869results about How to "Strong fluorescence" patented technology

An electroluminescent (EL) is provided comprising an anode, an organic electroluminescent element, and a cathode wherein the electroluminescent element contains, for example, a fluorescent 1,1′-binaphthyl derivative component of Formula (I) wherein R1, R2, R3 and R4 are individual substituents or a group of substituents, each of which may be selected from the group consisting of hydrogen, or alkyl of from 1 to about 25 carbon atoms; an alicyclic alkyl of from 3 to 15 carbon atoms; an aryl or substituted aryl with about 6 to about 30 carbon atoms; carbon atoms from 4 to 24 necessary to complete a fused aromatic ring of naphthalene, anthracene, perylene and the like; an alicyclic alkyl group with from about 3 to about 15 carbon atoms; a silicon atom which can be substituted with a trimethyl, diphenylmethyl, triphenyl group and the like; heteroaryl or substituted heteroaryl of from 5 to 24 carbon atoms, carbon atoms necessary to complete a fused heteroaromatic ring of furyl, thienyl, pyridyl, quinolinyl and other heterocyclic systems; an alkoxy, amino, alkyl amino or aryl amino of from 1 to about 25 carbon atoms; a halogen, a cyano group, and the like.

The invention relates to the field of specific molecular identification and diagnosis reagent and in particular discloses a near infrared fluorescent dye with structural formulas I and II; and the invention also discloses a near infrared molecular probe which is obtained through covalent bonding between the near infrared fluorescent dye with the structural formulas I and II and a ligand of specific molecules. The near infrared molecular probe can be used for early diagnosis of turmour diseases.

The invention discloses a magnetic luminescent composite nano-particle Fe3O4 / CdTe / SiO2 and a preparation method thereof. The method for preparing the magnetic luminescent composite nano-particle Fe3O4 / CdTe / SiO2 comprises the steps of: firstly preparing hydrophobic monodisperse Fe3O4 nano-particles by adopting a chemical oil-phase high-temperature method, and modifying the surfaces of the hydrophobic Fe3O4 nano-particles to ensure that the hydrophobic Fe3O4 nano-particles are dispersed in a water phase; preparing luminescent CdTe quantum dots of which the surfaces are provided with carboxyl groups, and precipitating the luminescent CdTe quantum dots on the surfaces of the magnetic Fe3O4 nano-particles through the co-precipitation; then utilizing ligand exchange to modify a silane coupling agent on the surfaces of the luminescent CdTe quantum dots; and finally forming an outermost SiO2 coating layer through silane or silicon ester hydrolysis. The diameter of the magnetic luminescent composite nano-particle Fe3O4 / CdTe / SiO2 is between 30 and 50nm; the magnetic luminescent composite nano-particle Fe3O4 / CdTe / SiO2has double functions of magnetism and fluorescence at the same time, has strong and durable fluorescence intensity after labeling rat bone marrow-derived mesenchymal stem cells, and apparently reduces cellular magnetic resonance signals. The particle has broad application prospect in the fields such as biological labeling, bioseparation and the like.

The invention discloses waterborne polyurethane-acrylate emulsion prepared by the seed emulsion polymerization method. The method comprises the following steps: performing vacuum dehydration treatment to polymer polyol or diol in advance, adding micromolecular chain extender A, adding diisocyanate to react under heat insulation condition; adding hydrophilic chain extender and cosolvent to react; adding functional monomer A and catalyst to react; cooling, adding viscosity reducer and neutralizer to react, adding deionized water while stirring at high speed to obtain emulsion, slowly adding the mixture of micromolecular chain extender B and deionized water to cure and obtain vinyl-terminated reticulated polyurethane emulsion; mixing anionic emulsifier, non-ionic emulsifier and initiator with deionized water, adding acrylate mixed monomer to prepare emulsion fast, then introducing nitrogen, adding reductant to initiate polymerization and ensure that the emulsion has blue fluorescence, then adding vinyl-terminated reticulated polyurethane emulsion, and standing under heat insulation condition to obtain the core-shell type polyurethane-acrylate emulsion. The emulsion disclosed by the invention has good water resistance and wear resistance and meets the requirement of environmental protection.

The present invention discloses a graphene quantum dot preparation method, belongs to the technical field of nanometer material preparation, and particularly relates to a graphene quantum dot preparation method. The technical scheme comprises that: a carbon material being subjected to deep oxidation is cut into graphene oxide nano-sheets, C=C bonds and C-C bonds of the graphene oxide are broken to prepare green fluorescence graphene oxide quantum dots, and a reduction or high temperature annealing method is further adopted to prepare the blue fluorescence graphene quantum dots. According to the present invention, the operations are simple, the raw materials are easy to obtain, and the prepared graphene quantum dots have characteristics of excellent monodispersity, good water solubility and strong fluorescence, and have potential application prospects in the fields of supercapacitors, lithium batteries, biological imaging, solar cells, field-effect transistors, OLEDs and the like.

The invention belongs to the field of nano material preparation, and particularly relates to water-soluble fluorescent magnetic nano particles and a preparation method thereof. The invention adopts the technical scheme that the method comprises the following steps of: preparing magnetic nano particles by adopting a solvent thermal method, coating a SiO2 shell layer on the surface of the magnetic nano particles by hydrolysis of ethyl orthosilicate under the alkali condition, and connecting -NH2 to the outermost layer through a silane coupling agent with amino; and finally, mixing two kinds of aqueous solution, adding a connecting agent such as ethylene dichloride (EDC) or the like, and connecting the magnetic nano particles and quantum dots through chemical bonds formed by condensation reaction between amino and carboxyl to obtain the fluorescent magnetic nano particles. The fluorescent magnetic nano particles obtained by the technical scheme have low toxicity, good stability and magnetic response and excellent fluorescence; and the method has short experimental period, simple and safe operation and low raw material cost, can be completed in a common chemical laboratory, and lays a foundation for wide popularization and application.

The present invention provides novel calibration devices for use with fluorescent nanocrystal labels. Methods of preparing and using the calibration devices are also provided. Monodispersed populations of nanocrystals are deposited on surfaces. The monodispersed populations are obtained by dissolving the nanocrystals in a polar solvent.

The invention relates to a high luminance, high efficiency indole 3,2-b carbazole derivatives organic electroluminescenct material, belonging to the organic electroluminescent material technical field. The general structural formula of the indole 3,2-b carbazole derivatives organic electroluminescent compound is in the picture; in which, R3, R7 is alkyl or the substitute aryl, R1, R2 or R4-R6, R8 is hydrogen atom, benzene, naphthaline, anthracene, fluorine, carbazole, triarylated amine, thiophene, pyridine, pyran, quinoline, pyrrole, furan or imidazole. The compound of the invention has high fluorescence in both solution and solid film and has high film forming ability, thermal stability and photostability.

The invention relates to a preparation method of disperse fluorescence red dye ink used in terylene ink-jet transfer printing. The ink comprises the following components, by weight, 30-40 parts of disperse fluorescence red dye color paste, 5-30 parts of humectant, 0.05-0.5 parts of surfactant, 0.1-0.5 parts of pH conditioning agent, 0.05-0.5 parts of antifoaming agent, and 28.5-64.8 parts of deionized water. The ink is water base type dye ink, having the advantages of simple preparation technology and stable storage. Through an ink jet printer, the ink is printed on transfer printing paper. After nature drying of the transfer printing paper, 180-220 DEG C and 10-50 seconds heat transfer technology is used to transfer and print an ink-jet printing pattern on a terylene fabric through a transfer printing machine. By testing, the terylene fabric has a fluorescence reflectivity of 5-8% and strong fluorescence effect.

The invention discloses a preparation method of a transparent nano-cellulose paper with fluorescence properties. According to the method, TEMPO (2, 2, 6, 6-tetramethylpiperidine-1-oxyl) is employed to perform oxidation modification on natural nano-cellulose fiber, and the coordination mechanism of rare earth complexes is utilized for the first time to graft a rare earth complex with fluorescence properties to the modified nano-cellulose fiber in situ so as to obtain a nano-cellulose sol with fluorescence properties, and finally through a high pressure filtration method, the self-assembled fluorescent transparent natural nano-cellulose paper can be synthesized by one step. The transparent nano-cellulose paper with fluorescence properties provided by the invention has the characteristics of naturalness, environmental protection, no toxicity or harm, high light transmission, good flexibility, easy excitation, and advanced synthetic process, etc.

The invention provides a test method for trypsin. The test method comprises the following steps that: the fluorescence intensity of a metal nanocluster is tested; the trypsin reacts with the metal nanocluster, so that a reaction product is obtained, and the fluorescence intensity of the reaction product is tested; the difference between the fluorescence intensity of the metal nanocluster and the fluorescence intensity of the reaction product is calculated, and according to the difference and a predetermined standard curve, the content of the trypsin is obtained. The test method provided by the invention adopts the metal nanocluster as a fluorescence probe, the metal nanocluster comprises protein and metal, the property of the trypsin in fluorescently quenching the metal nanocluster is utilized, moreover, the degree of fluorescence quenching is positively correlated to the concentration of the trypsin, and the fluorospectrophotometry is adopted to determine the content of the trypsin. The test method provided by the invention has the advantages of high accuracy, high sensitivity and high selectivity, and an experimental result shows that the sensitivity of the test method provided by the invention on the test of the trypsin is 1.0 multiplied by 10 negative 9g / mL.

The invention relates to a quinoline nitrile derivative. A method comprises the following steps of: reacting 2-methylquinoline serving as an initial raw material with the corresponding alkyl halide to obtain quaternary ammonium salt, performing Michael addition-elimination reaction on the quaternary ammonium salt and malononitrile, and performing Knoevenagel condensation reaction on the obtained compound and the corresponding aromatic aldehyde to obtain a target product. The aggregate or solid substance of the derivative has strong fluorescence and large wavelength, is a good aggregation-induced emission material, and has considerable application prospects in the fields of electroluminescent devices, fluorescent probes, intelligent materials, organism imaging and the like.

The invention discloses a preparation method of carbon quantum dots for detecting Fe<3+> in lake water. The method comprises the following steps: cutting up potatoes and putting into a reaction kettle, and mixing with secondary redistilled water to react for 2 hours at 180 DEG C; filtering by a filter membrane of which the aperture is 0.22 microns after cooling; dialyzing filtrate for 12 hours by a dialysis bag of which the molecular weight cutoff is 1000; and carrying out freeze drying to obtain the carbon quantum dots. The preparation method is sufficient in raw materials, and low in cost; the entire preparation process is relatively environment-friendly.

The invention discloses microcrystalline glass containing rare earth mixing yttrium aluminum garnet (YAG) phase and a preparation method thereof. A glass matrix material uses SiO2, B2O3, Na2O, BaO, K2O, ZnO, CaO and Li2O as raw materials and is obtained by melting and fusing, a general form of yttrium aluminum pomegranate stone microcrystal materials containing the rare earth is (Y1-XLnX)3A15O12, Ln is Ce, Eu or Nd, X=0.03-0.08, and the glass matrix material and the yttrium aluminum pomegranate stone microcrystal materials containing the rare earth are melted and fused according to the weight ratio of 95:4-6. The microcrystalline glass containing the rare earth mixing the YAG phase is obtained by annealing. The microcrystalline glass is semi-transparent, the microcrystalline glass containing the rare earth mixing the YAG phase is small in crystal particle, the microcrystalline glass is good in dispersibility of rare earth mixed YAG phase crystal, rare earth ion basically enters YAG crystal lattices, and the rare earth ion is also good in dispersibility, so that the microcrystalline glass is excellent in optical property and strong in fluorescence, and can be obtained through a two-step fusion method, melting and fusing temperature is low and lower than 100 DEG C, requirements of a preparation process are low, production cost is low, and the microcrystal materials are good in uniformity.

A compound represented by general formula (IA) or a salt thereof useful as a fluorescent probe for zinc: wherein R1 and R2 represent a hydrogen atom or a group represented by formula (A), wherein X1, X2, X3, and X4 represent a hydrogen atom, an alkyl group, a 2-pyridylmethyl group, or a protective group for an amino group, and m and n represent 0 or 1 provided that R1 and R2 do not simultaneously represent hydrogen atoms; R3 and R4 represent a hydrogen atom or a halogen atom; and R5 and R6 represent a hydrogen atom, an alkylcarbonyl group, or an alkylcarbonyloxymethyl group, and R7 represents a hydrogen atom or an alkyl group.

The invention provides a preparation method of a quaternary quantum dot CdSe@ZnS / Zns. The preparation method comprises the following steps: preparation a Cd-Zn precursor stock solution, preparing a Se precursor stock solution and a S precursor stock solution; injecting the Se precursor stock solution and S precursor stock solution into the Cd-Zn precursor stock solution in a container filled with inert gas, fully mixing and stirring to carry out reactions completely to obtain a CdSe@ZnS solution; fully mixing a Zn source with a mixed solution of long-chain aliphatic acid and long-chain alkane / alkene in a container filled with inert gas to obtain a Zn precursor stock solution; fully mixing a S source solution formed by long-chain mercaptan, trialkyl phosphine, and long-chain alkane / alkene to obtain an S source precursor solution; dissolving the Zn precursor stock solution into the CdSe@ZnS solution obtained in the step (2), and dropwise adding the S source precursor solution to carry out reactions for 30 to 120 minutes to cover the shell layer so as to obtain the CdSe@ZnS / Zns quantum dot.

The invention provides a preparation method of magnetic fluorescent composite nanospheres. The preparation method comprises the steps of (1) preparing CdSe quantum dots by taking Na2SO3, selenium powder, cadmium acetate, N-acetylcysteine and deionized water as raw materials; (2) with FeCl3.6H2O sodium acetate anhydrous and ethylene glycol as raw materials, reacting in an autoclave to obtain Fe3O4 nanoparticles; (3) preparing a Fe3O4@SiO2 product by taking the Fe3O4 nanoparticles, tetraethoxysilane, absolute ethyl alcohol, deionized water and ammonium hydroxide as raw materials; and (4) conducting amino modification on the surface of the Fe3O4@SiO2 by utilizing a silane coupling agent KH-550, then loading CdSe onto the surface of the SiO2 through reaction, so as to obtain the final product magnetic fluorescent composite nanospheres. The preparation method has the characteristics that the prepared CdSe quantum dots have excellent water solubility and excellent fluorescent property and are about 3-4nm in diameter; the Fe3O4 nanoparticles are even in particle size and have good dispersity; the Fe3O4@SiO2 nanoparticles have an obvious core-shell structure, shell layers are evenly coated and are consistent in thickness; the magnetic fluorescent composite nanospheres has strong magnetism and excellent fluorescence property and can be used for site-specific drug transportation in a biological body and the fluorescence imaging of the biological body.

The invention belongs to the field of chemical engineering, and particularly relates to a method for large-scale synthesization of fluorescent silver nano clusters by taking general modified DNA (Deoxyribose Nucleic Acid) as a stabilizer. The method mainly comprises the following steps: (1) mixing the general modified DNA with a silver ion solution and reacting in a refrigerator of 4 DEG C for 24 h; and (2) adding a NaBH4 solution into a mixed solution in the step (1) and reacting for 3 h at the room temperature of 10-25 DEG C to obtain a silver nano cluster solution. According to the method, the general modified DNA is taken as the stabilizer for the convenience of large-scale synthesization of the fluorescent silver nano clusters; and the synthetic method is economic, the particle size is smaller, the particle distribution is uniform, and strong fluorescent light can be generated.

The invention discloses a transcription factor detection method based on DNA-Ag nanoclusters molecular beacons and exonuclease III cycle signal amplification. The novel nanomaterial DNA-Ag nanoclusters molecular beacon is applied as a fluorescent probe to transcription factor detection for the first time. Also, based on the characteristic that fluorescence adjustment of DNA-Ag nanoclusters molecular beacons is carried out by an enzyme cleavable DNA fragment, exonuclease III is added to participate in signal transformation and also participate in enhancement of the detection signal. The transcription factor detection method provided by the invention has the advantages of no label, high selectivity, low cost and high sensitivity, and can realize high throughput detection of transcription factors in biological samples.

The present invention provides a process for producing a luminescent glass, comprising the steps of adsorbing, to a porous high silica glass, at least one metal component selected from the group consisting of elements of Groups IIIA, IVA, VA, VIA, VIIA, VIII, IB, IIB and IVB of the Periodic Table; and thereafter heating the porous glass in a reducing atmosphere. The luminescent glass obtained by the process is excellent in heat resistance, chemical durability, mechanical strength and other properties, and exhibits strong luminescence when irradiated with UV light or the like. The glass can be effectively used as a luminous body for lighting systems, display devices, etc.

The invention relates to a 2-(2'-hydroxyphenyl) benzothiazole chelated zinc derivative as well as a preparation method and an application thereof, belonging to the field of organic electroluminescentluminescent materials. The preparation method of the derivative comprises the following steps: firstly, introducing different substituent groups with electron-withdrawing or electron-donating capability in a benzothiazole benzene ring or a hydroxyphenyl benzene ring of a 2-(2'-hydroxyphenyl) benzothiazole matrix to obtain a substituted 2-(2'-hydroxyphenyl) benzothiazole ligand; coordinating with diatomic zinc to form a corresponding complex, and the like. The substituted 2-(2'-hydroxyphenyl) benzothiazole ligand can be prepared by a plurality of reactions, such as substituted aniline acylation, hydroxyl protection, hydroxyl thiocarbonate, Jacobson cyclization while hydroxyl deprotection, and the like or prepared by a direct reaction of O-amino thiophenol and substituted ortho-hydroxybenzoic acid. When applied to an organic electroluminescent luminescent device as an electronic transmission layer, the derivative has favorable electronic transmission performance and has performance superior to the most common electronic transmission material 8-hydroxyquinoline aluminum.

The invention discloses a preparation method of a kaolin / 1-butyl-3-methyl bromide imidazole intercalated nanocomposite. The method comprises the following steps: firstly, directly intercalating the kaolin by using dimethyl sulfoxide to obtain a kaolin / dimethyl sulfoxide intercalated composite; then intercalating the kaolin intercalated composite by using methyl alcohol to obtain a kaolin / methyl alcohol intercalated composite; and finally, enabling synthesized 1-butyl-3-methyl bromide imidazole and the kaolin / methyl alcohol intercalated composite to carry out intercalating reaction in room-temperature and atmospheric environment so as to obtain a kaolin / 1-butyl-3-methyl bromide imidazole intercalated nanocomposite. Through the preparation method of the kaolin / 1-butyl-3-methyl bromide imidazole intercalated nanocomposite, imidazole ionic liquid carries out intercalating reaction with the kaolin / methyl alcohol intercalated composite under the room-temperature and atmospheric environment for the first time so as to obtain the kaolin / 1-butyl-3-methyl bromide imidazole intercalated nanocomposite; and the kaolin / 1-butyl-3-methyl bromide imidazole intercalated nanocomposite is integral in structure, stable in property, good in heat resistance, fluorescence property and ultraviolet absorbency.

The invention discloses a preparation method of a Cu-Zn-In-S quantum dot luminescent thin film. The preparation method comprises the following steps: (1) adding cuprous chloride, indium chloride, zinc salt, a capping agent and a surface coating agent to a non-polar high boiling point organic solvent so as to obtain a Cu, In and Zn mixed precursor solution, stirring and heating under the atmosphere of nitrogen or inert gas so as to form a clear transparent solution; (2) adding an oleylamine solution of sulfur to the clear transparent solution obtained in the step (1), and heating for reacting so as to prepare a Cu-Zn-In-S quantum dot solution; (3) separating so as to obtain Cu-Zn-In-S quantum dots; (4) mixing the prepared Cu-Zn-In-S quantum dots with a component A of an LED (Light Emitting Diode) pouring sealant; (5) uniformly mixing a component B of the LED pouring sealant with a mixture obtained in the step (4), removing air bubbles, then coating a product on a glass substrate, and curing at a room temperature so as to obtain the Cu-Zn-In-S quantum dot luminescent thin film. The fluorescence spectra of the Cu-Zn-In-S quantum dot luminescent thin film prepared by the method can be adjusted. The Cu-Zn-In-S quantum dot luminescent thin film has the excellent fluorescence property of the Cu-Zn-In-S quantum dots and the good machining property of an organic silicon adhesive AB.

The invention discloses a malononitrile isophorone copper ion fluorescent probe and a preparation method thereof, and relates to the technical field of analysis and detection. The malononitrile isophorone copper ion fluorescent probe has good fluorescence property, and assists in selectively identifying copper ions in a buffering solution. The fluorescent probe has the advantages of low detection limit (only 0.2 muM), large Stokes shift, fluorescence enhancement, long-wavelength emission and visible-light discoloration. Copper ion naked eye detection can be realized with the fluorescence enhancement and visible-light discoloration properties. With the fluorescence enhancement response of the probe upon copper ions, the copper ions can be subjected to qualitative or quantitative analyses. The probe can enter HeLa cells and can show a red fluorescence image after a reaction with copper ions in the cells. Therefore, the copper ion fluorescent probe provided by the invention can be sued in copper ion detections of the environment and in biological cells.

The invention discloses a lanthanide rare earth coordinated cellulose medical material and a preparation method thereof. The medical material is prepared by oxidizing primary hydroxyl of cellulose into carboxyl and then coordinating with lanthanide rare earth metal ions, namely performing sol-gel self-assembling reaction to rare earth metal hydrate and cellulose the primary hydroxyl of which is selectively oxidized into carboxyl. The preparation method is simple in preparation technology and good in controllability. The material not only has excellent moisture absorption and preservation properties and breathability, and better biocompatibility and excellent degradability of cellulose materials, but also has antibacterial property of the rare earth complex, can be used for antibacterial and bacteriostasis wound dressing due to broad-spectrum antibacterial property, and can also be used for detection tracing, special marking and optical display of biomolecules; the lanthanide rare earth coordinated cellulose medical material can be prepared into powder, gel, thin films, sponge or other porous materials, thus expanding the clinical application range; and the lanthanide rare earth coordinated cellulose medical material can be doped or grafted with macromolecular compounds so as to enhance the antibacterial and bacteriostasis properties and promote therapeutic effect on wound recovery.

The invention relates to the field of biologic medicines, and discloses an albumin indocyanine green paclitaxel compound as well as a preparation method and an application thereof. The albumin indocyanine green paclitaxel compound consists of indocyanine green, paclitaxel and human serum albumin, wherein the indocyanine green and the paclitaxel are absorbed onto human serum albumin through a hydrophobic force. The compound is good in water solubility, biocompatibility and dispersity, can generate heat in laser radiation, can promote more material cells, can kill tumor cells, is further high in fluorescence property, and can instruct joint treatment of photo-thermal therapy and chemotherapy in a fluorescence imaging mode. The preparation of the albumin indocyanine green paclitaxel compound is simple to operate and can be applied to on-scale preparation of the albumin indocyanine green paclitaxel compound, and the raw materials are easily available.

The invention provides a method for inhibiting peroxidase activity by using fluorescent graphene quantum dots. The method comprises the following steps: (1) adding a carbon source into a certain amount of water to prepare a mixed solution, heating the solution until the moisture is completely evaporated, transferring the solution into a high pressure reactor, heating and reacting for a period of time, dissolving the product in water, regulating the pH value of the system to be neutral by using alkali liquor, purifying the product, and drying, thereby obtaining solid graphene quantum dots; and (2) dispersing the quantum dots obtained in the step (1) in secondary distilled water, taking a proper amount of quantum dot solution and enzyme solution, adding the solution into a buffer solution, adding a color developing agent and H2O2 after a period of time, uniformly shaking the mixed solution, rapidly adding the solution into a cuvette, measuring the light absorption value of the maximum absorption wavelength of the product on an ultraviolet-visible spectrophotometer, and performing blank sample control, thereby determining the relative enzyme activity. The graphene quantum dots are prepared by adopting low-price and readily available raw materials, and the method is green and environment-friendly. The structure of the enzyme can be changed by virtue of the interaction between the graphene quantum dots and zymoprotein, and regulation of the enzyme activity is realized.

The present invention discloses a method for preparing CdS and CdS / ZnS core-shell quantum dots, belonging to the semiconductor nanometer luminescent material technical field. The method is to dissolve cadmium or cadmium salt with a long chain fatty acid to form a precursor solution of Cd. Liquid paraffin is used for dissolving a sulfur powder to form a precursor solution of S; the precursor solution of Cd is reacted with the precursor solution of S to give a CdS quantum dot, and then zinc salt is used as a precursor of Zn for incrustation, (TMS)2S is a precursor of S for incrustation, and thus a shell precursor solution is obtained; finally, the shell precursor solution is reacted with the CdS quantum dot to form the CdS / ZnS core-shell quantum dots. The method is good in repetitiveness, simple in operation, and low in material cost, and can obtain the CdS and CdS / ZnS core-shell quantum dots with emission wavelengths being in the blue light region. The yield of the fluorescence quantum is high, the size distribution is uniform, and the stability is good. The fluorescence quantum can be widely applied to the fields such as blue light tags, illuminator members, solar batteries and quantum dot laser, etc.

The present invention provides a primer that effectively can detect, for example, the double helix structure of a nucleic acid. The primer is a labeled nucleic acid containing at least one structure represented by the following formula (16),where B is an atomic group having a nucleobase skeleton, E is an atomic group having a deoxyribose skeleton, a ribose skeleton, or a structure derived from either one of them, or an atomic group having a peptide structure or a peptoid structure, and Z11 and Z12 are each an atomic group that exhibits fluorescence and are identical to or different from each other.