90 results about "Antiallergic agent" patented technology

The present invention provides an 8-oxoadenine compound having immunemodulating activities such as an interferon inducing activity and useful as an antiviral agent and antiallergic agent, which is represented by the following formula (1): [wherein the ring A represents a 6-10 membered aromatic carbocyclic ring and the like, R represents a halogen atom, an alkyl group and the like, n represents an integer of 0-2, Z1 represents alkylene, X2 represents oxygen atom, sulfur atom, SO2, NR5, CO, CONR5, NR5CO and the like, Y1, Y2 and Y3 represent independently a single bond or an alkylene group, X1 represents oxygen atom, sulfur atom, NR4 (R4 is hydrogen atom or an alkyl group) or a single bond, R2 represents a substituted or unsubstituted alkyl group, R1 represents hydrogen atom, hydroxy group, an alkoxy group, an alkoxycarbonyl group or a haloalkyl group]or its pharmaceutically acceptable salt.

A drug for topically administration which is effective as an antiallergic agent. The drug for topically administration contains as an active ingredient an adenine compound represented by the general formula (1):[wherein ring A represents a 6 to 10 membered, mono or bicyclic, aromatic hydrocarbon or a 5 to 10 membered, mono or bicyclic, aromatic heterocycle containing one to three heteroatoms selected among 0 to 2 nitrogen atoms, 0 or 1 oxygen atom, and 0 or 1 sulfur atom; n is an integer of 0 to 2; m is an integer of 0 to 2; R represents halogeno, (un)substituted alkyl, etc.; X1 represents oxygen, sulfur, NR1 (R1 represents hydrogen or alkyl), or a single bond; Y1 represents a single bond, alkylene, etc.; Y2 represents a single bond, alkylene, etc.; Z represents alkylene; and at least one of Q1 and Q2 represents —COOR10 (wherein R10 represents (un)substituted alkyl, etc.), etc.] or a pharmaceutically acceptable salt of the compound.

The present invention provides an 8-oxoadenine compound having immunemodulating activities such as an interferon inducing activity and useful as an antiviral agent and antiallergic agent, which is represented by the following formula (1):[wherein the ring A represents a 6-10 membered aromatic carbocyclic ring and the like, R represents a halogen atom, an alkyl group and the like, n represents an integer of 0-2, Z1 represents alkylene, X2 represents oxygen atom, sulfur atom, SO2, NR5, CO, CONR5, NR5CO and the like, Y1, Y2 and Y3 represent independently a single bond or an alkylene group, X1 represents oxygen atom, sulfur atom, NR4 (R4 is hydrogen atom or an alkyl group) or a single bond, R2 represents a substituted or unsubstituted alkyl group, R1 represents hydrogen atom, hydroxy group, an alkoxy group, an alkoxycarbonyl group or a haloalkyl group]or its pharmaceutically acceptable salt.

The present invention provides an antiallergic agent containing, as an active ingredient, lactic acid bacteria selected from the group consisting of lactic acid bacteria of the species Lactobacillus acidophilus, Lactobacillus fermentum, and combinations thereof. The antiallergic agent is capable of improving allergic diathesis by reducing the IgE level, which is contributive to development of Type I allergy, and is easy to take and highly safe. The present invention also provides use of the antiallergic agent for reducing allergy, and a method for reducing allergy using the antiallergic agent.

A medicament for the preventive and / or therapeutic treatment of allergic diseases and / or endometriosis and / or hysteromyoma which comprises as an active ingredient a substance selected from the group consisting of a compound represented by the following general formula (I) and a pharmacologically acceptable salt thereof, and a hydrate thereof and a solvate thereof: wherein X represents a connecting group whose number of atoms in the main chain is 2 to 5 (said connecting group may be substituted), A represents hydrogen atom or acetyl group, E represents an aryl group which may be substituted or a hetero aryl group which may be substituted, ring Z represents an arene which may have one or more substitutents in addition to the group represented by formula —O-A wherein A has the same meaning as that defined above and the group represented by formula —X-E wherein each of X and E has the same meaning as that defined above, or a heteroarene which may have one or more substitutents in addition to the group represented by formula —O-A wherein A has the same meaning as that defined above and the group represented by formula —X-E wherein each of X and E has the same meaning as that defined above.

The present invention relates to a novel compound or a salt thereof, which is useful as a CRTH2 antagonist, especially as a medicament for disorder that participates eosinophil, for example, allergic disorder such as asthma, allergic rhinitis, allergic dermatitis, conjunctival inflammation, hives, eosinophilic bronchitis, food allergy, inflammation of the nasal sinuses, multiple sclerosis, angiitis, or chronic obstructive pulmonary disease (COPD) and the like.

A medicament for the preventive and / or therapeutic treatment of allergic diseases and / or endometriosis and / or hysteromyoma which comprises as an active ingredient a substance selected from the group consisting of a compound represented by the following general formula (I) and a pharmacologically acceptable salt thereof, and a hydrate thereof and a solvate thereof:wherein X represents a connecting group whose number of atoms in the main chain is 2 to 5 (said connecting group may be substituted), A represents hydrogen atom or acetyl group, E represents an aryl group which may be substituted or a hetero aryl group which may be substituted, ring Z represents an arene which may have one or more substitutents in addition to the group represented by formula —O-A wherein A has the same meaning as that defined above and the group represented by formula —X-E wherein each of X and E has the same meaning as that defined above, or a heteroarene which may have one or more substitutents in addition to the group represented by formula —O-A wherein A has the same meaning as that defined above and the group represented by formula —X-E wherein each of X and E has the same meaning as that defined above.

The invention relates to a whitening and moisturizing toner which is especially used for human face skin. The whitening and moisturizing toner is prepared by the following steps: heating 3-5 parts of 1,3-butylene glycol, 4-6 parts of sodium pyrrolidone carboxylate, 0.2-0.4 part of dipotassium glycyrrhizinate, 2-4 parts of NMF-50, 4-6 parts of antiallergic agent (CD-2901), 100-110 parts of pure water, 4-6 parts of hyaluronic acid (1%), 1.5-2.5 parts of arbutin, 4-6 parts of nonane diacid derivative and the like, keeping the temperature, and stirring. Compared with the prior art, the invention has the following advantages: 1. the whitening and moisturizing toner does not have the smell or color of Chinese medicinal herbs, and thus, is welcomed by users; 2. since the antiallergic agent (CD-2901) is added into the product, the whitening and moisturizing toner can prevent skin allergy, so the users can use the whitening and moisturizing toner safely; and 3. since the whitening agent, moisturizing agent and humectant are added into the whitening and moisturizing toner, the whitening and moisturizing toner not only can soften the skin, but also can perform the function of nourishing the skin.

Tricyclic triazolobenzazepine derivatives in the form or a prodrug are provided. The compounds according to the present invention are those represented by formula (I) and pharmacologically acceptable salts and solvates thereon. The compounds are useful as antiallergic agents and exhibit excellent bioavailability. wherein R1 represents hydrogen, OH, alkyl or phenyl alkyl, R2, R3, R4, and R5 represent hydrogen, halogen, optionally protected hydroxyl, formyl, optionally substituted alkyl, alkenyl, alkoxy or the like, and Q represents a group selected from the following groups (i) to (iv), halogen, or alkoxy:

The invention discloses a composition for clearing tooth stains, which belongs to the technical field of oral health preparation products. The composition comprises substance capable of generating oxygen radicals, substance capable of forming gel or colloid, stabilizer, pH adjustor, wetting agent, anti-allergic agent, xylitol, flavoring agent and deionized water; and the appearance shape of the composition is gel or colloid. The composition for clearing the tooth stains has the advantages of stable property, difficult decomposition and liquefaction and long-term storage at the normal temperature, and is convenient to store, transport and use, so the composition can be operated and used not only by professional doctors in dental clinics and but also by patients at home.

The invention discloses a mild moisturizing facial mask which comprises the following components in percentage by weight: 8-20 percent of a wetting agent, 0.1-0.5 percent of a thickening suspending agent, 0.2-2 percent of an antiallergic agent, 0.1-0.5 percent of a neutralizer, 0.1-0.8 percent, preferably 0.2-0.5 percent of a preservative, 0.4-0.7 percent of an anticorrosion synergistic agent, 0.05-0.2 percent of a solubilizer and the balance of water. The mild moisturizing facial mask disclosed by the invention is mild in components and low in addition amount of the preservative; various antiallergic agents are added and combined; no components leading to the sensitivity of skin are added; the stimulation to the skin is avoided; moisturizing ingredients can quickly infiltrate into the skin; besides, the skin and the damaged skin are subjected to water replenishing and restoring; energy and water required by the skin are supplemented; the moisturizing capability is strong; the mild moisturizing facial mask is mild and stimulation-free.

The invention relates to hand cream, in particular to hand cream containing rose essence and belongs to the field of cosmetics. The hand cream is rich in rose essence, rose is rich in haematochrome, uranidin, beta-carotene, quercitrin, fatty oil, organic acid and other cosmetic materials, further antiallergic agents are added in the rose essence, so that when used on hands, faces and the like, the rose essence can repair expanded blood capillaries and relieve redness and has the effect of whitening and moisturizing. Therefore, the hand cream containing rose essence has the effect of whitening and moisturizing and can fully improve skin quality of the hands in winter.

It is intended to provide an anti-allergic agent, which efficaciously relieves symptoms accompanying an allergic disease without causing any serious side effect. This object is achieved by providing an anti-allergic agent which contains, as an effective ingredient, proteins collected from royal jelly or purified royal jelly, or royal jelly or purified royal jelly containing the proteins.

The invention relates to the field of cosmetics, in particular to a face-cleansing type cosmetic containing daylily extract and a preparation method thereof. The face-cleansing type cosmetic comprises 5-15 parts of the daylily extract, 0.6-3.2 parts of mineral matter, 3-10 parts of face-cleansing type surfactant, 0.3-1.2 parts of an anti-inflammation and antiallergic agent, 2.5-6 parts of a skin whitening agent, 2-12 parts of humectant, 0.1-0.3 part of potassium hydroxide, 0.1-0.3 part of thickener, 1.5-5.8 parts of emulsifier, 0.2-1 part of preservative and 40-80 parts of deionized water. The cosmetic can be made into products such as facial cleanser, liquid face wash and face cleansing cream and has the advantages that foam is abundant, stability is good, and the cosmetic is mild and free of stimulation and has the functions of inhibiting bacteria and chelating heavy metal; skin color is improved, and the skin whitening effect is achieved if the cosmetic is used for a long time; mineral matter constituents are added, so that the cleansing effect is better; the cosmetic is used for cleaning the face, melanin precipitation and external dust adhesion are reduced, inertial skin is excited, and fatigue is removed.

The invention belonging to the field of cosmetics, and particularly relates to an Enteromorpha boiled alga clay mask and a preparation method thereof. The preparation method comprises the following steps: removing impurities from Enteromorpha, washing, drying until the algae become embrittled, stamping the dried Enteromorpha to granules, immersing in alcohol for 8-20 hours, filtering, boiling for 15-120 minutes, filtering to obtain alga clay, carrying out centrifugal dehydration and freeze-drying, and grinding into powder; weighing raw materials according to the formula; adding deionized water into the weighed Enteromorpha powder, and stirring to swell; and dissolving a moisturizer, an antioxidant, a metallic ion chelator, a preservative, a whitener, a deodorizer, a sebum inhibitor, a cutin dissolving agent, a bacteriostatic agent, an antiallergic agent and a nutrient additive in deionized water, adding the Enteromorpha clay, continuing stirring while adding a tackifying agent and deionized water, and stirring uniformly. The mask has the advantages of favorable moisturizing property, low cost and low price, obviously improves the skin color, moisturizes the skin, and prevents the skin from aging.

The invention belonging to the field of cosmetics, and particularly relates to a Sargassum horneri boiled alga clay mask and a preparation method thereof. The preparation method comprises the following steps: removing impurities from Sargassum horneri, washing, drying until the algae become embrittled, stamping the dried Sargassum horneri to granules, immersing in alcohol for 8-20 hours, filtering, boiling for 15-120 minutes, filtering to obtain alga clay, carrying out centrifugal dehydration and freeze-drying, and grinding into powder; weighing raw materials according to the formula; adding deionized water into the weighed Sargassum horneri powder, and stirring to swell; and dissolving a moisturizer, an antioxidant, a metallic ion chelator, a preservative, a whitener, a deodorizer, a sebum inhibitor, a cutin dissolving agent, a bacteriostatic agent, an antiallergic agent and a nutrient additive in deionized water, adding the Sargassum horneri clay, continuing stirring while adding a tackifying agent and deionized water, and stirring uniformly. The mask has the advantages of favorable moisturizing property, low cost and low price, obviously improves the skin color, moisturizes the skin, and prevents the skin from aging.

The invention relates to an antiallergic composition. The antiallergic composition comprises at least one antiallergic agent, at least one preservative and at least one lipophilic skin permeation enhancer, wherein in the antiallergic composition, the adding amount of the antiallergic agent is 0.01-20% of the total mass of the antiallergic composition, the adding amount of the preservative is 0.01-20% of the total mass of the antiallergic composition, and the adding amount of the lipophilic skin permeation enhancer is 60-95% of the total mass of the antiallergic composition. The antiallergic composition and paper have good antiallergic performance.

This invention is to provide an agent for therapy and prevention of allergic diseases which has no adverse action, shows a high safety even by administration for a long period and is able to be utilized to food and / or beverage, cosmetics, etc. which are used daily. To be specific, it provides antiallergic agent and anti-inflammatory agent characterized in containing at least one polyphenol selected from strictinin and methylated derivatives thereof as an effective ingredient; a method for the addition of an antiallergic agent for oral administration or an anti-inflammatory agent for oral administration which is characterized in containing at least one polyphenol selected from strictinin and methylated derivatives thereof as an effective ingredient to food and / or beverage for prevention, suppression and mitigation of allergic symptoms or inflammatory symptoms.

The present invention provides an antiallergic agent containing, as an active ingredient, lactic acid bacteria selected from the group consisting of lactic acid bacteria of the species Lactobacillus acidophilus, Lactobacillus fermentum, and combinations thereof. The antiallergic agent is capable of improving allergic diathesis by reducing the IgE level, which is contributive to development of Type I allergy, and is easy to take and highly safe. The present invention also provides use of the antiallergic agent for reducing allergy, and a method for reducing allergy using the antiallergic agent.

It is intended to provide an anti-allergic agent, which efficaciously relieves symptoms accompanying an allergic disease without causing any serious side effect. This object is achieved by providing an anti-allergic agent which contains, as an effective ingredient, proteins collected from royal jelly or purified royal jelly, or royal jelly or purified royal jelly containing the proteins.

An object of the present invention is to provide an antiallergic composition useful for preventing and treating allergies, its preparation method, and its use as food, beverages, and the like. The solution includes an anti-allergic composition, which contains lactic acid bacteria with the following effects as an active ingredient: lymphocytes derived from the spleen of mice sensitized with ovalbumin are suspended in a culture medium containing ovalbumin, and added to When the lactic acid bacteria to be tested are cultured, the production of interleukin 12 is equivalent to that when Lactobacillus casei-like KW3110 strain is used as the lactic acid bacteria to be tested, or more than 60% of that when Lactobacillus casei-like KW3110 strain is used as the lactic acid bacteria to be tested, and the interleukin 12 The production amount of 4 was less than 50% of the control without adding lactic acid bacteria. The present invention includes a method for obtaining lactic acid bacteria with high anti-allergic activity as an active ingredient of the anti-allergic composition of the present invention, and the application of the anti-allergic composition of the present invention in food, beverages, etc., and further includes a method for preparing the lactic acid bacteria with high anti-allergic activity. , for use as an orally administered antiallergic agent.

It is intended to find novel pharmaceutical use of sphingomyelin and to provide preventive or therapeutic agents for various diseases as well as a food and drink product and feed comprising any of these agents. The present invention provides a pharmaceutical agent which contains sphingomyelin as an active ingredient and is any of the following agents: 1) a sialomucin secretion promoter, 2) an agent for preventing drunken sickness (hangover), 3) an antiallergic agent, 4) an antioxidant, 5) an agent for defending against infection, 6) a hair growth agent, 7) a therapeutic agent for demyelinating disease, 8) an anti-pigmentation agent, 9) an anti-inflammatory agent, and 10) an agent for improving learning ability. The present invention also provides a food and drink product or feed, characterized by comprising the agent. It is preferred that the sphingomyelin should be derived from milk.

The invention belongs to the field of cosmetics, and particularly relates to acne removal cream and a preparation method thereof. Cymene-5-alcohol and hexamidine or hexamidine bis(isethionic acid) salts in the acne removal cream are major ingredients for sterilization, inflammation diminishing and acne removal; tagemete and paeonol can be matched for enhancing the acne removal effect; paeonol canpromote the blood circulation of the face skin, can activate the senile surface cells, enables the skin to be white and tender, achieves the anti-aging effect, and particularly has a good effect on whelks; tagemete achieves an obvious allergy inhibition effect through H2 acceptor retardation; the itching symptom can be effectively relieved; a proper proportion of other raw materials such as anti-allergic agents, thickening agents, emulsifying agents, water-retention agents, skin conditioning agents, emollients, penetrants, analgesics, antiallergic agents, preservatives and perfuming agents arematched; the finally prepared acne removal cream has the advantages that the recipe is reasonable; the use is convenient; the acne removal effect is good; the healing restoration is fast; during theacne removal, the effect of promoting the skin wound restoration can be achieved at the same time.

To provide a spraying device and a spraying method for moisture mist that supply at least a micro liquid to the eye, and can be used for dry eye symptom relief, drug delivery, allergy prevention, relaxation, and the like. The above-described problem is solved by a spraying device (1, 31) that supplies at least a micro liquid, and includes a spraying element (16) that sprays a mist-like substance containing the micro liquid onto a local region (50). The raw material is a liquid raw material or a solid raw material that may include a medicinal additive. The medicinal additive is preferably selected from among menthol, analgesics, antibiotics, antiallergic agents, steroids, intraocular pressure-lowering agents, and the like. The spraying device (1, 31) may be an eyeglasses-type spraying device (1) in which the local region (50) is configured by a rim (3) and a temple (6) of eyeglasses, or a cup-type spraying device (31) in which the local region (50) includes an opening (32).

The invention discloses a composition capable of blackening and conditioning hair. The composition comprises two or more than two ingredients selected from a humectant, a traditional Chinese medicinehair blackening agent, an antiallergic agent, and a mineral matter mixture; the traditional Chinese medicine hair blackening agent comprises black sesame extract, polygonum multiflorum extract, blacksoybean extract, and vernonia anthelmintica extract; the vernonia anthelmintica extract is capable of realizing up-regulation of melanin synthesis key regulatory factor MITF, and up-regulation of expression of melanin synthesis related proteins and propagation of melanin cells which are regulated by MITF, and promoting synthesis of hair melanin; the black sesame extract is capable of promoting melanoma cell tyrosinase activity, melanin formation, and melanocyte propagation, and blackening the hair. The composition is applied in cosmetics, is capable of nourishing and moisturizing hair mildly,promoting hair blackening activity, and blackening and conditioning hair.

Provided is an antiallergic agent including, as an active ingredient, a fermentation product of a propionic acid bacterium.

The present invention relates to a compound represented by the following formula (I), which is useful as an antiallergic agent and / or an anti-inflammatory agent, or a physiologically acceptable salt thereof and the like:wherein R1 and R2 are the same or different and each is an optionally substituted aryl group and the like, R3 is a hydrogen atom, a C1-6 alkyl group and the like, R4 and R5 are the same or different and each is a hydrogen atom, a halogen atom, a hydroxy group, a C1-6 alkyl group and the like, X is a single bond or —C(R6)(R7)—, R6 and R7 are the same or different and each is a hydrogen atom, a halogen atom, an optionally substituted C1-6 alkyl group and the like, or R6 and R7 optionally form, together with the carbon atom bonded thereto, an optionally substituted C3-8 cycloalkyl group and the like, ring group A is an azetidin-1-yl group and the like, m is 0, 1 or 2, and n is 0, 1 or 2.

The invention belonging to the field of cosmetics, and particularly relates to a Sargassum horneri alga powder mask and a preparation method thereof. The preparation method comprises the following steps: removing impurities from Sargassum horneri, washing, drying until the algae become embrittled, and pulverizing the dried Sargassum horneri to granules; regrinding the Sargassum horneri granules into powder, and screening to obtain Sargassum horneri powder; weighing raw materials according to the formula; adding deionized water into the weighed Sargassum horneri powder, and stirring to swell; and dissolving a moisturizer, an antioxidant, a metallic ion chelator, a preservative, a whitener, a deodorizer, a sebum inhibitor, a cutin dissolving agent, a bacteriostatic agent, an antiallergic agent and a nutrient additive in deionized water, adding the Sargassum horneri clay, continuing stirring while adding a tackifying agent and deionized water, and stirring uniformly. The mask has the advantages of favorable moisturizing property, low cost and low price, obviously improves the skin color, moisturizes the skin, prevents the skin from aging, reduces the wrinkles and is convenient to use.

The invention relates to the field of daily chemicals, in particular to a novel skin bacteriostat. The skin bacteriostat is characterized by being prepared from, by weight, 0.5-8% of humectants, 0.5-5% of emollient and 0.1-2% of an antiallergic agent; a bacteriostatic agent at least comprises, by weight, 0.1-1.5% of lysozyme, 0-0.2% of odorant and 0-0.4% of solubilizer; water is added until the total weight percentage is 100%. According to the principle of integration of prevention and treatment, the bacteriostatic agent which is natural, safe and free of irritation is adopted and matched with high-purity cosmetic materials, resistance of skin to external virus and bacteria invasion and irritation is improved while epidermis germs are killed, a natural protection barrier is formed for the skin, and the skin is well repaired, moisturized and cared to keep comfortable and healthy durably.