67 results about "Perfluorohexane" patented technology

Disclosed herein is an attenuation device, comprising a flexible housing and a high vapor pressure media having a vapor pressure approximately equal to the intravesical pressure of the bladder and a permeability of less than 1 ml / day at body temperature through the outer wall of the flexible housing. In one embodiment, the high vapor pressure media comprises perfluorooctylbromide. In another embodiment, the high vapor pressure media comprises perfluorohexane. In yet another embodiment, the high vapor pressure media comprises perfluorodecalin. Also disclosed herein is a method of treating a patient, comprising providing a compressible attenuation device and introducing within the attenuation device at least one high vapor pressure media.

Disclosed herein is an attenuation device, comprising a flexible housing and a high vapor pressure media having a vapor pressure approximately equal to the intravesical pressure of the bladder and a permeability of less than 1 ml / day at body temperature through the outer wall of the flexible housing. In one embodiment, the high vapor pressure media comprises perfluorooctylbromide. In another embodiment, the high vapor pressure media comprises perfluorohexane. In yet another embodiment, the high vapor pressure media comprises perfluorodecalin. Also disclosed herein is a method of treating a patient, comprising providing a compressible attenuation device and introducing within the attenuation device at least one high vapor pressure media.

A porous electrospun polymeric nanofiber liquid filtration medium, such as an electrospun mats, used for the removal of viral particles (e.g., parvovirus) and other particles in the 18 nm to 30 nm size range from fluid streams, having a mean flow bubble point measured with perfluorohexane above 100 psi. The electrospun medium includes nanofibers having an average fiber diameter of about 6 nm to about 13 nm, and the nanofiber liquid filtration medium has a mean pore size ranging from about 0.01 um to about 0.03 um, a porosity ranging from about 80% to about 95%, a thickness ranging from about 1 um to about 100 um, and a liquid permeability greater than about 10 LMH / psi. The high porosity of the electro-spun mats enable much higher water fluxes, thus reducing the time required to complete virus filtration steps on a fluid stream.

The invention relates to a preparation method of hollow mesoporous silica loaded by nanometer star-shaped gold particles. The method includes the steps of forming solid silicon wrapped by meso-porous silicon in an ethyl alcohol, ultrapure water and ammonia mixed solution with ethyl orthosilicate as a silicon source, etching the solid silicon through sodium carbonate to form hollow mesoporous silica, modifying the surface of the hollow mesoporous silica by sulfydryl and loading the surface of the hollow mesoporous silica with nanometer gold particles so that the hollow mesoporous silica can serve as seeds, making the seeds grow into the hollow mesoporous silica loaded by nanometer star-shaped gold particles in a chloroauric acid solution, and wrapping perfluorohexane and modifying polyethylene glycol with one end being -SH. The prepared nanometer particles have excellent biocompatibility and long in-vivo blood circulation time, have good US / CT / PA imaging and photo-thermal treatment effects and are wide in application prospects, and a new method is provided for development of multi-mode imaging contrast media and treatment integrated platforms.

The invention discloses a preparation method of perfluorohexane. The preparation method comprises the following steps that (1) by weight, hexafluoropropylene dimer, anhydrous hydrogen fluoride and electrolytic addition agents are prepared into an electrolyte for standby application; (2) the electrolyte is subjected to electrolytic dehydration for standby application; and (4) the dehydrated electrolyte is continuously added into an electrolytic bath to be subjected to electrofluorination reaction, a gaseous product obtained after electrolysis is condensed and rectified, and thus a perfluorohexane product is obtained. The advantages that the process is simple, the cost is low, the current efficiency is high, the operation cycle is long, and the product quality is stable are achieved.

The invention discloses a manufacture method for super-hydrophobic plastic. The manufacture method comprises the following steps: 1) performing condensation reaction of perfluoroalkane (including but not limited to perfluorobutane, perfluoropentane and perfluorohexane) and acrylic ester to get perfluoroalkyl acrylate; 2) mixing the silicon dioxide having three particle sizes (10-30 nanometer, 200-500 nanometer and 800-1200 nanometer) in mass ratio of 1:1:1 uniformly; 3) preparing the material: by mass, 15% of condensation compound of perfluoroalkyl acrylate, 15% of mixture of silicon dioxide, 70% of plastic resin (including but not limited to polyethylene resin PE, polypropylene resin PP, polycarbonate PC, polyamide PA, ABS resin and the like), 1%-5% of paraffin or chlorinated paraffin as an internal lubricant, and 1%-3% of stearic acid as an external lubricant, stirring fully to make the material mix uniformly; 4) manufacturing composite master batch by a extrusion moulding method in a double screw extruder at the temperature of 220-280 DEG C; 5) manufacturing various plastic products by using a extrusion, rolling process, injection moulding, spray, blow molding and so on.

The invention discloses a method for preparing a perfluorohexane surfactant serving as a main agent of an aqueous film-forming extinguishing agent directly. The method comprises the following steps of: performing ammonolysis reaction of perfluorohexane sulfuryl fluoride and diamine which serve as raw materials under the action of a catalyst to synthesize an amino sulfonamide compound without separation, and performing quaterisation reaction of the amino sulfonamide compound and chloroacetate to prepare a perfluorohexane betaine amphoteric surfactant which can be used for the aqueous film-forming extinguishing agent directly. The method has the characteristics of simple requirement on equipment, stable and convenient process, low energy consumption and no pollution; and the aqueous film-forming extinguishing agent prepared from the perfluorohexane betaine amphoteric surfactant serving as the main agent is short in fire control time and high in fire extinguishing efficiency, and all indexes reach the national standards of the industry.

The invention relates to a preparation method and application of an ultrasonic control type anti-tumor drug delivery system. The problems that existing tumor treatment drugs are low in drug loading capacity, are leaked when delivered, are low in tumor response sensitivity, slow in release and prone to causing drug resistance, and can not be controlled in vitro are solved effectively. The ultrasonic control type anti-tumor drug delivery system is established with hollow mesoporous titanium dioxide as the base body by being internally loaded with perfluorohexane and drug bleomycin, wrapped by an endogenous biological membrane-erythrocyte membrane and modified by tumor homing peptides; a nanoscale particle size distribution drug delivery system is prepared with hollow mesoporous titanium dioxide as the base body by being internally loaded with perfluorohexane and model drug bleomycin, wrapping surfaces of hollow mesoporous titanium dioxide by RBC, and being wrapped by an endogenous biological membrane-erythrocyte membrane; a tumor drug delivery system with a remote ultrasonic control function is established by modifying tumor homing peptide NGR tail ends with diacyl lipid.

The invention relates to a preparation method and a use of degradable polymer nano-microcapsules. The preparation method comprises the following steps of carrying out backflow deposition on an acrylic acid monomer to produce uncross-linked polymer nano-microspheres, carrying out backflow deposition to coat a disulfide bond cross-linked polymer shell layer on the surface of the uncross-linked polymer nano-microsphere by disulfide bond-containing N,N'-bis(acryloyl)cystamine as a cross-linking agent, transferring the prepared core-shell composite microspheres into ethanol or water, and carrying out uncross-linked polymer core etching to obtain the degradable polymer nano-microcapsules having monodispersity. The preparation method can be carried out fast, has simple aftertreatment processes, is free of an etching process adopting strong acid or strong alkali and is safe and efficient. After freeze-drying treatment, the degradable polymer nano-microcapsule can carry doxorubicin as a cancer-resistant drug and the cavity of the degradable polymer nano-microcapsule is further filled with perfluorohexane having ultrasonic response so that the degradable polymer nano-microcapsule is effectively used as an ultrasonic contrast agent and a drug carrier. The ultrasonic contrast agent can be fast decomposed to form very low molecular-weight linear molecules (Mn<5000) in the presence of glutathione or dithiothreitol as a reducing agent.

A process for preparing the ultrasonic microvesicle contrast medium by O / W emulsified solvent evaporating method and spray drying method includes such steps as dissolving ester in water, stirring while adding perfluorohexane liquid, homogenizing, mixing it with a physiocompatible solution containing hydroxyethyl starch, spray drying to obtain liposome microvesicles, and loading them in a vacuum environment while filling mixed F-C-N gas for disinfecting.

The invention discloses a non-ionic ammonium hydrogen fluoride etching solution with low surface tension. The non-ionic ammonium hydrogen fluoride etching solution consists of hydrogen fluoride, ammonium fluoride, an additive and deionized water, wherein preferably, the additive is selected from one or more of polyethylene glycol monoperfluorononylene ether, perfluorohexane sulfonic acid polyglycerol ester, octylamine, polyglycerol perfluorononylene ether, polyethylene glycol perfluorononylene methyl ether, and perfluorohexane sulfonic acid macrogol ester. A proper additive is added on the basis of the hydrogen fluoride etching solution in the prior art and can be dissolved into high-concentration hydrogen fluoride and ammonium fluoride without introducing any metal ion or negative ion, so that residues on the surface of an etched oxide layer are eliminated, low surface tension is achieved for the etching solution, the permeability of the etching solution is increased, and the etching solution can enter a pore of which the pore diameter is 2.5 mu m; the fluorocarbon chain of a fluorine surfactant in a surfactant composition has the properties of high surface activity, hydrophobicity and lipophobicity, so that the surface tension of the solution can be reduced greatly, the using amount of the etching solution is small, and the production cost is low.

A porous electrospun polymeric nanofiber liquid filtration medium, such as an electrospun mats, used for the removal of viral particles (e.g., parvovirus) and other particles in the 18 nm to 30 nm size range from fluid streams, having a mean flow bubble point measured with perfluorohexane above 100 psi. The electrospun medium includes nanofibers having an average fiber diameter of about 6 nm to about 13 nm, and the nanofiber liquid filtration medium has a mean pore size ranging from about 0,01 um to about 0,03 um, a porosity ranging from about 80% to about 95%, a thickness ranging from about 1 um to about 100 um, and a liquid permeability greater than about 10 LMH / psi. The high porosity of the electrospun mats enable much higher water fluxes, thus reducing the time required to complete virus filtration steps on a fluid stream.

The invention discloses a perfluorooctylbromide coated block polymer ultrasound microbubble contrast agent and a preparation method thereof. The perfluorooctylbromide coated block polymer ultrasound microbubble contrast agent refers to a perfluorooctylbromide coated mPEG-PLLA, PLGA-PEG-PLGA or mPEG-PCL block polymer ultrasound microbubble contrast agent. A preparation method of the agent comprises the steps of preparing an mPEG-PLLA, PLGA-PEG-PLGA or mPEG-PCL block polymer solution, adding perfluorooctylbromide perfluoropentane, perfluorohexane or perfluoropropane to the solution, and then preparing the ultrasound microbubble contrast agent by an electric internal cutting homogenizing, ultrasonic emulsifying or mechanical oscillating method. The perfluorooctylbromide coated block polymer ultrasound microbubble contrast agent provided by the invention is applied to preparation of an ultrasonic imaging diagnosis contrast agent. The high polymer material used by the perfluorooctylbromide coated block polymer ultrasound microbubble contrast agent is safe and nontoxic, and is obviously cheaper than synthetic phospholipids; the microbubble preparation process is simple and convenient; the novel perfluorooctylbromide coated block polymer ultrasound microbubble contrast agent has good potential prospect in clinical application.

The invention relates to the technical field of medicinal preparations, and in particular discloses a multimodal contrast agent and use thereof. The multimodal contrast agent is composite nanoparticles of mesoporous silica-supported copper sulfide and perfluorohexane; the cores of the composite nanoparticles are made from copper sulfide, and mesoporous silica is used as a shell for wrapping the copper sulfide; pores of the mesoporous silica are filled with the perfluorohexane, and the outer surface of the mesoporous silica is connected with polyethylene glycol. The multimodal contrast agent isapplied to an ultrasound imaging reagent, a photoacoustic imaging reagent, cavitation treatment and a photothermotherapy reagent. The multimodal contrast agent provided by the invention is low in cytotoxicity, good in biocompatibility, has the functions of bimodal imaging / photothermal therapy and cavitation treatment, realizes multi-mechanism treatment of tumor homologues, and improves the curative effect; furthermore, the multimodal contrast agent is simple in preparation process and low in cost.

The invention relates to the technical field of biomedicine and discloses low-intensity focused ultrasound response type phase-change thrombolysis nano particles which comprise shell polylactic acid-glycolic acid copolymer PLGA, wherein ferrosoferric oxide Fe3O4 is embedded into the shell; perfluorohexane PFH is coated in the shell; the shell is connected with CREKA polypeptide targeting fibrin. The low-intensity focused ultrasound response type phase-change thrombolysis nano particles can solve the problem of an unsatisfactory thrombolysis effect caused by limited drug loading capacity or drug inactivity of drug-loading nano particles in the prior art.

The invention relates to a magnetic resonance imaging (MRI)-oriented high intensity focused ultrasound (HIFU) synergist and a preparation method thereof. The MRI-oriented HIFU synergist comprises mesoporous nano particles, manganese oxide nano particles dispersed in the mesoporous nano particles, and guest molecules which are loaded in the mesoporous nano particles and are used for HIFU synergism. Manganese oxides and mesoporous hollow nano materials are combined, so that tumor parts are accurately positioned by manganese-based MRI and by using an imaging function of the materials, and high biocompatibility is achieved. Moreover, a large-cavity structure of the mesoporous material can be loaded on HIFU synergistic perfluorohexane, so that the treatment effect if HIFU can be improved.

A liquid / liquid extraction method is used for separating a perfluorinated polyether (PFPE) into two molecular-weight distributions using an alcohol or cyclic ether as one solvent and a fluorinated solvent as the other solvent. The more polar alcohol or cyclic ether solvent extracts the lower molecular weight PFPE and the less polar fluorinated solvent extracts the higher molecular weight PFPE. In addition, when the PFPE is a mixture of PFPEs with different end groups, such as a mixture of predominantly Z-Tetraol but with other PFPEs with Z-Dol end groups, there is an enrichment of the Z-Tetraol in the more polar solvent. The preferred PFPE is a mixture of PFPEs in as-purchased Z-Tetraol and the preferred solvents are methanol or trifluoroethanol as one solvent and a perfluorinated hydrocarbon, such as perfluorohexane, as the other solvent.

The present invention discloses a new type tobacco shreds expanding agent. It can be formed from dichloromonofluoethane and perfluoropentane or / and perfluorohexane according to a certain proportion or formed from pentafluoro-propane, pentafluorobutane and decafluoropentane or / and perfluorobutylmethyl-ether according to a certain proportion. It is characterized by that its ozone consumption latent energy value is zero or low, its boiling point is moderate, and it is safe and low-toxic, incombustible and volatile, and can be used as expanding agent for tobacco shreds instead of CFC-11 in tobacco industry.

The invention discloses a multifunctional ultrasonic contrast agent. The multifunctional ultrasonic contrast agent is of a core-shell structure, wherein a poly(lactic-co-glycolic acid) copolymer is used as a shell, perfluorohexane is used as a core, and superparamagnetic iron oxide and IR780 iodide are loaded in the poly(lactic-co-glycolic acid) copolymer. The invention also discloses a preparation method of the contrast agent. The preparation method comprises the following steps: (1) dissolving the poly(lactic-co-glycolic acid) copolymer, the superparamagnetic iron oxide, the IR780 iodide andthe perfluorohexane in an organic solvent to obtain a mixed solution; (2) adding a polyvinyl alcohol solution into the mixed solution obtained in the step (1), and carrying out ultrasonic emulsification to obtain an emulsion; and (3) stirring the emulsion obtained in the step (2), carrying out centrifuging, and washing a precipitate with water to obtain the multifunctional ultrasonic contrast agent. The contrast agent disclosed by the invention is a multifunctional contrast agent integrating near-infrared fluorescence / magnetic resonance / ultrasonic multi-mode development and photothermal therapy, and realizes photothermal therapy under the guidance of multiple image modes.

The invention discloses a method for preparing lithium fluorosulfonate by using an organometallic lithium reagent, which comprises the following steps: (1) slowly mixing and reacting the organometallic lithium reagent serving as a lithium source with fluorosulfonic acid under a low-temperature condition in the presence of perfluorohexane serving as a solvent to obtain a lithium fluorosulfonate crude product; and washing the crude product with a reaction solvent for 5 times; (2) carrying out vacuum pumping on the crude product, adding a poor organic solvent of lithium fluorosulfonate, washing for three times, and carrying out vacuum pumping on the poor organic solvent to obtain a solid; (3) adding carbonate, nitrile and alcohol organic solvents into the solid, extracting, filtering, concentrating, adding a low-polarity aprotic solvent into the concentrated solution, and carrying out static crystallization; and (4) filtering the crystals again, and carrying out vacuum drying to obtain the lithium fluorosulfonate product. The preparation steps are carried out without water under the protection of inert gas. According to the preparation method provided by the invention, the lithium fluorosulfonate can be prepared, the yield is high, the product quality is stable, and the content of impurities such as potassium ions, sodium ions, calcium ions, fluorine ions, sulfate ions and water in the product can be effectively reduced.

Devices for cerebral and systemic cooling via a patient's nasopharyngeal cavity are described. Cooling assemblies include at least one elongate tubular member having first and second lumens, a source of liquid coolant, a gas source communicating with the first lumen, and a switch for alternately connecting the liquid coolant source to the second lumen. The first lumen transports a compressed gas and the second lumen transports a volatile liquid. The pressurized fluid may be a perflurocarbon. The perfluorocarbon may be perfluorohexane, perfluoropentane, or 2-methyl-perfluoropentane. The gas may be air, oxygen, or a combination.

To provide a solvent composition capable of removing soils such as dusts and oils attached to the surface of an article made of an acrylic resin or an article coated with an acrylic resin, without damaging it. An azeotrope-like solvent composition comprising from 38 to 41 mass % of (2,2,2-trifluoroethoxy)-1,1,2,2-tetrafluoroethane and from 59 to 62 mass % of perfluorohexane. A mixed solvent composition comprising from 30 to 60 mass % of (2,2,2-trifluoroethoxy)-1,1,2,2-tetrafluoroethane and from 40 to 70 mass % of perfluorohexane.

A lithographic projection apparatus uses a volume of a second liquid to confine a first liquid to a space between the projection system and the substrate. In an embodiment, the first and second liquids are substantially immiscible and may be a cycloalkane, such as cyclooctane, decalin, bicyclohexyl, exo-tetrahydro-dicyclopentadiene and cyclohexane, another high-index hydrocarbon, a perfluoropolyether, such as perfluoro-N-methylmorpholine and perfluoro E2, a perfluoroalkane, such as perfluorohexane, or a hydrofluoroether; and water, respectively.

The invention discloses a targeted ultrasonic phase-change bimodal imaging nano contrast agent and a preparation method and an application thereof. The ultrasonic phase-change bimodal imaging nano contrast agent comprises a shell membrane and a core coated in the shell membrane, the core comprises Fe3O4 nanoparticles and liquid PFH (perfluorohexane), and the shell membrane comprises PLGA and phospholipid.

The invention relates to an etching solution and a processing technology for producing low-haze anti-glare glass by using the same. The low-haze anti-glare glass etching solution comprises the following components in percent by weight: 20-30% of perfluorohexane, 1-3% of a surfactant, 5-10% of fluoride salt, 10-15% of inorganic acid and 45-70% of pure water. The processing technology comprises thefollowing steps: putting cleaned glass into the etching solution, keeping the temperature of the glass etching solution at 60 DEG C, and carrying out a reaction for 20-50 minutes to directly obtain the low-haze anti-glare glass. Compared with a three-step anti-glare glass processing method, a one-step micro-fluorine etching technology has the advantages as follows: raw materials are saved, technological steps are reduced, and the cost is greatly reduced; the anti-glare glass formed by etching is widely applied to mobile phone screens, computer screens, LCD TVs and the like.

The invention relates to a nanoscale chitosan derivative ultrasonic contrast medium capable of converting surface charges and a preparation method of the contrast medium. According to the nanoscale chitosan derivative ultrasonic contrast medium, tween 20, lecithin and perfluorohexane are adopted for preparing a mixed suspension solution through a nano emulsion method, O-carboxymethyl chitosan is stirred and dispersed in the mixed suspension solution through a high-speed machine, and after low-speed centrifugation and filtering, the nanoscale chitosan derivative ultrasonic contrast medium, witha small and even particle size, capable of converting the surface charges is obtained. According to the prepared nanoscale chitosan derivative ultrasonic contrast medium capable of converting the surface charges, with the O-carboxymethyl chitosan as a shell membrane, a perfluorohexane solution is wrapped by the interior of the shell membrane, the particle size is 150-200 nanometers, the ultrasonic contrast medium can penetrate through the blood vessel endothelium and enter the tumor microenvironment and has targeting performance and high efficiency on tumor treatment, the ultrasonic contrastmedium and protein substances in the serum are not easily subjected to protein agglutination in the blood environment, and the ultrasonic contrast medium has good blood compatibility and stability andfurther has a good drug(doxorubicin)-loaded capacity.

The invention provides polydopamine perfluorohexane nanoliposome and a preparation method and application thereof, and relates to nano materials and biomedical materials. The preparation method comprises the steps that 1), perfluorohexane is subjected to ultrasonic emulsification and dispersion in ultrapure water to form uniform nano emulsion; 2), the nano emulsion is blended with ammonium hydroxide and an ethanol solution, a dopamine hydrochloride solution is added, and stirring, centrifuging and cleaning are conducted; 3), ferrous lactate is added into a perfluorohexane-polydopamine nanoparticle solution, and stirring, centrifuging and cleaning are conducted; 4), soybean lecithin, cholesterol and distearoyl phosphatidyl ethanolamine are dissolved in dichloromethane, a liposome film is synthesized through a rotary evaporator, and a liposome film solution is subjected to ultrasonic dispersion; and 5), the liposome film solution is added into the nanoparticle solution in the step 3), ultrasonic dispersion and self-assembly are conducted, centrifuging and cleaning are conducted, and the polydopamine perfluorohexane nanoliposome is obtained. The defect that perfluorohexane is insoluble in water is overcome, the size of nanoparticles is small, the nanoparticles can be passively targeted to tumor cells through the high-permeability long-retention effect, tumor microenvironment hypoxia is improved, and iron death of the tumor cells is triggered.

The invention discloses a method for preparing branched perfluorohexane. The method includes the following steps: (1) reacting a hexafluoropropene dimer adopted as a raw material to a catalytic hydrogenation reaction in a reactor to synthesize dodecafluorodihydrohexane; and (2) introducing the dodecafluorodihydrohexane prepared in the step (1), anhydrous hydrofluoric acid and conductive auxiliarydimethyl disulfide into an electrolytic tank and preparing the branched perfluorohexane by Simons electrochemical fluorination. The method of the invention uses the perfluoropropylene dimer as the rawmaterial, performs the hydrogenation to obtain the saturated hydrofluoroalkane, and then performs electrochemical fluorination to replace the hydrogen to obtain the branched perfluoroalkane. The method for preparing the branched perfluorohexane has the advantages of high hydrogenation conversion rate and good selectivity, and so the electrochemical fluorination efficiency is significantly improved and the production cost is greatly reduced.

The invention discloses a shredded tobacco expander, which is composed of dichlorofluoroethane and perfluoropentane or perfluorohexane in a certain proportion, and has zero or very low ozone depletion potential, moderate boiling point, safety and low Toxic, non-flammable, volatile and other characteristics, it can replace CFC-11 in the tobacco industry as tobacco expansion agent.

The invention relates to a method for preparing an ultrasonic microbubble contrast agent, in particular to a method for preparing an ultrasonic microbubble contrast agent in batches by using an O / W emulsification solvent evaporation method and a spray drying method, comprising the following steps: (a) dissolving the ester in water, stirring Adding perfluorohexane liquid to obtain liquid fluorocarbon colostrum; (b) homogenizing the obtained colostrum to obtain a uniform emulsion; (c) mixing the obtained emulsion with an equivalent amount of 6-10% hydroxyethyl starch Compatibility solutions are mixed, and liposome microbubbles are prepared by spray drying; and (d) after the microbubbles are placed in a vacuum environment for about 1 hour, a mixed gas of fluorocarbon and nitrogen is introduced until the air pressure is balanced with the atmospheric pressure, and after sterilization, the Stable ultrasound microbubble contrast agent. The invention also relates to the ultrasonic contrast agent produced by the above method, including liposome ultrasonic contrast agent and carbohydrate ultrasonic contrast agent. The produced ultrasonic contrast agent is safe, stable and has good imaging effect.