30results about How to "Prevent postoperative adhesions" patented technology

Production of amphiphilic chitose derivative and its usage are disclosed. The process is carried out by taking chitose as raw material, alkalizing, reacting with 4-methyl bromoethyl acid in 2-propanol medium to obtain 6-0-carboxy-propyl-chitose, purifying, and reacting with long-chain fatty acyl chloride to obtain N-acyl-6-0-carboxy-propyl-chitose. In chemical formula, R=-(CH) n, n=8, 10, 12, 14, 16 and 18. It has excellent biological compatibility and degradation, good tissue adhesion and mechanical strength. It can improve wound heal and have styptic and adhesion-preventing functions.

The invention discloses a medicinal sustained-release and hemostatic composition and a preparation method thereof, which belong to the technical field of novel hemostatic materials. The medicinal sustained-release and hemostatic composition comprises the composition of a medicament-loaded chitosan microsphere, chitosan and hyaluronic acid, wherein the medicament-loaded chitosan microsphere comprises medicinal grade chitosan and medicinal grade tranexamic acid. The novel hemostatic composition is prepared by using chitosan and the hyaluronic acid as a main hemostatic matrix, combining chitosan medicament sustained-release microsphere composite medicament, namely tranexamic acid, utilizing the special property of the chitosan with a hemostatic function and a medicament sustained-release function, and adopting the composition of the hyaluronic acid with good hemostatic function and high biocompatibility and the chitosan as the main matrix. The novel hemostatic composition has the advantages of stopping bleeding rapidly and releasing medicament / factors continuously and stably in a certain time, along with great economic and social benefits.

The invention discloses an anti-adhesion fiber membrane with hemostasis and antibiosis functions and a preparation method thereof. The preparation method comprises the following steps of: dissolving medicinal molecules into an organic or inorganic solvent to prepare a medicinal molecular solution; dissolving different high molecular materials into medicinal solutions of a hemostasis agent and an antibiosis agent respectively to prepare a high molecular solution; and performing electrostatic spinning on a mixed solution of organic high molecules and the hemostasis agent and a mixed solution of high molecules and the antibiosis agent to obtain a compound fiber material. In the invention, nanofiber is produced by using an electrostatic spinning technology; an organic high molecular solution and the medicinal molecules are mixed for electrostatic spinning to obtain the compound fiber material; by adjusting the high molecular material, the embedding amount and embedding rate of medicaments are increased, a fiber material which can keep the medicinal bioactivity and is used for controlling the release of different medicaments at different stages is prepared, and dual effects of preventing postoperative adhesion and postoperative infection can be achieved; and moreover, the entire preparation process is simple, has low cost, and has wide application prospect in the field of surgical operation.

The invention provides a hemostatic material based on chitosan, collagen and sodium carboxymethyl cellulose which includes chitosan, collagen and sodium carboxymethyl cellulose for forming hemostatic sponge of chitosan, collagen and sodium carboxymethyl cellulose.

A soluble hemostatic gauze for anti-inflammation and pain relieving and the preparing method, relating to field of medical sanitary goods. The hemostatic gauze comprises the following substance according to the percentage by weight: dibasic sodium phosphate 0.1-0.3%, sodium alginate 1-1.8%, carbomu 0.5-25, antibacterial drugs 1-10%, polyethylene glycol 1-2%, tuwen 1-4%, dimethicone 0.1-1%, sodium carboxymethylcellulose 0.2-0.8%, americaine 0.05% and the left is ethanol solution. The product possesses functions of special pain relieving, preventing adhesion after surgery besides functions of hemostatic, broad spectrum antibiotic and promoting wound healing, which is of great importance for relieving patient pain and improving their survival quality.

A gel made of hyaluronic acid alone which is hardly soluble in a neutral aqueous solution and which keeps its shape for at least one day in a neutral aqueous solution at 25° C.

The invention relates to a biodegradable and absorbable hemostasis composition. The hemostasis composition is prepared from hyaluronic acid and modified starch or hyaluronic acid, chitosan and modified starch. The hemostasis composition is capable of stopping bleeding rapidly and has the effect superior to that of the prior art.

Provided is an anti-adhesion medical material in which a polyhydric alcohol or a polyhydric alcohol aqueous solution containing a polyhydric alcohol is retained in a bioabsorbable base material that contains a bioabsorbable material and has a degree of swelling of 200 to 3,000 mass% and a water elution rate of 10 mass% or lower, and in which the residual amount of polyhydric alcohol after three hours of immersion in 25 DEG C water 50 or more times the total mass of the polyhydric alcohol aqueous solution or the polyhydric alcohol aqueous solution and the bioabsorbable base material is 30 mass% or less of the amount of polyhydric alcohol prior to immersion.

The invention discloses operation flushing fluid and particularly relates to an anti-adhesion flushing fluid for preventing operation adhesion. The anti-adhesion flushing fluid mainly comprises 1,4,5,6-tetralin-2-methyl-4-pyrimidine carboxylic acid, sodium chloride and water for injection. In the anti-adhesion flushing fluid for an operation, concentration of 1,4,5,6-tetralin-2-methyl-4-pyrimidine carboxylic acid is 0.1 to 40 g / L and concentration of sodium chloride is 1 to 50 g / L. The operation flushing fluid disclosed by the invention also can be added with a pH buffer. The inventor of the invention makes a series of animal experiments and researches to show that the human operation flushing fluid disclosed by the invention has an excellent operation cleaning effect and also has an excellent effect of preventing postoperative adhesion.

Disclosed is a soluble hemostatic gauze for diminishing inflammation, killing bacteria and calming pain, and its making method, which comprises the following raw materials (by weight portion), 0.1-0.3% of disodium hydrogen phosphate, 1-1.8% of sodium alginate, 0.5-2% of Carbomer, 1-10% of cationic surface active agent, 1-2% of polyethylene glycol, 1-4% of Tween-80, 0.1-1% of dimethyl silicon oil, 0.2-0.8% of sodium carboxymethylcellulose, 0.05% of benzocain and balancing ethanol solution.

The invention belongs to a medical biological material technology field, concretes a chitosan fiber film, wherein the fiber film is prepared from a chitosan spinning solution, which is a mixed solution containing chitosan, hexafluroisopropyl alcohol and acetate. The invention further provides a method for preparing the chitosan fiber film, and applications of the fiber film for preparing endocranium or endorhachis defect repairing material, cerebrospinal fluid leakage plugging material or a tissue adhesion prevention medicament.

The instant invention relates to a composition comprising at least one polymer having the structure A-B-A′, wherein A and A′ may be the same or different and each is a degradable polyester component and wherein B is the reaction product resulting from the reaction between a diol, having one or more pendant oligomeric or polymeric groups, and A and A′.Additionally, the invention also relates to the development of a bioresorbable patch comprising:(a) an adhesion barrier component comprising a composition according to the invention in the form of a film; and(b) an adhesive component comprising:(i) at least one synthetic adhesive polymer; and / or(ii) at least one polysaccharide.The present invention provides a method of wound healing, comprising administering the composition or patch.

The invention provides a single-sided adhesive hydrogel adhesive, which comprises a hydrogel body and a surfactant sprayed on the single side surface of the hydrogel body, and the hydrogel body comprises the following components in parts by weight: 10-15 parts of anionic monomer, 10-15 parts of cationic monomer, 0.5-1 part of photoinitiator and 0.25-1 part of cross-linking agent, 0.5-3 parts by weight of a coupling agent and 100 parts by weight of water; the weight part of the surface active agent is 0.01 to 0.05. According to the invention, the anionic monomer and the cationic monomer are mixed, the photoinitiator, the cross-linking agent and the coupling agent are added to form a polyelectrolyte hydrogel adhesive film, and the hydrogel body is subjected to single-side surface physical treatment by using the biocompatible surfactant, so that the long-term stable adhesion effect with the achilles tendon tissue interface can be realized; repair of damaged tissues is promoted, and postoperative adhesion existing in the achilles tendon repair process is effectively avoided.

A surgical follow-up anti-adhesion, bacteriostasis and healing promotion pasting film which can be pasted to a postoperative internal organ stitching surface to prevent postoperative adhesion, inhibit bacteria and promote wound healing is composed of a smooth surface PLGA film, a honeycomb PLGA chamber filled with perfluorocarbon, and a rough surface PLGA film with protrusions and small holes. The surface of the rough surface PLGA is plastered to wounds after the wounds are stitched by a doctor.

The invention discloses an isolating film of hygroscopicity and self-adhesion which is used for preventing postoperative synechia. The isolating film is characterized by comprising 65 percent to 99 percent of carboxylation chitosan, 1 percent to 10 percent of glycerin, 0 percent to 5 percent of citric acid, and the rest being water. The preparing steps are as follows: weighing the ingredients by weight percentage; adding the carboxylation chitosan into water and stirring for thorough dissolution; adding the other ingredients into the solution and stirring; pouring the mixed solution into a glass mold for self-leveling, drying the solution for forming film and then cooling to room temperature; and at last, stripping the film from the mold. The isolating film is bacteria-free; when being implanted in human bodies, the film immediately absorbs tissue fluid once in contact with surface of wound, thus having viscidity. The isolating film which is simple and convenient in clinic can be automatically adhered on surface of wound which needs isolating. Therefore, the isolating film has the efficacy of promoting wound healing and preventing tissues from adhesion.

The invention belongs to the technical field of medicine and sanitation, and particularly relates to preparation and application of biological adhesion enhanced temperature-sensitive chitosan-based postoperative adhesion prevention hydrogel. The preparation method comprises the following steps: 1, grafting hydroxybutyl groups on chitosan to prepare hydroxybutyl chitosan with temperature-sensitive performance; 2, grafting thioglycollic acid on the chitosan to prepare the thiolated chitosan with enhanced biological adhesion performance. and 3, physically mixing the hydroxybutyl chitosan solution and the sulfhydrylated chitosan solution according to a certain proportion to obtain the biological adhesion enhanced temperature-sensitive chitosan-based postoperative adhesion prevention hydrogel. The product has the following advantages: the product has reversible temperature-sensitive phase change ability, is a liquid with good fluidity at low temperature, is convenient to inject and use, can rapidly flow to fit and cover irregular wounds after being injected to the wounds, rapidly forms a hydrogel barrier at physiological temperature to isolate adjacent tissue or organ surfaces, and prevents postoperative adhesion.

The invention is concerned with the organism coupling material, which is collagen, or the production of hydrolyze material and carbodiimide after imperfective coupling reaction. The coupling material is with fluidity and conglutination, which can be use for antiseep and anti-conglutination processing in surgery. The coupling material of the invention is imperfective coupling when it is using, which continues reaction to finish coupling during the process, it can adhere to the organic surface by coupling reaction in order to prevent organic conglutination and body fluid effusion of the wound surface.

The invention discloses a hydroxyapatite-polylactic acid biological double-sided magical film, which is a double-sided film with one side being hydroxyapatite and the other side being polylactic acidwith a thickness of 0.01[mu]m-2mm; the film is prepared by combining hydroxyapatite with various nano-structures synthesized by a hydrothermal method with polylactic acid at normal temperature and pressure, and using an infiltration and evaporation film self-forming method. The invention also discloses application of the biological double-sided magical film in a tooth bone tissue repair or regeneration process. The biological double-sided magical film provided by the invention is an ideal, safe and excellent biological composite material which has different properties for cells on two surfaces, can promote bone repair while on one surface and prevent postoperative adhesion on the other surface, has simple preparation method and low cost, can be produced on a large scale and has a wide application prospect.

The invention discloses a preparation method of a porous hydrogel coating on the surface of a polypropylene patch. The preparation method comprises the following steps: ultrasonically cleaning and drying a polypropylene material; putting sodium bicarbonate into the polyvinyl alcohol solution, and slowly stirring until the sodium bicarbonate is completely dissolved; preparing a ferric chloride solution, mixing the ferric chloride solution with the solution, and fully and uniformly stirring to prepare a mixed solution; coating the surface of the dried polypropylene material with the prepared mixed solution, and freezing the polypropylene material at low temperature; finally, the frozen polypropylene material is taken out, unfrozen at room temperature and soaked in deionized water, and the polypropylene material with the porous hydrogel coating on the surface is obtained. The modification method is simple, mild in condition and easy to control. The modified material can keep the mechanical property of a polypropylene body not reduced, and the surface hydrophilicity and anti-inflammatory property of PP can be improved.

An antiadhesive material is provided and contains a poly-γ-glutamic acid having a weight-average molecular weight of 600,000 to 13,000,000, or a kinematic viscosity at 37° C. of 2 cSt to 15 cSt when dissolved in distilled water at a concentration of 0.05% by mass and / or a salt thereof, as an effective ingredient. The antiadhesive material may have any form such as powder or gel form, and therefore, for example, is easy to handle even in relatively localized surgery such as endoscopic surgery and can more reliably prevent adhesion.

Provided is a method for preventing postoperative adhesion of an organ in a wound site using the application of an antiadhesive material thereto. The antiadhesive material contains a poly-γ-glutamic acid having a weight-average molecular weight of 600,000 to 13,000,000, or a kinematic viscosity at 37° C. of 2 cSt to 15 cSt when dissolved in distilled water at a concentration of 0.05% by mass and / or a salt thereof, as an effective ingredient. The antiadhesive material may be in a form such as powder, and therefore, for example, is easy to handle even in relatively localized surgery such as endoscopic surgery and can more reliably prevent adhesion.

The invention discloses a soluble hemostatic gauze for diminishing swelling, resisting bacteria and relieving pain, and belongs to the technical field of a macromolecular material. The soluble hemostatic gauze is prepared from the following raw materials including L-glutamic acid-gamma-ethyl ester, turpentine, Epsilon-caprolactone, 1,8-diazabicyclo [5.4.0] undecane-7-alkene, 1.3 to 2.7 parts of N-(tertbutyloxycarbonyl) neovaricaine, konjac glucomannan, trifluoroacetic acid, trichloromethyl carbonate, acetic hydrobromate solution, tetrahydrofuran, dichloromethane, xylene and traditional Chinesemedicine extracts. The soluble hemostatic gauze can form a gel state substance after being in contact with blood, so that the soluble hemostatic gauze can be well pasted in the wound position for fast stopping bleeding, preventing adhesion and realizing absorption in the body, and uses good tissue compatible hemostatic materials. The soluble hemostatic gauze uses the antibacterial medicine. In the use process, the adhesion of the gauze fiber to the wound can be avoided; the fast healing of the wound position can be promoted; the multiplex excellent effects of stopping bleeding, protecting thewound, resisting bacteria and relieving pain can be achieved.

The invention discloses a hydroxyapatite-polylactic acid biological double-sided magical film, which is a double-sided film with one side being hydroxyapatite and the other side being polylactic acidwith a thickness of 0.01[mu]m-2mm; the film is prepared by combining hydroxyapatite with various nano-structures synthesized by a hydrothermal method with polylactic acid at normal temperature and pressure, and using an infiltration and evaporation film self-forming method. The invention also discloses application of the biological double-sided magical film in a tooth bone tissue repair or regeneration process. The biological double-sided magical film provided by the invention is an ideal, safe and excellent biological composite material which has different properties for cells on two surfaces, can promote bone repair while on one surface and prevent postoperative adhesion on the other surface, has simple preparation method and low cost, can be produced on a large scale and has a wide application prospect.

This invention is about a functional after-operation isolation membrane and method for making same. The functional after-operation isolation membrane is composed of the drugs taken by biodegradable isolation membrane host material, and the drugs contain antiphlogiston drugs, fibrin inhibitor drugs, calcium channel inhibitor drugs, anticoagulant drugs and antibiotics drugs or one or several kinds of Chinese patent drugs; while the isolation membrane host material is made of one or several kinds degradation rate differed materials, whose half-decay times are 1 week to 6 months. Alerting membrane materials kinds and charging amount, drugs kinds and charging amount and isolation membrane layers can make multifunctional, degradation rate different and drug-release characteristic different functional after-operation isolation membrane products, so as to adapt to different using demands. Experiments prove that this functional after-operation isolation membrane can effectively accelerate tissue healing after operation, diminish infection and prevent after-operation adhesions.

The invention is concerned with the organism coupling material, which is collagen, or the production of hydrolyze material and carbodiimide after imperfective coupling reaction. The coupling material is with fluidity and conglutination, which can be use for antiseep and anti-conglutination processing in surgery. The coupling material of the invention is imperfective coupling when it is using, which continues reaction to finish coupling during the process, it can adhere to the organic surface by coupling reaction in order to prevent organic conglutination and body fluid effusion of the wound surface.

The invention belongs to a medical biological material technology field, concretes a chitosan fiber film, wherein the fiber film is prepared from a chitosan spinning solution, which is a mixed solution containing chitosan, hexafluroisopropyl alcohol and acetate. The invention further provides a method for preparing the chitosan fiber film, and applications of the fiber film for preparing endocranium or endorhachis defect repairing material, cerebrospinal fluid leakage plugging material or a tissue adhesion prevention medicament.

The invention belongs to the technical field of medicine and health, and in particular relates to the preparation and application of a bioadhesion-enhanced temperature-sensitive chitosan-based anti-postoperative adhesion hydrogel, comprising the following steps: 1. Grafting hydroxybutane on chitosan Hydroxybutyl chitosan with temperature-sensitive properties prepared by the base group. 2. Preparation of thiolated chitosan with enhanced bioadhesive properties by grafting thioglycolic acid on chitosan. 3. The hydroxybutyl chitosan solution and the thiolated chitosan solution are physically mixed according to a certain ratio to obtain a bioadhesion-enhanced thermosensitive chitosan-based anti-postoperative adhesion hydrogel. The product of the present invention has the following advantages: it has the ability of reversible temperature-sensitive phase transition, and it is a liquid with good fluidity at low temperature, which is convenient for injection. Glue barriers isolate adjacent tissue or organ surfaces and prevent postoperative adhesions from forming.

The invention discloses operation flushing fluid and particularly relates to an anti-adhesion flushing fluid for preventing operation adhesion. The anti-adhesion flushing fluid mainly comprises 1,4,5,6-tetralin-2-methyl-4-pyrimidine carboxylic acid, sodium chloride and water for injection. In the anti-adhesion flushing fluid for an operation, concentration of 1,4,5,6-tetralin-2-methyl-4-pyrimidine carboxylic acid is 0.1 to 40 g / L and concentration of sodium chloride is 1 to 50 g / L. The operation flushing fluid disclosed by the invention also can be added with a pH buffer. The inventor of the invention makes a series of animal experiments and researches to show that the human operation flushing fluid disclosed by the invention has an excellent operation cleaning effect and also has an excellent effect of preventing postoperative adhesion.