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217 results about "Ionophore" patented technology
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An ionophore is a chemical species that reversibly binds ions. Many ionophores are lipid-soluble entities that transport ions across a cell membrane. Ionophore means "ion carrier" as these compounds catalyze ion transport across hydrophobic membranes such as liquid polymeric membranes (carrier-based ion selective electrodes) or lipid bilayers found in the living cells or synthetic vesicles (liposomes).
Compositions And Methods For Removing Scale And Inhibiting Formation Thereof
InactiveUS20100000579A1Inhibition formationExtension of timeOrganic detergent compounding agentsScale removal and water softeningGluconic acidCarboxylic acid
Compositions for removing scale and / or inhibiting formation thereof include an alkaline agent, a primary scale inhibitor, a secondary scale inhibitor and a solvent. The primary scale inhibitor may include phosphonic acid, salts of phosphonic acids and combinations thereof. Suitable secondary scale inhibitor may include aminocarboxylic acids, salts of aminocarboxylic acids, carboxylic acids, salts of carboxylic acids, polycarboxylic acids, salts of polycarboxylic acids, gluconic acids, salts of gluconic acids, steroids, tetrapyrrols, ionophores, 2,2′-bipyridine, dimercaptopropanol, ortho-phenanthroline and combinations thereof. The compositions may be prepared as a stable concentrates that have pH values greater than or equal to 11. The compositions may also be prepared on site as a use solution. Methods of using the compositions to extend system operating times and to remove scale from and / or inhibit formation of scale on an article are also disclosed.
Owner:DELAVAL HLDG AB
Point of care heparin determination system
ActiveUS7699966B2Rapid determinationImmobilised enzymesBioreactor/fermenter combinationsPoint of careReference sample
Owner:MEDTRONIC INC
Methods and compositions for the delivery of bioactive compounds
InactiveUS20110117026A1Low immunogenicityReduce gapUltrasonic/sonic/infrasonic diagnosticsOrganic active ingredientsDiseaseLipid formation
The present invention provides compositions comprising delivery systems comprising a lipid vehicle, a bioactive compound, and a polyanionic carrier macromolecule that is not a carrier polynucleotide, wherein the lipid vehicle encapsulates the polynucleotide of interest and the polyanionic carrier macromolecule, and wherein the delivery system is essentially free of carrier polynucleotides. Compositions also include delivery systems comprising a lipid vehicle and a bioactive agent, wherein the lipid vehicle encapsulates the bioactive agent, and wherein the lipid vehicle comprises a covalent bilayer or a core supported bilayer comprising polycationic lipids. Other compositions provided herein comprise a delivery system comprising a polypeptide of interest and a means for delivering the polypeptide into a cell. Also provided herein are methods for making the delivery systems, methods for delivering bioactive compounds, methods for treating a disease or unwanted condition in a subject with the delivery systems, and methods for detecting apoptosis in a cell.
Owner:THE UNIV OF NORTH CAROLINA AT CHAPEL HILL
Ion sensor for long term use in complex medium
Devices and methods for measuring a target ion concentration uses an electrode pair. The pair includes a working electrode and a reference electrode. The working and reference electrodes are ion-selective electrodes (ISEs). The reference ISE can include a sodium ISE. The ISE pair interacts with body fluids where a target ion concentration changes more than sodium ion concentration over time. Some ISE membranes of a pair vary essentially only in the ionophore. An ISE pair can determine the ratio of a target ion concentration to sodium ion concentration in vivo. Periodic measurement of sodium concentration in drawn blood can be used to calibrate an ISE pair and provide target ion concentration as an output. Or, a potassium / sodium ISE pair beneficially monitors potassium concentration changes over time in heart- or kidney-failure patients. Then, manual or automatic titration of a diuretic material can be implemented to maintain a desired potassium concentration.
Owner:MEDTRONIC INC
Multi-ionophore membrane electerode
InactiveUS20060060471A1Reduce driftImprove adhesionMaterial electrochemical variablesChemical speciesMembrane configuration
A polymeric membrane for ion sensitive measurement comprising a polymer, a lipophilic salt and at least two ionophores selective for different chemical species. The membrane may be used in a pseudo reference for measurement of a plurality of ions.
Owner:DREW SCI
Ionic electro-conductive resin and electro-conductive member for electrophotography
InactiveUS9086643B2Guaranteed mixConductive materialOrganic conductorsConductive polymerOrganic group
Owner:CANON KK
Ion selective electrodes for direct organic drug analysis in saliva, sweat, and surface wipes
InactiveUS20030121779A1Immobilised enzymesBioreactor/fermenter combinationsHydrophobic polymerMedication monitoring
A hand-held portable drug monitoring system to detect and quantitate cocaine and other organic drugs in saliva, sweat, and surface wipes by using an ion selective electrode or an array of ion selective electrodes. The ion selective electrode has a cast membrane reference electrode and a sensing electrode with a hydrophobic polymer, a plasticizer, and an ionophore selective for the organic drug to be tested. The ion selective electrode can be connected to a converter that coverts a voltage reading from the ion selective electrode to a quantitative drug concentration level. Also disclosed is the related method of using an ion selective electrode to detect an organic drug in saliva, sweat, and surface wipes, the method of testing electrical contact in an ion selective electrode, and the method of making a cast membrane reference electrode.
Owner:THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE NAVY
Novel composition for treating metabolic syndrome and other conditions
The invention relates to a composition that includes a first agent selected from the group consisting of an oxidative phosphorylation inhibitor, an ionophore, and an adenosine 5′-monophosphate-activated protein kinase (AMPK) activator; a second agent that possesses anti-inflammatory activity; and a third agent that possesses serotonin activity.
Owner:CHEN CHIEN HUNG
Pharmacological treatment of cognitive impairment
InactiveUS20080009475A1Improving function of individualImprove cognitive functionBiocideNervous disorderPharmacologyPharmacological treatment
Methods for treating an individual to improve cognitive function are provided. In the subject methods, an effective amount of a noncompetitive GABAA ionophore blocker is administered to the individual, resulting in an improvement in cognitive function of the host. The subject methods find use in a variety of different applications.
Owner:THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIV
Method of feeding the cattle with feed additives that increases beef production and reduces liver abscess
The present inventions relates to a method of increasing beef production in cattle with feed additives, comprising feeding cattle with feed, comprising an effective amount of an ionophore in combination with a macrolide antibiotic, and thereafter feeding cattle with feed, comprising zilpaterol and essentially no ionophore or macrolide antibiotic for the succeeding about 20 to 40 days.
Owner:INTERVET INT BV
Zinc ionophores as therapeutic agents
InactiveUS20030119805A1Avoid inactivationPromote absorptionBiocideHydroxy compound active ingredientsSodium PyrithioneMedicine
The present invention provides methods and compositions comprising one or more zinc ionophores for protecting tissue from the harmful effects of apoptosis in patients in need thereof. Concentrations of zinc-pyrithione and diethyldithiocarbamate in the picomolar to nanomolar range have a strong protective effect against apoptosis.
Owner:ZINC THERAPEUTICS CANADA
Water-Soluble, Fluorescent Compounds for Detection of Potassium Ions
ActiveUS20080311041A1Fluorescence enhancementShort timeBiocideMethine/polymethine dyesPotassium ionsWater soluble
The invention provides chromoionophore compounds comprising a triazacryptand (TAC) K+ ionophore conjugated to at least a first chromophoric moiety (e.g., xanthylium dyes and derivatives thereof). In related embodiments, the chromoionophore compounds further comprise a second chromophoric moiety which is insensitive to potassium binding by the TAC ionophore, thus providing for dual wavelength detection and absolute determination of K+ concentration. The invention further provides methods and kits for the determination of K+ concentrations in biological systems, either in vitro or in vivo, using embodiments of inventive chromoionophores.
Owner:RGT UNIV OF CALIFORNIA
Polycation transgene vector and method for synthesizing same
InactiveCN101338318AThe role of tumor targeting is obviousImprove adhesionVector-based foreign material introductionTumor targetingCyclodextrin
A novel nano polycation transgenic vector relates to a nano polycation transgenic vector of a cyclodextrin-polyethyleneimine-folacin ternary assembly structure which takes the cyclodextrin as a skeleton material and polymerizes the cyclodextrin after activated with small molecular polyethyleneimine(PEI) as well as couples the decorative folacin on the cyclodextrin-polyethyleneimine to manufacture the nano polycation transgenic vector with tumor targeting. The material composing method of the vector is simple and effective with a high recycling rate; the material is shown to have the characteristics of low poison and high transfecting efficiency by the filtering of a plurality of tumor cell strains and experiences in the body of a rat.
Owner:林李家宓 +2
Method of feeding the cattle with feed additives that increases beef production and reduces liver abscess
The present inventions relates to a method of increasing beef production in cattle with feed additives, comprising feeding cattle with feed, comprising an effective amount of an ionophore in combination with a macrolide antibiotic, and thereafter feeding cattle with feed, comprising zilpaterol and essentially no ionophore or macrolide antibiotic for the succeeding about 20 to 40 days.
Owner:INTERVET INT BV
Novel composition
This disclosure relates to a pharmaceutical composition that includes a first agent selected from the group consisting of an oxidative phosphorylation inhibitor, an ionophore, and an adenosine 5′-monophosphate-activated protein kinase (AMPK) activator; a second agent that possesses anti-inflammatory activity; and a third agent that is a serotonin metabolite.
Owner:CHEN CHIEN HUNG
Enzyme test peper for detecting hydrogen peroxide concentration
InactiveCN1821754AEasy to carryEasy to measureMaterial analysis by observing effect on chemical indicatorMicrobiological testing/measurementHydrogenEnzyme test
This invention relates to a kind of enzyme test paper capable of testing hydrogen peroxides in a sample quickly prepared by an enzymatic chromogenic reaction, which utilizes the adsorption action with anion carriers to fix the horseradish peroxide enzymes with positive charges and a developer on a carrier at the same time, which can test the existence of hydrogen peroxides with the concentration to 0.5mumol / L in the sample and the response time of the test paper is 1 minute.
Owner:SOUTH CHINA AGRI UNIV
Bio-compatible means for controlled drug delivery to tissue and method of use
There are provided bio-compatible means for delivery of at least one pharmaceutically active agent to a patient in need of same, comprising a bio-compatible, bio-degradable anionic or cationic carrier and at least one pharmaceutically active agent wherein the agent is cationic when the carrier is anionic and is anionic when the carrier is cationic. The delivery means further comprises at least one bio-compatible enclosing means for the carrier. This enclosing means may be bio-degradable or non bio-degradable and have a predetermined permeation gradient for the passage therethrough of the at least one pharmaceutically active agent. In an alternate embodiment the enclosing means may be biodegradable without a predetermined permeation gradient for the passage therethrough of the at least one pharmaceutically active agent. In all embodiments the active agent is ionically linked to the carrier and the carrier / active agent combination is enclosed in the enclosing means. There is also provided a method of administering at least one pharmaceutically active agent to the tissue surface of a subject in need of same at a rate dependent on the permeability and / or bio-degradability of the enclosing means of the delivery means which comprises contacting the tissue surface with a bio-compatible delivery means as described above.
Owner:ETHICON INC
Ion-selective solid-state polymeric membrane electrondes
InactiveUS20050006237A1Strengthen membraneMinimal and no failureWeather/light/corrosion resistanceVolume/mass flow measurementIon selective membraneElectron
An improved ion-sensing electrode for detecting ions or polyions is provided having an electrically conducting member sheathed or coated with a layer of insulation except at an exposed, uninsulated area, where the insulation free surface of the electrically conducting member is texturized, and a polymeric membrane coated on the insulation-free surface of the electrically conducting member, where the ion selective membrane includes an ionophore. The texturized surface improves the starting EMF stability and reproducibility of the ion-sensing electrodes, and further improves membrane adherence to the electrically conducting member.
Owner:RGT UNIV OF MICHIGAN
Potentiometric Electrode, Gradient Polymer, Uses And Method Of Preparation Therefor
ActiveUS20080000290A1Material analysis using sonic/ultrasonic/infrasonic wavesElectrolysis componentsElectricityElectrical connection
The present invention relates to a potentiometric electrode and gradient polymer, both comprising electrically conducting particles, which increase in concentration away from one surface, ionophore molecules, which increase in concentration towards the same surface surface, and an electrical connection which passes proximal to said electrically conducting particles. The invention further relates to devices incorporating said electrode or gradient polymer, and to a method for their preparation. The new materials are highly robust and reliable.
Owner:PION
Delivery of nucleic acid complexes from particles
Embodiments of the invention include particles with nucleic acid complexes, medical devices including the same and related methods. In an embodiment, the invention can include a method of making a medical device. The method can include contacting nucleic acids with cationic carrier agents to form nucleic acid complexes, adsorbing the nucleic acid complexes to porous particles to form nucleic acid complex containing particles, mixing the nucleic acid complex containing particles with a polymer solution to form a coating mixture, and applying the coating mixture to a substrate. In an embodiment, the method can include contacting nucleic acids with cationic carrier agents to form nucleic acid complexes, combining the nucleic acid complexes with a material to form nucleic acid complex containing particles in situ, mixing the nucleic acid complex particles with a polymer solution to form a coating mixture, and applying the coating mixture to a substrate. In an embodiment, the invention can include an implantable medical device including a substrate, an elution control matrix disposed on the substrate; a plurality of particles disposed within the elution control matrix, and a plurality of nucleic acid complexes disposed within the particles, the nucleic acid complexes comprising a nucleic acid and a cationic carrier agent. Other embodiments are included herein.
Owner:SURMODICS INC
Liposomes comprising amphipathic drugs and method for their preparation
The present invention provides a liposome having co-encapsulated in its intraliposomal aqueous core at least two amphipathic drugs, the liposomes being characterized by one of the following: the amphipathic drugs are co-encapsulated at a pre-determined ratio; the liposome comprises one or a combination of liposome forming lipids have a solid ordered to liquid disordered phase transition temperature above 37° C.; each of the amphipathic drugs exhibit a liposomal profile that corresponds to the profile of each drug when encapsulated as a single drug in the same liposome; and the liposome is absent of one or both of a transition metal and a ionophore. The invention also provides a method for preparing such liposomes. This method, taken together with the features of the liposomal composition, provides high loading and long term stability of the resulting co-encapsulated liposomal formulation.
Owner:YISSUM RES DEV CO OF THE HEBREWUNIVERSITY OF JERUSALEM LTD
Voltammetric Ion Sensor
InactiveUS20080011606A1Short response timeResponse time can be changedWeather/light/corrosion resistanceVolume/mass flow measurementSupport matrixQuantitative determination
A method for the quantitative determination of an ion in a fluid which comprises subjecting the fluid to voltammetry using a sensing electrode which comprises an electrically conducting support having a surface which is coated with a support matrix, the support matrix containing an electroactive species capable of being oxidised or reduced to form a charged species, and an ionophore.
Owner:ROCHE DIAGNOSTICS OPERATIONS INC +1
Intracellular nanosensors and methods for their introduction into cells
InactiveUS8263358B2Ultrasonic/sonic/infrasonic diagnosticsBioreactor/fermenter combinationsFluorescenceAbsorbance
The invention provides ion-selective sensors capable of selectively measuring ions, e.g., Na+, K+, Cl−, etc., in the cytosol of a single living cell. The sensor comprises one or more quantum dots or a fluorescent dye, a pH-sensitive dye, and optionally an ion-selective component such as an ionophore. These elements may, for example, be disposed in a polymer matrix. The polymer matrix comprises an internalizing moiety which enables the sensor to localize within the cytosol of a cell. The internalizing moiety comprises a small molecule or peptide such as an amine, antepennepedia, mastoparan, or melittin that react under acidic conditions to release a sensor from the confines of a endosome. Once in the cytosol the sensors may detect ionic analytes by selective ion extraction by the polymer, thereby inducing a pH change within the sensor which in turn changes the absorbance of the pH-sensitive dye. The change of absorbance may in turn attenuate the intensity of detectable emissions, e.g., fluorescence, from the quantum dot or dye by directly absorbing its fluorescence emission.
Owner:CHARLES STARK DRAPER LABORATORY
Cationic carriers for nucleic acid delivery
InactiveUS20190336608A1Efficient deliveryGood effectOrganic active ingredientsOrganic chemistryModified dnaIonophore
Compositions for nucleic acid delivery are provided which comprise a relatively low amount a permanently cationic lipid or lipidoid, such as a lipid comprising a quaternary ammonium group. The compositions are suitable for the delivery of chemically modified or unmodified DNA or RNA. Moreover, the compositions are suitable for local administration, such as by extravascular injection.
Owner:CUREVAC AG
System for drug iontophoresis driven by triboelectric field
The invention discloses a system for drug iontophoresis driven by a triboelectric field. The system comprises a friction generator, a rectifier, a drug ionophore and an electric field electrode, wherein the friction generator is connected with the rectifier; the rectifier comprises two DC output terminals, one of the DC output terminals is connected with the electric field electrode, and the other DC output terminal is connected with a drug acceptor so that a DC electric field is formed between the electric field electrode and the drug acceptor; the drug ionophore is arranged in a DC electric filed; and the friction generator is a film type friction generator, and is arranged in parallel with the electric field electrode and isolated by an insulation isolation layer from the electric field electrode. According to the system for drug iontophoresis driven by the triboelectric field, the stable pulse type DC electric field is formed between the electric field electrode and the drug acceptor so that the drug iontophoresis into human skin can be effectively and safely facilitated.
Owner:NAZHIYUAN TECH TANGSHAN LLC
Intracellular nanosensors and methods for their introduction into cells
InactiveUS20090142274A1Reduce intensityUltrasonic/sonic/infrasonic diagnosticsBioreactor/fermenter combinationsAbsorbanceFluorochrome Dye
The invention provides ion-selective sensors capable of selectively measuring ions, e.g., Na+, K+, Cl−, etc., in the cytosol of a single living cell. The sensor comprises one or more quantum dots or a fluorescent dye, a pH-sensitive dye, and optionally an ion-selective component such as an ionophore. These elements may, for example, be disposed in a polymer matrix. The polymer matrix comprises an internalizing moiety which enables the sensor to localize within the cytosol of a cell. The internalizing moiety comprises a small molecule or peptide such as an amine, antepennepedia, mastoparan, or melittin that react under acidic conditions to release a sensor from the confines of a endosome. Once in the cytosol the sensors may detect ionic analytes by selective ion extraction by the polymer, thereby inducing a pH change within the sensor which in turn changes the absorbance of the pH-sensitive dye. The change of absorbance may in turn attenuate the intensity of detectable emissions, e.g., fluorescence, from the quantum dot or dye by directly absorbing its fluorescence emission.
Owner:CHARLES STARK DRAPER LABORATORY
Oil-based adjuvants
The instant invention provides various formulations comprising combinations of immunostimulating oligonucleotides, polycationic carriers, sterols, saponins, quaternary amines, TLR-3 agonists, glycolipids, and MPL-A or analogs thereof in oil emulsions, use thereof in preparations of immunogenic compositions and vaccines, and use thereof in the treatment of animals.
Owner:ZOETIS SERVICE LLC
Ion-selective quantum dots
ActiveUS20080131909A1Improve photostabilityIncrease brightnessBioreactor/fermenter combinationsBiological substance pretreatmentsFluorescenceAbsorbance
The invention provides ion-selective sensors comprising quantum dots capable of selectively measuring ions, e.g., Na+, K+, Cl−, etc., in various environments, including in the cytosol of a living cell. Quantum dots are attractive probes for microscopy due to their photophysical advantages over fluorescent dyes, including prolonged photostability, brightness and quantum efficiency. In certain embodiments, a sensor comprises one or more quantum dots, a pH-sensitive dye, and optionally an ion-selective component such as an ionophore. These elements may, for example, be disposed in a polymer matrix. In certain embodiments, the sensors may detect ionic analytes by selective ion extraction by the polymer, thereby inducing a pH change within the sensor which in turn changes the absorbance of the pH-sensitive dye. The change of absorbance may in turn attenuate the intensity of detectable emissions, e.g., fluorescence, from the quantum dot by directly absorbing its fluorescence emission.
Owner:CHARLES STARK DRAPER LABORATORY
Oligopeptide-based pH-sensitive amphoteric ion and application thereof in medicament
ActiveCN102603866AGood blood compatibilityEfficient releasePeptidesPharmaceutical non-active ingredientsLipid formationLysosome
The invention relates to the field of accessories and preparations with medicinal functions, in particular to a kind of oligopeptide-based pH-sensitive amphoteric ion lipid (I) or (II). In the invention, the derivatives of the oligopeptide amphoteric ion lipid have different surface charges under different pH conditions and can take relatively strong negative charges in a physiological environment with pH near neutrality so that the lipid has good blood compatibility; when the lipid reaches a tumor part, the surface charges of the oligopeptide amphoteric ion lipid are reversed in an acidulous tumor environment, so that the original electronegativity is reversed into electropositivity; and a carrier with positive charges is easily combined with the surface of a tumor cell, and the tumor cell targeting can be effectively realized through an endocytosis path. In lysosome, a cationic carrier continuously realizes a function of proton sponge or a function of splitting lysosome membranes, and the two functions can ensure the integrity of the carrier, so that the carrier can safely escape to cytoplast or other organelles.
Owner:CHINA PHARM UNIV
Solid-state ion selective electrodes and methods of producing the same
InactiveUS20020038762A1Material analysis by electric/magnetic meansPolymer scienceHydrophobic polymer
The present invention relates to solid-state ion selective electrodes (ISEs), methods of producing same and devices containing same. The electrodes include: (a) an internal reference element which includes a homogenous conducting body; (b) a solid contact which includes a hydrophobic polymer, an ionophore and particles of conductive material and (c) an ion selective membrane which includes a hydrophobic polymer and an ionophore. The particles of conductive material are dispersed throughout the hydrophobic polymer of the solid contact. The method includes a the steps of: (a) providing an internal reference element which includes a homogenous conducting body; (b) preparing an emulsion which includes a hydrophobic polymer, an ionophore, particles of conductive material, and an organic solvent; (c) applying emulsion to the reference element and allowing the organic solvent to evaporate thereby causing a residue of the emulsion to form a solid contact adhering the reference element; (d) preparing a solution which includes ahydrophobic polymer, an ionophore and an organic solvent; and (e) applying the solution the solid contact and allowing the organic solvent to evaporate to form an ion selective membrane adhering the solid contact.
Owner:ADVANED MONITORING SYST
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