procedures and is added into the group prescription of the tobacco leaves, which increases the comfort of the oral cavity, decreases miscellaneous gases, softens the smoking gas, reduces the content of harmful substances in the cigarette and improves the safety of smoking. The invention has the advantages of simple and easy practice and strong practicality, which is beneficial to reducing the consumption of tobacco leaves and save tobacco leaf resources.

A zero-valent iron and biochar composite chemical for in-situ remediation of groundwater contaminated with chlorinated hydrocarbons is prepared from materials in percentage by weight as follows: 5%-30% of zero-valent iron powder, 8%-30% of a biochar source, 35%-85% of water, 0.1%-1% of a stabilizer, 1.5%-3% of a thickener, 0.3%-1% of an emulsifier and 0.01%-0.1% of a micronutrient source. The required raw materials are uniformly mixed by mixing equipment with high shearing for 15-30 min, and composite slurry which has good fluidity, is conducive to in-situ injection and can be stably stored is obtained. The prepared zero-valent iron and biochar source composite chemical has excellent fluidity and migration and diffusion capabilities and has a good remediation effect on complex contaminated sites containing both unsaturated and saturated chlorinated hydrocarbons. Besides, the selected raw materials are economic and available, the cost of the chemical is greatly reduced, and large-scale remediation of actual sites is facilitated.

The invention relates to a tea flower extract composition and its use in a cigarette. The tea flower extract composition comprises iron mercy goddess tea flower extract, robe tea flower extract, cassia tea flower extract and narcissus tea flower extract. The tea flower extract composition is added into the cigarette so that the cigarette has a harmonious fragrance. The tea flower extract composition can improve fullness of a cigarette fragrance and volatility of a cigarette fragrance without change of original cigarette performances and original cigarette processing processes. The tea flower extract composition has a sweet taste, promotes secretion of saliva of a smoker, improves miscellaneous gas and irritation and improves integral smoking quality.

The invention discloses a novel nano preparation with stable protein, as well as a preparation method and a purpose thereof. The invention is characterized in that: a protein coating is formed from albumin and other materials containing sulphydryl or disulfide bond through the cross linking of the disulfide bond; the protein coating contains free protein or protein derivatives which associate(s) with the protein coating, wherein, part of insoluble drugs are contained in the protein coating and part of such drugs are associated with the free protein or the protein derivatives, and the average diameter of protein coating particles is not more than 1 micron. The purpose of the preparation is to send water insoluble drugs into the bodies of living things.

The present invention is directed to ophthalmic compositions containing a gelling amount of a combination of galactomannan polysaccharides and borates. The compositions gel or partially gel upon administration to the eye. The present invention also discloses methods of topical ophthalmic administration of the compositions to the eye.

A process for improving the quality of novel alcohol by permeation, evaporation, separation and reforming relates to application of separation technique with pervaporation membrane in the field of alcohol. The technique of the invention is that raw material alcohol is maintained in constant relatively low temperature, the liquor is transferred to a silastic composite membrane device by a pump and the liquor conducts circular flow in the upper reaches of the membrane, the lower reaches of the membrane is maintained in vacuum state by a vacuum pump, ethanol and volatile flavoring substances are selectively separated by pervaporation and turn into permeation vapor, representative mouth feeling and flavoring substances are reformed or concentrated in vapor, a low temperature condenser is equipped in the lower reaches of the membrane, condensed liquor with different components quantity of mouth feeling and flavoring substances is achieved by time steps of condensing of the permeation vapor, the liquor made by time steps of condensing is reformed and novel alcohol with high quality is blended. The process has the advantages of simple technological process, compact equipment, high maneuverability, short treatment period, which can develop novel alcohol with low cost and poor quality into novel alcohol with high price and good quality.

The invention discloses a memantine hydrochloride capsule sustained-release preparation, wherein the preparation is composed of two parts, namely, immediate-release grains and sustained-release grains; the sustained-release part is composed of a blank pellet core, a medicine layer and a release control layer; and the immediate-release part is composed of a blank pellet core and a medicine layer. The capsule is uniform in content, good in release effect, stable in blood concentration, good for reducing the toxic and side effects of medicines, and is capable of being used for treating moderate-to-severe Alzheimer-type dementia, and the medicine-taking times of the patient are reduced,.

The invention discloses a pure natural plant lotion and a preparation method thereof and mainly relates to the field of daily lotion. The lotion is prepared from, by weight, 4-8 parts of sapindus, 1-3 parts of spina gleditsiae and 1-3 parts of tea seed cakes mainly through the steps of drying, smashing, repeated enzymolysis extraction, water extraction and clearing. The enzymolysis technology is used for promoting release and transformation of effective ingredients to obtain a natural plant extract solution containing abundant plant saponin and nutritional microelements. The lotion has a strong cleaning and decontaminating effect and a nourishing and health care function, is wide in application range and has high economic value.

The invention discloses a preparation method of gel type strong-base styrene anion exchange resin. The gel type strong-base styrene anion exchange resin disclosed by the invention is prepared by taking styrene, divinyl benzene, benzoyl peroxide, polyvinyl alcohol, gelatin, methylene blue, dichloromethane, 1,4-dichloromethoxybutane, anhydrous stannic chloride and trimethylamine as main raw materials through suspension polymerization reaction, chloromethylation reaction and amination reaction. The preparation method disclosed by the invention comprises the following steps of carrying out suspension polymerization reaction to synthesize a styrene-divinyl benzene cross-linked polymer, carrying out chloromethylation reaction of the styrene-divinyl benzene cross-linked polymer, and carrying out amination reaction of a chloromethylated styrene-divinyl benzene cross-linked polymer. The particle size range of the resin prepared by the method is 0.5-1.5 mm; the resin has a good property of removing sulfate and nitrate, a relatively high regeneration rate and the like; various physicochemical properties of the resin are good. Therefore, the resin disclosed by the invention can be applied in the sulfate and nitrate removing treatment process of water, and has good development prospects and practical significance.

The invention relates to a fatigue detection and regulation method based on an electroencephalogram and eye movement bimodal signal, belongs to the technical field of fatigue detection and regulation,and solves the problems in the prior art that the fatigue degree of a high-load operator cannot be continuously monitored and nerve regulation is not timely performed. A fatigue prediction model based on electroencephalogram-eye movement bimodal uses a machine learning method to analyze bimodal fusion features, that is, a fusion result of electroencephalogram features and eye movement features, recognizes the brain fatigue state of the operator, and according to the detection result, judges whether or not neuromodulation is required. If not required, the operator can continue to work and maintain high job performance. If necessary, a transverse brain intervention is applied by using transcranial direct current stimulation. Through bidirectional closed-loop fatigue monitoring and adaptiveregulation, the excitability of a cerebral cortex functional area is adjusted, thereby improving the physiological state of the operator and ensuring the efficiency and stability of the job performance.

A shoulder support device includes a flexible elastic continuous ring band and a slide adjustably movable on the band that divides the band into a pair of loops defining arm receiving apertures that are cupped over the curved deltoid region of each shoulder of a wearer to pull the shoulders back and downward under tension to achieve a correct posture position. The slide is moveable to adjust tension distributed to the wearer's shoulders. When the slide is positioned midway between the shoulder blades at the back of the wearer, it provides equal distributed tension on both shoulders. Moving the slide more to the left or more to the right allows the wearer to selectively adjust which shoulder receives more tension.

The invention discloses a bendazac lysine eye drops with reduced irritability, its preparation method and application, wherein the eye drop is prepared from bendazac lysine, thickening agent, buffering agent, preservative agent, isotonic agent, substance for reducing eye drop pungency and water for injection.

The invention relates to functional low-gram-weight cigarette paper, wherein the body phase thereof contains cut tobacco fibres or a first tobacco powder, a second tobacco powder is attached to the outer surface of at least one side of the body phase, and the first tobacco powder is the same as or different from the second tobacco powder. The invention further relates to a preparation method of the functional low-gram-weight cigarette paper. The preparation method comprises the following steps: (1) preparing paper pulp; (2) preparing special suspension stabilizing fluid for cigarette paper coating; and (3) making paper by a paper machine. The functional low-gram-weight cigarette paper disclosed by the invention is uniform in colouring and capable of improving the non-transparency of the cigarette paper; moreover, the functional low-gram-weight cigarette paper is good in stiffness and beneficial to roll; meanwhile, the functional low-gram-weight cigarette paper is good in ash wrapping force and capable of improving the smoking feeling of cigarettes. The functional low-gram-weight cigarette paper disclosed by the invention is also capable of effectively improving the sensory quality of the rolled cigarette produced during a smoking process and reducing harmful ingredients in the smoke of the cigarettes. Therefore, the functional low-gram-weight cigarette paper disclosed by the invention has a wide application prospect.

The present invention discloses a vertical falling type roller coaster track and an application method thereof. The vertical falling type roller coaster track is disposed in the middle of an existing roller coaster track, the existing roller coaster track is divided into two segments, the front segment is the track entering segment, the rear segment is the track sliding-out segment, a relatively high fall is formed between the track entering segment and the track sliding-out segment, and the vertical falling type roller coaster track is fixed between the track entering segment and the track sliding-out segment. The vertical falling type roller coaster track comprises a vertical tower frame and an elevating hanging frame vertically travelling in the vertical tower frame up and down, the elevating hanging frame is driven by a lifting device installed on the vertical tower frame to move up and down, and a buffer device and a locking device are installed between the elevating hanging frame and the vertical tower frame.

The present invention provides compositions for treating and / or preventing signs and symptoms associated with dry eye and / or ocular irritation, and methods of use thereof. Such compositions are provided in novel ophthalmic formulations that are comfortable upon instillation in the eye.

The invention discloses a lucidity maintaining device. The lucidity maintaining device is a head-mounted device and consists of a sensing controller and a head-mounted carrier which is sleeved at the head, wherein the sensing controller and the head-mounted carrier are mechanically fixed and electrically connected into a whole; the sensing controller comprises a micro-electromechanical system (MEMS) gyroscope, a control module and a power supply module; the head-mounted carrier comprises a vibration module and a wearable carrier for bearing the vibration module; the MEMS gyroscope performs real-time data acquisition and data processing on triaxial angular velocity signals; the control module is used for calculating and identifying the class of the head action of a person and executing instruction operation corresponding to the head action; the vibration module is used for providing consciousness vibration stimulation to the person. The lucidity maintaining device can realize consciousness vibration stimulation conveniently and timely, can select vibration modes and adjust vibration strength and frequency, achieves an obvious and continuous stimulation effect, is favorable for maintaining excellent lucidity of the person, and has wide application occasions.

The invention relates to the field of cosmetics and provides a co-conveying nano composition of phenylethyl resorcinol. The co-conveying nano composition comprises phenylethyl resorcinol, other skin whitening active components, a nano medicine carrier as well as solvent complex lipid and water, wherein the phenylethyl resorcinol accounts for 0.1-10% of the total mass of the co-conveying nano composition; the other skin whitening active components comprise at least one of an antioxidant, a cutin peeling type active substance, a melanosome transferring inhibition active substance, an anti-glycation active substance and an anti-allergic agent; the nano medicine carrier comprises raw materials of an emulsifier, a Anti-allergic agent and polyhydric alcohols. Due to compounding of different skinwhitening components and carrying of the nano medicine carrier, a remarkable synergetic effect can be achieved, irritation of high-concentration phenylethyl resorcinol can be remarkably reduced, andthe co-conveying nano composition is good in stability, excellent in skin whitening effect, good in water solubility, good in skin permeability and widely applicable to cosmetics.

The invention discloses a barrel-type fermentation method for cigar tobacco leaves. The barrel-type fermentation method includes the steps of performing processes of tobacco leave moistening and moisture regaining on raw tobacco leaves, accommodating the tobacco leaves obtained from the processes of tobacco leave moistening and moisture regaining in a wooden barrel and placing the wooden barrel into a fermentation chamber, fermenting for a 20-40 days. The cigar tobacco leaves fermented by the method are remarkably low in nicotine, intrinsic irritation of the tobacco leaves is improved, and intrinsic bitter taste of the tobacco leaves is eliminated.

The invention relates to the technical field of non-woven fabrics, and provides a preparation method for an antibacterial melt-blown non-woven fabric. The preparation method comprises the following steps of (1) carrying out oxygen plasma treatment on a polypropylene non-woven fabric, and carrying out graft modification on the polypropylene non-woven fabric to prepare a modified polypropylene non-woven fabric; (2) polymerizing an amino-terminated hyperbranched polymer with propylene diamine and methyl methacrylate as raw materials, and preparing a modified hyperbranched polymer through polycondensation of carboxymethyl chitosan and the amino-terminated hyperbranched polymer; and (3) adding a copper chloride solution into a modified hyperbranched polymer aqueous solution, dropwise adding a sodium borohydride solution under nitrogen protection and ice bath conditions, carrying out impregnation treatment on the modified polypropylene non-woven fabric in the modified hyperbranched polymer aqueous solution after the reaction is finished, and drying to obtain the antibacterial melt-blown non-woven fabric. The preparation method solves a problem that the melt-blown non-woven fabric in theprior art only has an efficient filtering effect and does not have antibacterial property.