160 results about "Biological dressing" patented technology

The composite spongy biological dressing contains chitosan, collagen and calcium alginate with weigh tmixing ratio o f 0.5-8:0.5-8:0.1-8. Its preparation method includes the following steps: selecting chitosan and collagen type I, adding calcium alginate, compounding and cross-linking, using buffer solution to make neutralization, emulsifying, prefreezing and one-step freeze-drying so as to obtain the invented dressing with good biological compatibility and strong adhesion property. Said invented dressing possesses active function of promoting wound healing and hemostatic action, can be combined with anti-bacterial medicine to obtain gene engineeirng dressing for curing wound surface infection, also can be combined with active growth factor or active cell to form gene engineering dressingfor curing intractable ulcer and burn wound surface.

The invention discloses a blending electric spun nanometer fiber film biological compress and preparing method in medicinal biological compress technical domain, which is characterized by the following: choosing chitose or polyvinyl alcohol or water-soluble antibacterial drugs as main raw material; adopting electrostatic spinning method; producing nanometer fiber film. This product possesses the advantages of higher strength, good air perviousness and good biological compatibility.

A moldable, bioresorbable, biocompatible, non-allergenic crosslinked collagen derivative dressing for the prevention of post extraction alveolar osteitis (dry socket) pain is disclosed along with methods for use of the gel. The dressing is placed at the time of surgery acting as a bone covering obtundant and physiologic scaffolding for the conduction of normal alveolar bone healing sequence of fibroblast ingrowth, blood vessel formation, and reossification of the extraction site defect. In one form, the dressing is a flowable, moldable, biocompatible, bioresorbable dressing prepared by reacting (i) a collagen derivative, such as gelatin or atelocollagen, and (ii) a non-cytotoxic crosslinking agent.

The invention discloses a method for preparing a nanosilver / nano silicon dioxide-containing antibacterial biological dressing, and relates to the field of antibacterial biological dressings. The nanosilver / nano silicon dioxide-containing antibacterial biological dressing is prepared by adding mixed solution of chitosan and polyvinyl alcohol and silver-carried silicon dioxide powder during the acetalation of the polyvinyl alcohol. The nanosilver / nano silicon dioxide-containing antibacterial biological dressing of the invention can accelerate the wound healing, slowly release the silver nanoparticles and continuously act on reproductive bacteria, has the characteristic of durable and high-efficiency sterilization and does not produce medicament resistance; and through the researches on the toxicity of the material to mouse fibroblast cells, the product does not produce obvious toxicity to the cells but promotes the growth of the cells.

The invention provides a biological dressing for treatment of a dermatological disease comprised of one or more resins or other film-forming agents, a topically acceptable volatile solvent, and a pharmacologically active agent. The combined one or more resins are present in a suitable amount such that the composition, when the solvent evaporates, will dry to form a solid coating that sticks to the skin, nail or mucosal membrane to which the composition is applied, and maintain the pharmacologically active agent over a sustained period of time in contact with sites on the skin or mucosal membranes exhibiting symptoms of the disease. Methods are provided for treating symptoms of dermatological diseases with such a pharmacological composition.

The invention provides hemostatic bacteriostatic biological dressing and a preparation method thereof. Nano silver and hemostatic medicament are uniformly distributed in a spongy or film-like biological dressing matrix made of a biological material, wherein the weight of the nano silver is 0.01 to 3 percent of the weight of the biological material, and the weight of the hemostatic medicament is 0.1 to 10 percent of the weight of the biological material. The method for preparing the spongy biological dressing comprises the following steps of: soaking the freeze-dried sponge into silver nitrate solution to prepare nano silver-carrying biological sponge at a high temperature under a high pressure, and soaking the nano silver-carrying biological sponge into solution containing the hemostatic medicament to obtain the spongy biological dressing by freeze drying. The method for preparing the film-like biological dressing comprises the following steps of: preparing biological material solution containing silver nitrate into nano silver-carrying solution at a high temperature under a high pressure, adding the hemostatic medicament into the cooled nano silver-carrying solution, casting the mixture to form a film, and drying the film at room temperature to obtain the film-like biological dressing. The hemostatic bacteriostatic biological dressing has the characteristics of safety, no toxicity, good biocompatibility and degradability and obvious bacteriostatic and hemostatic effects; and the preparation method is simple and has strong operability and low cost.

The invention discloses an antigen-free collagen aggregate and a preparation method thereof. The preparation method is characterized by comprising the following steps: with traceable animal skin or tendo calcaneus as a raw material, performing operations by the process such as fleshing, stripping fascia, degreasing, removing foreign protein and decellularizing; performing fine purification on the animal skin or tendo calcaneus, and then carrying out separation and purification on the collagen aggregate by the methods of acid fluffing, homogenizing, salting out for a plurality of times, centrifuging for a plurality of times and the like, thereby finally obtaining the antigen-free collagen aggregate. The collagen aggregate is a mixture of a collagen fiber and a collagen bundle, and has a periodic light and shade horizontal grain structure; and the space between the horizontal grains is about 67nm. The material has good biocompatibility, biodegradability, mechanical property and hemostatic performance, also has the characteristics of low antigenicity, biological activity and the like, and can be widely applied to preparation of biomedical materials such as a hemostatic material, a tissue engineering material, a biological dressing, a biodegradable medical suture and a plastic material.

The invention provides a collagen matrix freezing gel used for biomedical materials and a preparation method thereof. The collagen matrix freezing gel is the collagen extracted from skins or tendons of healthy domestic animals using the enzyme method with the molecular weight of 280 to 320kDa and a well maintained triple helical structure; the collagen reacts for 1 to 7 days in the condition of low temperature of 0 to minus 50 DEG C in a die after through cross linked and modified reaction with hydroformylation polysaccharide, then extrudes the die and is defrosted, thus forming the collagen matrix freezing gel. The preparation of the collagen matrix freezing gel of the invention in particular relates to the extraction of the collagen, the preparation of the hydroformylation polysaccharide and the synthesis of hydroformylation polysaccharide-collagen matrix freezing gel. The hydroformylation polysaccharide-collagen matrix freezing gel prepared by the invention improves the mechanical property, thermal stability and anti-enzyme degradation, etc., of pure collagen gels, and the freezing gel has the advantages of porosity, plasticity, hydrophilic property and non-toxicity, and can be used as biomedical materials such as bio-scaffold, cell cultivation, drug controlled release and biological dressings.

The invention relates to a medical biological dressing, particularly to a medical biological scar-inhibiting rhytidectomy dressing and a preparation method thereof. The dressing is composed of modified chitosan, silicone, glycerol, camellia oil, olive oil, almond oil, an aloe extracting solution, active growth factors, hyaluronic acid and a ginger extracting solution. With adoption of the formula, skin regeneration organs are retained and activated furthest, and a good foundation is laid for wound repair. The formula is reasonable and scientific and has the efficacies of clearing away heat and toxic materials, removing slough and promoting growth of tissue regeneration, promoting blood circulation and removing blood stasis, and relieving swelling and pain on scars, has an impressive preliminary therapeutic effect on scars of skin epidermis bruise, trauma, traumatism, burning, scald, and post-operation wound, has the advantages of high efficacy, rapid pain relieving, low possibility of infection, simple preparation method, and good convenience in usage and popularization, and is used for burning, scald, trauma, bruise, traumatism, post-operation wound hemostasis, inflammation diminishing, pain relieving, wound infection prevention, scar inhibition, skin wrinkle and crack prevention, and wrinkle inhibition.

A biodressing film for treating skin wound, burn and skin ulcer is prepared from chitosan as main raw material through acidolysis, adding gelatin and glycerin, neutralizing with dicarbonate, and filtering. Its advantages are high biocompatibility, netural antibacterial activity, and no poison and irritation.

The invention discloses an oxidation chitosan graft modified porcine dermal collagen micro-nano fiber membrane and a preparation method thereof. The oxidation chitosan graft modified porcine dermal collagen micro-nano fiber membrane is characterized in that the preparation method comprises the steps: by applying an electrostatic spinning technology and using traceable purified porcine dermis as a raw material and hexafluoroisopropanol as a solvent, stirring at 4-10 DEG C until the mixture is transparent, formulating to obtain electrostatic spinning mother liquor with concentration of 0.5-10%, and directly spinning to obtain the porcine dermal collagen micro-nano fiber membrane; then performing graft modification on the porcine dermal collagen micro-nano fiber membrane by using oxidation chitosan, thereby finally obtaining the oxidation chitosan graft modified porcine dermal collagen micro-nano fiber membrane. A membrane material not only has good bio-compatibility, biodegradability and mechanical properties, but also has anti-oxidation effects, antibacterial activities, anti-inflammation / wound healing promotion effects, anti-cancer / anti-tumor effects and antiviral effects of chitosan, is significantly better than a collagen composite membrane material prepared by using collagen as the raw material, and can be widely applied to the preparation of biomedical materials such as hemostatic materials, tissue engineering scaffold materials, biological dressings and the like.

The invention relates to a medical functional biological dressing and a preparation method thereof. The medical functional biological dressing comprises the following components: 68.5%-92.0% of calcium alginate fiber and 8%-31.5% of chitosan fiber. The preparation process comprises the following steps of: firstly, opening the calcium alginate fiber and the chitosan fiber and uniformly mixing; secondly, carding the fiber to form fiber webs by using a carding machine, paving the fiber webs and processing into non-woven fabric pieces by using a needle-punching process; and finally, cutting the non-woven fabric pieces into pieces by using a cutting machine. With adoption of the calcium alginate fiber and the chitosan fiber as the raw materials, the medical functional biological dressing provided by the invention has the advantages of good biocompatibility and excellent ability of absorbing effusion; a large amount of wound effusions can be rapidly absorbed to form gel, and thus a wet healing environment is provided for speeding healing of wound or wound surfaces; and the medical functional biological dressing has the capability of rapidly clotting blood and stopping bleeding and good antibacterial properties.

The invention discloses a preparation method of a silk fibroin aerogel. The silk fibroin aerogel is prepared from domestic silkworm silks, and a silk fibroin water solution is obtained by conducting degumming, dissolving and dialyzing; and the silk fibroin aerogel is prepared by the following steps: 1) concentrating the silk fibroin water solution by conducting room-temperature air blasting or thinning the silk fibroin water solution with the addition of de-ionized water, so that the concentration of the silk fibroin water solution is regulated to be 15-60mg / ml; 2) keeping the silk fibroin water solution in a container and conducting high-speed shearing on the silk fibroin water solution by virtue of a stirrer for 10-60min, so that a great amount of bubbles are formed and the silk fibroin water solution is converted into bubble-shaped liquid; and 3) freeze-drying the bubble-shaped liquid in a die, so that the silk fibroin aerogel is obtained. The aerogel prepared by the invention is quite low in density, and the aerogel has the advantages of being light in mass, high in specific surface area, good in biocompatibility and the like; the aerogel is especially applicable to such aspects as body liquid adsorption, biological dressings, sustained release of drugs, tissue repair and the like; and the aerogel has a broad prospect when used as a bio-medical material.

The invention provides a double-layered composite biological dressing and an adhesive-free compound technology thereof. The double-layered composite dressing comprises a chitosan fiber non-woven fabric layer and a spongy-shaped functional layer, wherein no adhesive is needed to bond the two layers. The preparation technology comprises the following steps: (1) chitosan fiber non-woven fabric is pre-cooled; (2) macromolecule chitosan, macromolecule collagen protein, micromolecule collagen protein and micromolecule chitosan in mass ratio of 0.7-1.3 to 0.1-0.3 to 0.7-1.3 to 0.1-0.3 are added in a faintly acid aqueous solution to prepare a spongy layer material solution; (3) the pre-cooled chitosan non-woven fabric is taken out and the spongy layer material solution is rapidly and uniformly sprayed on the non-woven fabric, wherein the spraying amount is 20-60 ml / 20*20 cm<2>; (4) the chitosan non-woven fabric sprayed with the spongy layer material solution is freeze-dried. The prepared double-layered composite dressing is firm in embedding connection between the two layers; the spongy functional layer has the function of promoting wound healing and prevents adhesion; the chitosan fiber non-woven fabric layer has the functions of favorable air permeability, comfort and bacterium resistance.

The invention relates the medical biomaterial technology field. The existing clinical hemostasis dressing is only used for stopping blood, while the new biological dressing is only used for cleaning and healing superficial wounds and lacks a specific direction for treating posttraumatic wound, in particular, sea battle injury. The aim of the invention is to provide a method for preparing a hemostasis dressing with good volume expansibility, permeability, as well as obvious direction to deal with high-permeability seawater. The method for preparing the hemostasis dressing uses sodium alginate mixed by chitosan and various Na<+> / Ca<2+> as the basic material to form a hemostasis sponge with good mechanical strength after being cooled and dried, and prepares asymmetric seawater hemostasis dressing with porous layer and compact layer by using polyvinyl alcohol as the surface coating material. The dressing shows high expansibility and good permeability according to the results of volume expansibility, permeability and sem observation, has rich porous layer and compact water-resistant layer in microstructure, and is applied for stooping blood and healing wounds in high-permeability seawater environment.

The invention provides a biological dressing for treatment of a dermatological disease comprised of a gum resin, a topically acceptable volatile solvent, and a pharmacologically active agent. The gum resin is present in a suitable amount that the composition, when the solvent evaporates, will dry to form a solid coating that sticks to the skin or mucosal membrane to which the composition is applied and maintain the pharmacologically active agent over a sustained period of time in contact with sites on the skin or mucosal membranes exhibiting symptoms of the disease. Methods are provided for treating symptoms of dermatological diseases with such a pharmacological composition. Biological dressings including tincture of benzoin and clotrimazole are shown to be efficacious for the long-term amelioration of symptoms of athlete's foot.

The invention discloses an antibacterial hydrogel dressing containing imidazolium bromide and a preparation method and application of the antibacterial hydrogel dressing. Antibacterial components, acrylamide and an initiator are composited to form a linear polymer; then the linear polymer is evenly dispersed into a gel carrier system with good biocompatibility; and through heating at the appropriate temperature and the repeated freezing-unfreezing process, the antibacterial hydrogel dressing containing the imidazolium bromide is prepared. The antibacterial hydrogel dressing has a unique three-dimensional network structure with the large water content, the antibacterial effective components and matrix macromolecules can be tightly combined together through chemical bonds, and the situationthat due to component losing, pollution to the surrounding environment is caused, or harm to body health is caused is avoided; and the hydrogel dressing has the good biocompatibility, antibacterial property, mechanical property and environmental friendliness, and will have the very wide application prospects in the field of biological dressings and medical dressings.

The invention relates to a medical biological dressing, and in particular relates to a medical biological wrinkle-removing and speckle-inhibiting dressing and a preparation method thereof. The dressing comprises hyaluronic acid, olive oil, collagen, geranium essential oil, camellia oil, apricot kernel oil, active growth factors, pearl powder, vitamin A, vitamin C, vitamin E, amino acid, garlic oil and mint oil. By adopting the formula, skin regeneration organs are reserved and activated to the most extent; the skin condition is improved; cell regeneration is promoted; the yield of skin collagen is increased; therefore, skin whitening, speckle removing and wrinkle smoothing are promoted; a good foundation is laid for repairing wounds; and the medical biological wrinkle-removing and speckle-inhibiting dressing has the excellent effects in early treatment of skin wrinkle, striae gravidarum, crows feet, stain and scar.

The present invention is crosslinked chitosan-quaternized hydrolyzed collagen preparing process and relates to antibiotic biological material preparation. The crosslinked chitosan-quaternized hydrolyzed collagen is prepared with silkworm pupa chitin and hydrolyzed collagen as material. The preparation process includes mixing two kinds of solution, adding crosslinking agent to perform crosslinking reaction, membrane concentration, regulating pH value, and volumetric or spray drying to produce powder. The present invention can prepare solution or sol product and into the product, various water soluble functional factors, such as skin growth factor, moisture maintaining factor, vitamin, etc. may be added to form multifunctional biological dressing.

The present invention relates to one kind of composite collagen-base rack material and its preparation and use. The material includes collagen and water soluble polysaccharide, and the polysaccharide is at least one of chitosan, salt of algal polysaccharide, proteoglycan, cellulose, carrageenan, acacia and starch. Collagen has natural 3D fiber network structure. The preparation process of the rack material with skin of mammal as material includes elimination of subcutaneous tissue with splitting machine, water soaking, defatting, ash soaking, deashing, splitting, softening, compounding, and Co-60 irradiation to sterilize. Functional material may be added into the composite collagen-base rack material for preparing biological dressing, artificial epidermis, artificial corium and artificial composite skin, and the composite collagen-base rack material may be used together with corollary ointment. The rack material has excellent water and steam penetrability and absorption.

The invention discloses an antibacterial silk fibroin material and a preparation method thereof. The antibacterial silk fibroin material is prepared from the components: silk fibroin and berberine, wherein the berberine is directly bonded with the silk fibroin through an intermolecular force. The method comprises the steps of preparing a silk fibroin solution, preparing a silk fibroin composite material, preparing the antibacterial silk fibroin material treated through water vapor, and preparing a glycerinum modified silk fibroin composite material modified. According to the antibacterial silk fibroin material provided by the invention, the silk fibroin is subjected to water vapor treatment and glycerinum modification, a secondary structure of the silk fibroin is changed, the antibacterial agent berberine can be uniformly dispersed into silk fibroin macromolecule absorbable materials, and the antibacterial agent is slowly released along with the swelling and the degrading of the silk fibroin macromolecule absorbable materials, so that the antibacterial silk fibroin material has long-acting slow-release mold resistance, can effectively prevent wound infection and promote heating aiming at 3 days of high risk periods of tissue infection, and can provide a new solution for coating materials, biological dressings or medical instruments.

The invention discloses a traditional Chinese medicine dressing for antibacterium and hematischesis and a production method thereof. A biological dressing prepared by taking cotton, gauze and non-woven fabrics as base materials, glycerin as a plasticizing agent and chitosan as a filmogen and dipping in a traditional Chinese medicine extracting solution for antibacterium and hematischesis can be widely used as a dressing for surfaces of wound caused by burning and hurting, has the characteristics of favorable biocompatibility, security, absorbing wound seepage, antibacterium, hematischesis, accelerating the concrescence of the wound, and the like and takes crudes as main materials.

The invention relates to a composite self-adhering elastic bandage of a functional biological dressing, which comprises a self-adhering elastic bandage and a functional biological dressing sheet. The functional biological dressing sheet is adhered to one end of the self-adhering elastic bandage by an adhesive or is sewn to be fixed at one end of the self-adhering elastic bandage; the functional biological dressing sheet is prepared by 68.5 percent to 92.0 percent of calcium alginate fibers and 8 percent to 31.5 percent of chitosan fibers, which are used as the raw materials; and the calcium alginate fibers and the chitosan fibers are processed by acupuncture to form a non-woven fabric sheet. The advantages of the self-adhering elastic bandage and the functional biological dressing sheet are combined; the effect of rapidly winding and binding a wound surface or a wound is achieved; the composite self-adhering elastic bandage for the functional biological dressing is convenient to rapidly treat the wound and the wound surface, can also be used for stopping bleeding and promoting wound healing and is suitable for emergency treatment such as first aid, field damage, movement damage and the like.

The invention discloses a biological dressing and making method of large-area skin defection therapy, which is characterized by the following: extracting silk protein from natural silk as the principal raw material; containing silk sponge cellular material single or composite with fabric netted reinforcing layer and perforated macromolecular film on the coverage of cellular material or reinforcing layer. The biological dressing provides good biological compatibility, softness-toughness, permeability of therapy medicine, strength and modulation of wound moisture, which is obvious to accelerate wound assimilation and easy to operate.

The invention discloses a preparation method of a biological dressing containing nano silver, zinc and bismuth, which comprises the steps of: synthesizing chitosan and / or a nano silver, zinc and bismuth compound as a chitosan derivative by using a solid phase synthesis method; dissolving into a solution; adding a proper quantity of glycerol, collagen and the like; and obtaining a film dressing by adopting a curtain coating film-forming method or obtaining a sponge dressing by using a freezing drying method. The biological dressing has the functions and the advantages of nano silver, zinc and bismuth, and chitosan or chitosan derivative, and has the characteristics of better contact bacteriostasis, wide antimicrobial spectrum, durable action time, wound repairmen, ulcer curing and the like.

Preparation and application of an antibacterial modified exosome burn wound healing-promoting biological dressing are disclosed. A raw dressing is a novel artificially modified exosome prepared by taking cell-derived exosome as a carrier of an antibacterial agent and combining with a broad-spectrum antibacterial agent; and the modified exosome is loaded into an asymmetric chitosan porous moisturizing dressing. The weight ratio of chitosan to water-absorbing molecules to the exosome to the antibacterial agent in the dressing is (40-60): (20-40): (5-20): (1-10). The dressing has a broad-spectrumantibacterial effect, a blood vessel repair promoting effect, a nerve repair promoting effect and a wound healing promoting effect. Meanwhile, the dressing has moisture retention, air permeability, barrier property, high strength and easy disclosure, and is a novel antibacterial compound dressing with a broad-spectrum antibacterial effect. The dressing is prepared through freeze-drying, has advantages of simple preparation process, low cost, outstanding treatment effect and good safety, and has remarkable medical value and industrialization potential.

The invention discloses a preparation method of a fish collagen combined chitosan biological dressing. The preparation method comprises the following steps: cutting clean fish wastes, from which surface impurities are removed, into fish meal of 50-200 meshes; putting the fish meal in an airtight container and then adding distilled water and a reaction enzyme into the airtight container, and stirring to form slurry; reacting the slurry under high pressure and ultrasonic treatment; after the reaction is finished, subjecting the slurry to purification treatment; adding chitosan to the purified slurry, heating until the temperature is in a range from 80 DEG C to 90 DEG C and stirring for 20-30 minutes; and finally, carrying out dialysis, concentration and drying, thereby obtaining the fish collagen combined chitosan biological dressing. The preparation method disclosed by the invention is simple in process, easy to implement, convenient to operate, and low in cost; the quickly extracted fish collagen is even in molecular weight distribution and few in impurities; the prepared biological dressing is good in mechanical strength, and has the effects of stopping bleeding and promoting wound healing, and also has the effect of antibiosis.

The invention relates to acellular polysaccharide dermal matrix materials and a production method and application thereof. The acellular polysaccharide dermal matrix materials comprise acellular dermal matrix materials and polysaccharide, wherein the polysaccharide solution is composite solution of carboxymethyl chitosan, chondroitin sulfate and hyaluronic acid. The production method includes: selecting encapsulated and sterilized PADM, weighing, compositing carboxymethyl chitosan, compositing chondroitin sulfate, crosslinking with glutaraldehyde, compositing hyaluronic acid, washing with a PBS buffer solution, encapsulating, sterilizing, and the like. Functional materials can be added into the acellular polysaccharide dermal matrix materials to produce biologic dressings, composite transplant stents and tissue engineering epidermis stents. The acellular polysaccharide dermal matrix materials are good in in-vitro degradability, high in tensile strength, high in water vapor permeability, high in porosity and excellent in antibacterial performance.

The invention relates to a multifunctional nanofiber wound repair biological dressing and a preparation method thereof, and belongs to the technical field of nanofiber materials. The dressing is prepared by a three-needle electrostatic spinning device, macromolecular spinning solution loading different functional substances are placed in a needle A, a needle B and a needle C, and the three needles simultaneously perform spinning to obtain the multifunctional composite nanofiber dressing. The dressing can meet the increasing demand of people for wound repair biological dressings, can effectively achieve various functions of inhibiting scars, eliminating edema, resisting bacteria, preventing infection and the like, and can effectively accelerate wound healing. Besides, the preparation process is simple and easy, and industrial production is easily realized.

The invention discloses a nano silver-porcine acellular dermal matrix (PADM) biological dressing and a preparation method thereof. The biological dressing comprises PADM and nano-silver particles assembled on the PADM, wherein, the content of the nano-silver particles is 435.66-447.66 mu g / g, and the particle size of the nano-silver particles is 55-75nm. The preparation method of the biological dressing comprises the following steps: (1) reducing silver nitrate with trisodium citrate to prepare nano silver solution; (2) carrying out gradient dehydration with alcohol and ultrasonic treatment on the PADM; and (3) placing the treated PADM obtained from the step (2) in the nano silver solution for self-assembly, thus finally obtaining the nano silver-PADM biological dressing. The biological dressing obtained in the invention has the advantages of strong antibacterial property, high biological safety and good tissue compatibility; and simultaneously, the process is simple, and the use is convenient.