31 results about "Intermittent hypoxia" patented technology

The present invention relates to systems and methods for providing a short-acting analgesic agent in the management of pain during labor, wherein the system enables efficient, real-time prediction of contractions for the coordinated administration of analgesia such that the peak effectiveness of the analgesic coincides with the intermittent pain of labor.

The invention relates to a method for detecting an intermittent high-resistance grounding fault through intermittent detection and belongs to the field of emergency protection circuit devices. The method comprises the steps that detected forward fault pulses of intermittent power counted within a preset time window and the result of pulse counting is compared with a preset counting threshold when the timing is ended; if a counted value exceeds the preset counting threshold, a fierce transient state is deemed to occur within short time and a relay protection system gives out an alarm of the detected grounding fault as the intermittent high-resistance fault. The method for detecting the intermittent high-resistance grounding fault through intermittent detection has the advantages that the intermittent high-resistance grounding fault can be detected more sensitively, the faulted line can be removed, the sensitivity of a power supply line protection device is improved, the protection effect of the existing relay protection system / device is fully exerted, the continuous and stable operation of the entire medium-voltage power distribution system is improved and the safety performance of the entire power supply system is guaranteed. The method can be widely used in the field of high-resistance grounding fault detection and the relay protection of the medium-voltage power distribution system with a neutral point which is effectively grounded.

The invention provides an animal experimental device used for providing an intermittent hypoxia environment. The device comprises an air controlling device and a breeding cabin, wherein an oxygen controlling electromagnetic valve (1), an air exhaust controlling electromagnetic valve (2) and a nitrogen controlling electromagnetic valve (3) of the air controlling device are provided with an air inlet and an air outlet respectively; the oxygen controlling electromagnetic valve (1) is electrically connected with an oxygen circulation control timer (4) to form an oxygen controlling unit; the nitrogen controlling electromagnetic valve (3) is electrically connected with a nitrogen circulation control timer (7) to form a nitrogen controlling unit; the oxygen controlling unit and the nitrogen controlling unit are connected in parallel and connected to a DC power supply (15); the air exhaust controlling electromagnetic valve (2) is connected with a rectifying diode and then connected to the oxygen controlling unit and the nitrogen controlling unit respectively; the breeding cabin is provided with an oxygen inlet, a nitrogen inlet and an air vent; the oxygen inlet is communicated with the air outlet of the oxygen controlling electromagnetic valve (1); the nitrogen inlet is communicated with the air outlet of the nitrogen controlling electromagnetic valve (3); and the air vent is communicated with the air inlet of the an air exhaust controlling electromagnetic valve. The device can be well applied to simulative experiments of sleep apnea.

The invention relates to an activation method of a fuel cell stack, and relates to the technical field of fuel cells. According to the mainly adopted technical scheme, the activation method of the fuel cell stack comprises the following steps: S1, introducing hydrogen into an anode of a to-be-activated cell stack, introducing air or oxygen into a cathode of the to-be-activated cell stack, and enabling the cell stack to be in an open circuit state; S2, carrying out intermittent oxygen deficit treatment on the cell stack; wherein the intermittent hypoxic treatment comprises the following steps:carrying out hypoxic operation on the cell stack to enable the cell stack to be in an oxygen starvation state, and then carrying out reduction operation; and S3, starting a load, selecting a constantcurrent test mode, loading the cell stack to a set current, enabling the cell stack to be in a stable working state, and performing intermittent anoxic treatment on the cell stack. The method is mainly used for shortening the activation time of the fuel cell stack, improving the activation efficiency and reducing the use amount of hydrogen in the activation process.

The invention relates to an experimental animal feeding cabin, which is the big and small mice feeding cabin for simulating the symptom of intermittent anaerobic respiration of animal. One side of hypoxia feeding cabin is further connected with a buffering cabin formed from a closed cabin body and a feeding cage track such that the feeding cabin loading the big mouse is timed to stay between the hypoxia feeding cabin and the outside along the feeding cage track so as to simulate the big mouse model of SAS by the long-period intermittent breathing hypoxia gas. There is no need to timely and frequently discharge the nitrogen in the hypoxia feeding cabin, thus, the consumption quantity of the nitrogen is greatly reduced and the experiment cost is reduced by a wide margin.

The invention relates to an experimental animal feeding cabin, which is the big and small mice feeding cabin for simulating the symptom of intermittent anaerobic respiration of animal. One side of hypoxia feeding cabin is further connected with a buffering cabin formed from a closed cabin body and a feeding cage track such that the feeding cabin loading the big mouse is timed to stay between the hypoxia feeding cabin and the outside along the feeding cage track so as to simulate the big mouse model of SAS by the long-period intermittent breathing hypoxia gas. There is no need to timely and frequently discharge the nitrogen in the hypoxia feeding cabin, thus, the consumption quantity of the nitrogen is greatly reduced and the experiment cost is reduced by a wide margin.

The invention discloses an intermittent hypoxia system comprising a sealing tank (1), an oxygen concentration detector (2), a nitrogen flow control valve (4), an air flow control valve (5), an in-box gas replacement control valve (6) and an air pump (7), wherein the nitrogen flow control valve (4), the air flow control valve (5), the in-box gas replacement control valve (6) and the air pump (7) are connected with a PLC (programmable logic controller) (3), the oxygen concentration detector (2) is arranged at the top of the sealing tank (1) and distant from a sealing cover (11), the left side and the right side of the sealing tank (1) are provided with nitrogen inlets (41 and 42) which are connected with a nitrogen gas source (43) connected with the nitrogen flow control valve (4) externally, the front side wall of the sealing tank (1) is provided with an air inlet (51) connected with the air pump (7) connected with the air flow control valve (5) externally, and the rear side wall of the sealing tank (1) is provided with an air outlet (61) connected with the in-box gas replacement control valve (6) arranged externally. The intermittent hypoxia system is capable of simulating experiment environment of intermittent hypoxia.

The invention discloses an intermittent hypoxia rat model for children obstructive sleep apnea hypopnea syndrome, which belongs to an experimental apparatus in medical experimental field and solves the shortcomings of the current intermittent hypoxia rat model for children obstructive sleep apnea hypopnea syndrome, comprising a box body, wherein a partition A, a partition B, a door A and a door B are arranged in the box body. The inner cavity of the box body is divided into a hypoxia chamber, a transition chamber and an animal chamber. The animal chamber communicates with air, and the door A and door B can slide upwards and downwards to open. An animal breeding box is arranged in the box body, and the animal breeding box can move leftwards and rightwards. The hypoxia chamber is provided with a nitrogen valve and a oxygen concentration sensor. The invention is mainly applied to the animal experiments in the medical field.

The invention relates to a device for a cell intermittent hypoxia experiment. The device comprises a cell cultivation case formed by a closed case body, a cell cultivation dish, a humidity and temperature control device, an oxygen gas source, a carbon oxygen gas source, a nitrogen gas source and a main controller. The gas sources are respectively connected with the cell cultivation case through corresponding gas conveying pipelines, control valves are arranged in the gas conveying pipelines, and the main controller controls the control valves to periodically adjust the oxygen content in the cell cultivation case to be changed between a high state and a low state. Due to the fact that the device is provided with the humidity and temperature control device, environment in the case body is made to be suitable for the growth of cells, the main controller controls the control valves to periodically adjust the oxygen content in the cell cultivation case to be changed between the high state and the low state to form a periodic hypoxia environment, the periodic hypoxia environment can be created, and then the study of intermittently-hypoxic cells is carried out.

The invention provides a system for evaluating AMS (acute mountain sickness) risk on the basis of IHT (intermittent hypoxia training) dynamic performance. The system comprises a data collection module, a data processing module, a robust enhancement module and an AMS severity degree monitor, wherein the data collection module obtains SpO2 (peripheral oxygen saturation) information from a pluralityof continuous IHT periods; the data processing module carries out abnormal value processing, filtering and data segment division on the obtained SpO2 information to select a hypoxia data segment; an index acquisition module obtains DSI (Dynamic SpO2 Index) of the hypoxia data segment, wherein the DSI is duration for keeping the SpO2 to be at a set ratio or above, and is marked as [tao]i; the robust enhancement module carries out robustness enhancement on the DSI [tao]i to obtain an index [tao]r; and the AMS severity degree monitor compares a preset reference value with the [tao]r 4to evaluatethe AMS. By use of a human hypoxia stress response dynamic process reflected by continuous physiological information in the IHT, the invention puts forward the novel system for predicting the DSI by the AMS.

The invention relates to a cell culture fluid used for inducing umbilical cord mesenchymal stem cells into neural stem cells, and a using method thereof. In the method, UC-MSC is efficiently induced into NSC within a short time by utilizing an intermittent hypoxia induction method through induced culture fluid containing basic fibroblast growth factors, epidermal growth factors and astragaloside, the technical defect in the prior art of over-long induction time can be effectively overcome, and large-scale clinical promotion is facilitated.

The invention relates to an exosome derived from a mesenchymal stem cell. The exosome is prepared by intermittent hypoxic stimulation of the mesenchymal stem cell. The exosome prepared from the invention has stronger tissue and organ ischemia-reperfusion injury protective effect, and the biological effect of unit exosomes is improved, and treatment of diseases such as ischemic heart disease is more facilitated.

The invention relates to an experimental animal feeding cabin, in particular to a vertical lifting intermittent hypoxia rat and mouse feeding cabin, which comprises feeding cages, hypoxia feeding cabins formed by closed cabin bodies and buffer cabins formed by closed cabin bodies. An isolating cabin door is arranged between each buffer cabin and each hypoxia feeding cabin. The buffer cabins are overlaid on the hypoxia feeding cabins. A buffer cabin door is arranged at the top of each buffer cabin. The feeding cages are respectively arranged above the hypoxia feeding cabins and the buffer cabins. A feeding cage lifting driving device drives the feeding cages to periodically pass through the buffer cabins to get in and out of the hypoxia feeding cabins. Since the feeding cages, the buffer cabins and the hypoxia feeding cabins are vertically arranged and the feeding cages are driven to be lifted up and lowered down by using the feeding cage lifting driving device, the vertical lifting intermittent hypoxia rat and mouse feeding cabin has the advantages that the occupied area is smaller, the field utilization ratio is higher, the noise is low, the manufacturing of linear tracks is not needed, the structure is compact, the working reliability is higher, the feeding cabin is convenient to control and the manufacturing cost is lower.

The invention relates to novel atmospheric-pressure intermittent hypoxia and hyperoxia training equipment and system and a training method of the equipment. The training equipment feeds back the flowand pressure of various gases in real time through a gas control module. A gas production module controls the pressure, the gas production and the proportion and flow of mixed gas according to a command to achieve atmospheric pressure and generation of hypoxia and hyperoxia gases. A breathing training module mixes the various gases generated by the gas production module into the mixed gas used fortraining, the mixed gas is exchanged with outside air to achieve air balance, and the atmospheric-pressure hypoxia and hyperoxia mixed gas is generated, so that the training equipment achieves atmospheric-pressure alternating hypoxia and hyperoxia training. Atmospheric-pressure intermittent hypoxia and hyperoxia training is conducted, intelligent control is achieved, the hypoxia and hyperoxia alternating time and the exposure time in hypoxia and hyperoxia are regulated dynamically, and thus the equipment can deal with a specific situation larger or smaller than extreme life indicators in time. The IHT technology can be safely applied to the fields of disease treatment, prevention and rehabilitation of people in need.

An approach is provided for minimizing capacitance requirements of a filter capacitor of a charging device for an intermittent load. A method for charging an intermittent load that is able to pulse on and off periodically without compromising the utility of the load. The method comprises setting timestamps relating to a waveform of an input Alternating Current (AC) voltage. The timestamps are synchronized to the AC voltage and comprise on times and off times that turn the intermittent load off and on. The method further comprises charging the intermittent load during the on times. Therefore, the capacitance of the filter capacitor used for the intermittent load can be significantly reduced since there will be no voltage drop when the intermittent load has been turned off.

The invention provides an intermittent hypoxia device for experimental animals, which comprises an oxygen gas source connected with an experimental chamber through an air-intake conduit. A computer controls an electromagnetic valve so that the oxygen gas source supplies oxygen to the experimental chamber intermittently. The bottom of the experimental chamber is provided with an exhaust conduit which is controlled by the electromagnetic valve and is used for exhausting experimental gases. The intermittent hypoxia device for the experimental animals has the advantage of being suitable for various respiratory hypoxia experiments. The computer controls the electromagnetic valve so that the oxygen gas source supplies oxygen to the experimental chamber intermittently, therefore the experimentaldata is accurate.

The invention discloses a novel use of low-oxygen system used for the treatment of myocardial ischemia and myocardial infarction. The invention also discloses the application of oxygen in the manufacture of myocardial ischemia and myocardial infarction treatment equipments. The invention also discloses a method of treating mammal's myocardial ischemia and myocardial infarction using intermittent low oxygen dealing to carrying out treatment. The invention proves that the intermittent low oxygen dealing has significant therapeutic effect for big mouse myocardial ischemia and myocardial infarction; it provides new approach for clinical therapeutic of myocardial ischemia and myocardial infarction as a new interfere therapeutic means.

The invention discloses an intermittent hypoxia system, which comprises a sealed box (1), an oxygen concentration measuring and controlling device (2), a nitrogen flow control valve (4) connected to a PLC (3), and an air flow control valve ( 5), the gas replacement control valve (6), the air pump (7), and the oxygen concentration controller (2) in the box are set on the top of the sealed box (1) and away from the sealing cover (11), and the sealed box (1) Nitrogen gas inlets (41, 42) are provided on the left and right side walls of the box, which are connected to the nitrogen gas source (43) connected with the nitrogen flow control valve (4) externally, and the front side wall of the sealed box (1) is provided with an air connection port. The inlet (51) is connected to the air pump (7) with an air flow control valve (5) connected to the outside, and the rear side wall of the sealed box (1) is provided with an air outlet (61), which is connected to the air in the box outside. Displacement control valve (6) is connected. The invention provides an intermittent hypoxia system capable of simulating the experimental environment of intermittent hypoxia.

The invention discloses the use of intermittent hypoxia in improving cognitive function. Intermittent hypoxia is to give oxygen in the form of hypoxia-normal oxygen alternately. The time of hypoxia is 2-6 hours, and the oxygen partial pressure is 70.8-141.2mmHg; the time of normoxia is 18-22 hours, and the oxygen partial pressure For: 140.8-181.2mmHg; continuous treatment for 7-42 days. The intermittent hypoxia scheme of the present invention can be used to improve the cognitive function of mammals, improve the ability of learning and memory, and treat cognitive dysfunction and senile dementia of mammals.

The invention discloses a sleep apnea hypopnea hypoventilation syndrome animal model device and method. The sleep apnea hypopnea hypoventilation syndrome animal model device comprises a cabin body, amain control module, a sleep deprivation model device and an intermittent combined hypoxia and hypercapnia model device; the intermittent combined hypoxia and hypercapnia model device comprises at least two gas sources, one gas source is carbon dioxide gas, and the other gas source is air or oxygen; the main control module is used for controlling the oxygen concentration and the carbon dioxide concentration in the cabin body by controlling the gas supply states of the two gas sources according to the acquired oxygen concentration data and the acquired carbon dioxide gas concentration data, sothat intermittent combined hypoxia and hypercapnia is simulated; and meanwhile, the main control module also controls the sleep deprivation model device to cooperate to complete simultaneous simulation of intermittent combined hypoxia and hypercapniain a sleep deprivation state. The superposition of the three model factors can be closer to the pathophysiological mechanism for simulating the humanobstructive sleep apnea hypopnea hypoventilation syndrome.

The invention discloses a cell intermittent hypoxia experiment device which comprises an upper sleeve and a lower supporting cylinder which are distributed in the direction from top to bottom, a clamping structure is arranged between the upper sleeve and the lower supporting cylinder, an air pressure detection structure and an air conditioning structure are arranged on the upper sleeve, and the air pressure detection structure is composed of an airtight column and an air diaphragm. The air conditioning structure is composed of a first connecting air nozzle and a connecting ring sleeve, a three-way air inlet part is arranged in the air conditioning structure, the clamping structure is composed of a connecting ring frame and a threaded ejector rod, the tail end of the connecting ring frame is installed on the circumferential outer wall of the lower supporting cylinder, and a threaded positioning block is fixedly installed at the center point of the connecting ring frame; and the threaded positioning block is in threaded connection with the threaded ejector rod. In the using process, the device can be suitable for various cell sample experiments, in the experiment process, the air content in the device can be accurately controlled, and the device is good in air tightness and easy to regulate and control.

The invention discloses a small molecule drug and its application in treating intermittent hypoxia, and relates to the technical field of medicine. The drug includes GSK2606414 and milk thistle extract, which can significantly improve hippocampus-dependent cognitive function decline; it has a certain effect on the improvement of hippocampal synaptic plasticity, and can inhibit the activation of the PERK pathway. The drug is administered in the amount of 45-55 mg / kg of GSK2606414 and 32.4-50 mg / kg of milk thistle extract per day, administered once a day or divided into 2-4 times, taking 12-14 days or longer.

The invention relates to an experimental animal feeding cabin, in particular to a vertical lifting intermittent hypoxia rat and mouse feeding cabin, which comprises feeding cages, hypoxia feeding cabins formed by closed cabin bodies and buffer cabins formed by closed cabin bodies. An isolating cabin door is arranged between each buffer cabin and each hypoxia feeding cabin. The buffer cabins are overlaid on the hypoxia feeding cabins. A buffer cabin door is arranged at the top of each buffer cabin. The feeding cages are respectively arranged above the hypoxia feeding cabins and the buffer cabins. A feeding cage lifting driving device drives the feeding cages to periodically pass through the buffer cabins to get in and out of the hypoxia feeding cabins. Since the feeding cages, the buffer cabins and the hypoxia feeding cabins are vertically arranged and the feeding cages are driven to be lifted up and lowered down by using the feeding cage lifting driving device, the vertical lifting intermittent hypoxia rat and mouse feeding cabin has the advantages that the occupied area is smaller, the field utilization ratio is higher, the noise is low, the manufacturing of linear tracks is not needed, the structure is compact, the working reliability is higher, the feeding cabin is convenient to control and the manufacturing cost is lower.

The invention provides a preparation method and system of mixed gas for preparing an intermittent hypoxia animal model, mainly relates to the technical field of medical experiments. The system comprises a plurality of gas mixing devices for generating hypoxia gas, a cage box which is used for placing experimental animals and which is supplied with gas through the gas mixing devices, and a waste gas treatment device, wherein the waste gas treatment device is communicated with the cage box through a waste gas outlet pipe; the gas mixing devices are communicated with the cage box through a mixed gas inlet pipe, and the multiple gas mixing devices are connected to the mixed gas inlet pipe in parallel. Gas is mixed in the gas mixing devices in advance, then the mixed gas is input into the cage box for animal modeling, the gas mixing time can be shortened, animal modeling is more facilitated, the modeling efficiency is high, the success rate is high, meanwhile, batch animal modeling can be conducted, and the animal modeling efficiency is improved. The modeling time is shortened, the cost is reduced, the application range is wide, two airflow layouts are used for experimental animals with different body types and sizes, and the practicability is high.

The invention relates to an experimental animal feeding cabin, which is the big and small mice feeding cabin for simulating the symptom of intermittent anaerobic respiration of animal. One side of hypoxia feeding cabin is further connected with a buffering cabin formed from a closed cabin body and a feeding cage track such that the feeding cabin loading the big mouse is timed to stay between the hypoxia feeding cabin and the outside along the feeding cage track so as to simulate the big mouse model of SAS by the long-period intermittent breathing hypoxia gas. There is no need to timely and frequently discharge the nitrogen in the hypoxia feeding cabin, thus, the consumption quantity of the nitrogen is greatly reduced and the experiment cost is reduced by a wide margin.

The invention discloses a device and method for treating low-carbon urban sewage through synchronization of anaerobic ammonia oxidation coupling denitrifying phosphorus removal and endogenous denitrification, and belongs to the field of biological sewage treatment. Urban sewage enters an endogenous denitrification coupling dephosphorization SBR reactor for anaerobic stirring, energy is provided for glycogen inside denitrification glycogen-accumulating organisms decomposition cells, volatile fatty acid VFA in sewage is absorbed for synthesizing an internal carbon source PHA to be stored into the body, meanwhile, the denitrification phosphate-accumulating organisms are subjected to anaerobic phosphorus release, and VFA in the sewage is absorbed for synthesizing PHA to be stored into the body; after anaerobic stirring is finished, precipitation and drainage are performed, outlet water is drained into a middle water tank; then, water containing ammonia nitrogen and phosphate in the middle water tank is made to enter an integrated partial nitrification anaerobic ammonia oxidation SBR reactor, intermittent hypoxia aeration stirring is performed, and water is drained and drained into a water outlet tank; the outlet water of the integrated partial nitrification anaerobic ammonia oxidation SBR reactor is made to enter the endogenous denitrification coupling dephosphorization SBR reactor for hypoxia aeration stirring. According to the method, organic carbon sources in raw water are efficiently utilized, and the aeration rate is saved.

The present invention relates to the construction of an animal model, specifically a method for establishing a mouse model of obstructive sleep apnea with aortic dissection. In the method, a subcutaneous pump is used to continuously perfuse angiotensin II in an intermittent hypoxia simulation chamber to establish a mouse model. Animal model, the method of the present invention establishes a mouse model of obstructive sleep apnea with aortic dissection, which combines the IHR curve of an adult patient with simulated severe OSAS and the AD mouse model induced by Ang II to evaluate this new mouse model Finally, we were able to demonstrate that the IH group had a higher rate of AD formation, a larger maximum aortic diameter, and a lower cumulative survival rate than the control group. These phenotypic data are consistent with findings in humans. Therefore, we established a reliable and easy-to-use mouse model to study the role of OSAS in AD.

The invention relates to an exosome derived from a mesenchymal stem cell. The exosome is prepared by intermittent hypoxic stimulation of the mesenchymal stem cell. The exosome prepared from the invention has stronger tissue and organ ischemia-reperfusion injury protective effect, and the biological effect of unit exosomes is improved, and treatment of diseases such as ischemic heart disease is more facilitated.