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Pharmaceutical composition for preventing and treating rheumatoid arthritis

A composition and technology for arthritis, applied in the direction of drug combinations, antipyretics, anti-inflammatory agents, etc., can solve problems such as interference with innate immunity and adaptive immunity, and harm

Inactive Publication Date: 2010-05-05
SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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  • Claims
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AI Technical Summary

Problems solved by technology

However, any of the regulatory pathways targeted by biological agents also play a key role in normal cells, and interfering with these regulatory pathways has potential harm to the body's innate and adaptive immunity

Method used

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  • Pharmaceutical composition for preventing and treating rheumatoid arthritis
  • Pharmaceutical composition for preventing and treating rheumatoid arthritis

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Experimental program
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Embodiment 1

[0025] Embodiment 1 Pharmacological experiment of the present invention

[0026] Experimental Materials

[0027] Drugs and Reagents

[0028] Chicken type II collagen (C II): Chondrex, Redmond, WA 98052, USA; incomplete Freund's adjuvant (IFA) Difco Laboratories, Detroit, MI; phosphate-buffered saline (PBS): prepared by our laboratory, in Dissolve 8gNaCl, 0.2g KCl, 1.44g Na in 800ml distilled water 2 HPO 4 and 0.24g KH 2 PO 4 . Use hydrochloric acid to adjust the pH to 7.4, add water to make up to 1L, filter and sterilize before use; Dimethyl sulfoxide (DMSO) is a product of Sigma Company; 1640 medium: Jinuo Biomedical Technology Co., Ltd.; Calf Serum: Minhai Biological Co., Ltd.; 96-well flat bottom plate, CORNING; 70 μm cell grinding filter, BD Falcon; 15ml, 50ml centrifuge tubes, BD Falcon; 0.22μm filter, Millipore; 1ml screw-top syringe, BD Braun tee, Braun company of Germany; Methotrexate sheet: Shanghai Pharmaceutical (Group) Co., Ltd. Xinyi Pharmaceutical General ...

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Abstract

The invention discloses a pharmaceutical composition for preventing and treating rheumatoid arthritis. The traditional Chinese medicine raw materials for constituting active ingredients of the pharmaceutical composition by weight are as follows: 5.5-6.0mg of berberine, 0.3-0.4mg of palmatine, 1.5-2.0mg of jatrorrhizine, 1.5-1.8mg of magnoflorine, 0.1-0.2mg of phellodendrine, 0.2-0.3mg of coptisine, 55-60mg of baicalin, 1.5-2.0mg of baicalein, 5.0-7.0mg of wogonoside, 0.03-0.05mg of wogonin, 20-25mg of geniposide, 0.1-0.2mg of crocin and 0.25-0.3mg of chlorogenic acid. The results of pharmacological tests show that the pharmaceutical composition can significantly reduce the disease severity of CIA mice with the rheumatoid arthritis, significantly improve the inflammation and the immune injury situation at lesion sites in comparison with a control group and be used for preparing drugs for preventing and treating the rheumatoid arthritis.

Description

technical field [0001] The invention relates to traditional Chinese medicine, in particular to a pharmaceutical composition for preventing and treating rheumatoid arthritis. Background technique [0002] Rheumatoid arthritis (Rheumatoid arthritis) is a chronic systemic autoimmune autoimmune disease characterized by joint synovitis. Synovitis is persistent and recurrent, which can lead to the destruction of cartilage and bone in the joint, joint dysfunction, and even disability. It is a chronic systemic inflammatory disease of unknown etiology, with chronic, symmetrical, polysynovial arthritis and extra-articular lesions as the main clinical manifestations, and belongs to autoimmune inflammatory disease. It often occurs in small joints such as hands, wrists, and feet, and it is easy to recur and is symmetrically distributed. In the early stage, joints are red, swollen, hot, painful, and dysfunctional. In the late stage, joints may be stiff and deformed in varying degrees, a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7048A61K31/4375A61K31/473A61K31/352A61K31/194A61K31/216A61P19/02A61P29/00
Inventor 张卫东窦圣姗柳润辉刘晓华单磊苏娟沈云亨李慧梁徐希科刘心如
Owner SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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