67 results about "Stenocardias" patented technology

The present invention relates to traditional Chinese medicine for treating coronary heart disease and stenocardia is made from (by wt.%) salvia root 50-97%, notoginseng 2-48% and borneol 0.2-3%, in which the salvia root and notoginseng and hot extracted with water, then filtering, concentrating, alcohol precipitating, standing still, recovering ethyl alcohol, concentrating, into extractum, further blended with borneol and adjuvant polyglycol-6000 to form into product.

Preferred embodiments of the present invention are related to novel therapeutic drug combinations and methods for treating and / or preventing pulmonary arterial hypertension and / or stable angina. More particularly, aspects of the present invention are related to therapeutic combinations comprising a Rho-kinase inhibitor, such as fasudil, and one or more additional compounds selected from the group consisting of prostacyclins, such as iloprost, endothelin receptor antagonists, PDE inhibitors, calcium channel blockers, 5-HT2A antagonists, such as sarpogrelate, selective serotonin reuptake inhibitors, such as fluoxetine, statins, and vascular remodeling modulators, such as Gleevec.

The invention relates to an Oral Delayed Immediate Release formulation comprising a compressed core containing one or more active substances surrounded with a coating, wherein release of active substance from the core is caused by rupture of the coating after a definite lag-time, said core comprising one or more immediate release carriers and having no substantial swelling properties upon exposure to gastrointestinal fluids. The invention further relates to formulations containing an Immediate Release formulation combined with one or more Oral Delayed Immediate Release formulations with different lag-times and to a method of preparing an Oral Delayed Immediate Release formulation.The Oral Delayed Immediate Release formulation may be used for the application of active substances whenever a certain lag-time before release is advantageous, such as in be the case of anti-asthmatics, anti-emetics, cardiotonics, vasodilators, anti-vertigo and anti-meniere compounds, anti-hypertensives, sedatives, anti-depressants, anti-anxiety compounds, cortico-steroids, general anti-inflammatory compounds, anti-inflammatory compounds for gastrointestinal use, anti-ulceratives, analgetics, anti-aritmics, anti-rheumatics, anti-arthritic compounds and anti-angina compounds.The Oral Delayed Immediate Release formulation may also be used for the application of biological active compounds such as proteins, peptides, enzymes, vaccines and oligonucleotides.

The invention discloses a Chinese medicinal herb composition for treating hypertensive heart disease and a preparation method thereof, wherein the Chinese medicinal herb composition mainly comprises American ginseng, astragalus mongholicus, stigma croci, poria cocos, radices trichosanthis, semen boitae, dalbergia wood, radix ophiopogonis, radix paeoniae alba, selfheal, natural borneol (d-borneol) and uncaria; the Chinese medicinal herb composition has the effects of benefiting qi and nourishing blood, stopping cardiac pain, regulating qi, eliminating the sense of suppression in the chest and calming the nerves; besides, the Chinese medicinal herb composition has good relief effect on palpitation, choking sensation in chest and stenocardia caused by the hypertensive heart disease, and also has obvious treatment effect on the hypertensive heart disease. As a result, the Chinese medicinal herb composition is an ideal medicine for treating the hypertensive heart disease, and is safe and completely free of side-effect.

A method of treating or preventing a disease or condition in a subject that was previously treated with at least one thienopyridine is described. The method includes administering to the subject an effective amount of at least one reversible, short-acting P2Yi2 inhibitor. The described method can be used for subjects diagnosed with symptoms such as stable or unstable angina, vascular ischemic events, atherosclerosis, acute coronary syndrome, as well as STEMi or N-STEMI. The described method can also be used for patients having previously received a stent, such as a bare metal stent or a drug-eluting stent, and the treatment or prevention of stent thrombosis. The method can be used prior to, during, or after an invasive procedure such as coronary artery bypass grafting, percutaneous coronary intervention, or other general surgical procedure.

A compound represented by general formula (I):a salt thereof, a solvate thereof, or a prodrug thereof wherein all symbols are as defined in the specification has an antagonistic activity against CXCR4 and is therefore useful as a preventive and / or therapeutic agent for CXCR4-mediated diseases, for example, inflammatory and immune diseases (for example, rheumatoid arthritis, arthritis, systemic erythematosus, retinopathy, macular degeneration, pulmonary fibrosis, transplanted organ rejection, etc.), allergic diseases, infections (for example, human immunodeficiency virus infection, acquired immunodeficiency syndrome, etc.), psychoneurotic diseases, cerebral diseases, cardiac / vascular disease (for example, arteriosclerosis, myocardial infarction, stenocardia, cerebral infarction, chronic arterial occlusive disease, etc.), metabolic diseases, and cancerous diseases (for example, cancer, cancer metastasis, etc.), a preventive and / or therapeutic agent for cancerous diseases or infections, or an agent for regeneration therapy.

The invention discloses an Amlodipine Besylate oral disintegration tablet, wherein the principal drug employs Amlodipine Besylate, the auxiliary materials include lactose, mannitol, crystalline cellulose, low substituted methylcellulose propylene glycol ether, cross bonding polyvinylpyrrolidone, sodium hydrogen carbonate, citric acid, Aspartame, perfume compound, magnesium stearate, The tablet has good treatment action for hypertension and stenocardia.

Provided are a histamine-H3 receptor antagonist; and a preventive and / or a remedy for metabolic system diseases such as obesity, diabetes, hormone secretion disorder, hyperlipemia, gout, fatty liver, circulatory system diseases, for example, stenocardia, acute / congestive cardiac insufficiency, cardiac infarction, coronary arteriosclerosis, hypertension, nephropathy, sleep disorder and various diseases accompanied by sleep disorder such as idiopathic hypersomnia, repetitive hypersomnia, true hypersomnia, narcolepsy, sleep periodic acromotion disorder, sleep apnea syndrome, circadian rhythm disorder, chronic fatigue syndrome, REM sleep disorder, senile insomnia, night worker sleep insanitation, idiopathic insomnia, repetitive insomnia, true insomnia, electrolyte metabolism disorder, and central and peripheral nervous system diseases such as bulimia, emotional disorder, melancholia, anxiety, epilepsy, delirium, dementia, shinzophrenia, attention deficit / hyperactivity disorder, memory disorder, Alzheimer's disease, Parkinson's disease, sleep disorder, recognition disorder, motion disorder, paresthesia, dysosmia, epilepsy, morphine resistance, narcotic dependency, alcoholic dependency. The histamine-H3 receptor antagonist comprises a piperidine derivative compound of formula (I) [wherein X1 and X2 independently represent a nitrogen atom or CH; Y represents a specific group; X3 represents Os—(CH2)m; R1 and R2 independently represent a hydrogen atom, a halogen atom, a linear or branched lower alkyl group, a lower alkoxy group, or an acetyl group substituted with 2 or 3 fluorine atoms; s is 0 or 1; and m is an integer to make (m+s) 0 or from 1 to 4], or its pharmaceutically-acceptable salt.

The invention relates to a ginseng stem leaf total sapogenin oral pharmaceutical preparation as well as a preparation method and an application thereof, belonging to the field of traditional Chinese medicines. Total aglycone extracted from ginseng stem leaf is hydrolyzed to obtain ginseng stem leaf total sapogenin, and the ginseng stem leaf total sapogenin is made into an efficient preparation by matching with a special auxiliary material, thereby the bioavailability of the ginseng stem leaf total sapogenin can be greatly improved. The preparation has obvious curative effect in the aspect of curing diseases such as coronary heart disease, stenocardia, miocardial infarction, hepatitis, tumour, pulmonary heart disease, high blood pressure, and the like or the aspect of preventing depressive illness and senile-resistant.

The invention discloses a Diltiazem Hydrochloride slow release type micro-drop pill and the process for preparation, which comprises mixing two or more Diltiazem Hydrochloride micro-drop pills by a finite proportion, packing into hard gelatin capsule or pressing into tablet. The preparation can be used for the prevention and cure of hypertension and stenocardia diseases triggered by blood pressure and heart rate rise within several hours after getting up.

The invention relates to an extract of preventing and treating coronary heart disease and stenocardia and a preparation method and application thereof. The preparation method comprises the following steps of: 1, extracting medicinal materials such as red-rooted salvia root and pseudo-ginseng to obtain an extraction solution; 2, separating the extraction solution by using macroporous resin to obtain an extract; and 3, taking the extract and borneol together serving as medicinal active ingredients to prepare a medicinal preparation.

The invention discloses a Chinese medicinal herb composition for treating hypertensive heart disease and a preparation method thereof, wherein the Chinese medicinal herb composition mainly comprises American ginseng, astragalus mongholicus, stigma croci, poria cocos, radices trichosanthis, semen boitae, dalbergia wood, radix ophiopogonis, radix paeoniae alba, selfheal, natural borneol (d-borneol) and uncaria; the Chinese medicinal herb composition has the effects of benefiting qi and nourishing blood, stopping cardiac pain, regulating qi, eliminating the sense of suppression in the chest and calming the nerves; besides, the Chinese medicinal herb composition has good relief effect on palpitation, choking sensation in chest and stenocardia caused by the hypertensive heart disease, and also has obvious treatment effect on the hypertensive heart disease. As a result, the Chinese medicinal herb composition is an ideal medicine for treating the hypertensive heart disease, and is safe and completely free of side-effect.

The invention discloses a gingko drop pill for prevention and cure of cardio-cerebrovascular diseases, which mainly solves the problem of slow effect caused by the slow absorption rate of the ginkgo tablet during the disease treatment process. The drop pill comprises the following constituents with parts by weight, ginkgo leaf extract 1-60 parts, red sage root extract 0-60 parts, ground substance 20-80 parts. The content of active bilobanone ingredient in the medicament is 1-60%, the content of bilobalide is 0.5-6%.

The invention discloses a Chinese herba preparation for treating a coronary heart disease. The Chinese herba preparation is prepared by the following traditional Chinese medicines in parts by weight: 20-150 parts of salvia miltiorrhiza, 20-100 parts of kudzuvine root, 10-100 parts of ligusticum wallichii, 1-50 parts of radix ophiopogonis, 1-50 parts of ginseng, 1-50 parts of pseudo-ginseng, 1-30 parts of hawthorn, 1-30 parts of trichosanthes kirilowii maxim, 1-30 parts of allium macrostemon and 1-30 parts of flowers carthami. The Chinese herba preparation is an oral preparation, a sub-lingual preparation and an injection preparation. The Chinese herba preparation is in such ways of tablets, capsules, granules, soft capsules, pills, syrups and injections. The salvia miltiorrhiza, the kudzuvine root, the ligusticum wallichii, the radix ophiopogonis, the ginseng, the pseudo-ginseng, the hawthorn, the trichosanthes kirilowii maxim, the allium macrostemon and the flowers carthami are mixed for use in the Chinese herba preparation, so as to obviously alleviate stenocardia and improve myocardial ischemia. The invention further provides a preparation method of the Chinese herba preparation for treating the coronary heart disease. The salvia miltiorrhiza, the kudzuvine root, the ligusticum wallichii, the radix ophiopogonis, the ginseng, the pseudo-ginseng, the hawthorn, the trichosanthes kirilowii maxim, the allium macrostemon and the flowers carthami are crushed proportionally, extracted with ethanol, purified by macroreticular resin, condensed and dried to obtain dried powder and an extract, and finally the preparation is obtained.

The invention provides a drug, namely ginkgo biloba general vein medicine for treating a cardiovascular disease. The drug is prepared from the following components in parts by weight of 300-400 parts of ginkgo leaf, 30-80 parts of pseudo-ginseng, 300-400 parts of root of red-rooted salvia, 100-200 parts of ligusticum wallichii, and 100-200 parts of astragalus mongholicus. The drug has the effects of invigorating bolt elimination, regulating qi to alleviate pain, expanding coronary or cerebral arteries, restricting platelet aggregation, reducing blood fat and blood viscosity, and the like. The drug is used for treating coronary heart disease, stenocardia, myocardial infarction, cerebral arteriosclerosis, hyperlipidemia, apoplexy (apoplexia) and sequelae thereof; and furthermore, the drug also has good analgesic anti-inflammatory effects. The drug has significant curative effects on the cardiovascular disease, thoracic obstruction caused by qi-stagnation and blood stasis, namely coronary heart disease angina, giddiness namely cerebral arteriosclerosis and the like, is rapid to recover after being taken, low in recurrence rate, high in security, free of side effect, simple and convenient to prepare, and the like.

The invention relates to a preparation technology for the blend oil of roots of kudzu vine and penoy seeds. The preparation technology comprises the following steps: firstly, cutting the roots of kudzu vine into slices in thickness of 0.1 to 0.3 cm, heating and steaming, then adding ethyl alcohol, carrying out ultrasonic treatment at a frequency of 2KHZ to 45 KHZ for 5 to 10 min, filtering, then mixing the filtrate with oil residue produced after single pressing, heating to a temperature of 35 DEG C to 50 DEG C and keeping the temperature for 15 to 20 min, then carrying out ultrasonic treatment at 30KHz to 40KHz for 5 to 10 min, and heating to a temperature of 35 DEG C to 50 DEG C and keeping the temperature for 15 to 20 min; then combining the mixture with crude oil produced after single pressing, then carrying out ultrasonic treatment again, after insulation treatment, carrying out rotary evaporation at a temperature of 60 to 65 DEG C, and completely volatilizing the ethyl alcohol, namely, obtaining primary oil, and then obtaining the blend oil of roots of kudzu vine and penoy seeds through corresponding treatments of deacidification, decoloration and deodorization. The prepared blend oil of the roots of kudzu vine and the penoy seeds can be in industrialized volume production, can serve as edible blend oil for long term use, has a better health caring effect, can lower blood pressure and resist cancer, and has better effects on typhoid fever, headache, dysphoria with smothery sensation and consumptive thirst, diarrhea diseases, dysentery, ecchymosis, stenocardia and epicophosis.

The present invention relates to a kind of medicine prepared with effective components extracted from natural plant medicine materials and for treating cardiac and cerebral vascular diseases and its preparation process. The medicine consists of gensenoside Rb3 in 1-90 wt% and medicinal supplementary material the rest. The medicine is prepared into tablet, coated tablet, oral controlled release preparation, capsule, etc. and is used in treating hyperlipemia, atherosclerosis, coronary heart disease and other cardiac and cerebral vascular diseases.

The invention provides homoisoflavonoid compounds, which are prepared by the following steps: grinding dwarf lilyturf tuber, adding extraction solvent into the ground dwarf lilyturf tuber according to a weight / volume ratio of the medicinal material to the solvent of 1:(6-10), performing normal-temperature extraction or reflux extraction, mixing extract solution, concentrating under reduced pressure, dissolving the extract in water, extracting in an organic solvent, recovering solvent to obtain coarse total homoisoflavonoid, loading onto a macroporous resin for eluting to obtain total homoisoflavonoid active part extract, and obtaining the homoisoflavonoid compounds by separation by normal silica gel, reversed silica gel and aluminum oxide column chromatography. A cell level H9C2 cardiac muscle cell line oxygen-glucose deprivation pharmacological model proves that the homoisoflavonoid compounds have anti-myocardial ischemia activity and can be used for preparing medicines for treating cardiovascular diseases such as ischemic heart diseases, coronary diseases, myocardial ischemia, myocardial infarction, stenocardia, arrhythmia and cardiac insufficiency. The general structural formula of the compound is shown below.

The invention discloses a medicinal composition for treating cardiovascular and cerebrovascular diseases, and a preparation method and application of the medicinal composition. The medicinal composition can prolong coagulation time, reduce cholesterol levels and contribute to reducing the formation rate of thrombus and atherosclerosis, can be used for treating cerebrovascular diseases such as cerebral ischemia, cerebral thrombosis, cerebral embolism and the like, and cardiovascular diseases such as coronary disease, hypertension, hyperlipaemia, atherosclerosis, myocardial ischemia, arrhythmia, heart failure, stenocardia, myocardial infarction and the like, particularly has good treatment effect when used for continued treatment on patients suffering the cardiovascular and cerebrovascular diseases after emergency treatment, and is a new choice for clinical medication.

The invention provides a Chinese medicine composition used for curing coronary heart disease, angina, arrhythmia and high blood fat and a preparation method thereof. The Chinese medicine composition consists of components as follows: 5 to 20 weight percentage of musk, 12 to 50 weight percentage, 60 to 250 weight percentage of sodium taurocholate, 12 to 50 weight percentage of toad venom, 30 to 120 weight percentage of pearl, 40 to 160 weight percentage of borneol, 1500 to 15000 weight percentage of panax pseudo-ginseng wallich, 150 to 600 weight percentage of ginseng and 50 to 200 weight percentage of the dry extract of buffalo horn. The Chinese medicine composition of the invention can improve blood circulation, dilate coronary arteries, enhance myocardial ischemia, decrease crown arteries resistance, regulate cardiac rate, lower blood pressure, reduce myocardium metabolism, decrease consumed oxygen of myocardium and relieve or eliminate angina via the synergistic and beneficial antagonistic effect of the medicine. As a great amount of the sodium taurochlate is adopted, product cost is reduced while drug effect is ensured as much as possible, thus reducing the economic burden of a patient.

The invention discloses a preparation method of an injection for treating cardio-cerebral vascular diseases. The preparation method is characterized by comprising the following steps of: a, adding ethanol into a medical medicinal material such as panax notoginseng, heating for refluxing to prepare a panaxtriol extracting solution; b, primarily clarifying the panaxtriol extracting solution prepared in a; c, concentrating the panaxtriol extracting solution subjected to the primary clarification in b and separating through using macroporous resins, wherein the separation process is used for primary purification; and d, ultrafiltering the panaxtriol extracting solution subjected to the primary purification in c to prepare panax notoginseng saponins; and then processing the panax notoginseng saponins to prepare a finished product. The prepared injection for treating the cardio-cerebral vascular diseases has light colour, low content of impurities, high content of active ingredients, high bioavailability and good safety, is beneficial to absorption by a human body as well as can satisfy first-aid requirements of patients suffered from various cardio-cerebral vascular diseases such as cerebral thrombosis, cerebral infarction, stenocardia, myocardial infarction and the like; furthermore, the injection can be used as an excellent agent for inhabiting blood platelet congregating and has the efficacies of reducing blood viscosity and increasing cerebral blood flow.

The present invention relates to a medicine composition for curing angiocardiopathy and cerebrovascular diseases and its preparation method. The prescription of said medicine composition is formed from ginseng (or ginseng stem and leaf portion or red ginseng or pilose asiabell root) or its extract and red peony total glucoside or white peony total glucoside. Said medicine composition can be made into injection preparation and oral preparation.

The invention discloses a Chinese medicinal composition for treating cardiovascular diseases, which is prepared mainly from raw material herbs of pseudo-ginseng, Chinese sumac, Chinese angelica root, motherwort, astragalus root, ginseng or Codonopsis pilosula, any one of the compositions may also comprise baras camphor, rosewood oil, liquidambar orientalis mill, musk or musk ketone. The invention also discloses preparations using any one of the medicinal compositions as the effective constituents, preferably drop pills. The auxiliary materials of the drop pill substrate can be polyethylene glycol or natural materials, especially those of plant sources.

A Chinese medicine for treating the acute or chronic myocardial ischemia diseases is prepared from 4 Chinese-medicinal materials: notoginseng, Chuan-xiong rhizome, dalbergia wood and valeriana officinalis. Its advantages are quickly taking its high curative effect (2-3 min), low dosage and no toxic by-effect.

The invention relates to a traditional Chinese medicine composition, a medicine containing the composition, a preparation method for the medicine and an application of the medicine, wherein, the compositions by weight portion of the composition are 0.4 to 4 portions of Chuanxiong rhizome, 0.6 to 6 portions of ginseng, 0.1 to 3 portions of alisma orientale, 0.5 to 5 portions of sandalwood, 0.5 to 3 portions of dwarf lilyturf root, 0.5 to 5 portions of Salvia miltiorrhiza, 0.1 to 3 portions of shizandra, 0.1 to 3 portions of kudzu, 0.1 to 1 portion of pseudo-ginseng and 0.001 to 0.1 portion of borneol; and the compositions can come from traditional Chinese medicines or traditional Chinese medicine water extract equivalent to the crude medicine amount of the traditional Chinese medicines. The traditional Chinese medicine composition can be used for treating diseases such as coronary heart disease, angina pectoris and so on.

The present invention discloses oral disintegrant tablet of total arasaponin and its preparation process. The oral disintegrant tablet consists of total arasaponin 5 weight portions, disintegrant 5-10 weight portions, lubricant 1-5 weight portions, filler 5-15 weight portions and corrective 1-7 weight portions. The disintegrant consists of cross-linked polyvidone and carboxymethyl starch sodium in the weight ratio of 1 to 0.1-1, and the corrective consists of mannitol and aspartame in the weight ratio of 5 to 0.1-3. The oral disintegrant tablet is prepared through a direct tabletting process or through a wet pelletizing and tabletting process. The present invention has the functions of promoting blood circulation to disperse blood clots and dredging meridian, and is used in treating apoplexy, hemiplegia, chest arthralgia caused cardiodynia, etc.

The invention relates to a pharmaceutical composition for treating angina pectoris type coronary heart disease and process for preparation, wherein the composition is prepared from giant knotweed rhizome, panicled swallowwort root, Siberian solomonseal rhizome, mimosa-tree bark, cattail pollen and borneo camphor through steps of boiling, extracting, drying, disintegrating, proportioning, finally making powders, capsules and pills.

A medicine for treating coronary heart disease and angina pectoris and a preparation method thereof. Soybean oil 5-100; beeswax 0.1-3; hydrogenated palm oil 0.4-10; soybean lecithin 0.2-5; methyl silicone oil 0.01-0.5; gelatin 8-150; glycerin 3-80; distilled water 8-150; Esters 0.01-0.8, the preparation method is to use appropriate amount of distilled water, gelatin, glycerin, and ethyl p-hydroxybenzoate to prepare glue; add quantitative beeswax and hydrogenated palm oil to soybean oil, and heat to make the above two substances in soybean oil Completely dissolve, cool, add soybean lecithin, stir well to make it uniform; then add gypenosides, hawthorn extract, and kudzu root flavonoids powder that have been passed through a 60-mesh sieve one by one, stir well to make it evenly mixed, and pass through a colloid mill for 2 times , add methyl silicone oil, let it stand, and vacuumize until the air bubbles in the liquid are basically removed, and set aside; use the gelatinized pellets that have been melted, each containing 580mg, and the thickness of the rubber is about 0.85-0.95mm, and the pellets are made by pressing.

The invention provides a detection method of a medicament for treating coronary disease and stenocardia. The detection method comprises the step of identifying a hawthorn extract in the medicament by adopting a thin layer chromatography, wherein the conditions of the thin layer chromatography are that the mixed solution of a solution A, a solution B and a solution C which are in a volume ratio of (15-25):(2-6):(0.1-1.0), preferably 20: 4:0.5, is used as a developing agent, wherein the solution A is selected from benzene, methylbenzene, dichlorotoluene, chloroform and diethyl ether; the solution B is selected from ethyl acetate, ethyl formate, acetone, alcohol and methyl alcohol; and the solution C is selected from acetic acid, methanoic acid and glacial acetic acid. The detection method has the advantages of high sensitivity, good repeatability, no interference from negative control, and strong maneuverability in the whole testing process, and can be used as one index for controlling the inherent quality.

The invention discloses a Miao ethnomedicine for treating coronary heart disease. The Miao ethnomedicine is composed of the following medicinal materials in mass ratio: 20-30 of herba epimedii, 20-30 of astragalus membranaceus, 30-40 of the root of red-rooted salvia, 20-30 of ligusticum wallichii, 20-30 of radix paeoniae rubra, 20-30 of schisandra chinensis, 20-30 of radix pseudostellariae, 10-15 of rhizoma atractylodis macrocephalae, 15-20 of rhizoma smilacis glabrae, 10-15 of pericarpium citri reticulatae, 10-15 of paniculate swallowwort root, 15-20 of rhizoma cyperi, 15-20 of fructus crataegi, 10-15 of rhizoma acori graminei, 15-20 of angelica sinensis, 15-20 of cassia twig, 15-20 of radix curcumae, and 30-40 of tuber fleeceflower stem. The Miao ethnomedicine for treating coronary heart disease disclosed by the invention is unique in formulation, convenient for taking and effective in treatment; effective components of various medicinal materials are in synergistic effect; the Miao ethnomedicine has the effect of relieving and treating the latent, stenocardia, myocardial infarction and cardiac failure patients, and is suitable for treating coronary heart disease patients.