40 results about "Ectopic pregnancy" patented technology

The invention discloses an ectopic pregnancy and pregnant days colloid gold detection agent and manufacturing method thereof used for the problem of fast detection for pregnancy, comprising a piece of detecting test paper and urine sample treatment solution; wherein, the detecting test paper consists of a base plate, a cellulose nitrate membrane, a gold label anti-Beta HCG monoclone antibody layer, an Alpha-HCG monoclone antibody line, a sheep anti-rat polyclonal antibody line, an absorbing pad and a sample pad; the matching composition of the urine sample treatment solution is that: 12.5 to 18.0 portions of disodium hydrogen phosphate dodecahydrate, 1.2 to 1.7 portions of sodium dihydrogen phosphate dihydrate, 40.0 to 48.0 portions of sodium chloride and 4600 to 5300 portions of distilled water; the ectopic pregnancy and pregnant days colloid gold detection agent and manufacturing method of the invention are characterized by fast and simple detection, the operation of blood-drawing detection for 2 to 6 hours can be replaced by 2 to 3 minutes with time-saving, manual-saving and cost-saving; besides, the ectopic pregnancy and pregnant days colloid gold detection agent and manufacturing method thereof have the advantages of detecting ectopic pregnancy and pregnant days in a semiquantitative way, etc., and can be used for external detection of the pregnant condition and artificial abortion and assisted diagnosis.

The present invention relates to a novel method of determining the existence of a normal pregnancy which has a high likelihood of culminating in a term pregnancy, by measuring hyperglycosylated hCG in a pregnant woman and comparing the concentration of measured hyperglycosylated hCG with a predetermined value. A measurement of hyperglycosylated hCG above the predetermined value, for example, about 13 ng / ml, is evidence of a high likelihood of a normal pregnancy. A measurement below the predetermined value is evidence of an abnormal pregnancy (ectopic pregnancy or miscarriage). Further analysis of the patient in the event that the measurement falls below the predetermined value is made by intravaginal or abdominal ultrasound to determine whether or not the pregnancy is ectopic or will likely result in a spontaneous abortion (miscarriage). This point-of-care (POC), over-the-counter (OTC) or professional laboratory application is unexpectedly rapid and highly predictive of pregnancy outcome in women exhibiting symptoms of pregnancy.

The invention relates to a traditional Chinese medicinal composition for treating ectopic pregnancy, which comprises the following raw materials (by weight portion): seed of cowherb 10-30g, sappan wood 6-10g, root of red rooted saliva 10-20g, lycopus 9-12g, achyranthes and cyathula root 10-20g, motherwort 10-20g, Ligusticum wallichii 10-20g, Chinese angelica root 10-30g, atractylodes rhizome 6-10g, bupleurum root 6-12g, cyperus tuber 10-15g, spicebush root 9-15g, curcuma root 9-15g, prepared rhizome of rehmannia 10-30g, spatholobus stem, white mustard seed 10-15g, poria cocos wolf 10-20g, root of herbaceous peony 10-30g, licorice root 6-10g.

The present invention relates to methods for determining a risk or identifying a condition associated with the presence of ectopic pregnancy in a subject as well as testing a candidate compound for a therapeutic activity against an ectopic pregnancy and sorting patients based on the risk of having ectopic pregnancy. Specifically, the methods utilize novel marker proteins for assessing the risk of the patient having ectopic pregnancy.

A method for determining the likelihood of an ectopic pregnancy and spontaneous miscarriage is described, by measuring the levels of markers, especially hCG and CA-125 which have been found to be characteristic of these conditions. Preferably measuring these biomarker levels at earliest possible presentation of patients with general clinical5 symptoms and applying cut-off values described determines the likelihood of an ectopic pregnancy and spontaneous miscarriage.

The invention relates to a traditional Chinese medicine prescription for treating ectopic pregnancy, which is composed of the following traditional Chinese medicines in weight: 10g of red peony root, 10g of peach kernel, 15g of root of red rooted salvia, 10-15g of root-bark of peony, 10g of pollen typhae, 10g of trogopterus dung, 10g of frankincense, 10g of myrrh, 10g of burreed tuber, 10g of curcuma zedoary, 10g of rhizoma corydalis, 10g of white atractylodes rhizome, 15-30g of trichosanthes root, 10-15g of fruit of princesplume ladysthumb and 1 or 2 centipedes. The traditional Chinese medicines are decocted by a decocting machine and the decoction is bottled with 250 ml per bottle. The method for taking the medicine is as follows: one bottle of medicine is taken in a warm way respectively after breakfast and supper, a course of treatment lasts for 7 days, and ectopic pregnancy can be cured after 5-7 courses of treatment. The traditional Chinese medicine prescription for treating ectopic pregnancy has rich medicine sources, low price and no toxic side effects, treats both principal and secondary aspects of disease, and is an effective medicine for conservative treatment of ectopic pregnancy.

The present invention concerns methods of identifying extra-uterine (or ectopic) pregnancies and involves the screening of samples for the presence of certain molecules now known to be markers of extra-uterine pregnancies. The present invention provides a method for identifying an ectopic pregnancy, said method comprising the steps of: (a) providing a sample from a subject; (b) identifying a level of one or more of: (i) inhibin / activin BETA b subunit gene (ii) activin B (iii) cysteine-rich secretory protein 3 (CRISP-3); and / or (iv) carboxypeptidase-B1 (CPB1) (v) SLP1 (vi) elafin (vii) prolactin in the sample, wherein the level of inhibin / activin BETA b subunit gene, activin B, CRISP-3, SLP1, elafin, prolactin and / or CPB1 is associated with, or indicative of, an ectopic pregnancy.

The present invention relates to a method, based on the hormone Inhibin-A, of diagnosing, screening and differentiating between normal pregnancies and abnormal pregnancies. The method can be used to differentiate between viable and non-viable pregnancies. Particularly, Inhibin-A can also be used in a method and kit for the diagnosis of ectopic pregnancy.

The invention provides a human chorionic gonadotropin semi-quantitative detection test paper and a preparation method thereof. The test paper adopts a non-mouse free [beta] antibody to ensure that the concentration detection range is wider; in addition, the test paper is provided with at least three test strips, the concentration in a wider range can be subjected in semi-quantitative determination by determining whether the detection lines of the test strips develop color or not, the subjective determination of the color depth is not needed, and the determined concentration range is more accurate. The invention also provides a reagent cup containing the test paper. The reagent cup is convenient and sanitary to use, and is suitable for on-site, instant and rapid detection. The invention also provides the application of the test paper and the reagent cup in detecting human pregnancy cycle, ectopic pregnancy, abortion and trophoblastic lesion.

The invention pertains to methods for treating ectopic pregnancy. More particularly, the present invention relates to methods for treating unruptured ectopic pregnancy using a non-surgical method comprising the administration of an EGFR inhibitor alone or in combination with an anti-metabolite e.g. methotrexate (MTX). The methodology is potentially applicable to treatment of unruptured ectopic pregnancies of all sizes.

The invention discloses a traditional Chinese medicine for treating ectopic pregnancy. The traditional Chinese medicine for treating the ectopic pregnancy is prepared from the following medicines in parts by weight: 3-8 parts of leech, 3-8 parts of gadfly, 25-35 parts of Ligusticum wallichii, 5-10 parts of liquorice, 20-30 parts of sea-buckthorn, 15-25 parts of moutan bark, and 15-25 parts of red paeonia. The traditional Chinese medicine has the functions of removing heat to cool blood, activating blood to remove stasis, removing blood stasis and lumps and tonifying spleen and qi.

A method for determining the likelihood of an ectopic pregnancy and spontaneous miscarriage is described, by measuring the levels of markers, especially hCG and CA-125 which have been found to be characteristic of these conditions. Preferably measuring these biomarker levels at earliest possible presentation of patients with general clinical symptoms and applying cut-off values described determines the likelihood of an ectopic pregnancy and spontaneous miscarriage.

The invention relates to an orally taken medicine for treating an old ectopic pregnancy and a preparation method thereof. The orally taken medicine comprises the following components in part by weight: 1-3 parts of safflower, 1-3 parts of salvia miltiorrhiza, 1-3 parts of radix paeoniae rubra, 1-3 parts of radix aucklandiae, 1-3 parts of ligusticum wallichii, 1-3 parts of peach kernel, 1-3 parts of rhizoma corydalis, 1-3 parts of shixiao powder, and 1-3 parts of raw cassia twig. The preparation method of the medicine comprises the following steps: selecting high-quality, clean and first-grade safflower, salvia miltiorrhiza, radix paeoniae rubra, radix aucklandiae, ligusticum wallichii, peach kernel, rhizoma corydalis, shixiao powder and raw cassia twig, and smashing the various drugs into particles for standby application; putting the smashed granular drugs into a cloth bag, tying the opening of the cloth bag, soaking the cloth bag with the smashed granular drugs in clean water for about 30 minutes on the premise that water permeates the drug tissue, further, placing the soaked drugs and clarified liquor for soaking the drugs into a drug decocting machine, pouring cooled boiled water of which the water surface is 35 mm higher than the drugs into the drug decocting machine for carrying out primary decoction for 30 minutes, filtering away drug liquor, pouring lukewarm cooled boiled water again for carrying out secondary decoction for 25 minutes, mixing the drug liquors, concentrating the mixed drug liquor into 1620 ml of 50% traditional Chinese medicine liquor, bagging, sealing, and then, placing the traditional Chinese medicine liquor in a refrigerator for preservation for standby application.

The invention discloses a screening method for differentially expressed proteins of heterotopic-pregnancy and non-pregnancy decidua tissue. The method is characterized by comprising the following steps: carrying out proteomics analysis to discover specific proteins and differential proteins of heterotopic-pregnancy and non-pregnancy decidua tissue; subjecting the specific proteins and differential proteins to separation and purification; and using the purified specific proteins and differential proteins as special biological markers for discrimination of intrauterine and extrauterine pregnancy. After pregnancy, specific proteins can be synthesized in the bodies of both a mother and a fetus. Detection of the specific proteins with different methods is beneficial for diagnosis of pregnancy. Searching for a special marker for pregnancy, especially for distinguishing intrauterine and extrauterine pregnancy, is of critical significance to determination of clinical medical liabilities and medical jurisprudence and is a great breakthrough to the basic theory of medical science.

The invention relates to an application of Calponin-h2 (CNN2) as a marker for diagnosing ectopic pregnancy. The invention discloses for the first time that CNN2 can be used as a specific serum markerfor early diagnosis of ectopic pregnancy, and has good sensitivity and specificity. The application of CNN2 in the auxiliary diagnosis of ectopic pregnancy can promote the timeliness and accuracy of diagnosis and effectively improve the early diagnosis rate of ectopic pregnancy.

The invention discloses a traditional Chinese medicine for treating ectopic pregnancy. The traditional Chinese medicine consists of the following raw material components in parts by weight: 6-8 parts of lignum sappan, 10-20 parts of radix achyranthis bidentatae, 10-25 parts of radix linderae, 15-25 parts of semen brassicae, 20-40 parts of poria, 10-30 parts of rhizoma ligustici wallichii, 10-16 parts of rhizoma sparganii, 6-12 parts of myrrh, 6-12 parts of radix trichosanthis, 6-18 parts of peach kernel, 5-10 parts of rhizoma corydalis, 12-18 parts of herba polygalae japonicae, 5-12 parts of hirudo, 6-18 parts of pangolin scales, 6-12 parts of herba cynomorii, 10-20 parts of radix polygalae, 20-40 parts of liquorice root and 30-50 parts of radix arnebiae seu lithospermi. The traditional Chinese medicine disclosed by the invention is good in effect, safe and free from side effects, convenient to take and low in production cost; and the traditional Chinese medicine, which is capable of promoting blood circulation and removing blood stasis, tonifying qi and preventing exhaustion and capable of treating both symptoms and root causes, is an ideal medicine for treating the ectopic pregnancy.

The invention discloses a medicinal composition for treating ectopic pregnancy and a preparation method thereof. The medicinal composition is prepared from the following main medicinal materials and auxiliaries in parts by weight: 50-80 parts of radices trichosanthis, 100-160 parts of rhizoma atractylodis macrocephalae, 50-80 parts of centipede, 60-96 parts of scorpion, 60-96 parts of ground beetle, 60-96 parts of madder, 60-96 parts of rhizoma sparganii, 40-64 parts of curcuma zedoary, 40-64 parts of astragalus membranaceus, 40-64 parts of lithospermum, 50-80 parts of immature bitter orange and 50-80 parts of liquorice. The medicament for treating ectopic pregnancy, prepared by the extraction method is simple in extraction process steps, is suitable for industrial production, has the advantages of high content of effective components, remarkable curative effect, good effect, safety, no side effect and low production cost, is convenient to take, and is an ideal medicine for activating blood to remove stasis, tonifying qi and preventing exhaustion, and treating both symptoms and root causes of ectopic pregnancy.

The invention discloses a method for reducing an ectopic pregnancy occurrence rate of test-tube baby patients by virtue of elective embryo transfer. The method comprises the following steps: detecting the content of interleukin-8 (IL-8) in a specimen by using a liquid chip high-throughput protein analysis technique (LHTPA); performing elective embryo transfer according to a morphological evaluation method and the content of the interleukin-8 (IL-8) in the specimen, and transferring an embryo of which the IL-8 is negative in the culture solution, that is, the IL-8 concentration in the culture solution is less than 0.19pg / ml; screening to-be-transferred embryos for transferring on the same day of embryo transfer by using the method if the operating time of collecting the specimen and detecting the IL-8 is 4-6 hours, wherein the ectopic pregnancy occurrence rate after embryo transfer by using the negative IL-8 in the human embryo culture solution before transfer is 1.10%, while the ectopic pregnancy occurrence rate after embryo transfer by using positive IL-8 is 10.34%. Therefore, the elective embryo transfer is performed by using the method, so that the ectopic pregnancy occurrence rate can be obviously reduced, and an occurrence rate of maternal complications during early pregnancy and a maternal death rate are further reduced.

The invention discloses a traditional Chinese medicine composition for treating ectopic pregnancy. The ectopic pregnancy is caused by embryo ectopia and has the adverse effects of obstruction of qi and blood circulation and embryo growth, stasis generation, vein disrepair, failure of blood to circulate in the vessels, blood overflow to the lateral lower abdomen, abdominal pain because of blood stasis and hemorrhage bleeding symptom because of violent vaginal bleeding traumata. Therefore, the traditional Chinese medicines including cycas revoluta flower, Indian rorippa herb, urena roots, polygonum criopolitanum, marigold, Chinese elder herb, wild groundnut seeds, allium macrostemon, butterbur, honey-fried licorice roots, roots of unarmed glorybower and honeysuckle stems which have the effects of promoting blood circulation to remove blood stasis, removing heat to cool blood, eliminating disease and killing fetus, tonifying middle-jiao and qi as well as resisting bacteria and detoxifying are selected to be prepared into a decoction. Clinical tests prove that the traditional Chinese medicine composition has the total efficiency of 97.0%.

The invention pertains to methods for treating ectopic pregnancy. More particularly, the present invention relates to methods for treating unruptured ectopic pregnancy using a non-surgical method comprising the administration of an EGFR inhibitor alone or in combination with an anti-metabolite e.g. methotrexate (MTX). The methodology is potentially applicable to treatment of unruptured ectopic pregnancies of all sizes.

A novel therapeutic agent for ectopic pregnancy having a therapeutic effect for ectopic pregnancy, especially unruptured ectopic pregnancy, and a novel method of screening a therapeutic agent for ectopic pregnancy are disclosed. The therapeutic agent for ectopic pregnancy contains as an effective ingredient a suppressor of brain-derived neurotrophic factor (BDNF) and / or of brain-derived neurotrophic factor receptor (TrkB). The method of screening a therapeutic agent for ectopic pregnancy includes measuring the kinase activity of TrkB in the presence of a test substance and the kinase activity of TrkB in the absence of the test substance; and selecting the test substance which decreases the kinase activity of TrkB.

The invention relates to a Nutritional digestive juice for chlamydia neutralization, in particular to a prescription of a cell culture medium used when a urethritis patient needs the examination of the chlamydia cell culture after using a large amount of clinical antibiotics and a preparation method of the cell culture medium. The genital tract chlamydia trachomatis infection is one of the most common diseases which are sexually transmitted. Chlamydia trachomatis is also regarded as the important cause of the pelvic inflammatory disease and the sequelae (tubal infertility and ectopic pregnancy) thereof. The chlamydia cell culture method is the most sensitive and the most reliable method used for examining the chlamydia. The culture medium can detect out the positive result of the genital tract chlamydia after the large amount of clinical antibiotics is used, thereby having the function of the clinical diagnosis guidance and the clinical treatment and the important meaning of preventing the abuse of the antibacterial drugs.

The invention discloses a Chinese herbal medicine for treating ectopic pregnancy, which is characterized by consisting of the following components in part by weight: 25 to 35 parts of root of red-rooted salvia, 25 to 35 parts of Chinese angelica, 25 to 35 parts of ginseng, 15 to 25 parts of frankincense, 15 to 25 parts of myrrh, 15 to 25 parts of peach seed, 25 to 35 parts of astragalus, 15 to 25 parts of notoginseng root, 15 to 25 parts of twotooth achyranthes root, 5 to 15 parts of common burreed rhizome, 5 to 15 parts of zedoary and 15 to 25 parts of red paeony root. A method for preparing the Chinese herbal medicine comprises the following steps of: adding 1,000 parts of water to boil in a casserole, decocting the components over slow fire, uniformly mixing three-time boiled supernatant, filtering and bottling, and sterilizing at a high temperature for later use. In the Chinese herbal medicine, the root of red-rooted salvia is taken as a monarch medicament, the Chinese angelica and ginseng are taken as ministerial medicaments, the frankincense, myrrh, peach seed and astragalus are taken as adjuvant medicaments, and the notoginseng root, twotooth achyranthes root, common burreed rhizome, zedoary and red paeony root are taken as conductant medicaments. A Chinese herbal medicinal composition for treating the ectopic pregnancy has the advantages of good effect, no side effect and low production cost, and is an ideal medicament for activating blood circulation and eliminating stasis, tonifying qi and preventing exhaustion and treating both symptoms and root causes of the ectopic pregnancy.

A pregnancy monitoring device and method improve detection in the first trimester of the occurrence of ectopic pregnancy and the occurrence of multiple foetuses. The device includes a sample absorbing member and an analyser to analyse a plurality of sequential a biological liquid samples and computing means to determine an ovulation date and deviations in the measured quantity of hCG from predetermined values which are indicators of ectopic pregnancy or multiple pregnancy. The device and method enables early detection of ectopic pregnancy or multiple pregnancy.

The invention provides a traditional Chinese medicine for treating ectopic pregnancy and a preparation method. The traditional Chinese medicine comprises the following raw medical materials: dianthus superbus, rhizome of common lophantherum, leaf of belgaum walnut, whole herb of lindernia ciliate, winged euonymus twig, calophyllum inophyllum, salvia, root of torpedograss, whole herb of glossogyne tenuifolia, vernonia cinerea, scutellaria indica and whole herb of viola japonica. The traditional Chinese medicine has an exact curative effect on ectopic pregnancy, has no toxic or side effects and has fewer adverse reactions.

A one-step diagnostic device for simultaneously detecting and distinguishing between a normal pregnancy and an ectopic pregnancy and methods for preparing the device are disclosed. Utilizing the device and principles of the present invention, normal pregnancy and ectopic pregnancy can be rapidly and accurately determined at an early stage by immunologically detecting the morphological differences between human chorionic gonadotropin (hCG) and modified forms thereof, which are secreted into the body fluid of a pregnant female.

A traditional Chinese medicine formula for treating early-stage ectopic pregnancy. The formula is characterized by comprising the following components: 10 g of mung bean, 10 g of hawthorn, 10 g of radix salviae miltiorrhizae, 10 g of rhizoma zedoariae, 10 g of cowherb seed, 10 g of forsythia, 8 g of dragon's blood, 8 g of caulis lonicerae, 8 g of teasel root, 5 g of pangolin, 3 g of unprocessed Radix Aconiti, and one centipede. A method is as below: the medicines are decocted with water, and one dosage should be taken in three times in one day. The formula solves the of lack of cure to early-stage ectopic pregnancy and the problems of slow effectiveness, poor effect, aggravation of the conditions in the case of late treatment in the existing traditional Chinese medicine formula for treating ectopic pregnancy, and is applicable to ectopic pregnancy caused by qi deficiency in spleen and kidney and weak constitution.

The invention discloses a traditional Chinese medicine composition for treating ectopic pregnancy, wherein the medicine raw materials and the weight ratio are as follows: 10-30 parts of salvia miltiorrhiza, 10-20 parts of angelica, 5-15 parts of curcuma, 10-20 parts of coix seed, comfrey 10‑20 parts, 5‑15 parts of red peony, 10‑20 parts of red vine, 10‑20 parts of safflower, 5‑15 parts of orange peel, 10‑20 parts of Achyranthes bidentata, 10‑20 parts of curcuma, 10‑20 parts of peony bark 10-20 parts of Hedyotis diffusa, 10-20 parts of Amethyst, 5-15 parts of Zhuru, 10-20 parts of Rhubarb, 10-20 parts of Kelp, 10-20 parts of Podophyllum, 5-15 parts of Licorice. The traditional Chinese medicine composition of the invention has the effects of eliminating symptoms and blood stasis, promoting qi and relieving pain, and has remarkable curative effect and reliable effect on treating ectopic pregnancy.