119 results about "INTESTINAL ULCERATION" patented technology

The invention provides a health-care flour composition and food and a preparing method thereof. According to the preparing method, hericium erinaceus and flour are used as main raw materials, swelling agents, sweetening agents, oil, salt and the like are added and mixed with water, and then rolling, forming, baking, oil injection and cooling are carried out to obtain various foods made of flour or pastries such as cookies, cakes and noodles. The health-care flour composition and food are even in texture, capable of being stored for a long time easily, good in mouthfeel and rich in nutrient, and market vacancy is filled. The health-care flour composition and food have definite effects in repairing gastric mucosal damage caused by chronic gastritis, or gastric ulcers or duodenal ulcers, relieving abdominal pains caused by chronic gastritis, or gastric ulcers or duodenal ulcers, inhibiting helicobacter pylori, and assisting the treatment of chronic gastritis, gastric ulcers and duodenal ulcers.

The invention discloses a new Chinese medicine composite for treating duodenal ulcer and a preparation method thereof. The Chinese medicine composite mainly comprises the following active pharmaceutical ingredients of stir-fried frankincense, stir-fried myrrh, semen coicis, lignum dalbergiae odoriferae, pericarpium citri reticulatae, fructus hordei germinatus, medicated leaven, radix trichosanthis, tuckahoe, rhizoma coptidis, baikal skullcap root, radix sophorae flavescentis, densefruit pittany root-bark, Chinese wolfberry root-bark, white flower patrinia herb, fructus amomi, lignum aquilariae resinatum, aspongopus, rhizoma corydalis, raw radix astragali, rhizoma dioscoreae, radix codonopsis and white peony root, and the like. The Chinese medicine composite can be prepared to be any common oral preparation according to the conventional Chinese medicine preparation method. The Chinese medicine composite can obviously improve epigastric pain, vague pain and complaint, hemorrhea, gastric perforation, obstruction and the like, which has definite clinical effect, obvious curative effect and fast desired effect. Due to the combination of the medicines both as food and medicine according to state-promulgated pharmacopoeia, the Chinese medicine composite of the invention has the advantages of low cost, basically no toxic side effect and the like.

The invention discloses a rhodiola rosea compound composition for treating peptic ulcer. The rhodiola rosea compound composition is a preparation prepared from the following active pharmaceutical ingredients in parts by weight: 4.2-7.2 parts of rhodiola rosea, 14-26 parts of poria cocos, 10.5-19.5 parts of dandelion, 10.5-19.5 parts of capillary artemisia, 10.5-19.5 parts of white atractylodes rhizome, 7-13 parts of pogostemon cablin, 7-13 parts of raw malt, and 3.5-6.5 parts of fructus amomi rotundus. The compound composition disclosed by the invention is exact in compatibility of medicines, quite less in medical ingredients, not only capable of ensuring medicine efficacy and reducing side effects, but also capable of effectively treating gastric ulcer, duodenal ulcer, and erosive gastritis, and provides a new administration choice for the clinical treatment of the peptic ulcer.

The invention relates to a dietetic therapy meal auxiliary or meal replacement product for gastric ulcer and duodenal ulcer. The main components and a preparation method are as below: first conducting superfine grinding on chicken's gizzard membrane, cape jasmine, a honeysuckle decoction, a kiwi fruit powder, pine pollen, a fingered citron powder, lily, processed licorice, clove and litchi into a powder, and adding a coix seed powder, a Poria powder, a wheat germ powder, a Chinese yam powder and a walnut powder; or decocting the materials with water, filtering the decoction and spraying a filtrate into the coix seed powder, the Poria powder, the wheat germ powder, the Chinese yam powder and the walnut powder; conducting high temperature slaking on the mixture; adding xylo oligosaccharide, a Lactobacillus acidophilus powder, a bifidobacterium powder, a natto powder, a yeast powder, an L-arabinose powder and a spirulina powder; mixing uniformly; and conducting subpackaging. The invention employs reasonable compatibility of materials which are used as both food and medicine and utilizes the principle of balance constitution in traditional Chinese medicine, so that the human body can restore balance and achieve the stable state of health through diet. The product reduces incidence of diseases related to gastric ulcer and duodenal ulcer physique and has the advanategs of safety, effectiveness, little toxic or side effect, common food as the main raw materials, low price and easiness for people to accept.

Methods of treating, reducing, or preventing a disease or symptom relating to a disease such as oral mucositis, gingivitis, periodontitis, gastric mucositis, inflammatory fibrosis, gastritis, colitis, ileitis, Crohn's disease, chronic inflammatory intestinal disease, inflammatory bowel syndrome, chronic inflammatory bowel disease, celiac disease, ulcerative colitis, a gastric ulcer, a peptic ulcer, a buccal ulcer, a nasopharyngeal ulcer, an esophageal ulcer, a duodenal ulcer, a gastrointestinal ulcer, an autoimmune disorder, inflammation associated with cancer, cancer treatment, or radiation, and / or pain that include: identifying a patient in need of treatment; and administering a therapeutically effective amount of at least one cationic steroid antimicrobial (CSA), or a pharmaceutically acceptable salt thereof. Kits comprising such compositions and instructions on such methods are also contemplated herein.

The invention discloses vonoprazan fumarate dispersible tablets, used for treating gastric and duodenal ulcers. The vonoprazan fumarate dispersible tablets are prepared from vonoprazan fumarate, with the addition of adjuvant materials. The vonoprazan fumarate dispersible tablets are rapid in disintegration and absorption, high in bioavailability, convenient to take, low in content of intestinal residues, light in side effects, sweet in taste and fragrant; and especially, the dispersible tablets are easy to improve the medication compliance of patients.

The invention provides a combined drug of pantoprazole and domperidone and in particular provides application of pantoprazole and domperidone to preparing combined injections for treating gastric ulcer, duodenal ulcer, gastro-esophageal reflux diseases or functional dyspepsia. The invention also provides the combined injections for treating gastric ulcer, duodenal ulcer, gastro-esophageal reflux diseases or functional dyspepsia, including different specifications of unit preparations, pantoprazole and domperidone for simultaneous, respective or successive administration and preparations prepared by pharmaceutically acceptable vectors. The weight ratio of pantoprazole and domperidone is 1:1-5:1, and the pantoprazole and domperidone contain excipients, stabilizing agents, etc. Through combined injection administration, the invention improves the bioavailability of pantoprazole and domperidone and ensures the treatment effects to be obviously better.

The invention discloses a preparation method of a medicine for treating peptic ulcers. The method comprises the following steps: (1) weighing raw medicinal materials in parts by weight: 17 to 23 parts of potentilla anserina, 7 to 12 parts of poria cocos, 5 to 9 parts of oriental wormwood, 5 to 9 parts of pogostemon cablin, 5 to 9 parts of raw malt, 3 to 7 parts of mangnolia officinalis, 3 to 7 parts of perilla leaves and 3 to 7 parts of caulis perllae; (2) pulverizing the potentilla anserina to form powder for later use; firstly adding 55-95v / v% (volume per volume) ethyl alcohol into the other medicinal materials except for the potentilla anserina for extracting, filtering to obtain an alcohol extract for later use, decocting filter residue by adding water, combining the alcohol extract with the filter residue, concentrating and then adding the potentilla anserina powder and pharmaceutically acceptable auxiliary materials so as to obtain the medicine. The medicine is less in medicinal flavor according to a specific dosage proportion, and can be used for effectively treating gastric ulcers, duodenal ulcers and erosive gastritis, thereby providing a new medicine selection for clinic treatment of the peptic ulcers. Meanwhile, the pharmacological test proves that the pharmacological activity of the medicine is improved in manners of double alcohol-water extraction and pulverization of the potentilla anserina into medicinal powder, so that the economical utilization of medicinal material resources is realized.

The present invention relates to a kind one active enzymes, including lysozyme, glycose oxidase and casease, and their composition capable of constituting medicine and health food for preventing and treating gastric ulcer, duodenal ulcer and chronic gastritis and enzyme containing cosmetics. The present invention discloses the medicine recipe for treating gastric ulcer, duodenal ulcer and chronic gastritis effectively, and the medicine has obvious functions of sterilizing, inhibiting gastric acid secretion and repairing gastric mucous membrane to cure the said diseases radically. The present invention also discloses the cosmetic composition containing active enzyme and the cosmetic composition can nourish and care skin and sterilize to prevent bacterial infection.

The invention provides a traditional Chinese medicine preparation for treating peptic ulcer, mainly gastric ulcer and duodenal ulcer. Due to the functional characteristics of strengthening the body resistance, removing the necrotic tissue and promoting tissue regeneration, the preparation can promote reversion and repair of pathological tissues, thereby solving the problem that clinically obstinate cases are short of a traditional Chinese medicine preparation with obvious curative effect. The preparation is prepared from 14 traditional Chinese medicines, namely ginseng, astragalus root, tuckahoe, bighead atractylodes rhizome, white peony root, hyacinth bletilla, angelica, immature bitter orange, amomum fruit, officinal magnolia bark, cinnamon, costus root, licorice and rhubarb. The preparation has the functions of dissipating blood stasis, removing the necrotic tissue, astringing ulcer, promoting tissue regeneration, invigorating qi and strengthening the body resistance. Based on different characteristics of each traditional Chinese medicine raw material, the preparation is prepared into granules by the steps of pretreatment such as volatilization, solvent extraction and the like, and then concentration, air drying and sterilization based on proportions and time. The traditional Chinese medicine preparation for treating peptic ulcer provided by the invention has the characteristics of obvious therapeutic effect, no adverse reaction and the like, and can be widely popularized in the field of traditional Chinese medicine clinic.

The invention discloses a medicament for treating chronic gastrointestinal tract diseases and a preparation method of the medicament. The medicament comprises vinegar-processed corydalis yanhusuo, vinegar-processed cyperus rotundus, dried tangerine peel, bran-parched atractylodes macrocephala, aucklandia lappa, fructus amomi, parched endothelium corneae gigeriae galli, bran-parched atractylodes lancea, parched hawthorn fruit, charred medicated leaven, dark malt, astragalus membranaceus, codonopsis pilosula, cuttlefish bone, calcined concha ostreae, roasted fructus aurantii immaturus, coptis chinensis and honey-fried licorice root. The preparation method is simple. With the compatibility of the above medicinal materials, the whole formulation has the effects of promoting Qi circulation to relieve pain, invigorating the spleen and stomach and promoting digestion to eliminate food stagnation, is used for relieving the syndrome of weakness of the spleen and stomach, manifested by the symptoms of gastric distention, pain of the chest, hypochondrium and belly, poor appetite, nausea and vomiting, is suitable for treating gastritis, gastric ulcer, duodenal ulcer and the like, achieves the effect of treating both symptoms and root causes of a disease, and can not only effectively relieve the patient's discomforts but also eliminate pathogenic causes by invigorating the spleen and stomach, with no recurrence.

The invention relates to casing smooth muscle collagen preparation method and functional study. In the method, smooth muscles in casing of animals such as sheep and cattle are used as raw materials, and collagen is extracted from the smooth muscles in the casting by processes of washing, acidic and alkaline treatment, heating, stewing, cooling, soaking in alcohol, drying and crushing; and the treated casing smooth muscle collagen is yellowish solid particles. The method has the advantages that: the process flow is simple; the equipment is easy to configure and operate; the energy consumption is low; and the yield is high. The functional study on the casing smooth muscle collagen particles shows that the casing smooth muscle collagen can be developed as a novel assistant medicament for treating gastrointestinal ulcer, diabetes, cancers and other diseases, can serve as a health-care product for promoting digestion and absorption, protecting human gastroenteric mucosa and improving body immune function, can be used as a component of toothpaste for protecting teeth and treating dental ulcer, can be used as a component of cosmetics and has special skin-beautifying, skin-care and anti-wrinkle functions.

The present invention provides a medicine composition for effectively curing the diseases of gastritis, gastric ulcer and duodenal ulcer. Said medicine composition contains sodium hyaluronate, zinc salt and conventional medicinal auxiliary material.

The invention discloses a lansoprazole N crystal form and a preparation method and application thereof. The X-ray powder diffraction of the lansoprazole N crystal form has characteristic peaks when the diffraction angle 2(theta) is 5.438, 7.062, 8.230, 9.216, 11.022, 11.789, 12.610, 13.541, 20.603, 21.862 and 26.242. The preparation method comprises the following steps of: dissolving lansoprazole in ethyl acetate or a mixed solvent of n-butyl alcohol and water; cooling to separate out crystals; and filtering and drying to obtain the lansoprazole N crystal form. The new lansoprazole crystal form disclosed by the invention is easy to prepare; the preparation method requires little solvent and is simple to operate, and the production cost is low; the reaction conditions are mild, and the control is easy; and the reproducibility is good, and a target product crystal form can be stably obtained. Through the method disclosed by the invention, the prepared lansoprazole crystal form has high purity and low impurity content, maintains all pharmacologic characteristics of lansoprazole, and can be used for treating gastric ulcer, duodenal ulcer and reflux esophagitis and eradicating helicobacter pylori.

The invention provides a medicinal composition for treating gastric ulcer and duodenal ulcer. The medicinal composition is prepared from 18-22 g of omeprazole, 300-600 g of licorice root, 250-500 g of white peony root, 100-300 g of Rhizoma Corydalis, 50-200 g of cuttlebones, 100-300 g of Radix Codonopsis and 100-250 g of Fructus Aurantii. The medicinal composition has practicable and effective effects on the gastric ulcer and duodenal ulcer, and can maximally reduce the repeated attack of the gastric ulcer and duodenal ulcer in order to reach the purpose of treating both manifestation and root cause of diseases.

The invention relates to a new application of plumbagin, particularly to an application of the plumbagin in preparing drugs for inhibiting tumor angiogenesis, psoriasis, Kaposi's sarcoma, diabetic retinopathy, aleukemic leukemia, rheumatoid arthritis, duodenal ulcer, myeloma, and lymphomata. The experimental results show that the plumbagin can inhibit the proliferation, migration and canalization of endothelial cells, and inhibit the angiogenesis of chick embryo allantoic membrane. Therefore,the plumbagin can be used for preparing drugs for inhibiting the angiogenesis.

The invention discloses a mixed-grain full-nutrition formulation food for patients with gastrointestinal tract malabsorption and pancreatitis, and relates to the technical field of healthcare foods. The food is prepared by mixing millet, corn starch, protolysate powder, lactalbumin, glucose, traditional Chinese medicine extracting liquid, honey, medium-chain triglyceride and stevioside. The food is good in mouth feel, excellent in effect, convenient to eat and suitable for auxiliary treatment of the patients with digestive system diseases such as gastrointestinal tract malabsorption, chronic gastroenteritis, gastric ulcer, duodenal ulcer and pancreatitis, and also can serve as a daily healthcare product for preventing the digestive system diseases.

The present invention provides stomach-protecting flour. The stomach-protecting flour is prepared from the following raw materials by weight in parts: 200 to 250 parts of flour, 10 to 15 parts of dry Chinese yam, 5 to 10 parts of poria cocos, 3 to 6 parts of hericium erinaceus, 3 to 8 parts of semen euryales, 2 to 4 parts of medicated leaven, 3 to 5 parts of fried malt, 2 to 3 parts of fried hawthorn, 2 to 4 parts of tangerine seeds, 3 to 5 parts of radish root, 3 to 5 parts of astragalus membranaceus, 3 to 5 parts of codonopsis pilosula, 3 to 5 parts of polygonatum sibiricum, 1 to 3 parts of bletilla striata, 1 to 3 parts of magnolia officinalis, 2 to 3 parts of cinnamomum cassia and 2 to 4 parts of fried glycyrrhiza. The stomach-protecting flour includes the Chinese medicine herbs with effects of promoting digestion, warming spleen and stomach for dispelling cold, harmonizing stomach, tonifying spleen, promoting tissue regeneration, recovering gastrointestinal mucosa and the like. So the stomach-protecting flour is suitable for the populations suffering from gastritis, gastrointestinal ulcers, indigestion and the like. The stomach-protecting flour has a good stomach-protecting healthcare effect.

The invention relates to a hericium erinaceus beverage capable of invigorating the stomach and nourishing the stomach, and a preparation method of the hericium erinaceus beverage, wherein the hericium erinaceus beverage is prepared from 0.1%-15% of hericium erinaceus as a raw material component. The hericium erinaceus beverage is good in quality, color and mouth feel, free from color brown stains, clear and transparent in liquid, free from mushroom flesh precipitation, and free from flavor changes; the hericium erinaceus beverage has the efficacies of repairing gastric mucosa damage caused by chronic gastritis, gastric ulcers or duodenal ulcers, alleviating abdomen pains caused by the chronic gastritis, the gastric ulcers or the duodenal ulcers, being capable of performing auxiliary treatment on the chronic gastritis, the gastric ulcers and the duodenal ulcers, and restraining helicobacter pylori, and is suitable for crowds suffering from gastric diseases (the chronic gastritis, the gastric ulcers and the duodenal ulcers) to drink.

The invention provides a medicament of an ilaprazole chemical structure and application thereof. The medicament comprises the following components in parts by weight: 200 parts of ilaprazole or pharmaceutically acceptable salts and hydrates thereof, 0.5-2 parts of nitromidazoles antibiotics and 1-5 parts of quinolones antibiotics. The inhibition activity of the medicament composition is at least 3-4 times higher than the activities of the omeprazole and the antibiotic medicaments or the combined activity of ilaprazole, amoxicillin and clarithromycin, the medicament can be used for more effectively inhibiting or killing helicobacter pylori and treating duodenal ulcer, gastric ulcer and / or chronic gastritis.

The present invention discloses the application of natural beta-carotene oil and natural beta-carotene crystal in treating gastrointestinal diseases and protecting gastrointestinal mucous membrane. Animal experiment shows that natural beta-carotene oil, natural beta-carotene crystal, mixture of natural beta-carotene oil and natural beta-carotene crystal, and several monomers of natural beta-carotene have the functions of treating gastric ulcer, duodenal ulcer, gastritis, enteritis, etc. in high curative effect, and the function of protecting gastrointestinal mucous membrane.

The invention discloses a formula and administration method of a traditional Chinese medicine for treating stomach troubles, and relates to the technical field of traditional Chinese medicine formulas. The traditional Chinese medicine is prepared from, by mass, 10-20 parts of Radix Codonopsis, 25-30 parts of cuttlebone, 5-15 parts of Fritillaria cirrhosa, 4-8 parts of corydalis tuber, 6-10 parts of dried orange peel, 10-15 parts of Rhizoma Cyperi, 20-30 parts of stir-fried malt, 5-10 parts of safflower, 3-5 parts of rheum officinale, 4-8 parts of licorice root, 10-20 parts of Radix Astragali and 10-15 parts of bletilla striata. The traditional Chinese medicine has substantial curative effects on gastric ulcer, duodenal ulcer, superficial gastritis and other gastric cavity distending pains, and acid regurgitation, hiccup singultation, reflux esophagitis and other common digestive system diseases, and is obviously better than common western medicine therapies. The traditional Chinese medicinal disease treatment characteristics of efficiency, effectiveness, low price, and simultaneous treatment of principal and subordinate symptoms are emphasized.

The invention belongs to the technical field of medicines, and concretely relates to a rabeprazole sodium hydrate and its preparation method. The rabeprazole sodium hydrate obtained in the invention contains one crystal water, has a good stability, and has an unobvious moisture absorption weight increment under highly humid conditions, and the gastric acid secretion inhibition effect of the hydrate is 20% higher than that of a rabeprazole sodium tablet. The invention also relates to applications of compositions of the hydrate in the treatment of digestive system diseases comprising duodenal ulcer, gastric ulcer, reflux esophagitis and the like.

The present invention provides eight-ingredient stomach strengthening and digestion promoting granule as Chinese medicine preparation for treating chronic gastritis, gastric ulcer and duodenal ulcer and its preparation process. The Chinese medicine preparation is prepared with eight kinds of Chinese medicinal materials, including chicken's gizzard membrane, white atractylodes rhizome, clove, etc. The preparation process includes crushing coix seed and chicken's gizzard membrane into fine powder, decocting other Chinese medicinal materials to obtain decoction, concentrating the decoction into dense paste, mixing the fine powder and the dense paste to form soft material, sieving, pelletizing, drying, finishing and bagging. The Chinese medicine preparation has obvious curative effect, and low cost.

The invention discloses powder for treating peptic ulcer. The powder is prepared by a method comprising the following steps: (1) weighing the following medicinal raw materials in parts by weight: 7-13 parts of bighead atractylodes rhizome, 7-13 parts of poria cocos, 7-13 parts of seed of vigna umbellata, 5-10 parts of radix astragali, 5-10 parts of herba artemisiae scopariae, 5-10 parts of dandelion, 3-7 parts of bitter apricot seed, 3-7 parts of radix platycodi, 3-7 parts of stem or leaf of pogostemon cablin, 2-3 parts of dried ginger and 2-3 parts of ginseng; and (2) smashing the medicinal raw materials until particle size is 300-500 meshes, and uniformly mixing the ground medicinal raw materials so as to obtain the powder. The pharmaceutical composition disclosed by the invention, on the basis of a synergistic effect among the medicinal raw materials which are subjected to reasonable combination, is effective on treating gastric ulcer, duodenal ulcer and erosive gastritis; therefore, a new choice is provided for clinical medication of treating the peptic ulcer.

The invention discloses a preparation method of a medicine for treating peptic ulcer. The preparation method comprises the following operating steps: (1) weighing the following raw materials in parts by weight: 7-13 parts of bighead atractylodes rhizome, 7-13 parts of poria cocos, 7-13 parts of seed of vigna umbellata, 5-10 parts of radix astragali, 5-10 parts of herba artemisiae scopariae, 5-10 parts of dandelion, 3-7 parts of bitter apricot seed, 3-7 parts of radix platycodi, 3-7 parts of stem or leaf of pogostemon cablin, 2-3 parts of dried ginger and 2-3 parts of ginseng; and (2) adding water with the weight 8-15 times that of the raw materials into the raw materials for decocting and extracting for three times, wherein the extraction for the first time lasts for 10-20min and the extraction for the second time and the extraction for the third time respectively last for 30-60min, and combining decoctions so as to obtain the medicine for treating peptic ulcer. The medicine disclosed by the invention, on the basis of a synergistic effect among the medicinal raw materials which are subjected to reasonable combination, is effective on treating gastric ulcer, duodenal ulcer and erosive gastritis; therefore, a new choice is provided for clinical medication of treating the peptic ulcer. The preparation method disclosed by the invention, by virtue of a water-decocting process, can be used for simply and safely preparing a medicine or an extract which is concrete in efficacy on treating peptic ulcer; and the preparation method is conductive to saving production cost and is convenient for industrial production.

Methods of treating, reducing, or preventing a disease or symptom relating to a disease such as oral mucositis, gingivitis, periodontitis, gastric mucositis, inflammatory fibrosis, gastritis, colitis, ileitis, Crohn's disease, chronic inflammatory intestinal disease, inflammatory bowel syndrome, chronic inflammatory bowel disease, celiac disease, ulcerative colitis, a gastric ulcer, a peptic ulcer, a buccal ulcer, a nasopharyngeal ulcer, an esophageal ulcer, a duodenal ulcer, a gastrointestinal ulcer, an autoimmune disorder, inflammation associated with cancer, cancer treatment, or radiation, and / or pain that include: identifying a patient in need of treatment; and administering a therapeutically effective amount of at least one cationic steroid antimicrobial (CSA), or a pharmaceutically acceptable salt thereof. Kits comprising such compositions and instructions on such methods are also contemplated herein.

The invention discloses a fibronectin (FN) oral agent for preventing and curing gastric and intestinal ulcers. The FN oral agent is characterized by comprising the following components in percentage by weight: 0.05-0.20% of FN, 0.01-0.15% of active small molecule peptide, 1-5% of lysyme, 10-20% of sweetening agent and the balance of water. The FN oral agent disclosed by the invention takes the bioactive ingredient, namely FN, as a core functional component assisted by the active small molecule peptide, lysyme, xylitol and the like, so that the FN oral agent can effectively promote proliferation of mucous epithelium and cells, can participate in cell metabolism and activate the cells, and not only can effectively cure peptic ulcers including gastric ulcer, duodenal ulcer and the like, but also can achieve effects of resisting aging, maintaining beauty, improving immunity and the like.

The invention provides a traditional Chinese medicine composition for preventing and treating constipation. The raw materials of the traditional Chinese medicine composition comprise honeysuckle stems and leaves. The traditional Chinese medicine composition can be used for preparing drug or health-care food which is clinically used for promoting peristalsis and preventing and treating constipation, , and is used for preventing, controlling and treating diseases such as intestinal obstruction caused by poor peristalsis and constipation and colonic ulcer and complications of the diseases. The traditional Chinese medicine composition is simple in preparation process, low in energy consumption, pollution-free, safe and convenient and easy to store, has definite effects, and is easy to produce industrially.