66 results about "Hyperbranched polyglycerol" patented technology

The invention discloses application of hyperbranched polyglycerol modified magnetic nanoparticle microspheres in chemiluminescence immune assay. By utilizing the hyperbranched polyglycerol modified magnetic nanoparticle microspheres, a nanometer microsphere material of which the surface is hydrophilic and which is enriched in functional groups is prepared. When a chemiluminescence diagnostic agent based on the hyperbranched polyglycerol modified magnetic nanoparticle microspheres is actually used, the reagent can well inhibit nonspecific adsorption of proteins, and the antibody coupling amount is 2-3 times higher than that of commercial magnetic microspheres. In the project-based performance analysis, the diagnostic agent based on the magnetic microspheres can greatly enhance the reaction between antigens and antibodies. When the reagent is compared with a commercial magnetic microsphere reagent, the sensitivity is improved by 4-5 times, and the upper detection limit is improved by 1.3 times, so that the detection range is improved by nearly 6.5 times.

The present invention concerns a process for producing hyperbranched, dendritic polyglycerol from glycerol comprising the following steps: (a) adding in a vessel glycerol and a CaO-based catalyst, (b) flushing an inert gas, preferably carbon dioxide, to the resulting mixture and hermetically closing the reaction vessel, allowing pressure to build up from 1 to 10 bar above atmospheric, preferably from 2 to 6 bar; (c) heating the reaction mixture at a reaction temperature of at least 100 DEG C and below its boiling point; (d) maintaining the reaction conditions until at least 40 wt.% of glycerol is polycondensed and converted into hyperbranched polyglycerol, with concomitant water formation,, (e) separating the dendritic polyglycerol from other components present in the mixture; such as water, catalyst and reaction by-products such as hydroxyacids and glycerol carbonate esters obtained by condensation of deprotonated glycerol and carbon dioxide as well as minor amounts of cyclic compounds. (i) characterized in that, the calcium based catalyst is nanostructured calcium oxide in the form of a powder of mean particle size smaller than 100 nm measured according to ASTM D4464

A delivery system using materials that form a liquogel or nanocarrier are described. The delivery system comprises hyperbranched polyglycerols (HPGs). The delivery system can include a drug or therapeutic agent and this system can be used to administer the drug or therapeutic agent locally. The delivery system provides for controlled release of the drug or therapeutic agent.

Core-shell particles and methods of making and using thereof are described herein. The core is formed of or contains one or more hydrophobic materials or more hydrophobic materials. The shell is formed of or contains hyperbranched polyglycerol (HPG). The HPG coating can be modified to adjust the properties of the particles. Unmodified HPG coatings impart stealth properties to the particles which resist non-specific protein absorption and increase circulation in the blood. The hydroxyl groups on the HPG coating can be chemically modified to form functional groups that react with functional groups and adhere the particles to tissue, cells, or extracellular materials, such as proteins.

The invention discloses an application of a hyperbranched polyglycerol modified nanosphere to immunochromatography. In the application of the hyperbranched polyglycerol modified nanosphere to immunochromatography disclosed by the invention, a hydrophilic hyperbranched modified nanosphere material rich in functional groups is prepared by means of the hydrophilic performance of hyperbranched polyglycerol, and an immunochromatographic test strip of hyperbranched polyglycerol modified nanosphere is prepared in combination with dry immunochromatography. In practical application, when the test strip established by the system disclosed by the invention is applied to disease detection, compared with a common microsphere test strip, the test strip is stronger in sensitivity, wide in detection range and excellent in performance, and correlation, repeatability and stability satisfy the production requirements.

The invention discloses hyperbranched polyglycerol modified latex microsphere enhanced immunoturbidimetry and an application thereof. A latex microsphere material which is hydrophilic on surface and is rich in functional groups is prepared by using the hyperbranched polyglycerol modified latex microspheres. In actual use, when an immunoturbidimetric reagent of the hyperbranched polyglycerol modified latex microspheres is used, the reagent can be used for inhibiting nonspecific adsorption of proteins well and the antibody coupling rate is further higher than that of common commercialized latex microspheres. In project performance analysis, the latex microsphere reagent can be used for greatly enhancing reaction between antigens and antibodies. Compared with common commercialized latex microsphere reagents, the latex microsphere reagent has the advantages that the sensitivity and detection range are obviously improved and the hyperbranched polyglycerol modified latex microsphere enhanced immunoturbidimetry has excellent performances of relevance, stability and repeatability.

A method of improving heart function in a subject, the method comprising administering an effective amount of a hyperbranched polyglycerol to a subject. The improvement in heart function may include one or more of an increase in myocardial contractile function, reduced or absent fibrosis, an increase in mechanical efficiency of the heart, an increase in ejection fraction, an increase in glucose oxidation or a decrease in fatty acid oxidation, as determined by conventional methods known in the art.

The invention discloses a hydrocarbon fuel composition with high heat sink. The hydrocarbon fuel is composed of the following raw materials in weight percentage: 100% of a hydrocarbon fuel and 0.01%-5% of HPG-C16. The invention discloses a novel hydrocarbon fuel composition, HPG-C16 (cetyl grafted hyperbranched polyglycerol) is used as an initiator to promote the cracking degree of hydrocarbon fuel, enhance heat sink of the hydrocarbon fuel, improve the heat absorption capacity of the hydrocarbon fuel, and proposes a novel development direction for the application of HPG-C16.

Core-shell particles and methods of making and using thereof are described herein. The core is formed of or contains one or more hydrophobic materials or more hydrophobic materials. The shell is formed of or contains hyperbranched polyglycerol (HPG). The HPG coating can be modified to adjust the properties of the particles. Unmodified HPG coatings impart stealth properties to the particles which resist non-specific protein absorption and increase circulation in the blood. The hydroxyl groups on the HPG coating can be chemically modified to form functional groups that react with functional groups and adhere the particles to tissue, cells, or extracellular materials, such as proteins.

The invention discloses a hyperbranched star-shaped polyion liquid as well as a preparation method and an application thereof. The hyperbranched star-shaped polyion liquid takes hyperbranched polyglycerol as the core and a polyion liquid as the arm and is prepared as follows: firstly, hyperbranched polyglycerol and a chain transfer agent 2-(butyl trithiocarbonate)-2-methylpropinate are subjected to a condensation reaction, a macromolecular chain transfer agent is synthesized, then, the macromolecular chain transfer agent is used for initiating RAFT polymerization of a 4-halogenated methyl styrene monomer, a hyperbranched star-shaped copolymer is obtained, finally, the hyperbranched star-shaped copolymer and a nitrogen-containing heterocyclic compound react, and the hyperbranched star-shaped polyion liquid is synthesized. The hyperbranched star-shaped polyion liquid is used as a reductant and a stabilizer during preparation of gold nanoparticles, and the gold nanoparticles with good stability and uniform particle size distribution are prepared under the mild condition.

An aqueous heat treatment liquid composition exhibiting a favorable rust resistance with a high cooling capability and a high uneven-cooling resistance is provided. The aqueous heat treatment liquid composition contains a hyperbranched polyglycerol. A mass average absolute molecular weight of the aqueous heat treatment liquid composition is preferably in a range of 5,000 to 500,000. When the aqueous heat treatment liquid composition is used for quenching of a metallic component, the aqueous heat treatment liquid composition can exhibit a favorable rust resistance with a high cooling capability and a high uneven-cooling resistance.

The invention relates to a modified latex immunonephelometry kit for improving a detection rate of pathogenic strain antibodies of helicobacter pylori. The kit is formed by a reagent 1, a reagent 2, a calibration product, a low-value quality control product and a high-value quality control product which are placed. Through the identification and classification of the helicobacter pylori strains in the earlier stage, the detection rate of the pathogenic strains is improved. In the antigen coating process, 4-(4,6-dimethoxytriazine-2-yl)-4-methylmorpholine hydrochloride (DMTMM) is selected as a cross-linking agent for binding of latex microspheres decorated by hyperbranched polyglycerol and antigens, coupling antigen conformation is protected by using the hydrophilic property of the hyperbranched polyglycerol while the coupling efficiency is increased, and the specific binding of the antigens and the antibodies is improved. In the preparation process of the reagents, a novel surfactant of decyl polyglucoside is selected for effectively improving the scavenging activity of reagent lipid impurities and protein impurities under the combined action with other active agents, stabilizers, protective agents and preservatives.

The invention discloses a concrete air entraining agent with good foam stability. Characterized in that it is characterized in that it comprises, the feed additive is prepared from the following raw materials in parts by weight: 20 to 30 parts of a rosin-based hyperbranched surfactant, 5 to 10 parts of 1,4-cyclohexanedimethanol bis(3,4-epoxycyclohexaneformic acid)ester / 4,4-cyclohexanedimethanol bis(3,4-epoxycyclohexaneformic acid) ester, 0.1 to 1.5 parts of phytolaccaside C, 5 to 10 parts of 2-acrylic-hexahydro-4,7-methylene-1H-indenyl ester / 2-hydroxy-3-butenyl glucosinolate / vinyltrimethoxysilane / polyethylene glycol monoallyl ether copolymer, 8 to 15 parts of hyperbranched polyglycerol and 70 to 90 parts of water. The invention also discloses a preparation method of the concrete air entraining agent. The concrete air entraining agent disclosed by the invention is good in air entraining effect, good in compounding property with other additives and high in adaptability to concrete, and can effectively improve the bubble stability of fresh concrete, remarkably improve the strength of the concrete and improve the workability, durability and freezing resistance of the concrete.

The invention discloses an umbilical cord preservation fluid and an umbilical cord preservation method. The umbilical cord preservation fluid is prepared from 15-20 mmol of hyperbranched polyglycerol,99-101 mmol of lacturonic acid, 24-26 mmol of monopotassium phosphate, 4-6 mmol of magnesium sulfate, 4-6 mmol of adenosine, 2-4 mmol of glutathione reduction type, 6-10 mg of dexamethasone, 0.5-1.5mmol of allopurinol, 50-70 mmol of sucrose, 40-60 g of dextran, 18-22 mg of verapamil, 4-6 ml of sodium hydroxide and 19-21 ml of potassium hydroxide. When an umbilical cord is preserved , the cleanedumbilical cord is cut into small sections with the length of 3-5 cm, then immersed into a preservation liquid and preserved in an environment with the temperature of 3-5 DEG C. By adopting the preservation liquid, the problem that the umbilical cord cannot be preserved for a long time after being isolated can be effectively solved.

The invention discloses a polymer oil-displacing agent based on a fluorine-containing hyperbranched multi-arm polyacrylamide polymer and application of the fluorine-containing hyperbranched multi-arm polyacrylamide polymer in the polymer oil-displacing agent. The structural formula of the fluorine-containing hyperbranched multi-arm polyacrylamide polymer is as shown in the formula I, wherein a core A is hyperbranched polyglycerol with end groups containing hydroxyls; an arm B is a copolymer formed by acrylamide, sodium acrylate, a fluorine-containing hydrophobic monomer and a zwitter-ion choline base functional monomer; in the copolymer, a polyacrylamide chain segment, a sodium polyacrylate chain segment, a poly-fluorine-containing hydrophobic chain segment and a poly-zwitter-ion choline chain segment are sequentially connected, and the other end of the polyacrylamide chain segment is grafted to the core A. By virtue of the three-dimensional spherical hyperbranched multi-arm structure and fluorine-containing chain segment of the fluorine-containing hyperbranched multi-arm polyacrylamide polymer, the anti-shear performance of the polymer can be improved, and the polymer is endowed with favorable anti-salt performance due to a zwitter-ion choline base functional chain segment.

The invention discloses a preparation method of a fluorine-containing hyperbranched multi-arm polyacrylamide polymer. The method includes the following steps that 1, hyperbranched polyglycerol with terminal groups containing hydroxyl reacts with a redox initiator under an inert atmosphere, and reaction liquor 1 is obtained; 2, acrylamide monomers, sodium acrylate monomers, fluorine-containing hydrophobic monomers and zwitter-ion choline functional monomers are sequentially and slowly added into the reaction liquor 1 for a graft copolymerization reaction, and the polymer is obtained. The structural formula of the fluorine-containing hyperbranched multi-arm polyacrylamide polymer is shown as the formula I. The shear resistance of the fluorine-containing hyperbranched multi-arm polyacrylamide polymer can be improved due to the three-dimensional spherical hyperbranched multi-arm structure and the fluorine-containing hydrophobic chain segment of the polymer, and the polymer has good salt resistance due to the zwitter-ion choline functional chain segment. The preparation method is simple, aqueous-phase synthesis is adopted, conditions are mild, safety is guaranteed without toxicity, and a series of products can be prepared.

The present invention relates to a highly water-dispersible hyperbranched polyglycerol surface-modified graphene preparation method, which comprises: 1) mixing graphite oxide and glycidol, and carrying out ultrasonic dispersion; 2) pouring the dispersion liquid into a flask, heating and stirring so as to initiate a glycidol ring-opening polymerization reaction, cooling the obtained colloidal solution to a room temperature, re-dispersing, carrying out an ultrasound treatment, adding acetone, standing, precipitating a black solid from the solution, removing the supernatant to obtain the black solid, repeatedly performing three times, and carrying out vacuum drying to obtain black powder; and 3) dispersing the black powder, carrying out water bath ultrasound, adding a reducing agent to the dispersion liquid at a room temperature, stirring, carrying out dialysis, carrying out centrifugation, and carrying out freeze-drying on the precipitate so as to obtain the finished product. Compared with the method in the prior art, the method of the present invention has the following beneficial effects that (1) the operation is simple, green, and non-toxic; (2) the ring-opening polymerization of the reactant glycidol is easily achieved; and (3) the graphene water-dispersibility is improved.

This invention provides the use of a polymer comprising a hyperbranched polyether polyol such as hyperbranched polyglycerol as a serum albumin substitute. Also provided are high molecular weight hyperbranched polyglycerol polymers suitable for a variety of medical and non-medical uses including methods for making such high molecular weight polymers.

The invention discloses a hyperbranched polyglycerol ester bio-based plasticizer for polylactic acid (PLA) and a preparation method thereof, and belongs to the technical field of preparation of bio-based plasticizers. The hyperbranched polyglycerol ester plasticizer is obtained by taking bio-based glycerol as a raw material through the preparation of polyglycerol, the preparation of hyperbranchedpolyglycerol and the preparation reaction of hyperbranched polyglycerol ester. The preparation process is simple and feasible, the raw materials are low in price, non-toxic, environment-friendly, safeand stable, the prepared plasticizer has good compatibility with polylactic acid, and the processability, tensile strength and mechanical properties are remarkably improved.

A process for producing hyperbranched, dendritic polyglycerol from glycerol comprising the steps of adding in a vessel glycerol and a CaO-based catalyst, flushing an inert gas to the resulting mixture and hermetically closing the reaction vessel, allowing pressure to build up from 1 to 10 bar above atmospheric, and heating the reaction mixture at a reaction temperature of at least 100° C. and below its boiling point. The process further comprising the steps of maintaining the reaction conditions until at least 40 wt. % of glycerol is polycondensed and converted into hyperbranched polyglycerol, with concomitant water formation, and separating the dendritic polyglycerol from other components in the mixture. The calcium based catalyst is nanostructured calcium oxide in the form of a powder of mean particle size smaller than 100 nm measured according to ASTM D4464.

The invention discloses a cyclodextrin hyperbranched derivative and a preparation method thereof. The preparation method comprises the steps: with cyclodextrin as a starting raw material, carrying outring-opening reaction on glycidyl under the alkaline condition so as to prepare cyclodextrin grafted hyperbranched polyglycerol; then reacting the cyclodextrin grafted hyperbranched polyglycerol withepoxy chloropropane to obtain cyclodextrin grafted hyperbranched polyglycerol glycidyl ether; and finally, grafting epoxy groups on hyperbranched polyglycerol glycidyl ether molecules by utilizing molecular ring-opening cyclodextrin with primary amine or secondary amine groups to obtain the cyclodextrin hyperbranched derivative. According to the preparation method, epoxy groups are modified on cyclodextrin hyperbranched polyglycerol, and then amino ring-opening epoxy groups on micromolecular amine are used for performing micromolecular amine modification, so that the cationic property of amino is retained; meanwhile, hydroxyl is generated by epoxy ring opening, so that the hydrophilicity of the final cyclodextrin hyperbranched derivative is ensured.

A hyperbranched polyglycerol is employed as a process stabilization aid of pregnant liquor of a Bayer process of producing alumina from bauxite. The hyperbranched polyglycerol has a molecular weight of from about 1,000 to about 1,000,000.

Provided are an ink composition for bioprinting and a hydrogel formed therefrom, wherein the ink composition: a monomer or macromer having a photocurable functional group; and acrylic hyperbranched polyglycerol (AHPG).

The invention discloses a wound care spray. The spray is characterized by being prepared from the following raw materials in parts by weight: 6-12 parts of borneol modified hyperbranched polyglycerol,5-10 parts of a water-soluble chitosan quaternary ammonium salt, 1-4 parts of plant polysaccharides, 0.5-2.5 parts of vitamins, 0.1-0.4 part of polyaminopropyl biguanide amidated norfloxacin, 5-10 parts of traditional Chinese herbal medicine extract, and 90-110 parts of distilled water. The invention also discloses a preparation method of the wound care spray. The wound care spray disclosed in the invention can avoid wound infection, promote wound healing and new skin growth, can use a spraying manner to reach the deep part of an affected part, and has a good curative effect on wounds withoutany side effects, and no scars are left after healing.

The invention provides a method for grafting hyperbranched polyglycerol on the carbon fiber surface based on a plasma technology. The method is characterized by comprising the following steps: step 1,removal of an epoxy coating on the carbon fiber surface; step 2, preparation of plasma activated carbon fibers; step 3, preparation of a hyperbranched polyglycerol N,N-dimethyl formamide solution; step 4, ultrasonic infiltration of the activated carbon fibers; step 5, grafting and purification of the activated carbon fibers. The method provided by the invention has the benefits that the surface depth of each of the carbon fibers treated by adopting the plasma technology is not more than 100 mu m, so that the strength of each of carbon fiber bodies cannot be damaged; with the adoption of an ultrasonic infiltration treatment method, the activated carbon fiber bundles which are mechanically meshed with one another due to rough surfaces can be separated from one another and are uniformly dispersed in an organic solvent, so that the grafting probability of carbon fiber surface active groups with the hyperbranched polyglycerol is improved.

The invention discloses a multi-nano transmission system which is obtained by dissolving host molecules and guest molecules in water according to an equal molar ratio, fully stirring for reaction, dialyzing and freeze-drying, wherein the guest molecules are obtained by coupling DSPE-PEG-NHS with amantadine hydrochloride under an alkaline condition. The preparation method of the host molecules comprises the following steps: firstly, taking beta-cyclodextrin as an initial raw material, carrying out ring opening on glycidol under the alkaline condition to obtain beta-cyclodextrin grafted hyperbranched polyglycerol beta-CD-HPG; then taking dicarbonyl imidazole as a coupling reagent, and linking tris (2-aminoethyl) amine to hydroxyl of beta-CD-HPG so as to obtain beta-cyclodextrin grafted hyperbranched polyglycerol grafted tris (2-aminoethyl) amine beta-CD-HPG-TAEA; and then carrying out targeted modification on the beta-CD-HPG-TAEA by using a targeted reagent so as to obtain the host molecules. The multi-nano transmission system can load small molecular drugs and nucleic acid fragments at the same time, and the loaded small molecular drugs and nucleic acid fragments can be flexibly adjusted according to use requirements.

The invention discloses thermal transfer printing ink and a preparation method thereof. The thermal transfer printing ink is prepared from the following components in parts by weight: 15 to 25 parts of heat transfer printing disperse dye, 1 to 4 parts of rosin polyether sulfonate, 0.1 to 0.5 part of graphene, 10 to 15 parts of betaine, 1 to 3 parts of rose extract, 15 to 20 parts of hyperbranched polyglycerol, 1 to 2 parts of water-soluble chitosan, 0.1 to 0.5 part of preservative, 0.3 to 0.6 part of macromolecular surfactant, 30 to 40 parts of water and 10 to 20 parts of alcohol solvent. The invention also discloses a preparation method of the thermal transfer printing ink. The thermal transfer printing ink is high in fixation rate, antibacterial, good in storage stability, high in printing fluency, excellent in color reducibility, remarkable in waterproof, scratch-resistant and sun-proof effects, safe and environment-friendly to use and not liable to age, and white smoke and odor cannot be generated during color development of the ink.

The invention belongs to the technical field of membrane filtration, and particularly relates to a hyperbranched polymer for efficiently recovering boron and an ultrafiltration process thereof. The invention discloses a hyperbranched polymer for efficiently recovering boron, the hyperbranched polymer is a hyperbranched polyhydroxy polymer, and the hyperbranched polyhydroxy polymer is one of hyperbranched polyglycerol and a Diol-HPEI polymer; the hyperbranched polyglycidol is synthesized through an anion ring-opening polymerization reaction of glycidol on a pentaerythritol (THME) core, NaOCH3 is used as a catalyst, and 1, 4-dioxane is used as a reaction medium; and the Diol-HPEI polymer is synthesized by grafting glycidol to hyperbranched polyethyleneimine (HPEI) molecules through an epoxy amine nucleophilic addition reaction. The invention also discloses an ultrafiltration process of the hyperbranched polymer for efficiently recovering boron, which comprises the following steps: S1, dissolving the hyperbranched polymer in a solution containing boric acid, and adjusting the pH value; and S2, after adjustment is completed, stirring for 50-70 min, and then using an ultrafiltration membrane for filtering the solution.

A method of scale inhibition treatment of a water system comprising introducing an aqueous scale inhibiting composition into the water system wherein the aqueous scale inhibiting composition comprises a carboxylated hyperbranched polyglycerol.

The invention discloses a two-dimensional hyperbranched polyanion nanosheet modified nanofiber scaffold and a preparation method and application thereof. A nanofiber composite (PCL-GO-HPGS) is specifically provided, and is a material obtained after the surfaces of polycaprolactone fibers are coated with hyperbranched polyglycerol surface modified graphene oxide. By using the nanofiber composite material as the scaffold, the adhesion and proliferation performance of IPS cells can be improved, the dryness of the IPS cells can be efficiently maintained, and premature non-directional differentiation is avoided. In the neural differentiation phase, the PCL-GO-HPGS scaffold is capable of promoting directional differentiation of embryoids formed by the IPS cells to neuronal cells and simultaneously inhibiting differentiation of the IPS cells to astrocytes. The PCL-GO-HPGS nanofiber composite material can be used as the novel nanofiber scaffold with hyperbranched molecular multivalent bonds and capable of promoting bio-adhesive performance, and has a wide application prospect in treatment of diseases such as stem cell differentiation and nerve tissue regeneration.