613 results about "Naringin" patented technology

This invention provides a novel medical appliance for repairing, regenerating, maintaining, and / or augmenting a bone. The medical appliance generally includes an osteoinductive agent, an osteoinductive enhancer, and a carrier matrix. Also disclosed are methods, compositions, kits, and bone matrix formulations for regenerating, maintaining, and / or augmenting a bone. Exemplary preferred osteoinductive agents include growth factors such as BMP and TGF-β. Exemplary preferred osteoinductive enhancers include phytoestrogens such as naringin.

The invention discloses a production method for honey pomelo preserved fruit, which comprises the following steps: preprocessing fresh honey pomelo, clearing and sterilizing, cutting the honey pomelo into petals of fresh fruit and separating peel from pulp; dicing the honey pomelo peel by a machine, grading to obtain qualified honey pomelo fruit dices; debittering the fruit dices under vacuum condition; surging and separating under vacuum to obtain sugared honey pomelo preserved fruit dices; blanching the sugared honey pomelo preserved fruit dices in a blancher; drying the honey pomelo preserved fruit dices and cooling quickly; sterilizing and polishing; and packaging. In the invention, honey pomelo fruit dices are debittered and sugared under a vacuum condition, thus shortening debittering and sugaring time, reducing debittering and sugaring temperature, having good debittering and sugaring effects; the honey pomelo preserved fruit contains low content of naringin, the sugaring on the surface and in the inner part of finished products is even, the original state of the organizational structure and natural color of honey pomelo peel can be maintained, the appearance is bright without cementation; and the honey pomelo preserved fruit has proper chew flexibility and good taste, and the original natural flavor of honey pomelo peel can be smelt.

The invention relates to a method for preparing naringin or hesperidin, which comprises the following operating steps of: 1) drying and crushing fruits, fruit peels and fruit residues containing the naringin or the hesperidin, and respectively filling the crushed materials into an extraction kettle of a pressure solvent extraction device; 2) selecting an extraction solvent, setting an extraction pressure, an extraction temperature, an extraction static time and an extraction frequency, extracting with the pressure solvent extraction device, and collecting the extract liquor; and 3) concentrating the extract liquor in vacuum, centrifugating the extract liquor or filtering the extract liquor to remove insoluble substances, adjusting pH of the clear liquid, cooling the clear liquid to crystallize or precipitate, recrystallizing the coarse crystals, drying the coarse crystals, or re-dissolving the precipitate for re-precipitation, and obtaining a pure product of the naringin or the hesperidin. Compared with the conventional solvent extraction method, ultrasonic-assisted extraction method and microwave-assisted extraction method, the preparation method has the advantages of high speed, capability of repeatedly extracting, safety, high efficiency, and simple post treatment such as concentration and purification.

The invention discloses a method for controlling the quality of immature bitter orange. The method combines the infrared spectrum technology and index component content test, and comprises the following steps: the immature bitter orange is subjected to the infrared spectrum test; and Synephrine, naringin, hesperidin in the immature bitter orange are subjected to content test. The method for controlling the quality has the advantages of convenience and rapidness and strong specificity, and can control the quality of the immature bitter orange comprehensively, accurately and effectively.

The invention relates to a composition for curing gastrointestinal functional disorders, a preparation method thereof and an application thereof in preparing drugs for curing the gastrointestinal functional disorders. The bulk drugs of the composition comprise radix bupleuri, radix glycyrrhizae preparata, fruit of immature citron and white paeony root, which follow a weight proportion of 6:6:6:6-9. The composition comprises the following components by weight percent: 24.5-46.5% of total flavonoids, 10.5-31.6% of total saporins, 17.0-35.4% of naringin, 1.1-8.5% of glycyrrhizic acid and 3.2-13.7% of paeoniflorin. The preparation method is as follows: condensing water solution of the bulk drugs; using macroporous absorption resin for absorption, continuing to wash till the state of colorlessness after the water solution completely passes through a resin column; using 50-85% by weight of ethanol for elution, and collecting eluent; reducing the pressure of solvent, recovering the solvent, drying the solvent, and finally obtaining the composition. Compared with decoction and western medicines, the extract of the composition achieves better and more obvious effect in curing the gastrointestinal functional disorders.

An application of naringenin and its salt in preparing the medicines for treating cough and resolving phlegm is disclosed. Said naringenin is prepared from naringin through hydrolysis or from the natural medicinal materials through extracting, or by chemical synthesis. Its advantages are high curative effect and no toxic by-effect.

The invention discloses a method for separating high-purity hesperidin, neohesperidin, naringin and synephrine from fructus aurantii Immaturus, and relates to a method for extraction of effective components of traditional Chinese medicines. The method includes the following steps: (1) enzymolysis, (2) extraction, (3) membrane separation, (4) synephrine separation, (5) naringin separation, (6) neohesperidin separation, and (7) hesperidin separation. The method has the advantages that the method overcomes the shortcomings in prior art, provides a new effective method which is easy to industrially produce, and is capable of combined extraction and separation various effective components in the fructus aurantii Immaturus, the method has the advantages of simple operation, high extraction rate, and high purity of the effective components, and the effective components all are separated, and easy to use.

The invention discloses the application of naringin in preparing healthcare products of oral nursing, belonging to technical field of organic compound and healthcare products of oral nursing, which is characterized in that: the naringin is used as active component of natural plant having the action of anti-inflammatory and arresting bleeding and is added into health care products of oral nursing during preparing process for health care products of oral nursing. The application of the naringin has the advantages of safely using in healthcare products of oral nursing such as dental paste, mouth wash and dentifrice powder and also having obvious action of anti-inflammatory and stypticity.

A process for extracting naringoside from medicinal materials including crushing, extracting more times, filtering, collecting filtration, concentrating, depositing in alcohol, column separation, eluting with organic solvent, volatilizing solvent, and recrystallizing more times. Its advantages are high extracting rate (85% or more), and high purity (95%).

Alpha-L-rhamnosidase and a preparing method and applications thereof are disclosed. The amino acid sequence of the alpha-L-rhamnosidase is shown as SEQ ID NO.1. The recombinase is high in optimum temperature, good in thermal stability, and capable of efficiently expressing target protein under preferred conditions, so that the recombinase has wide applications in the fields of selective hydrolysis of rutoside, hesperidin, naringin, prunin, saikoside and other flavonoid compounds connecting alpha-rhamnoside or rhamnose in terpene fragrance precursor compounds, and the like.

In the invented method, citrus bioflavonoid and corresponding enzyme are used as raw materials, being dissolved in organic solvent, adding glucoside solution at concentration of 1-100g / L, under pH value of 3.0-7.0 and temperature of 20-65 deg.C for 20-60 min. After separation and purification, obtained is citrus bioflavonoid monoglycoside. With this invention, naringoside enzymolysis and cirmtim enzymolysis method for production of naringen in monoglycoside and hesperetin monoglycoside, compared with chemical method, has advantages of:easily to be controlled of enzymolysis, mild reaction, less by-products and easy to be separated of products. By using this invented method, the enzymolysis of naringoside and cirmtim for production of naringenin monocoside and hesperetin monoglycoside can be effectively controlled, and only the first glycosidic bond is broken, so obtained is highest yield of naringenin monoglycoside, hesperetin monoglycoside and rhamnose.

Disclosed are a debittered honey pomelo preserve and a production method; the skinned honey pomelo cavernous body or unskinned honey pomelo cavernous body peeled from the honey pomelo is taken as raw material; the raw material is put into the soy milk at a weight ratio of 1:2-3, insulated at a temperature of 55-66 DEG C for 2-4 hours and debittered; the plant enzyme in the soy milk is used to effectively reduce the content of the bitter principle naringin in the raw material; and the debittered material is molded, sugared and dried to obtain the debittered honey pomelo preserve. In the preparation process of the invention, the raw material is put into heated soy milk and debittered; upon tests, the debittered raw material and the debittered honey pomelo preserve prepared thereof have obviously lower content of bitter principle naringin, so as to achieve significant debittering effect.

The invention provides a method for preparing phloretin. The method comprises the following steps of: heating, hydrolyzing and purifying to obtain the phloretin under the action of dilute acid by using naringin dihydrochalcone. The naringin dihydrochalcone is prepared by the following method: performing catalytic hydrogenation on naringin under the medium pressure, normal temperature or heating action by using hydrogen in the presence of alkali liquor and rare metal catalyst, and collecting the naringin dihydrochalcone from the reaction system. The method is easy to operate, low in cost and high in product quality, and large-scale application of phloretin on the medicine, food and cosmetics can be well met.

The invention discloses a quality detection method of a Chinese traditional patent medicine fallopia multiflora (thunb.) harald-aloe constipation relieving capsules for treating constipation. According to the quality detection method, the ginseng, the citrus aurantium, the aloe and the donkey-hide gelatin in the preparation are identified through a thin layer chromatography method while the 2,3,5,4'-tetrahydroxyl diphenylethylene-2-O-beta-D-glucoside content of the fallopia multiflora (thunb.) herald and the naringin content of the citrus aurantium in the preparation are determined by using HPLC. According to the present invention, the quality detection method has characteristics of stability, reliability, strong specificity and good reproducibility; and with the method, the quality of the fallopia multiflora (thunb.) harald-aloe constipation relieving capsules can be completely and effectively controlled, the stability of the product quality is easily achieved, the clinical medication safety and effectiveness can be ensured, and the medical and market needs can be well met.

A medicine for treating acute and chronic bronchitis features that its active component is naringoside. Its advantages are high curative effect and no toxic by-effect.

The invention relates to a method for extracting hesperidin and naringin by microwave-assisted extraction (MAE), which belongs to the field of analytical chemistry. The method includes quantitatively weighing sample, extracting hesperidin and naringin from the sample in mixed solvent of water and organic solvent in a microwave-assisted extraction device by selecting microwave power and extraction time through MAE, centrifuging, collecting the supernatant, diluting, and analyzing and measuring the content of hesperidin and naringin by HPLC. The method is simple and rapid, and has less sample usage amount, good repeatability, and high recovery rate. The method in combination with the HPLC can be used for accurately measuring the content of hesperidin and naringin in fruit juice, fresh fruit and Chinese traditional medicine, and evaluating quality thereof.

A method to encompass a citrus-based cream or gel composition that is highly stable and all-natural from components in situ by removing undesired components from citrus, producing such cream or gel with desired components and texture according to intended use, either as a cosmetic or medicinal lotion, a cream base, or as a food ingredient with nutraceutical and / or binding properties for use in as example analogue meats. The method comprises the steps of grinding whole citrus fruit or peel adjusted via rate of heating and pH to optimize gel consistency and desired residual bioflavonoids rather than maximizing pectin production. Citrus-derived components such as, but not limited to, d-limonene, naringin, and psoralen are added to and blended with the gel for applications which require concentrations higher than found in vivo.

The invention belongs to the field of processing of grapefruits, and discloses pure natural honey grapefruit tea jam dense pulp and a preparation method thereof. The pure natural honey grapefruit tea jam dense pulp is prepared by preferably selecting the following raw materials, by mass, 10% of grapefruit peel, 50% of grapefruit pulp, 17% of rock candy, 10% of honey, 0.3% of grapefruit flowers, 0.5% of arabian jasmine flowers, 1% of honeysuckle, 1% of chrysanthemum, 0.2% of puer tea, 1% of green tea, 1% of black tea, 1% of rose, 1% of fructus lycii, 1% of lemon, 2% of red jujube with pits removed, 1% of hawthorn, 1% of fresh ginger and 1% of neohesperidin dihydrochlcone. L-cysteine in the pure natural honey grapefruit tea jam dense pulp is combined with vitamin C in grapefruit, when the pure natural honey grapefruit tea jam dense pulp is eaten frequently, the pure natural honey grapefruit tea jam dense pulp can clear heat, decrease internal heat, and whiten skin; naringin in grapefruit can lower the viscosity of blood, reduce formation of thrombosis, scatter body melanin in the body rapidly and relieve dark skin, and the edible value and therefore the nutritional effects of grapefruits can be improved.

The invention provides a preparation method of naringenin. The preparation method comprises the following steps: (1) preparing solution of naringin in lower alcohol or lower ketone solvent, leading the naringin in the prepared solution to be subjected to acid hydrolysis in an acidic condition to obtain naringenin, distilling under reduced pressure to remove solvent to obtain a naringenin crude product; (2) dissolving the naringenin crude product in absolute ethanol or absolute methanol, adding active carbon, stirring to decolor; and (3) filtering the active carbon, separating and purifying the prepared solution to obtain the naringenin. The preparation method has the advantages of few reaction steps, less used solvent, less emission of the 'three wastes', mild reaction condition and complete reaction and easy operation, is suitable for industrial production, and has higher practical value; and the prepared product has more stable quality, the purity is higher than 99 percent, which is higher than the drug standard.

The invention relates to a method for preparing a rod-like imprinted polymer capable of efficiently separating naringin in a water phase. The rod-like imprinted polymer which is an adsorption material having specific recognition capability for naringin organic molecular medicaments with =O and -OH groups can be prepared by an emulsion polymerization method, with the naringin, hesperidin, the naringin or dihydrochalcone as an imprinting molecules, cyclodextrin as a functive and hexamethylene diisocyanate as a cross-linking agent. The prepared rod-like imprinted cyclodextrin polymer has larger specific area and pore volume, benefits the contact of a substrate with a combined locus and improves the capacity. The rod-like molecular imprinted polymer (RMIP) has high affinity and selectivity to the naringin (NG). When the concentration of the NG is 0.02mg / ml, the imprinted molecule alpha reaches 1.53.

A new aurantiamarin synthesizing technique relates to a method for synthesizing new aurantiamarin by using naturally abstracted naringin as raw materials. The traditional aurantiamarin synthesizing technique has the problems of low efficiency and high cost or the problems of hard condition, complex operation and long production period. The synthesizing method of the invention using naringin as raw materials comprises the steps of: a. synthesizing acetophenone-4'-beta-new flavedo glucoside and b. synthesizing new aurantiamarin. The synthesizing technique of the invention needs no hard condition, has simple operation, short period, and stable and easily controlled synthesizing condition, and is easy to separate and purify. The product yield of new aurantiamarin is equal to or more than 95% and the purity is equal to or more than 96% by using proline as an efficient catalyst for synthesizing new aurantiamarin, the production cost is low, the environmental pollution is small and the technique is suitable for industrializing production of the new aurantiamarin.

The invention relates to an anti-allergy repair composition including, by weight, 5-20 parts of a pomelo fruit extract, 5-20 parts of a moringa pterygosperma seed extract, 100-200 parts of a purslaneextract, 0.5-1 part of grapefruit essential oil, and 30-50 parts of hydroxyphenylpropanamidobenzoic acid. The main component, naringin, in the pomelo fruit extract and the moringa pterygosperma seed extract have synergistic effect, so that the product can quickly relieve itch and red skin and eliminating edema; the purslane extract and the grapefruit essential oil have synergistic effect, so thatthe product can repair and nourish damaged skin due to allergy; in addition, the pomelo fruit peel is rich in volatile oil and flavones, so that great anti-inflammation and antibacterial activities are achieved; by means of the antibacterial effect of itself, the components serve as a plant preservative and are matched with the hydroxyphenylpropanamidobenzoic acid, so that the preservative can replace a conventional preservative and achieves preservative effect with higher safety.

The invention discloses a pericarp ferment mask and a preparation method thereof. The pericarp ferment mask comprises a mask cloth and a mask liquid. The mask cloth is immersed in the mask liquid. The mask liquid comprises, by weight, 4-6 parts of a pericarp ferment stock solution, 4-6 parts of mucopolysaccharide, 3-5 parts of glycerin, 3-4 parts of an emulsifier, 2-4 parts of arbutin, 2-4 parts of mushroom glucan, 1-3 parts of hyaluronic acid, 1-3 parts of collagen peptide powder, 1-2 parts of vitamin E, 4-6 parts of propylene glycol, 1-1.5 parts of a thickening agent, 0.4-0.8 parts of dipotassium glycyrrhizinate, 0.1-0.3 parts of an antiseptic, 0.05 parts of essence and 50-70 parts of deionized water. The preparation method creatively uses a pericarp ferment in cosmetics. The pericarp ferment is rich in naringin and a plurality of vitamins. Through natural fermentation of pericarp, active ingredients of the pericarp are fully dissolved out and can be absorbed easily by skin.

The invention discloses a method for simultaneously determining twenty-two flavones and phenolic acids in citrus fruits by adopting high performance liquid chromatography-diode array detector-fluorescence detector (HPLC-DAD-FLD). The method is capable of simultaneously determining twenty-two phenolic compounds in citrus fruits such as gallic acid, synephrine, chlorogenic acid, protocatechuic acid,caffeic acid, p-coumaric acid, rhamnosylvitexin, eriocitrin, ferulic acid, rutin, benzoic acid, narirutin, naringin, hesperidin, diosmin, neohesperidin, quercetin, naringenin, kaempferol, nobiletin,hesperetin, acacetin and the like, derivatization is not needed, and the method is high in accuracy, high in sensitivity and excellent in repeatability.

The invention discloses a method for producing a fermented product of debitterized honey pomelos. A honey pomelo pulp raw material is washed and disinfected, and is debitterized under thermal insulation for 2 to 4 hours at a temperature of between 55 and 66 DEG C by soy milk with the weight ratio of between 1 to 2 and 3, the debitterized honey pomelo pulp is pulped by adding enzyme and is enzymolyzed by heating to obtain juice of the enzymolyzed and debitterized honey pomelo, the juice of the enzymolyzed and debitterized honey pomelo is sterilized; the sugar and acid degree of the enzymolyzed and debitterized honey pomelo is adjusted; and zymogen is added into the enzymolyzed and debitterized honey pomelo for fermentation to obtain a semi-finished product of the fermented product of the debitterized honey pomelos; and the semi-finished product is put into a tank for aging and afterripening to obtain a finished product. When alcohol active dry microzyme is added for fermentation, debitterized honey pomelo wine is obtained; and when acetic acid bacteria is inoculated for fermentation after the alcohol active dry microzyme is added for fermentation, debitterized honey pomelo vinegar is obtained. The method utilizes phytoenzyme contained in the soy milk to effectively reduce the content of bitter principle-naringin in the honey pomelo pulp raw material, and the measurement shows that the contents of naringin are low in the honey pomelo pulp raw material after the debitterization and the fermented products of the debitterized honey pomelos prepared by the honey pomelo pulp raw material. The debitterized honey pomelo wine produced by the method has natural colour and luster and fragrance of honey pomelos, and the produced debitterized honey pomelo vinegar is clear and transparent, and has the fragrance of vinegar and honey pomelos.

The invention relates to a method to extract naringin monomer from pomelo (like Shatian pomelo), slicing up or crush pomelo, extracting by water for one or many times, filtering and combining filtrates; condensing the filtrate into extract, applying the extract on column after alcohol deposition or directly, making column separation, and eluting by organic solvent; volatilize the solvent from the eluent to obtain rough product; then recrystallizing for many times to obtain naringin crystal. The extraction yields of naringin from Shatian pemelo are all above 85% and the naringin monomer content in the obtained naringin sample reaches above 98%.

The invention provides a method for simultaneously extracting synephrine and flavonoids from immature bitter oranges. The method comprises the steps as follows: the immature bitter oranges are smashed and extracted, acid is added to an extract for precipitation, and hesperidin is obtained; a precipitated filtrate is subjected to three steps of concentration including ultrafiltration membrane concentration and / or nanofiltration membrane concentration, vacuum decompression concentration and flue gas concentration, then a condensed extract is obtained, and is subjected to extraction, mixing with petroleum ether, crystallization and suction filtration, and then synephrine is obtained; the suction filtration liquid after suction filtration is condensed and mixed with ethanol, mixed liquor is formed and treated by macroporous adsorption resin, and neohesperidin and naringin are obtained. The ultrafiltration membrane concentration and / or nanofiltration membrane concentration and the flue gas concentration adopted by the method for simultaneously extracting synephrine and flavonoids from the immature bitter oranges can all reduce energy consumption, so that the solvent recovery rate is increased, and the filtrate treatment cost is lowered; differences between synephrine and other flavonoids in an extracting agent are used for separation and purification, therefore, the production process can be simplified, the production cost can be lowered, and the resource utilization rate can be increased.

The invention discloses a naringin solid dispersion, and the preparation method and the application thereof. The naringin solid dispersion contains naringin and vector material. The mass ratio of naringin and the vector material is 1:2 to 1:5. The vector material is any one of or any mixture of polyethylene glycol, polyvinyl pyrrolidone and poloxamer. The preparation method of the naringin solid dispersion is to get the naringin, the vector material and the other regular auxiliary materials by melting method, solvent method, solvent-melting method, spray drying method or freeze-drying method. The application of the naringin solid dispersion is to apply in preparing pharmaceutical preparations or healthfood. The invention of the naringin solid dispersion is to disperse naringin by solid dispersion technique, which improves the solubility in water and dissolution rate in vitro and at the same time enhances the bioavailability.

The present invention mainly relates to a preparation method of Mao pomelo peel total flavone, Mao pomelo peel total flavone dispersing tablet, naringoside and rhoifolin and their application. The pomelo peel is a high-grade Chinese medicinal material for relieving cough and resolving phlegm. The flavone component in the Mao pomelo peel is its main effective component, in the Mao powder peel total flavone the naringoside and rhoifolin contents are higher, and are above 85% of the total flavone. Said invention provides a solvent method to make extraction, and makes the extract undergo the processes of concentration, precipitation and recrystallization so as to obtain the above-mentioned products.

The invention provides a near-infrared on-line detection method used in production process of a traditional Chinese medicine containing naringin. The method comprises the following steps: collecting a sample in the production process of the traditional Chinese medicine containing naringin, and acquiring a near-infrared spectrum of the sample; measuring the content of naringin in the sample by using the existing technology; establishing a detection model by using chemometrics software according to the near-infrared spectrum of the sample and the naringin content measured by using the existing technology, wherein the spectrum range of the near-infrared spectrum of the detection model is 1100-2300nm; and acquiring the sample to be detected, and measuring the content of naringin and the spectrum similarity degree by using the detection model. By adopting the near-infrared on-line detection method used in the production process of the traditional Chinese medicine containing naringin, the problems that a quality analysis method is low in efficiency and too many raw materials are wasted in the production process of the traditional Chinese medicine containing naringin are effectively solved.