131 results about "Musk ketone" patented technology

The invention aims to provide a method for detecting main medicinal components of musk pain relieving cream. Specifically, a target product is extracted by distillation of water steam, and to-be-detected target components are dissolved by an organic solvent and are detected by a gas chromatographic method. According to the method, special distillation extraction equipment and the organic solvent are used for distillation extraction so as to realize accurate extraction of the to-be-detected target components such as ultralow-content musk ketone; the content of the musk ketone, camphor, menthol, borneol, cinnamaldehyde and eugenol can be simultaneously accurately detected by one step; the method disclosed by the invention has the advantages of providing an extraction and measurement method for the low-content musk ketone, solving the problem of specificity of a method for simultaneously extracting and detecting other volatile components, being simple and convenient to operate and having a good application value.

The invention discloses a Chinese medicinal composition for treating cardiovascular diseases, which is prepared mainly from root of red rooted saliva, haw thorn, Chinese angelica root, motherwort, astragalus root, ginseng or Codonopsis pilosula, any one of the compositions may also comprise baras camphor, rosewood oil, liquidambar orientalis mill, musk or musk ketone. The invention also discloses preparations using any one of the medicinal compositions as the effective constituents, preferably drop pills. The auxiliary materials of the drop pill substrate can be polyethylene glycol or natural materials, especially those of plant sources. The medicament has quick effect and good therapeutic action for coronary disease and angina pectoris.

The invention relates to a rheumatalgia-relieving plaster comprising the following constituents (by weight ratio): radix aconiti kusnezoffii 10-120, Chinese ephedra 10-120, asarum herb 10-120, notopterygium root 10-120, spicebush root 10-120, dahurian angelica root 10-120, galange oil 10-120, levisticum 10-120, Clematis chinensis 10-120, radix aconiti 1-30, Cinnamomum cassia 10-100, safflower 10-100, peach kernel 10-100, sappan wood 1-30, red peony root 10-100, frankincense 1-20, myrrh 1-20, Chinese angelica root 10-100, centipede 1-30, snake slough 1-30, futokadsura stem 10-100, achyranthes and cyathula root 10-100, dipsacus root 1-30, cortex acanthopanacis 1-30, knoxia root 10-100, musk ketone 0.01-0.5, dragon's blood resin 1-30, oil of Chinese cinnamon 1-30, borneol 0-120, menthol 0-120, hot pepper 10-200, clove sweet basil oil 0-100, Laurocapram 0-30, camphor 0-120, and methyl salicylate 0-100.

The invention discloses a Chinese medicinal composition for treating cardiovascular diseases, which is prepared from root of red rooted saliva, notoginseng, safflower, Chinese angelica root, motherwort, astragalus root, ginseng or Codonopsis pilosula, any one of the compositions may also comprise baras camphor, rosewood oil, liquidambar orientalis mill, musk or musk ketone. The invention also discloses preparations using any one of the medicinal compositions as the effective constituents, preferably drop pills. The auxiliary materials of the drop pill substrate can be polyethylene glycol or natural materials, especially those of plant sources. The medicament has quick effect and good therapeutic action for coronary disease and angina pectoris.

The invention discloses a chrysanthemum essence for hand cream, which is characterized by comprising the following components by weight percent: 2 parts of vetiver oil, 2 parts of cinnamon bark oil, 14 parts of sandal oil, 28 parts of alpha-terpineol, 8 parts of jasmine fragrance base, 36 parts of geranium oil, 20 parts of ylang ylang oil, 30 parts of hydroxycitronellal, 20 parts of lavender oil, 12 parts of bergamot oil, 8 parts of isoeugenol, 2 parts of iris resin, 2 parts of musk ketone, 8 parts of Peru musk, 16 parts of heliotropin and 2 parts of vanillin. The chrysanthemum essence for the hand cream is suitable for fragrance products of white cream, skin milk, fragrant molasses and the like, has no defect of discoloration, and has the advantages of pure and rich fragrance, strong durability, extremely less using quantity and the like.

The invention discloses a three-dimensional porous titanium substrate lead dioxide electrode which comprises a porous titanium substrate, wherein interlayers are arranged on two side surfaces of the porous titanium substrate in a thermal deposition manner; the interlayers consists of a tin-antimony oxide; a lead dioxide surface active layer is arranged on the interlayer on one side surface of the porous titanium substrate in an electric deposition layer. The invention further provides a preparation method of the three-dimensional porous titanium substrate lead dioxide electrode, and further provides application of the three-dimensional porous titanium substrate lead dioxide electrode in musk ketone in degraded wastewater. In the musk ketone in the degraded wastewater, the three-dimensional porous titanium substrate lead dioxide electrode is taken as an anode, copper foil as a cathode and a sodium sulfate solution as an electrolyte, electrocatalytic oxidation is implemented for 1-2 hours, and then degradation treatment on the musk ketone in the wastewater can be completed. When the musk ketone is degraded by using the three-dimensional porous titanium substrate lead dioxide electrode under an electrifying condition, the degradation time is short, the degradation rate is high, and the operation is convenient.

The invention relates to a preparation method of 3-methyl-normuscone musk (musk ketone), which mainly includes the steps of: (1) obtaining hexadecanedione-(2, 15) by using 1, 10-dibromodecane to react with acetylacetic ether under the existence conditions of inorganic alkali and phase transfer catalyst; (2) under the existence condition of the catalyst, obtaining a target from the hexadecanedione-(2, 15) by 'cyclization' and 'hydrogenation' in turn. The invention is characterized in that the phase transfer catalyst in step (1) is a quaternary alkylammonium salt containing C [12] to C [25]; simultaneously, the reaction of the 1, 10-dibromodecane and the acetylacetic ether is carried out in an aprotic polarity solvent. Compared with the prior art, the musk ketone preparation method proposed by the invention has the advantages of simple process and high yield; the invention is a musk ketone preparation method with more commercial values.

The invention discloses a Chinese medicinal composition for treating cardiovascular diseases, which is prepared mainly from root of red rooted saliva, notoginseng, fleece-flower root, Chinese angelica root, motherwort, astragalus root, ginseng or Codonopsis pilosula, any one of the compositions may also comprise baras camphor, rosewood oil, liquidambar orientalis mill, musk or musk ketone. The invention also discloses preparations using any one of the medicinal compositions as the effective constituents, preferably drop pills. The auxiliary materials of the drop pill substrate can be polyethylene glycol or natural materials, especially those of plant sources.

The invention relates to a freeze-dried powder injection containing musk ketone for treating apoplexy, which is prepared from Chinese herbs including musk, curcuma aromatica, cape jasmine and borneol through extraction processes.

The invention discloses a Chinese medicinal composition for treating cardiovascular diseases, which is prepared from root of red rooted saliva, notoginseng, kudzuvine root, , Chinese angelica root, motherwort, astragalus root, ginseng or Codonopsis pilosula. One of the compositions may also comprise baras camphor, rosewood oil, liquidambar orientalis mill, musk or musk ketone. The invention also discloses preparations using any one of the medicinal compositions as the effective constituents, preferably drop pills. The auxiliary materials of the drop pill substrate can be polyethylene glycol or natural materials, especially those of plant sources. The medicament has quick effect and good therapeutic action for coronary disease and angina pectoris.

The invention relates to an externally-used medicinal preparation for treating tinea and dermitis and process for its preparation, wherein the raw materials include hibiscus bark, Sichuan aconite root, Kusnezoff monkshood root, jack-in-the-pulpit tuber, pinellia tuber, toad skin, snake slough, asaryl, sulfur, orpiment, white alum, zanthoxylum piperitum, flavescent sophora root, corktree bark, Chinese mugwort leafmulberry leaf, toasted garlic, cow-bezoar, musk ketone, oxytetracycline powder, diphenhydramine powder, chlorpheniramine and vinegar.

The invention provides a method for synthesizing high-grade perfume, i.e., high-value musk perfume cyclopentadecanone (macrocyclic musk ketone), from Malania oleifera oil. The Malania oleifera oil is used as a raw material and subjected to saponification, acidification, recrystallization, ozonization, oxidation, esterification, cyclization and reduction successively so as to prepare cyclopentadecanone. The method is high in yield, good in benefits and low in cost and overcomes the shortcomings of complex production process, low yield, high cost and no market advantage in the prior art. The Malania oleifera oil contains 40 to 60% of tetracos-15-enoic acid which is an ideal raw material for synthesis of the high-value musk perfume. Tetracos-15-enoic acid is a necessary nutriment for development of the brain, exerts critical effect on improvement of the activity of cranial nerves and prevention of encephalasthenia, has good curative effect on cardiovascular diseases and diseases caused by autoimmune deficiency, and can be used as a medicine and a health product.

The invention discloses a Chinese medicinal composition for treating cardiovascular diseases, which is prepared from root of red rooted saliva, notoginseng, acanthopanax root, Chinese angelica root, motherwort, astragalus root, ginseng or Codonopsis pilosula, any one of the compositions may also comprise baras camphor, rosewood oil, liquidambar orientalis mill, musk or musk ketone. The invention also discloses preparations using any one of the medicinal compositions as the effective constituents, preferably drop pills. The auxiliary materials of the drop pill substrate can be polyethylene glycol or natural materials, especially those of plant sources. The medicament has quick effect and good therapeutic action for coronary disease and angina pectoris.

The invention relates to a process for preparing musk ketone, which comprises the following steps of: adopting catalyzing ethyl acetoacetate and 1,10-dibromodecane as raw materials to generate 2,15-hexadecanedione through sodium hydride (calcium hydride or a mixture formed by sodium hydride and calcium hydride) and organic base under the homogeneous condition; and then adding dehydrated silica gel to perform a closed loop and hydrogenation reduction reaction so as to prepare 3-methyl cyclopentadecanone. The reaction time is short (2 to 4 hours). The yield is greatly improved (by over 90 percent). The technology has mild reaction, high yield and few three wastes and is suitable for industrial production.

The invention discloses a Chinese medicinal composition for treating cardiovascular disease. the composition is mainly prepared from radix notoginseng, radix puerariae as raw material; also can further comprises Angelica sinensis or Herba Leonuri or Astragalus membranaceus or ginseng or radix codonopsis; and can also comprises borneol or Dalbergia odorifera oil or styrax or musk or musk ketone in any of the formula. The invention also discloses a preparation with any of the aforesaid Chinese medicinal composition as effective ingredient, preferably dripping pill. Its dripping pill substrate adjuvant can be polyethylene glycol or plant original substrate adjuvant. The inventive medicament has rapid action, and good therapeutic action in treating angina pectoris of coronary heart disease.

The invention discloses a method for preparing musk ketone efficiently and mildly. The method comprises the following steps: crushing musk, sieving musk, soaking musk by using ethanol, performing reflux extraction by using ethanol, and performing reflux extraction by using water to obtain a filtrate; soaking a filter residue by using hot water, and performing hot-pressing distillation extraction to obtain a hot-pressed extract; concentrating the hot-pressed extract and the filtrate, centrifuging, washing, and dissolving in distilled water to obtain a dissolved solution; adjusting the pH of the dissolved solution, filtering by using a ceramic membrane, circularly washing, adding pure water for dissolving, decolorizing, filtering, and performing spray drying to obtain the musk ketone. By the method, the purity of the musk ketone can be increased, and reaches above 99%; the preparation process is simple, and easy to operate; a treatment condition is mild, so that the musk ketone is not affected; the extracting effect is good, more than 99% of the musk ketone in the musk can be extracted; the method has the advantages of high efficiency, rapidness, achievement of high purity, and the like.

The invention discloses a Chinese medicinal composition for treating cardiovascular diseases, which is prepared from root of red rooted saliva, notoginseng, Chinese sumac, Chinese angelica root, motherwort, astragalus root, ginseng or Codonopsis pilosula, any one of the compositions may also comprise baras camphor, rosewood oil, liquidambar orientalis mill, musk or musk ketone. The invention also discloses preparations using any one of the medicinal compositions as the effective constituents, preferably drop pills. The auxiliary materials of the drop pill substrate can be polyethylene glycol or natural materials, especially those of plant sources. The medicament has quick effect and good therapeutic action for coronary disease and angina pectoris.

The invention discloses a Chinese medicinal composition for treating cardiovascular diseases, which is prepared mainly from root of red rooted saliva, notoginseng, dragon's blood resin, Chinese angelica root, motherwort, astragalus root, ginseng or Codonopsis pilosula, any one of the compositions may also comprise baras camphor, rosewood oil, liquidambar orientalis mill, musk or musk ketone. The invention also discloses preparations using any one of the medicinal compositions as the effective constituents, preferably drop pills. The auxiliary materials of the drop pill substrate can be polyethylene glycol or natural materials, especially those of plant sources. The medicament has quick effect and good therapeutic action for coronary disease and angina pectoris.

The invention provides refreshing perfume containing natural plants, which is particularly suitable for bedrooms, living rooms, ballrooms, dining rooms, hotels, cinemas, offices, classrooms and other public places. The refreshing perfume containing the natural plants provided by the invention can purify air, protect environment and refresh. The perfume is prepared from the following raw materials: 40 to 60 percent of absolute alcohol, 22 to 28 percent of essence, 1.7 to 2.3 percent of citric acid, 4.5 to 5.5 percent of epoxy resin, 0.1 to 0.5 percent of musk ketone, 0.5 to 1.5 percent of muskiness, 0.5 to 1.5 percent of fixative, 0.02 to 1.2 percent of glacial acetic acid, 0.1 to 0.5 percent of bromogeramine, 0.2 to 1.2 percent of vanillin, 4.0 to 6.0 percent of bulbus fritillariae cirrhosae, 6.0 to 8.0 percent of dandelion, 4.5 to 6 percent of hematoxylon, 2.3 to 3 percent of common cnidium fruit, 0.02 to 0.2 percent of rose oil, and 4.0 to 6.0 percent of fresh tea leaves.

The invention discloses a Chinese medicinal composition for treating cardiovascular diseases, which is prepared mainly from root of red rooted saliva, notoginseng, bitter orange, Chinese angelica root, motherwort, astragalus root, ginseng or Codonopsis pilosula, any one of the compositions may also comprise baras camphor, rosewood oil, liquidambar orientalis mill, musk or musk ketone. The invention also discloses preparations using any one of the medicinal compositions as the effective constituents, preferably drop pills. The auxiliary materials of the drop pill substrate can be polyethylene glycol or natural materials, especially those of plant sources. The medicament has quick effect and good therapeutic action for coronary disease and angina pectoris.

The invention discloses an amber essence, which is characterized by comprising the following components by weight part: 2 parts of rock rose absolute, 1 part of vetiver oil, 0.2 part of patchouli oil, 1 part of lemon oil, 0.6 part of rose absolute oil, 1 part of hydronaphthalene, 0.4 part of cedar oil, 0.4 part of tuberose absolute, 0.6 part of decoloration oak moss oil, 0.1 part of ambergris tincture, 0 .6 part of iris extract, 1 part of sweet orange oil, 1 part of musk ketone, 0.8 part of vanillin, 2 parts of methyl ionone, 0.8 part of sandalwood oil, 6 parts of tricyclo [5.2.1.02,6] decane -3 (4,5), 8 (9) - dimethanol 4, 0.4 part of hydroxymethyl formic acid tricyclo [5.2.1.02,6] decane, and 18.6 parts of ethanol. The amber essence of the formula is suitable for cream, lotion, shampoo and other flavored products, and has the advantages of pure and rich fragrance, long-lasting fragrance, very low consumption and the like.

The invention discloses a Chinese medicinal composition for treating cardiovascular disease. The composition is mainly prepared from Salvia miltiorrhiza, Borneo or Dalbergia odoriferous oil or styrax or musk or musk ketone as raw material; also can further comprises Angelica sinensis or Herba Leonuri or further step comprises Astragalus membranaceus or ginseng or radix codonopsis. Its processing steps comprises preparing Salvia miltiorrhiza into water extract or alcohol extract or preparing Salvia miltiorrhiza and Angelica sinensis or Herba Leonuri or Salvia miltiorrhiza and Astragalus membranaceus or ginseng or radix codonopsis pilosulae into water extract or alcohol extract respectively or together, performing primary clarification, performing ultra filtration treatment, concentrating, and mixing with Borneo or Dalbergia odoriferous oil or styrax or musk or musk ketone. The invention also discloses a preparation with any of the aforesaid Chinese medicinal composition as effective ingredient, preferably dripping pill. Its dripping pill substrate adjuvant can be polyethylene glycol or plant original substrate adjuvant. Inventive medicament has rapid action, and good therapeutic action in treating angina pectoris of coronary heart disease.

The invention provides a method for determining the content of musk ketone in artificial musk, and the method comprises the following steps: step 1, preparing the solution of an artificial musk test sample and musk ketone reference solutions; step 2, by using a capillary gas chromatography, assaying the reference solutions to acquire a standard curve; and step 3, determining the content of musk ketone in the artificial musk test sample according to the standard curve. The method for determining the content of musk ketone in artificial musk of the present invention is simple and reliable, thus being suitable for industrial mass production.

The invention discloses a Chinese medicinal composition for treating cardiovascular diseases, which is prepared mainly from notoginseng, haw thorn, Chinese angelica root, motherwort, astragalus root, ginseng or Codonopsis pilosula, any one of the compositions may also comprise baras camphor, rosewood oil, liquidambar orientalis mill, musk or musk ketone. The invention also discloses preparations using any one of the medicinal compositions as the effective constituents, preferably drop pills. The auxiliary materials of the drop pill substrate can be polyethylene glycol or natural materials, especially those of plant sources. The medicament has quick effect and good therapeutic action for coronary disease and angina pectoris.

The invention discloses an Ylang ylang oil rose essence which is characterized in that the rose essence comprises the following components according to the content of the weight percent: alcohol, phenylmethyl acetate, orris oil, jonone, Ylang ylang oil, rose oil, citronellol, musk ketone, geranium oil, hyacinthin, sandalwood oil, vanillin and jasmine fragrance base. The Ylang ylang oil rose essence of the formula is applied to flavoring products such as ointment frost, latex, shampoo and the like and has the advantages of pure and rich fragrance, strong durability, extremely few consumption and the like.

The invention belongs to the field of drug detection, relates to a method for detecting musk ketone and aims at providing the method for detecting the musk ketone, wherein the method is simple to operate, strong in specificity, stable and good in repeatability. The detection method adopts the high performance liquid chromatography for determination, and the detection condition and the method are as follows: the chromatographic condition is that octadecylsilane chemically bonded silica is taken as a filling agent; methanol-water (90-95): (5-10) or acetonitrile-water (90-95): (5-10) is adopted as a mobile phase; and the detection wavelength is 283nm. Control solution is prepared as follows: precisely weighing an appropriate amount of musk ketone control, dissolving the musk ketone in acetonitrile or methanol, and preparing test solution by taking a musk or musk-containing preparation as a detection object. The control solution and the test solution are respectively precisely sucked and injected into a liquid chromatographic instrument for determination. The detection method does not need to carry out pre-column derivatization, the sample preparation is simple, the requirements on equipment conditions are not high, the specificity is strong, the stability and the repeatability are good, and the operation is convenient.

The invention discloses a Chinese medicinal composition for treating cardiovascular diseases, which is prepared mainly from raw material herbs of pseudo-ginseng, Chinese sumac, Chinese angelica root, motherwort, astragalus root, ginseng or Codonopsis pilosula, any one of the compositions may also comprise baras camphor, rosewood oil, liquidambar orientalis mill, musk or musk ketone. The invention also discloses preparations using any one of the medicinal compositions as the effective constituents, preferably drop pills. The auxiliary materials of the drop pill substrate can be polyethylene glycol or natural materials, especially those of plant sources.

The invention discloses a compound essential oil for refreshing, awakening brain and eliminating fatigue; lemon oil, resuscitation aroma oil, peppermint oil, musk ketone, jasmine oil and bergamot oil are evenly mixed according to a certain proportion, then borneol is added for intensive mixing, thus preparing the compound essential oil. The compound essential oil of the invention for refreshing, awakening brain and eliminating fatigue can be widely used for the people with excessive anxiety, fatigue, malaise, dizziness, headache, poor spirit and so on. The essential oil can be applied at forehead, eyebrow center, two temporal parts (Taiyang points) and peripheral parts of nostrils and can be used as electric heating incense tablet by paper absorption and packaging; at the same time, the essential oil can also be heated and emitted by an electric heating incense device.

The invention discloses a method for degrading musk ketone under natural light by utilizing titanium dioxide / charcoal hybrid aerogel. The method comprises the following steps: with titanium tetrachloride as a precursor, absolute ethyl alcohol as a solvent, resorcinol and furfural as precursors of an organic phase, propylene epoxide as an inducer of network gel and ethyl acetoacetate as a complexing agent, preparing a titanium dioxide / charcoal hybrid aerogel material by a one-step sol-gel method; adding the dioxide / charcoal hybrid aerogel into wastewater containing musk ketone to have degradation reactions under the condition of natural light, wherein a dark reaction is carried out firstly for 15 minutes, and the following light reaction lasts for 60-90 minutes under the condition of natural light. The method for degrading musk ketone under the natural light by utilizing titanium dioxide / charcoal hybrid aerogel is convenient to operate; compared with a traditional degradation method, the method disclosed by the invention has the advantages that the degradation time is short, degradation can be performed under natural light, and the degradation rate is high.

The invention discloses a medicament for preventing in-stent restenosis after coronary stent implantation and a preparation method. The medicament is prepared into 1000 parts from, by weight, 800-1200 parts of tanshinone, 200-300 parts of hirudin, 20-30 parts of camphol and borneol and 6-9 parts of musk ketone. The medicament has the advantages of effective treatment, no toxic and side effects and capabilities of decreasing occurrence rate of in-stent restenosis after coronary stent implantation, obviously improving clinical symptoms of patients and reducing long-term risks of thrombosis of the patients, and is obvious in clinical effect. The medicament provides a new choice for preventing ISR (in-stent restenosis) after coronary stent implantation.