31results about How to "Reduce chemical degradation" patented technology

The present invention provides compositions containing clopidogrel, present as a free base or a pharmaceutically acceptable salt thereof, and sulfoalkyl ether cyclodextrin (SAE-CD). The compositions can be liquid, suspension or solid compositions. They can be adapted for oral, peroral or parenteral administration. The SAE-CD serves to aid in dissolution and stabilization of the clopidogrel in aqueous media. The stability of clopidogrel against hydrolytic degradation, thermal degradation, and photolytic degradation are improved. SAE-CD provides improved results over other cyclodextrin derivatives. The SAE-CD-containing composition of clopidogrel can be provided in liquid form, solid form or as a reconstitutable powder. Both ready-to-use and concentrated liquid compositions can be prepared. The liquid composition is optionally available as a clear solution. The compositions herein can be administered perorally or parenterally and provide substantial pharmacokinetic, pharmacodynamic and / or therapeutic advantages over a tablet composition administered perorally and excluding SAE-CD.

A fibrillation-resistant insulin analogue may be a single-chain insulin analogue or a physiologically acceptable salt thereof, containing an insulin A chain sequence or an analogue thereof and an insulin B chain sequence or an analogue thereof connected by a polypeptide of 4-10 amino acids. The fibrillation-resistant insulin analogue preferably displays less than 1 percent fibrillation with incubation at 37° C. for at least 21 days. A single-chain insulin analogue displays greater in vitro insulin receptor binding than normal insulin while displaying less than or equal binding to IGFR than normal insulin. The fibrillation-resistant insulin may be used to treat a patient using an implantable or external insulin pump, due to its greater fibrillation resistance.

The present invention provides compositions containing clopidogrel, present as a free base or a pharmaceutically acceptable salt thereof, and sulfoalkyl ether cyclodextrin (SAE-CD). The compositions can be liquid, suspension or solid compositions. They can be adapted for oral, peroral or parenteral administration. The SAE-CD serves to aid in dissolution and stabilization of the clopidogrel in aqueous media. The stability of clopidogrel against hydrolytic degradation, thermal degradation, and photolytic degradation are improved. SAE-CD provides improved results over other cyclodextrin derivatives. The SAE-CD-containing composition of clopidogrel can be provided in liquid form, solid form or as a reconstitutable powder. Both ready-to-use and concentrated liquid compositions can be prepared. The liquid composition is optionally available as a clear solution. The compositions herein can be administered perorally or parenterally and provide substantial pharmacokinetic, pharmacodynamic and / or therapeutic advantages over a tablet composition administered perorally and excluding SAE-CD.

Methods are disclosed for chemically stabilizing a polymer stent after sterilization. The stent is exposed to a temperature above ambient for a period of time after radiation sterilization. The exposure reduces the concentration of free radicals generated by the radiation.

Protection of proteins against fibrillation may be afforded by introduction of certain histidine substitutions into the protein, such that a pair of histidines are present with sufficient spacing as to allow the histidines to coordinate with zinc. In the case of insulin, introduction of histidine residue substitutions at residues A4 and A8 together or a histidine residue substitution at residue B1, provides increased resistance to fibrillation while maintaining at least a majority of the activity of the insulin analogue. Introduction of a histidine residue substitution at residue A8 restores at least a portion of fibrillation resistance that may have been harmed by substitutions present on the B-chain such as those present in fast-acting insulins. Proteins protected by such histidine substitutions may be used to provide a pharmaceutical composition. A method of treating a patient includes administering a physiologically effective amount of the pharmaceutical composition to the patient.

The invention discloses a fuel cell composite proton exchange membrane and a preparation method thereof. PTFE is placed in a dopamine buffer solution for modification treatment, the coating conditions are accurately controlled by adjusting the angle of the membrane in the solution and the like, the hydrophilicity of the treated PTFE is remarkably improved, a high-boiling-point solvent can be directly used for casting the membrane, and the composite proton exchange membrane is prepared and obtained. The prepared fuel cell composite proton exchange membrane has the advantages of being low in thickness, long in service life and good in performance. The operation process has the characteristics of simplicity, safety, easiness in scale expansion and industrialization, and can be used for producing the proton exchange membrane of the fuel cell.

The invention discloses a method for preparing a fructus corni or cornus formula granule by using a continuous dynamic countercurrent extraction technology. The method comprises the following steps: a) removing impurities and residual kernels from fructus corni or cornus; b) continuously putting fructus corni or cornus pieces into extraction pipes of a continuous countercurrent extraction device,continuously reverse adding hot water into the tail ends of all-level extraction pipes, continuously dynamic countercurrent extracting, collecting an extracting solution and discharging drug residue;c) cooling and filtering the extracting solution, reducing pressure for concentrating filtrate into a clear paste; d) spray-drying the clear paste, thereby acquiring dry extract powder; e) dryly granulating the dry extract powder, thereby acquiring the end product. According to the invention, the production processes of continuous countercurrent extraction, high-temperature instant sterilization,vacuum concentration, spray drying and dry granulation are adopted, and various technological parameters are researched, so that content of active ingredients in the formula granule can continuously and stably reach a higher level and the product quality of the fructus corni or cornus formula granule can be promoted.

The invention discloses a stable triprolidine hydrochloride-containing oral solution agent and a preparation method thereof, and belongs to the field of medicine preparations. The oral solution is used for treating diseases such as allergy, common cold and rhinitis. The triprolidine hydrochloride-containing oral solution preparation has the advantages that the medicine use safety is higher; the bitter taste is reduced; the stable triprolidine hydrochloride-containing oral solution agent is particularly suitable for children to use. The oral solution preparation has the pH being 4 to 7, so thatthe stability of the preparation is higher.

A method is provided for improving metallic nanostructure stability. The method provides a substrate, and using a physical vapor deposition (PVD) process for example, deposits metallic nanostructures having a first diameter overlying the substrate. Some examples of metallic nanostructures include Ag, Au, and Al. The metallic nanostructures are annealed in an atmosphere including an inert gas and H2. The annealing temperature is less than the melting temperature the metal material in bulk form. In response to the annealing, stabilized metallic nanostructures are formed. If the stabilized metallic nanostructures are exposed to an ambient air environment the stabilized metallic nanostructure maintain the first diameter. Typically, the metallic nanostructures are initially formed having a rectangular shape with corners. After annealing, the stabilized metallic nanostructures have a dome shape.

The invention discloses a preparation method of herba violae formula granules. The preparation method comprises the steps: a, herba violae is broken or chopped, and thus herba violae decoction piecesare obtained; b, the herba violae decoction pieces are continuously input into extracting pipes of a continuous countercurrent extracting machine, hot water is added continuously and reversely into the tail ends of all the stages of extracting pipes for continuous dynamic countercurrent extracting, and an extracting solution is collected; c, the extracting solution is filtered, superhigh-temperature instantaneous sterilization is conducted, and filtrate is subjected to decompression concentration to form clear paste; d, auxiliary materials are added into the clear paste for dissolving, and spray drying is conducted to obtain dry extract powder; and e, preparation auxiliary materials are added into the dry extract powder, and dry granulation is conducted to obtain the herba violae formula granules. According to the preparation method of the herba violae formula granules, production processes of continuous countercurrent extracting, superhigh-temperature instantaneous sterilization, decompression concentration, spray drying and dry granulation are adopted, thus the content of effective components in the herba violae formula granules can reach the high level continuously and stably, it is guaranteed that the active component transfer rate and that of herba violae standard decoction are consistent, and the product quality of the herba violae formula granules is improved.

The invention belongs to the field of pharmaceutical preparations, and particularly relates to a compound oral solution preparation containing triprolidine. According to the compound triprolidine hydrochloride oral solution, pharmaceutically acceptable auxiliary materials are used, a dosage is accurately divided, and medication safety is improved; an aromatic and a sweetening agent are added, so the mouth feel of the solution is good; and the dosage is accurately divided by using a graduated dropper, so the compound triprolidine hydrochloride oral solution is particularly suitable for children. The compound triprolidine hydrochloride oral solution disclosed by the invention is controllable in quality, high in stability, simple in process, easy to absorb and exact in curative effect, and can better meet clinical requirements.

The method of directly using ordinary food to construct a nutrient nano-carrying system is characterized by: (1) mixing food raw materials with a lipid content of less than 12% and nutrients at a mass ratio of 4-200:1, and then performing nano-processing, so that the particle diameter The distribution peak is below 600nm; (2) In the solution system, the concentration of the solution is adjusted to 0.5%-55% based on the quality of nano-food, and then the pH is adjusted to 2.2-13, and the ionic strength is converted to a sodium ion concentration of 0.001mol / L to 5mol / L, adopt ultrasonic oscillation of 0-65W / cm2, the temperature is 0-85°C, after 1-48 hours of aggregation process; or, in the solid state, control the temperature at 0-230°C and the pressure at 0.05-4MPa, The relative humidity is 0-100%, after 2-80 hours of accumulation; (3) Vacuum packaging, storage at room temperature or low temperature. The present invention wraps nutrients in nano-food clusters to realize the delivery of nutrients, improves stability, can be stored in liquid or solid state, can reduce or even avoid the degradation of nutrients, and has loose post-processing conditions; Greater improvement.

Methods are disclosed for chemically stabilizing a polymer stent after sterilization. The stent is exposed to a temperature above ambient for a period of time after radiation sterilization. The exposure reduces the concentration of free radicals generated by the radiation.

The invention discloses a preparation method of fresh ginger formula particles. The preparation method comprises the steps that a, fresh ginger is subjected to impurity removing, cleaned, crushed or chopped, and thus fresh ginger decoction pieces are obtained; b, the fresh ginger decoction pieces are continuously input into a continuous dynamic countercurrent extracting machine, hot water is addedreversely for continuous dynamic countercurrent extracting, and an extracting solution is collected; c, the extracting solution is filtered, superhigh-temperature instantaneous sterilization is conducted, and filtrate is subjected to decompression concentration into clear paste; d, auxiliary materials are added into the clear paste for dissolving, and spray drying is conducted to obtain dry extract powder; and e, preparation auxiliary materials are added into the dry extract powder, and dry granulation is conducted to obtain the fresh ginger formula particles. According to the preparation method of the fresh ginger formula particles, continuous countercurrent extracting, superhigh-temperature instantaneous sterilization, decompression concentration, spray drying and dry granulation production technologies are adopted, all technological parameters are researched, thus the content of effective components in the fresh ginger formula particles can reach the high level continuously and stably, it is guaranteed that the active component transfer rate is consistent with the active component transfer rate of fresh ginger standard decoction, and the product quality of the fresh ginger formula particles is improved.

The invention relates to a preparation method of crocin double-layer coated microcapsules, which is characterized by comprising the following steps: A, weighing crocin, a metal chelating agent, tremella polysaccharide, an auxiliary color agent, an emulsifier, a high-molecular polymer, grease and the balance of water according to a mass ratio; b, crocin, a metal chelating agent, tremella polysaccharide and an auxiliary color agent are mixed and then added into water, and the mixture is stirred to be uniform to serve as a water phase; c, mixing and uniformly stirring an emulsifier, a high-molecular polymer and grease to serve as an oil phase; d, adding the water phase and the oil phase into a high-pressure homogenizer, and homogenizing to obtain crocin single-layer coated microemulsion; e, preparing an external water phase; f, coating the crocin single-layer coated micro-emulsion and an outer water phase, and adding the crocin single-layer coated micro-emulsion into the outer water phase through an SPG membrane emulsification method to obtain a micro-capsule suspension; and G, carrying out spray drying on the microcapsule suspension to obtain the crocin double-layer coated microcapsule. The product disclosed by the invention has the advantages that crocin is not easy to fade and good in stability.

The invention discloses a cetirizine hydrochloride oral solution, which comprises cetirizine hydrochloride, mannitol, hydroxy propyl cellulose and water. The oral solution provided by the invention effectively covers up the strong titter taste of the active component cetirizine, obviously improves the stability of the oral solution, effectively reduces the chemical degradation and the toxic or side effects of the cetirizine, reduces the molecular aggregation phenomenon of the active component, reduces the using risk and improves the medicine safety.

A method of improving antibody manufacturability or developability through a computational approach.

The invention discloses a preparation method of radix stemonae or honey-fried radix stemonae formula granules. The preparation method comprises the following steps that a, radix stemonae or honey-fried radix stemonae is crushed into coarse particles; b, the coarse particles are continuously input into extraction pipes of a continuous dynamic countercurrent extraction machine, hot water is reversely and continuously added at the tail ends of the extraction pipes of each grade for continuous dynamic countercurrent extraction, an extracting solution is collected, and medicine residues are discharged; c, the extracting solution is filtered and subjected to high temperature instantaneous sterilization, and filtrate is concentrated under reduced pressure to form a clear paste; d, excipients areadded to the clear paste for dissolution, and spray drying is performed to obtain dry extract powder; and e, preparation excipients are added to the dry extract powder, and dry granulation is performed to obtain the radix stemonae or honey-fried radix stemonae formula granules. The preparation method adopts a production process of continuous countercurrent extraction, high temperature instantaneous sterilization, pressure-reduced concentration, spray drying and dry granulation, and researches various process parameters, so that the content of effective elements in the formula granules can becontinuously and stably maintained to achieve a higher level, it is ensured that the active ingredient transfer rate is consistent with standard decoction, and the product quality of the radix stemonae or honey-fried radix stemonae formula granules is improved.

The invention discloses an ambroxol hydrochloride oral solution. The ambroxol hydrochloride oral solution consists of ambroxol hydrochloride, polyethylene glycol, hydroxy propyl cellulose, L-cystine, saccharose, sodium benzoate and distilled water. The ambroxol hydrochloride oral solution is suitable in taste, effectively covers intense bitter taste of active ingredients, and is convenient to take orally and high in stability.

The invention relates to an electrolyte battery electrode component having a layer having a surface adjoined by electrolyte in the battery and provided with a fluid-conducting channel structure. In this context, it is envisaged that through the fluid-conducting structure has channels having channel depths in the range from 10 to 200 μm and / or at least 50% of the thickness of the active layer.

The present invention belongs to the technical field of organic electroluminescence, and discloses an organic light-emitting diode (OLED) and a preparation method thereof. The OLED comprises a substrate, a first electrode, a hole transport layer, a compound EML, an electron transport layer and a second electrode which are stacked in order. The compound EML comprises a luminescence unit set formedby n luminescence units, and an exciton-retared layer stacked at one side of the luminescence unit set; and each luminescence unit comprises a luminescence layer and an efficiency-enhanced layer stacked at one side of the luminescence layer. The efficiency-enhanced layers and the exciton-retared layers are added in the OLED to effectively improve the efficiency roll-off of the OLED, improve the luminous efficiency of the device and prolong the use life of the device.

A method is provided for improving metallic nanostructure stability. The method provides a substrate, and using a physical vapor deposition (PVD) process for example, deposits metallic nanostructures having a first diameter overlying the substrate. Some examples of metallic nanostructures include Ag, Au, and Al. The metallic nanostructures are annealed in an atmosphere including an inert gas and H2. The annealing temperature is less than the melting temperature the metal material in bulk form. In response to the annealing, stabilized metallic nanostructures are formed. If the stabilized metallic nanostructures are exposed to an ambient air environment the stabilized metallic nanostructure maintain the first diameter. Typically, the metallic nanostructures are initially formed having a rectangular shape with corners. After annealing, the stabilized metallic nanostructures have a dome shape.

The invention discloses a compound preparation for treating cold. The compound preparation is a liquid preparation, comprises a solution consisting of purified water, dextromethorphan hydrobromide, acetaminophen and phenylephrine hydrochloride, and further comprises a pH regulator, a preservative, an antioxidant, a sweetening agent and a cosolvent. According to the compound oral solution containing the acetaminophen, the dextromethorphan hydrobromide and the phenylephrine hydrochloride, a flavoring agent is added, so that the compound oral solution tastes good and is particularly suitable for children; a pH regulator buffer system is adopted, so that the pH value of the product is stable; a bacteriostatic agent is added, so that microbial growth can be prevented, and chemical degradation is remarkably reduced; the compound oral solution consisting of the acetaminophen, the dextromethorphan hydrobromide and the phenylephrine hydrochloride is high in stability; the antioxidant is added, so that the chemical degradation is remarkably reduced; and the preparation process is simple, the quality is controllable, the production cost is low, and the compound preparation is suitable for large-scale production.

The invention discloses a preparation method of chrysanthemum formula granules. The preparation method comprises the steps: a, chrysanthemum is crushed or chopped to obtain chrysanthemum decoction pieces; b, the chrysanthemum decoction pieces are continuously input into a continuous dynamic countercurrent extracting machine, hot water is reversely added, continuous dynamic countercurrent extraction is conducted, and an extracting solution is collected; c, the extracting solution is filtered, ultra-high temperature instantaneous sterilization is conducted, and filter liquor is subjected to decompression concentration to be clear paste; d, auxiliary materials are added into the clear paste and dissolved, and spray drying is conducted to obtain dry extract powder; and e, pharmaceutical adjunct is added into the dry extract powder, dry granulating is conducted, and thus the chrysanthemum formula granules are obtained. The preparation method adopts production processes such as continuous countercurrent extracting, ultra-high-temperature instantaneous sterilization, decompression concentration, spray drying and dry granulating, all process parameters are researched, thus the content of active ingredients in the chrysanthemum formula granules can reach the high level continuously and stably, it is ensured that the transfer rate of the active ingredients is consistent with chrysanthemum standard decoction, and the product quality of the chrysanthemum formula granules is improved.

The invention discloses a preparation method of radix bupleuri or vinegar-baked bupleurum root formula granules. The preparation method comprises the steps that a, radix bupleuri or vinegar-baked bupleurum root is crushed into coarse particles; b, the coarse particles are continuously input into a continuous dynamic countercurrent extraction machine, hot water is reversely added for continuous dynamic countercurrent extraction, and an extracting solution is collected; c, the extracting solution is filtered and subjected to high temperature sterilization, and filtrate is concentrated under reduced pressure to form a clear paste; d, excipients are added to the clear paste for dissolution, and spray drying is performed to obtain dry extract powder; and e, preparation excipients are added to the dry extract powder, and dry granulation is performed to obtain the radix bupleuri or vinegar-baked bupleurum root formula granules. The preparation method adopts a production process of continuouscountercurrent extraction, high temperature instantaneous sterilization, pressure-reduced concentration, spray drying and dry granulation, and researches various process parameters, so that the content of saikosaponin a and saikosaponin-d in the radix bupleuri or vinegar-baked bupleurum root formula granules can be continuously and stably maintained to achieve a higher level, it is ensured that the active ingredient transfer rate is consistent with the radix bupleuri standard decoction, and the product quality of the radix bupleuri or vinegar-baked bupleurum root formula granules is improved.

The invention discloses a method for preparing formula granules from flos inulae or honey flos inulae. The method comprises the steps: a, a flos inulae medicinal material is pretreated or processed; b, flos inulae or honey flos inulae decoction pieces are continuously input into extraction tubes of a continuous countercurrent extractor, hot water is continuously added into the tail ends of all thestages of extraction tubes counter, continuous dynamic countercurrent extracting is carried out, an extracting solution is collected, and drug residue is discharged; c, the extracting solution is filtered to be subjected to superhigh-temperature instantaneous sterilization, and filtrate is subjected to decompression concentration to form clear paste; d, the clear paste is added with ingredients to be dissolved, and spray drying is carried out to obtain dry extract powder; and e, the dry extract powder is added with preparation ingredients, and the formula granules are obtained by dry granulation. Production processes of continuous countercurrent extracting, high-temperature instantaneous sterilization, decompression concentration, spray drying and dry granulation are adopted, all technological parameters are researched, thus the content of effective components in the formula granules can continuously and stably reach the high level, it is guaranteed that the active component transferrate is consistent with that of standard decoction, and the product quality of the formula granules prepared from the flos inulae or the honey flos inulae is improved.

Method of treating or preventing trichomoniasis or T. vaginalis infection in a subject in need thereof, the method involving administering to the subject a therapeutically effective amount of secnidazole or a pharmaceutically acceptable salt in a microgranule formulation, wherein the microgranule formulation comprises a plurality of microgranules. The subject can also have bacterial vaginosis, is HIV-positive, and / or is suffering with metronidazole-resistant trichomoniasis and / or tinidazole-resistant trichomoniasis. The subject can also be a sexual partner of a person with trichomoniasis. The microgranule formulation can also be administered with paromomycin, tinidazole, metronidazole, boric acid or a combination thereof. Pharmaceutical compositions and uses for treating or preventing trichomoniasis or T. vaginalis infection in a subject in need thereof are also contemplated herein.

The invention discloses a preparation method of herba houttuyniae formula granules. The preparation method comprises the steps that a, herba houttuyniae is crushed or cut up to obtain herba houttuyniae decoction pieces; b, the herba houttuyniae decoction pieces are continuously conveyed into a continuous dynamic countercurrent extractor, hot water is continuously and reversely added into the tailends of all levels of extraction pipes, continuous dynamic countercurrent extracting is conducted, an extracting solution is collected, and decoction medicine residues are discharged; c, the extracting solution is filtered, ultra-high temperature instantaneous sterilization is conducted, and filtrate is subjected to decompression concentration into sugarless paste; d, auxiliary materials are addedinto the sugarless paste, dissolving is conducted, and spray drying is conducted to obtain dry extract powder; and e, preparation auxiliary materials are added into the dry extract powder, and dry granulation is conducted to obtain the herba houttuyniae formula granules. According to the preparation method, a continuous countercurrent extraction, ultra-high temperature instantaneous sterilization, decompression concentration, spray drying and dry granulation production technology is adopted, all technological parameters are studied, thus the contents of effective constituents in the herba houttuyniae formula granules can reach the high level continuously and stably, it is ensured that the transfer rate of the active constituents is consistent with that of herba houttuyniae standard decoction, and the product quality of the herba houttuyniae formula granules is improved.

The method of directly using ordinary food to construct a nutrient nano-carrying system is characterized by: (1) mixing food raw materials with a lipid content of less than 12% and nutrients at a mass ratio of 4-200:1, and then performing nano-processing, so that the particle diameter The distribution peak is below 600nm; (2) In the solution system, the concentration of the solution is adjusted to 0.5%-55% based on the quality of nano-food, and then the pH is adjusted to 2.2-13, and the ionic strength is converted to a sodium ion concentration of 0.001mol / L to 5mol / L, adopt ultrasonic oscillation of 0-65W / cm2, the temperature is 0-85°C, after 1-48 hours of aggregation process; or, in the solid state, control the temperature at 0-230°C and the pressure at 0.05-4MPa, The relative humidity is 0-100%, after 2-80 hours of accumulation; (3) Vacuum packaging, storage at room temperature or low temperature. The present invention wraps nutrients in nano-food clusters to realize the delivery of nutrients, improves stability, can be stored in liquid or solid state, can reduce or even avoid the degradation of nutrients, and has loose post-processing conditions; Greater improvement.