84 results about "Bragg peak" patented technology

The present invention provides an increased degree of uniformity of radiation dose distribution for the interior of a diseased part. A particle beam therapy system includes a charged particle beam generation apparatus and an irradiation apparatus. An ion beam is generated by the charged particle beam generation apparatus. The irradiation apparatus exposes a diseased part to the generated ion beam. A scattering device, a range adjustment device, and a Bragg peak spreading device are installed upstream of a first scanning magnet and a second scanning magnet. The scattering device and the range adjustment device are combined together and moved along a beam axis, whereas the Bragg peak spreading device is moved independently along the beam axis. The scattering device moves to adjust the degree of ion beam scattering. The range adjustment device moves to adjust ion beam scatter changes caused by an absorber thickness adjustment. The Bragg peak spreading device moves to adjust ion beam scatter changes arising out of an SOBP device. These adjustments provide uniformity of radiation dose distribution for the diseased part.

A charged particle beam extraction system and method capable of ensuring higher safety when extraction of an ion beam is on / off-controlled during irradiation of the ion beam for treatment. The charged particle beam extraction system comprises a charged particle beam generator including a synchrotron, a range modulation wheel (RMW) for forming a Bragg peak width of a charged particle beam extracted from the charged particle beam generator, a gate signal generator for controlling start and stop of extraction of the charged particle beam from the charged particle beam generator in accordance with a rotational angle of the RMW, and an irradiation control / determination section for determining whether the start and stop of extraction of the charged particle beam is controlled at desired timing by the gate signal generator.

The invention comprises a multi-field charged particle irradiation method and apparatus. Radiation is delivered through an entry point into the tumor and Bragg peak energy is targeted to a distal or far side of the tumor from an ingress point. Delivering Bragg peak energy to the distal side of the tumor from the ingress point is repeated from multiple rotational directions. Preferably, beam intensity is proportional to radiation dose delivery efficiency. Preferably, the charged particle therapy is timed to patient respiration via control of charged particle beam injection, acceleration, extraction, and / or targeting methods and apparatus. Optionally, multi-axis control of the charged particle beam is used simultaneously with the multi-field irradiation. Combined, the system allows multi-field and multi-axis charged particle irradiation of tumors yielding precise and accurate irradiation dosages to a tumor with distribution of harmful irradiation energy about the tumor.

The invention relates to treatment of solid cancers. More particularly, the invention relates to a combined rotation / raster method, referred to as multi-field charged particle cancer therapy. The system uses a fixed orientation proton source relative to a rotating patient to yield tumor irradiation from multiple directions. The system combines layer-wise tumor irradiation from many directions with controlled energy proton irradiation to deliver peak proton beam energy within a selected tumor volume or irradiated slice. Optionally, the selected tumor volume for irradiation from a given angle is a distal portion of the tumor. In this manner ingress Bragg peak energy is circumferentially spread about the tumor minimizing damage to healthy tissue and peak proton energy is efficiently, accurately, and precisely delivered to the tumor.

The invention relates generally to treatment of solid cancers. More particularly, the invention relates to enhancing synchrotron acceleration cycle usage efficiency by adjusting the synchrotron's acceleration cycle to correlate with a patient's respiration rate where efficiency refers to the duty cycle or the percentage of acceleration cycles used to deliver charged particles to the tumor. The system senses patient respiration and controls timing of negative ion beam formation, injection of charged particles into a synchrotron, acceleration of the charged particles, and extraction to yield delivery of the particles to the tumor at a predetermine period of the patient's respiration cycle. Independent control of charged particle energy and intensity is maintained during the timed irradiation therapy. Multi-field irradiation ensures efficient delivery of Bragg peak energy to the tumor while spreading ingress energy about the tumor.

The invention relates to treatment of solid cancers. More particularly, the invention relates to a combined rotation / raster method, referred to as multi-field charged particle cancer therapy. The system uses a fixed orientation proton source relative to a rotating patient to yield tumor irradiation from multiple directions. The system combines layer-wise tumor irradiation from many directions with controlled energy proton irradiation to deliver peak proton beam energy within a selected tumor volume or irradiated slice. Optionally, the selected tumor volume for irradiation from a given angle is a distal portion of the tumor. In this manner ingress Bragg peak energy is circumferentially spread about the tumor minimizing damage to healthy tissue and peak proton energy is efficiently, accurately, and precisely delivered to the tumor.

The invention relates generally to treatment of solid cancers. More particularly, a method and apparatus for efficient radiation dose delivery to a tumor is described. Preferably, radiation is delivered through an entry point into the tumor and Bragg peak energy is targeted to a distal or far side of the tumor from an ingress point. Delivering Bragg peak energy to the distal side of the tumor from the ingress point is repeated from multiple rotational directions. Beam intensity is proportional to radiation dose delivery efficiency. The multi-field irradiation process with energy levels targeting the far side of the tumor from each irradiation direction provides even and efficient charged particle radiation dose delivery to the tumor. Preferably, the charged particle therapy is timed to patient respiration via control of charged particle beam injection, acceleration, extraction, and / or targeting methods and apparatus.

The invention concerns a device and a process for adjusting the range of an ion beam, in particular for irradiation in tumor therapy. For this purpose, first the reference position of a target volume to be irradiated is determined. Subsequently, the range of an ion beam is configured such that said beam is adjusted to the reference position of the target volume, in such a manner that the Bragg peak, i.e. the maximal energy loss and thereby the maximal damage occurs in the region of the target volume which is to be destroyed. In the case that it has been determined that the reference position has been altered by a movement of the target volume, the ion beam is then deflected from the beam axis such that the ion beam is directed to various regions of a range modulator, in order that the ion beam experience a correspondingly adjusted energy loss in passing through the range modulator. This energy loss is adjusted to correspond to the change in position of the target volume in such a manner that the change in position is compensated for by the adjustment of the range of the ion beam, and the Bragg peak is returned to the region within the target volume.

The invention relates generally to treatment of solid cancers. More particularly, a method and apparatus for efficient radiation dose delivery to a tumor is described. Preferably, radiation is delivered through an entry point into the tumor and Bragg peak energy is targeted to a distal or far side of the tumor from an ingress point. Delivering Bragg peak energy to the distal side of the tumor from the ingress point is repeated from multiple rotational directions. Beam intensity is proportional to radiation dose delivery efficiency. The multi-field irradiation process with energy levels targeting the far side of the tumor from each irradiation direction provides even and efficient charged particle radiation dose delivery to the tumor. Preferably, the charged particle therapy is timed to patient respiration via control of charged particle beam injection, acceleration, extraction, and / or targeting methods and apparatus.

An ion radiation therapy machine provides a control of the range of the ion beam that a Bragg peak of the beam is located according to a determined gradient of the dose plan.

A charged particle beam extraction system and method capable of ensuring higher safety when extraction of an ion beam is on / off-controlled during irradiation of the ion beam for treatment. The charged particle beam extraction system comprises a charged particle beam generator including a synchrotron, a range modulation wheel (RMW) for forming a Bragg peak width of a charged particle beam extracted from the charged particle beam generator, a gate signal generator for controlling start and stop of extraction of the charged particle beam from the charged particle beam generator in accordance with a rotational angle of the RMW, and an irradiation control / determination section for determining whether the start and stop of extraction of the charged particle beam is controlled at desired timing by the gate signal generator.

The invention comprises a multi-field charged particle irradiation method and apparatus. Radiation is delivered through an entry point into the tumor and Bragg peak energy is targeted to a distal or far side of the tumor from an ingress point. Delivering Bragg peak energy to the distal side of the tumor from the ingress point is repeated from multiple rotational directions. Preferably, beam intensity is proportional to radiation dose delivery efficiency. Preferably, the charged particle therapy is timed to patient respiration via control of charged particle beam injection, acceleration, extraction, and / or targeting methods and apparatus. Optionally, multi-axis control of the charged particle beam is used simultaneously with the multi-field irradiation. Combined, the system allows multi-field and multi-axis charged particle irradiation of tumors yielding precise and accurate irradiation dosages to a tumor with distribution of harmful irradiation energy about the tumor.

A phantom for heavy ion radiation therapy provides characterization of an ion beam that may enter but not exit from the phantom. The phantom may include multiple materials and multiple spatially dispersed ion detectors to obtain signals that may be fit to known beam curves to accurately characterize the location and other parameters of Bragg peak of a given ion beam within a patient.

Treatment planning methods are provided that determine the variability of relative biological effectiveness (RBE) along a beam line and calculate, among other things, what intensity of hadron beam such as a proton or a carbon ion beam should be applied to achieve a desired biological dose at treatment site of a patient afflicted with a medical condition. Typically, three or four RBE values at three or four corresponding spacially-dispersed intervals along the beam line are calculated. In one embodiment, two RBE values for the spread-out Bragg peak (SOBP) region of the treatment site; one for the proximal section and one for the declining distal section is calculated. A third and different RBE value may be determined for the distal edge region of the SOBP. A fourth value may also be calculated for a pre-SOBP region.

A particle beam treatment device includes an irradiation nozzle which moves a particle beam in a direction which is perpendicular to an advancing direction; a dose monitor which measures the dose of the particle beam; a planning part which sets the irradiation dose applied to a target volume; and a controlling part which controls the irradiation dose applied to a target volume based on irradiation dose set value which is set by a value measured by the dose monitor and the planning part, wherein the planning part stores the absorbed dose distribution data in the depth direction which is prepared in advance using the absorbed dose at the reference depth which is a predetermined position nearer to an incident side of the particle beam than the position of Bragg peak as the reference and calculates the irradiation dose set value using the absorbed dose at the reference depth.

The invention relates to a device and a method for demarcating and calibrating a dose monitoring detector in heavy ion beam cancer treatment. The structure of the device is characterized in that a collimator, the dose monitoring detector, a mini ridge-shaped filter, a water tank and a standard ionization chamber are arranged on a beam flux axis in sequence. The standard ionization chamber is arranged inside the water tank. The depth position of an irradiation beam mini spread-out Bragg peak in water is obtained by measuring absorbed dose of the standard ionization chamber at different depth in aqueous medium. At the depth position, the dose monitoring detector is demarcated and calibrated by the standard ionization chamber so as to obtain demarcating and calibrating factors of the measurement of the dose monitoring detector for the mini spread-out Bragg peak cancer treatment beam with a Gauss arrangement. With the demarcating and calibrating factors, the entire process of three-dimensional conformal irradiation therapy with uniform physical absorption dose or uniform biological effective dose in a tumor target volume can be conveniently controlled, the requirements of the treatment of different clinical cases in practical clinical treatment are satisfied, and the treatment efficiency of a treatment device is improved.

The invention provides a sea surface wind direction extraction method based on a ship-borne high-frequency ground wave beyond visual range radar, belongs to the field of ocean remote sensing, and solves the problems that an existing sea surface wind direction extraction method is small in detection range and has no continuity, and the system is complicated. The sea surface wind direction extraction method comprises the following specific steps: obtaining a first-order sea clutter widening spectrum in a distance door by using a single receiving array element; determining corresponding positive and negative Bragg peak values and a spatial resolution of a sea clutter incidence direction according to a first-order sea clutter space-hour distribute property; obtaining a sea surface wind direction according to the relative strength of the positive and negative Bragg peak values; applying the sea surface wind direction to a resolution unit of each sea area in the distance door and extracting the wind directions of all the sea areas in the distance door; comparing the sea surface wind directions of the resolution units of the adjacent sea areas and eliminating wind direction blurs to obtain the sea surface wind direction of the distance door; and repeating the steps until the sea surface wind directions of all the distance doors are obtained. The sea surface wind direction extraction method based on the ship-borne high-frequency ground wave beyond visual range radar is used for monitoring the sea environment.

A dose calculator for heavy-ion therapy systems uses a limited number of spread out Bragg peak models obtainable by a particular therapy system, the models which may be adjusted in energy (offset) and dose contribution (treatment time) to produce a unique composite dose having a complex dose profile with limited reduced time.

A multi-field cancer therapy apparatus and method of use thereof is described increasing dimensionality of incident tumor treatment angles while minimizing distance between a final beamline focusing magnet and the patient. Increased dimensionality of incident tumor treatment angles is achieved through coordinated use of one or more of: a rotatable targeting magnet; a first patient rotation platform rotating the patient around, without intersecting, a vertical axis; a second patient rotation platform rotating a body part through a movable vertical axis; and patient tilt. The increased charged particle incident angle dimensionality distributes Bragg peak tail energy about the tumor. Dynamic energy and / or intensity control of the charged particle beam as a function of efficiency of beam delivery based on tumor shape further reduces Bragg peak tail energy delivered to healthy tissue about the tumor.

The present invention relates to a collimator for flow pixel proton therapy, comprising an irradiation region for controlling the intensity of protons to be irradiated by directing shapes of various spaces, wherein a plurality of micro-motors arranged at both sides and a plurality of spread panels arranged in the center are connected to each other, one to one, by an elastic reel, relatively far micro-motors and spread panels are connected to each other by a ratio of the same number, and the plurality of spread panels arranged in the center, which are divided in half and moved to both sides by the opposite micro-motors, are allowed, by the micro-motors, to be in a stress release state of being unwound by the elastic reel. A method for manufacturing a damper and a compensator for proton therapy, which have been conventionally manufactured by hand, is provided to use reverse collimation through a collimator, thereby collimating spread panels at a section requiring spread at the Bragg peak, determining the shape of the section and a damping section through a program, and applying the same to tumor treatment.

The invention discloses a method for measuring the water depth of a shallow sea based on a double-frequency high-frequency ground wave radar. According to the method, the water depth of the shallow sea is measured by using the double-frequency high-frequency ground wave radar. Under the condition of shallow water, the water depth influences a sea surface radial flow detection result, and the position of a Bragg peak approaches a zero frequency along with the reduction of the water depth. On the basis of the influence, a new monotone function about the water depth is constructed, and the waterdepth is calculated according to the measurement result of Doppler frequency shift of the sea surface radial flow of the same position by using two working frequencies of the double-frequency high-frequency ground wave radar. The technical scheme provides a new method for detecting the water depth, the double-frequency high-frequency ground wave radar can measure the water depth of the shallow sea during sea dynamic element detection; and the water depth of shallow water with a large area can be detected; and an operation amount is low, and the method is high in accuracy and robustness.

The invention concerns a device and a process for adjusting the range of an ion beam, in particular for irradiation in tumor therapy. For this purpose, first the reference position of a target volume to be irradiated is determined. Subsequently, the range of an ion beam is configured such that said beam is adjusted to the reference position of the target volume, in such a manner that the Bragg peak, i.e. the maximal energy loss and thereby the maximal damage occurs in the region of the target volume which is to be destroyed. In the case that it has been determined that the reference position has been altered by a movement of the target volume, the ion beam is then deflected from the beam axis such that the ion beam is directed to various regions of a range modulator, in order that the ion beam experience a correspondingly adjusted energy loss in passing through the range modulator. This energy loss is adjusted to correspond to the change in position of the target volume in such a manner that the change in position is compensated for by the adjustment of the range of the ion beam, and the Bragg peak is returned to the region within the target volume.

The invention provides a method and system for recognizing a high-band first-order Bragg peak and a split spectrum peak thereof, and relates to a method and system for recognizing a first-order Bragg peak and a split spectrum peak thereof, which solves the problems that a convention method easily generates bad recognition effect of the Bragg peak, low measurement precision and unavailable recognition of the split spectrum peak under complicated clutter / target background and variable marine environment. The method comprises the following steps of: extracting trend features of the first-order Bragg peak by a method for detecting multi-scale filtering and ridge features, recognizing the Bragg peak by combining overall features of amplitude, continuity, symmetry and the like, and recognizing features of a Bragg split spectrum peak caused by severe-shear ocean currents. The system is used for calculating trend information by a trend information extraction module first, constructing a detection band by combining the ocean currents, extracting peak values and recognizing the split spectrum peak by a split spectrum peak recognition module. The method and the system are suitable for obtaining the ocean information in ocean environment sensing, and the process of rejecting ocean clutters in the target detection.

The invention relates to a device used in 3-D conformal radiotherapy to gross tumor volume with heavy ion beams, comprising a magnet scanning system, a beam monitor system, a mini-ridge filter, a range shifter, a multi-leaf collimator and a patient body surface compensator, which are sequentially arranged on the body surface of the patient. The centers of the components and the center of the gross tumor volume are located at the beam axis. The invention overcomes the defects that the conformality is low and the scatterer impairs beam quality in current 2-D conformal radiotherapy by heavy ion beams based on a passive beam flow distribution system, and adopts 3-D conformal irradiation without the scatterer needed in current 2-D conformal radiotherapy, thus improving conformality in the therapy to the gross tumor volume with heavy ion beams. The invention can protect the health organs around the gross tumor volume to the largest extent and reduce incidence of disease at the normal organs without reducing the rate of using large quantity of Bragg peak to efficiently kill the cells in the gross tumor volume, thus improving curative effect of the heavy ion beams.

A charged particle beam irradiation system in which the energy, Bragg peak, and irradiation depth of a charged particle beam, with which a patient is to be irradiated, can be checked in real time just before actual irradiation. Just before the actual irradiation, by providing a high-speed steering magnet with 100% current, a checking beam is intentionally hit into a beam damper. By using a dosimeter and a dose measuring device in front thereof, extraction beam intensity is measured. By using a multi-layer beam monitor, a dose distribution thereof is measured. Accordingly, just before the actual irradiation, the energy, Bragg peak, and irradiation depth of the charged particle beam, with which the patient is to be irradiated, can be checked accurately and in real time. When the beam has a desired dose distribution as a result of checking, continuously, extraction control is performed.

A phantom for heavy ion radiation therapy provides characterization of an ion beam that may enter but not exit from the phantom. The phantom may include multiple materials and multiple spatially dispersed ion detectors to obtain signals that may be fit to known beam curves to accurately characterize the location and other parameters of Bragg peak of a given ion beam within a patient.

Disclosed is a first-order sea clutter detection method based on least squares approximation. The invention relates to a first-order sea clutter detection method, and aims to solve the problem that the found Bragg peak position is inaccurate and the false alarm rate is high in the prior art. The method comprises the following steps: calculating the theoretical Bragg frequency fB based on the working frequency f0 of radar, defining a noise zone on each sea element, and calculating the threshold of each sea element; detecting sea area sea state data according to the radar, determining the maximum radial velocity Vm of ocean current, and calculating the maximum Bragg frequency offset Delta fm; determining a search scope according to Delta fm and fB, determining a suspected point of the Bragg peak, confirming the threshold of the amplitude of the suspected point, and judging whether the current sea element is effective; for the effective sea elements, taking the neighboring points of an appropriate number of suspected points to form a point set, and acquiring the approximation function of the point set using a least squares approximation method; and finally, taking the peak point of the approximation function as a Bragg peak. The first-order sea clutter detection method is applied to the field of high-frequency ground wave radar detection.

A dose calculator for heavy-ion therapy systems uses a limited number of spread out Bragg peak models obtainable by a particular therapy system, the models which may be adjusted in energy (offset) and dose contribution (treatment time) to produce a unique composite dose having a complex dose profile with limited reduced time.

A particle beam treatment device includes an irradiation nozzle which moves a particle beam in a direction which is perpendicular to an advancing direction; a dose monitor which measures the dose of the particle beam; a planning part which sets the irradiation dose applied to a target volume; and a controlling part which controls the irradiation dose applied to a target volume based on irradiation dose set value which is set by a value measured by the dose monitor and the planning part, wherein the planning part stores the absorbed dose distribution data in the depth direction which is prepared in advance using the absorbed dose at the reference depth which is a predetermined position nearer to an incident side of the particle beam than the position of Bragg peak as the reference and calculates the irradiation dose set value using the absorbed dose at the reference depth.

The invention is related to a method and apparatus for verifying the beam range in a target irradiated with a charged hadron beam, such as a proton beam. The beam range is the location of the Bragg peak in the target, being the location where the largest portion of the dose is delivered. The method utilizes a prompt gamma camera provided with a slit-shaped opening, so as to be able to produced a 1-dimensional profile of the dose distribution along the beam line. The camera is mounted with the slit oriented perpendicularly to the beam line. The method comprises the steps of calculating a position of the camera with respect to a target, for a plurality of beam energies and spots to be irradiated. The method further comprises the steps of verifying the beam range for said plurality of spots, and delivering a value representative of the difference between the estimated beam range and the actual beam range. The apparatus of the invention is provided with a positioning module for positioning the camera.