74 results about "Insulin syringe" patented technology

Disclosed is a portable automatic insulin syringe device adapted to enable an injection of liquid medicine for a prolonged time, including a syringe pump having a pump housing, further including a blood sugar measuring unit mounted at one side of the pump housing and adapted to measure a blood sugar level of a user, a control unit for controlling the blood sugar measuring unit and the syringe pump, and a display unit for simultaneously displaying the quantity of insulin dispensed to a user and the blood sugar level measured by the blood sugar measuring unit.

The invention relates to a self-destruction insulin syringe capable of replacing needles, comprising a needle cylinder, a push rod, a rubber plug and a needle stand. The needle cylinder is provided with the linkage needle stand which is supported and fixed at the front end of the needle cylinder by a support seat, and the needle stand extends downwards to form a fixing ring. A snap ring is formed on the upper end of the linkage needle stand and extends into the inner hole of the fixing ring to be blocked and fixed with the fixing ring, and the wall of the inner hole of the linkage needle stand is provided with a big groove. The upper end of the support seat extends into the inner hole of the linkage needle stand, a first elastic pawl gathering together to the center is formed on the upper end of the support seat, the outer side of the upper end of the support seat is provided with a circle of boss, and the boss is located in the big groove and can slide vertically along the big groove. A first elastic support claw is formed at the lower end of the linkage needle stand, and correspondingly, the inner wall of the needle cylinder is provided with a small groove in which the first elastic support claw can be embedded. The outer side of the lower end of the support seat is provided with a circle of convex circular bead which abuts against the first elastic support claw. By adopting the syringe with the structure, because the needle stand and the needle cylinder are in detachable connection, needles with different specifications can be replaced as required, and the needle stand can retract to the needle cylinder after injection.

The invention relates to an insulin syringe needle with a needle tip protection function. The insulin syringe needle comprises a needle body, a needle seat, a main shell and an outer jacket, and is characterized in that a trigger pipe, a front casing pipe and a spring are arranged in the main shell, the trigger pipe is used for protecting an injection section of the needle body before the application, and the front casing pipe is used for protecting the injection section of the needle body after the application. Before the application, the trigger pipe stretches out of the main shell and stays at a needle body protection stage, and the front casing pipe is arranged in the main shell; after the application, the trigger pipe is arranged in the main shell, the front casing pipe stretches out of the main shell and stays at a needle body protection state. The unlocking of the trigger pipe and the front casing pipe is correlated to the state whether the syringe needle is prepared for injection or not, and the unlocking of the trigger pipe and the front casing pipe is triggered by utilizing a tail cover and the needle seat when in installation, and safety and convenience in use can be improved.

The present invention is directed to an immediate release and extended release capsule or capsule fill which mitigates the abuse of abuse-susceptible active pharmaceutical ingredients by direct intravenous injection. The fill comprises a parenteral abuse resistant liquid formulation which when mixed with water and heated, results in a turbid, viscous or bubbling mixture that is not injectable with a standard insulin syringe. The abuse-susceptible active pharmaceutical ingredient is selected from the group consisting of opiates, opioids, tranquillizers, stimulants and narcotics.

The insulin syringe with magnified sheath is a syringe with a transparent outer sleeve constructed of a material capable of magnifying printed information. The outer sleeve is slidably attached to the syringe barrel and can lock into a retracted position where it surrounds the syringe barrel and magnifies the dosage indicia thereon while exposing the syringe needle for use or can lock into an extended position where it surrounds the needle to help prevent inadvertent needle sticks.

The present invention relates to an insulin pump having triple functions for the efficient regulation of a blood glucose concentration and an insulin injection system comprising the same. The insulin pump comprises an insulin syringe into which an insulin is stored, a pump to pressurize the insulin syringe in response to a programmed control signal, a control device that generates the programmed control signal to control the pump, a mode selection button to determine an insulin injection mode, and an operating button to command an insulin injection. The insulin injection mode is comprised of a base mode that continuously infuses the insulin at a basic rate to control a blood glucose concentration at a fasting, a food mode that infuses the insulin at a bulk to control the blood glucose concentration after food intake, and an activation mode that infuses the insulin in pulses for a predetermined time period. Preferably, the insulin pump complementarity cooperates with a physiological saline syringe pump that infuses physiological saline solution immediately after the infusion of the insulin at the activation mode.

The invention discloses a safety insulin syringe which comprises a needle holder. A needle tube assembling base is arranged in the needle holder, an insulin pen puncture needle and an insulin injection needle are arranged on the upper portion and the lower portion of the needle tube assembling base respectively, a self-locking base is arranged at the other end of the needle holder, one end of the self-locking base is connected with the other end of the needle holder in a sleeved mode, a push tube is arranged in the self-locking base, one end of the push tube is located in a needle holder cavity and penetrates through the needle tube assembling base to be located in an assembling portion, the other end of the push tube abuts against a self-locking piece on the inner wall of an inner cavity of the self-locking base, an opening in the other end of the self-locking base is connected with one end of a needle protective sleeve, the other end of the needle protective sleeve is suspended in the air, and the needle protective sleeve is connected with the needle holder cavity through a spring. According to the safety insulin injection needle, a built-in safety injection needle structure is adopted, the outer portion of the insulin injection needle is sleeved with the protective sleeve which can be flexibly stretched and retracted, a self-locking mechanism is used for limiting the protective sleeve, the self-locking mechanism can be automatically opened after an insulin pen is screwed into the needle holder, the protective sleeve can produce vertical elastic displacement freely, and normal insulin injection is conducted.

The invention discloses an insulin syringe, which comprises a core rod, a piston and an outer tube, wherein the outer tube comprises a conical head, a tube body and a turned edge, the front end of the conical head is connected with an injection needle base, the rear end of the conical head is connected with the tube body, and the front end of the piston is provided with a core column matched with the conical head. The rear end of the tube body is provided with the turned edge for hand holding, and the core rod is provided with a groove; the turned edge is provided with a limit sheet which can be embedded into the groove to lock a push rod, and the limit sheet is in embedded connection with the turned edge; and the rear part of the core rod is provided with an annular sheet. The limit sheet is provided with a bolt for blocking the groove. The core rod is a cross core rod, side walls are mutually vertical, side arms are provided with rolled leaves arranged in axial symmetry, the rolled leaves comprise upper rolled leaves and lower rolled leaves which are alternately arranged along the axial direction, and grooves are formed between the upper rolled leaves and the lower rolled leaves. The insulin syringe has the advantages of simple structure, safety, reliability and low cost.

A needle-exchangeable and self-destruction insulin syringe comprises a barrel (1), a push rod (2), a rubber piston (3) and a needle seat (4). The barrel (1) is provided with a connection needle seat (7) matched with a needle hub (5). The connection needle seat (7) is supported and fastened at the front end of the barrel by a support seat (8). The needle hub (5) is extended downwards to form a fixing ring (9). A snap ring (10) is formed at an upper end of the connection needle seat (7). The snap ring (10) is protruded into the bore of the fixing ring (9) and locked with the fixing ring (9). A large groove (13) is provided in the wall of the bore of the connection needle seat (7). The upper end of the support seat (8) is protruded into the bore of the connection needle seat (7). First elastic detents (14) are formed at the upper end of the support seat (8) and come together towards the center. A ring of flange (15) is provided at the outside of the upper end of the support seat, and falls in the large groove (13), capable of sliding up and down along the large groove (13). First elastic support pawls (16) are formed at the lower end of the connection needle seat (7), and the inner wall of the barrel is correspondingly provided with a small groove (17) in which the first elastic support pawls (16) can be embedded. A ring of flange shoulder (18) is provided at the outside of the lower end of the support seat, and abuts against the first elastic support pawls (16).

A multifunctional glucose monitoring system and method of measuring glucose level, determining insulin dosage, and indicating insulin dosage on a syringe is disclosed. The multifunctional glucose monitoring system includes standard functionality with respect to acquiring a blood glucose reading. However, in addition, the multifunctional glucose monitoring system includes a dosage algorithm for calculating an insulin dosage based on the blood glucose reading and any other useful parameters, and includes a built-in marking device for marking the calculated dosage level on the barrel of an insulin syringe that is installed in the body of the multifunctional glucose monitoring system. A method includes the steps of measuring the glucose level, determining an insulin dosage, and indicating the insulin dosage on a syringe.

The present invention relates to an automatic insulin injector, which can be a rotary shaft only as a piston advance device to remove the vertical load imposed on the rotary shaft, thereby improving durability. The automatic insulin injector comprises: a syringe having a water injector containing insulin therein, and a piston inserted into the rear end of the water injector to provide the water injector with discharge pressure of insulin; a syringe receiving The housing of the space, the syringe receiving space has a partition wall formed at the rear end thereof; a rotating shaft having a non-circular cross-section and a predetermined length; a power supply device for rotating the rotating shaft at a predetermined speed; one providing advancement of the piston by pushing the piston A powered push plate assembly, the push plate assembly having a disc portion formed with an external thread on its outer circumferential surface, and an engagement hole axially coupled with a rotating shaft at its central portion, through which the rotating shaft can move back and forth; and A hollow cylindrical push plate housing, which is inserted into the syringe receiving space at the rear end of the water injector, allowing the piston to pass therethrough, the push plate housing is formed with an inner thread on the inner circumferential surface, which engages with the outer thread of the disc-shaped portion , so that the disc-shaped portion spirally moves back and forth.

The invention provides a small-dose safety destructing insulin syringe, comprising a hollow syringe, a push rod capable of sliding in the syringe and a rubber plug mounted at the front end of the push rod, wherein a needle stand detached from the syringe is mounted at the front end of the syringe, a frustum is formed at the front end of the push rod, at least two elastic hooks are mounted at the lower end of the needle stand, a locking ring in interference fit with the inner wall of the syringe is arranged under the elastic hooks, a first elastic pawl clamped with the frustum is arranged in the hole in the locking ring, a card core capable of extending into the hole in the elastic hooks is formed on the locking ring, the chamber of needle stand is blocked by the card core, a grab is arranged on the card core, the frustum at the front end of the push rod can be clamped with the first elastic pawl in the locking ring, the locking ring is driven by drawing the push rod down to slide down so that the grab is clamped with the elastic hooks, the needle stand is driven by the locking ring to be detached from the inner wall of the syringe. The invention has the beneficial effect: the needle stand can be detached from the inner wall of the syringe by applying less pulling force, the bubble can not be generated at the top of the rubber plug, the residue amount of injection solution in the syringe after injection is less.

The invention discloses a needle disassembly and assembly sharps box for an insulin syringe. The key points of the technical scheme are that it includes a box body and a box cover, and the box cover is provided with a needle unloading device for screwing off the needle head on an insulin injection pen. The needle unloading device includes a rotating wheel, a driving motor, and a control switch. A connecting sleeve is arranged on the box cover. The rotating wheel includes a rotating cylinder that can be inserted into the connecting sleeve. The outer sleeve of the rotating cylinder is equipped with a bearing and then inserted into the connecting sleeve Inside, the rotating wheel is provided with a needle drop hole; the box cover is also provided with a needle loading device for screwing the needle to the insulin injection pen. The needle loading device includes two rotating wheels, two driving motors, two control switches, and the box cover There are two sets of connections on the top, the two rotating wheels include two rotating cylinders that can be inserted into the two connecting sets, the outer sleeves of the two rotating cylinders are provided with bearings and then plugged into the two connecting sets, and the two rotating wheels are provided with pinholes. The sharps box can realize the automatic disassembly and assembly of needles, thereby helping to improve the efficiency of disassembly and assembly of needles.

The present invention discloses a safe and adjustable insulin syringe needle. The safe and adjustable insulin syringe needle comprises an inner shell, a protective sleeve, a locking ring, a spring, aneedle body, a needle seat and a depth adjusting sleeve, and the inner shell is provided with track changing devices, external threads, a first elastic arm and an adjusting lug; the depth adjusting sleeve is provided with internal threads and adjusting grooves; the protective sleeve is provided with guide lugs, downward pressing lugs and downward pressing inclined planes; the locking ring is provided with through grooves, elastic arms and positioning baffle blocks; and the positioning baffle blocks are provided with second sliding inclined planes and transition inclined planes. Before injection, the safe and adjustable insulin syringe needle can adjust gears to control injection depth according to individual conditions of patients so as to meet injection requirements of different people; and in addition, after the injection is completed, the needle can be automatically hidden, is not exposed due to mistaken touch, avoids causing injury to people, plays effects of avoiding cross infection, and can also be prevented from risks of being repeatedly used.

A stabbing-preventing insulin syringe needle comprises a connecting block, a guide rod and a first sleeve, a conical hole is formed in the top end of the connecting block; a through hole is formed inthe bottom of the conical hole, a needle head is fixedly connected to the inner wall of the through hole, the outer surface of the needle head is sleeved with a guide rod, the top of the guide rod isfixedly connected to the bottom of the connecting block, first sliding blocks are fixedly connected to the outer surfaces of the left end and the right end of the guide rod respectively, and a supporting plate is fixedly connected to the bottom of the guide rod. According to the stabbing-preventing insulin syringe needle, the guide rod, the first sleeve and the first spring are arranged; the needle head sleeves the inner walls of the first sleeve and the guide rod; the needle head is prevented from being exposed and stabbing a user or a patient when not used, and the needle head can be prevented from being polluted by the external environment; the safety coefficient is high, the depth of the needle penetrating into the skin of a patient is limited, the pain of the patient is relieved, thefirst spring rebounds after injection is completed, the needle is automatically pulled out, operation is easy, and the labor intensity of medical staff is relieved.

The invention discloses an intelligent insulin syringe production line. The intelligent insulin syringe production line comprises a guide rail; the guide rail is sequentially provided with a syringe discharging and automatic conveying mechanism, a syringe feeding mechanism, a syringe dispensing mechanism, an ultraviolet UV glue curing syringe mechanism, a syringe silicon oil spraying mechanism, anautomatic image identifying and removing mechanism, a syringe protective sleeve automatic assembling mechanism and a finished product discharging mechanism, wherein each mechanism is internally provided with a syringe placing and clamping template; each syringe placing and clamping template is fixed to the guide rail; and the syringe placing and clamping templates are a plurality of positioning rods which are arranged in an overall line. The intelligent insulin syringe production line disclosed by the invention realizes continuous automatic control on an insulin syringe production process, prevents cross contamination caused by a middle transportation link and multiple manual assembly, is controllable in a running process, technological conditions and product quality, and realizes high production efficiency.

The invention discloses a full-function insulin syringe which comprises an insulin injection pen and a blood glucose collecting part. The injection amount of insulin is accurately controlled by utilizing the structures of a spiral propelling rod and a spiral propelling sleeve. Through time setting, light flickering and sound making, a patient is reminded of injection regularly. The situation thatinjection is forgotten or excessive injection occurs is avoided. A guarantee is provided for safety of the patient. A chip can be connected with a mobile phone APP to detect the injection dosage and the blood sugar value at regular time. A mobile phone stores data to form a data set of the patient, and the data set is taken to doctors regularly to form health evaluation. A glucometer is provided with the sound device, and blood glucose data are directly read out. A range is set in advance in the chip. If the blood glucose is within the range, the sound prompt can turn on and flicker a green light, on the contrary, the prompt does not turn on or flicker a red light. The life health of the old people is better protected through the design.

The invention discloses a needle treatment device for insulin injection. The device comprises a box body, a needle head clamping button, a needle core and needle seat separation button and a needle core disinfection and melting button are fixedly mounted at the left end of the top of the box body in sequence from left to right; a guide rail is fixedly installed at the position, close to the top, in the box body, a driving motor is fixedly installed on one side of the guide rail, and the driving motor is fixedly connected with a lead screw through the output end of one side of the driving motor. The invention discloses the needle treatment device for insulin injection. The insulin syringe needle can be treated immediately after being used; a high-frequency electromagnetic coil heating method is adopted; the needle core and the needle base are separated and separately treated, the collected needle core is disinfected and melted through heating of the high-frequency electromagnetic coil,the risk that an insulin pen user is stabbed is effectively reduced, iatrogenic infection is reduced, the psychological pressure of injection personnel is reduced, and meanwhile the whole device is simple and easy to implement.

The invention discloses a pop-up insulin pen. The pop-up insulin pen comprises an outer pen container, an insulin pen cartridge and an inner pen container, wherein the insulin pen cartridge is arranged inside the outer pen container, the inner pen container is arranged between the insulin pen cartridge and the outer pen container and is in threaded connection with the inner pen container, a protecting sleeve is arranged at the bottom of the outer pen container, a spring is arranged between the protecting sleeve and the insulin pen cartridge, the two ends of the spring are fixedly connected with the bottom of the insulin pen cartridge and the protecting sleeve respectively, an insulin syringe needle is connected to the bottom of the insulin pen cartridge and is arranged inside the spring, baffles are arranged at the top of the protecting sleeve, and limiting plates are arranged on the outer wall of the insulin pen cartridge. By means of the pop-up insulin pen, a patient conveniently adjusts the pressure inside the insulin pen cartridge according to actual demands to achieve the purpose of controlling the injection speed of insulin, the probability that the hands of the patient are punctured can also be greatly lowered, and the pop-up insulin pen is simple in structure and high in practicability.

A multifunctional glucose monitoring system and method of measuring glucose level, determining insulin dosage, and indicating insulin dosage on a syringe is disclosed. The multifunctional glucose monitoring system includes standard functionality with respect to acquiring a blood glucose reading. However, in addition, the multifunctional glucose monitoring system includes a dosage algorithm for calculating an insulin dosage based on the blood glucose reading and any other useful parameters, and includes a built-in marking device for marking the calculated dosage level on the barrel of an insulin syringe that is installed in the body of the multifunctional glucose monitoring system. A method includes the steps of measuring the glucose level, determining an insulin dosage, and indicating the insulin dosage on a syringe.

The invention discloses an insulin syringe with a needle protection structure, and relates to the technical field of medical instruments. The lower side of the driving frame is screwed with the lower side of the outer ring wall of the medicine storage tube through a hinge, and the upper side of the driving frame is connected with the upper side of the outer ring wall of the medicine storage tube through a hasp; the sealing ring is fixed on the right side wall of the medicine storage pipe and the left side wall of the driving frame; the driving pipe is inserted and fixed on the right side wall of the driving frame; the piston plate is arranged in the driving frame; the push rod is fixed on the right side wall of the piston plate, and the other end of the push rod is arranged in the driving pipe in a penetrating manner; the driving mechanism is arranged on the outer side of the pushing rod; the protective sleeve is fixed on the left side wall of the medicine storage tube and sleeves the outer side of the discharge tube; the protective insertion tube is inserted into the outer peripheral wall of the protective sleeve; the connecting spring is embedded in the peripheral wall of the protective sleeve; the limiting mechanism is embedded in the outer side wall of the protective sleeve, and the needle head can be limited in the injection process, so that the needle head cannot incline, and injection is facilitated.

Provided is a safe insulin syringe needle. The safe insulin syringe needle comprises a needle body, a needle seat, a middle sleeve, a trigger tube, a front sleeve and a spring, and is characterized inthat the trigger tube is provided with an elastic arm, the needle seat is provided with a lug boss, when the needle is in use, the axial direction relative movement relation between the trigger tubeand the needle seat is used, the lug boss touches the elastic arm and forces the elastic arm to be deformed by being bent outwards to take up the position in front of the spring, so that the trigger tube can obtain temporary elastic recoil performance with the help of the spring within the distance of the movement of the trigger tube, and after the lug boss is separate from the elastic arm, the elastic recoil performance of the trigger tube is automatically relieved. The safe insulin syringe needle solves the problem that a single-spring structure adopted in a departed method cannot reserve the tentative elastic recoil performance of the trigger tube.

The invention provides an establishing method of a lung cancer animal model with an inflammation foundation. The method includes the following steps of firstly, establishing pBabe-CMV-EGFP-puro plasmids; secondly, establishing an EGFP over-expression system mediated by reverse transcription viruses; thirdly, establishing lung cancer cell lines for stably expressing EGFP; fourthly, establishing an inflammation model; fifthly, establishing the lung cancer animal model with the inflammation foundation, wherein 1*107 lung cancer cell lines stably expressing the EGFP are prepared into a cell suspension, 75 microliters of cell suspension is injected into a left lung of a naked mouse with lung inflammation from the gap of a back rib through an insulin syringe, the mouse is fed continuously for 2 weeks, and then the lung cancer animal model with the inflammation foundation is obtained. The EGFP used in the establishing method can produce fluorescent light, light-emitting strength can be detected by a corresponding instrument device, and therefore the existence of lung cancer can be proved.

The invention discloses a buckling and pressing type insulin syringe and belongs to the technical field of insulin injection. The buckling and pressing type insulin syringe comprises an injection drug bottle, a needleless syringe, an upper pressing cover and a lower pressing seat, wherein the upper pressing cover and the lower pressing seat are separately arranged; the injection drug bottle is arranged in the upper pressing cover; the needleless syringe is arranged on the lower pressing seat; a bottle mouth of the injection drug bottle is connected with the input end of the needleless syringe; the function start end of the needleless syringe is arranged at the top end of the upper pressing cover. The insulin syringe subverts the traditional needle and tube syringe in design and adopts an injection method of buckling and pressing a round button to make the pushing distance shorter, thereby fundamentally improving the operation convenience.

The invention discloses a pen insulin syringe needle picking and collecting drum and its picking and collecting method. Unreasonable disposal of waste syringe can hurt others as well as pollute environment. Besides, a patient's finger is very easy to be stabbed by a syringe needle for not correctly sheathing a needle cap on the syringe needle of the pen syringe needle. The pen insulin syringe needle picking and collecting drum comprises a drum body, a clamping component, a pressing arm and a tail thread cover; the drum body is composed of a storage drum body and a rotary picking drum body which are integrally shaped; an outlet end of the inner cavity of the rotary picking drum body is connected with an inlet end of the inner cavity of the storage drum body, an outlet end of the storage drum body is in threaded connection with the tail thread cover; the outlet end of the rotary picking drum body is provided with an outside thread, a pressing arm comprises an arm rod, a holding pawl, a slide rod and an opening seal spring; the clamping component comprises a clamping nut, a slide ring, a connecting pipe and a pressing ring. The pen insulin syringe needle picking and collecting drum can intensively store the waste pen insulin syringe needle and avoid the stabbing risk caused by freely discarding the needle.

The invention provides an insulin syringe intelligent device. The insulin syringe intelligent device comprises an intelligent device body and a matched intelligent mobile device, wherein a collecting unit collects the times of 'Ka' sound generated when insulin is injected, and records the times in a micro-control unit, and a communication unit transmits the times information to the matched intelligent mobile device through a wired / wireless communication manner for storage and display; the matched intelligent mobile device collects the basic information of a user, such as the body height, body weight, age and gender through a basic data entry unit, collects the detailed diet intake information of the user through a diet collecting unit, and finally provides the suggested insulin injection dose through calculation and analysis.

The invention belongs to the field of medical apparatus, and relates to improvement of a general insulin special refill structure for a pen insulin syringe. Currently, when known pen insulin syringes are used for general insulin, refills still have abundant residual insulin after being used, thereby causing waste. When injection of an inner plunger of the refill of the pen insulin syringe stops, the convex plunger is tallied with the top of a refill bottle and fills the whole space. The invention has the advantages of capability of reducing the residual insulin in the refill of the general insulin refill, simple implementation and obvious economic benefit.

The invention discloses a pop-up insulin syringe needle. The pop-up insulin syringe needle comprises an insulin pen, an injection syringe is arranged at one end of the insulin pen, a slide groove penetrates through an inner cavity of the injection syringe, an electromagnet is arranged on the inner wall of the slide groove, a magnet is arranged at one side of the electromagnet, a mechanical seal isarranged at one side of the magnet, a liquid injection pipe is arranged in an inner cavity of the slide groove, a nut is arranged on the outer wall of the liquid injection pipe, and a solid block isarranged at one side of the nut. By means of the pop-up insulin syringe needle, through the arrangement of the mechanical seal and the solid block, when a telescopic hose is aged after being used fora long time, medicine liquid is prevented from flowing out of gaps between the liquid injection pipe and the slide groove; meanwhile, the arc solid block can prevent dust from entering the slide groove from the gaps between the liquid injection pipe and the slide groove, and the service life is prolonged. According to the principle that objects with the same magnetism are repellant, a magnetic field of the electromagnet is utilized to push the magnet, the liquid injection pipe is driven to move in the side groove, a traditional push-pull structure is changed, and the pop-up insulin syringe needle is convenient to use; meanwhile, by means of the pop-up syringe structure, the using safety is improved.

The invention belongs to the field of medical appliances, and relates to a suspension type refill of an insulin injection pen. In the prior art the injection pen uses a glass bead mixing method, which has a certain problems of safety hidden danger and much residual liquid. In the inventive method, a large amount of granulate solid materials replacing residual liquid and mixing uniformly the medicine liquid are still in the refill. The replacement materials have ability to intercept and capture the sedimentation insulin. The total amount of the replacement materials is less than residue space formed by a refill bottle, a bottle hood and termination stroke of a piston. The invention has the beneficial effect to eliminate the safety hidden danger and save 5% of the insulin, and has obvious effect.