127 results about "Vaginal Suppository" patented technology

The invention relates to an expandable vaginal suppository which comprises a first expansion carrier; a stype layer comprising active constituents and a matrix is used for at least covering an end part of the first expansion carrier; the vaginal suppository is expanded in a water solution with the pH value of 3.0-8.0 according to the predetermined expansion value; and the expansion value of the first expansion carrier in the saturated water absorption process is 1-30. The vaginal suppository can be fully and selectively contacted with vaginal epithelium and mucosal wall, the bioavailability of active drugs is averagely improved by 20-40%, and different positions of a suppository body can be expanded to different degree, so that the problem of low possibility of cleaning a sliver vaginal suppository is thoroughly solved and the problems of poor user compliance, strong discomfort and the like are avoided.

The endometriosis treatment protocol provides for administering to a female patient in need of treatment for endometriosis a pharmaceutical composition in a form suitable for vaginal or rectal delivery having a pharmaceutically effective amount of an aromatase inhibitor, which may be either a steroid or non-steroidal. The pharmaceutical composition may be formed as a vaginal suppository, a rectal suppository, a vaginal gel, a rectal gel, a vaginal cream or a rectal cream. The pharmaceutical composition may optionally have pharmaceutically effective amounts of progesterone and calcitriol, and may be administered in combination with an oral COX-2 inhibitor. Alternatively, the pharmaceutical composition comprises an aromatase inhibitor administered vaginally or rectally and is administered in combination with oral calcitriol and the oral COX-2 inhibitor. The aromatase inhibitor is either steroidal or non-steroidal.

A topical composition for relief from certain menopausal, peri- and post-menopausal symptoms is disclosed, consisting of a low dosage of progesterone, testosterone and estriol in a pharmaceutically acceptable topical carrier in a weight ratio of from about 1:0.1:0.01 to about 1:0.1:0.02, respectively. In a preferred single dose, the three active ingredients are present as follows: (a) from about 20 to about 35 mg progesterone; (b) from about 2 to about 3.5 mg testosterone; and (c) from about 0.2 to about 0.7 mg estriol. A preferred carrier is cocoa butter, and a preferred single dose form is a vaginal suppository.

The invention relates to a Baofukang suppository with an expansion carrier, which is a vaginal suppository prepared by the following components in parts by weight: 60-100 parts of zedoary oil, 60-100 parts of borneol and matrix and 500-2,000 parts of expansion carrier; the surface of the expansion carrier is coated with a drug containing layer formed by at least a part of active ingredients and at least a part of matrix, and the expansion value of the expansion carrier is greater than 1.5. The Baofukang suppository has the benefits that the Baofukang suppository is convenient to use and long in effect time and takes effect fast; the pollution to clothes is avoided; an active drug can be uniformly distributed on a whole vaginal wall and uterine cervix, and permeated into a deep site of mucosa ruffles; surprisingly, the technological effects can still be realized under the conditions that even polyethylene glycol is not used and water is almost not used; the effective rate to mycotic vaginitis is 96.2%; and the effective rate to senile vaginitis is 96.6%.

The invention relates to a lactobacillus expansible vaginal suppository as well as a preparation method and a detection method thereof. The expansible vaginal suppository comprises an expansion vector and a drug-containing matrix which coats the surface of the expansion vector and is formed by lactobacilli and a matrix, wherein the lactobacilli include lactobacillus plantarum, lactobacillus acidophilus, lactobacillus fermentum, lactobacillus salivarius, lactobacillus crispatus, lactobacillus casei, lactobacillus paracasei, lactobacillus rhamnosus, lactobacillus reuteri and lactobacillus bulgaricus, and the various lactobacilli can develop a significant synergistic effect together; and the drug-containing matrix further consists of an emulsifier, a sustained-release agent and carnauba wax. The lactobacillus expansible vaginal suppository provided by the invention, on the basis of seven unique advanced technologies, has effects of preventing effusion of medicine liquid, guaranteeing high stability, guaranteeing a lasting curative effect and the like.

The secnidazole vaginal suppository of the present invention is composed of the following components: main ingredient secnidazole 500g, auxiliary material 36 type mixed fatty acid glyceride 2300g, made into 1000 suppositories, each weighing 2.8 grams, the 36 type mixed Fatty acid glycerides are a mixture of triglycerides, diglycerides and monoglycerides, and the melting point of type 36 mixed fatty acid glycerides is 35-37°C. The drug of the secnidazole suppository of the present invention is directly absorbed through the vagina, and will not cause damage to the heart, kidney and liver after testing. The curative effect is good, there is basically no side effect, the proportion is simple, and the use is convenient. The invention also discloses the preparation process of the secnidazole vaginal suppository at the same time.

The present invention is compound preparation for treating womení»s inflammation, and belongs to the field of medicine technology. Each 1000 application units of the compound preparation consists of ornidazole 100-1000 g, butoconazole nitrate 10-500 g and policresulen 50-300 g. The compound preparation may be prepared into different forms, including vaginal suppository, vaginal effervescent tablet, vaginal tablet, vaginal gel, etc. The compound preparation has the functions of resisting anaerobic bacteria, resisting protoplasm, resisting mildew and resisting aerobion, and may be used in treating various womení»s infectious diseases, such as bacterial vaginitis, mycotic vaginitis, protozoal vaginitis, non-specific vaginitis, mixed infectious vaginitis, pruritus vulvae, etc.

The invention belongs to the field of veterinary medicine, and particularly relates to a rifaximin vaginal suppository for livestock and a preparation method for the same. The suppository contains the following components: 8.5-25.5 parts by weight of rifaximin solid dispersion, 30-88 parts by weight of matrix, 6.0-12.5 parts by weight of water, 0.01-1.0 parts by weight of surfactant, 0.01-10.0 parts by weight of synergist and 0.01-5.0 parts by weight of preservative, wherein the rifaximin solid dispersion is obtained by melting 7.3-21.9 parts by weight of solid dispersion carrier in a water bath at 70-80 DEG C, and then adding the used 2-16 parts by weight of absolute ethyl alcohol to dissolve 1.2-3.6 parts by weight of rifaximin to obtain rifaximin solution, uniformly stirring, steaming away the absolute ethyl alcohol in the water bath at 70-80 DEG C, and then rapidly cooling and solidifying. The suppository disclosed by the invention can ensure the uniform dispersion of main medicine and overcome the problems of low heat resistance and long melting time limit of glycerin gelatine matrix.

The invention relates to a Baicao expandable vaginal suppository for clearing gynecologic inflammation, and a preparation method and a detection method thereof. The expandable suppository comprises a traditional Chinese medicine composition, a matrix and an expansion carrier. The traditional Chinese medicine composition and the matrix form a medicine-containing matrix, which is coated on the surface of the expansion carrier. The traditional Chinese medicine composition is prepared from sophora root, the tuber of stemona, Fructus Cnidii, agrimony, Folium Callicarpae Formosanae, alum, borneol, camphor and boric acid; and the medicine-containing matrix includes an acidifier and hydrogenated lecithin, which cooperate to promote absorption of the traditional Chinese medicine composition. The expandable vaginal suppository is prepared into an osmotic pump expandable vaginal suppository, which has the function of zero level slow release, so as to fully play the therapeutic effect of the expandable suppository. And the Baicao expandable vaginal suppository employs seven unique technologies, and has the beneficial effects of prevention of outflow liquid, high stability, lasting effect and prevention of secondary infection.

A composite vegetative estrin medicine in the form of suppository, gel or film for treating vagititis and improving the toughness of vagina and its resistance to bacteria is proportionally prepared from vegetative estrin, cnidiadin, borneol, and at least one of matrine, phellodendrine, berberine, etc and their physiocologically acceptable salts.

The invention relates to a Fukang expandable vaginal suppository, and a preparation method and a detection method thereof. The expandable suppository comprises active ingredients, a matrix and an expansion carrier. The active ingredients and the matrix form a drug-containing matrix, which is coated on the surface of the carrier. The active ingredients include walnut oil and further include motherwort and radix polygonati officinalis. The additional motherwort and radix polygonati officinalis can improve the curative effect of the Fukang expandable vaginal suppository on symptoms of leukorrhea with reddish discharge and bearing-down pain in lower abdomen; the starch sodium glycolate and walnut oil are prepared into a solid dispersion to improve the solubility of walnut oil and reduce volatilization of walnut oil; the stearic acid palmitic acid glycol ester improve the stability of the suppository; and the dextrin increases cohesiveness of the expandable suppository and is beneficial to forming the expandable suppository. The Fukang expandable vaginal suppository employs six unique technologies, and has beneficial effects of prevention of outflow liquid, high stability, lasting curative effect and prevention of secondary infection.

The invention relates to a compound metronidazole expansion suppository. The compound metronidazole expansion suppository is vaginal suppository prepared by metronidazole, total saponins of ginseng stems and leaves, and vitamin E which are taken as active ingredients, and proper matrix; an expandable expansion carrier is arranged in the suppository; a medicated layer formed by the active ingredients and the matrix is coated on the surface of the expansion carrier; after saturated water absorption, the expansion carrier has the radial expansion value more than 1.1. The invention also provides a detection method of the compound metronidazole expansion suppository. The method comprises the contents such as expansion value measurement, weight difference measurement, etc. The expansion suppository applies six original technologies including 'one-time suppository filling integrated forming' technology, 'inner core expansion factor control' technology, 'human engineering suppository type' technology, 'treatment-cleaning integration' dosage form, 'vaginal inner-attached administration' technology and 'side leakage prevention suppository body design'; the medicated layer of the compound metronidazole expansion suppository is fully contacted with the inner wall of the vagina, so that liquid medicine is prevented from flowing outside; the compound metronidazole expansion suppository also has the effect of cleaning the vagina so as to prevent superinfection.

The invention belongs to the technical field of medical devices, and particularly discloses a vaginal suppository doser which comprises a medicine tube. The medicine tube is provided with a first cavity and a second cavity for containing a suppository. The first cavity and the second cavity are separated by a partition plate. A first through hole and a second through hole are formed in the partition plate. A piston rod is arranged in the first cavity. The front end of the piston rod is provided with a medicine pushing head corresponding to the first through hole in position and a pushing rod corresponding to the second through hole in position. The size of the medicine pushing head is matched with that of the first through hole, and the size of the pushing rod is matched with that of the second through hole. One end of the second cavity is provided with a flexible arc-shaped plate for sealing the second cavity. One end of the pushing rod abuts against the flexible arc-shaped plate. Thevaginal suppository doser is suitable for the suppository, can accurately send the suppository medicine to a diseased region during dosing, is clean and sanitary, reduces cross infection, can controlthe dosing depth and is suitable for dosing by a patient himself / herself.

The present invention relates to a vaginal suppository comprising an inert vehicle and lactic acid or a salt thereof for the treatment and / or prophylaxis of disorders in the urogenital tract. It also relates to the use of such a suppository for the production of a medicament for the treatment and / or prophylaxis of disorders in the urogenital tract as well as to a method for the treatment and / or prophylaxis of disorders in the urogenital tract.

The invention relates to a wintergreen barberry root suppository and a sustained and controlled release wintergreen barberry root suppository, belonging to the technical field of pharmaceuticals. The preparation is prepared by the following steps: using wintergreen barberry roots as raw materials and carrying out steps of pulverization, reflux extraction, decompression concentration, pH regulation, and the like to obtain a tan wintergreen barberry root extract; using the tan wintergreen barberry root extract as an active pharmaceutical ingredient and adding a fat-soluble suppository matrix orsustained and controlled release macromolecular materials to prepare the wintergreen barberry root suppository or the sustained and controlled release wintergreen barberry root suppository. The preparation has obvious anti-inflammatory effect and can be prepared into a rectal suppository used for treating internal hemorrhoids and rectal inflammations and a vaginal suppository used for treating vaginitis and acute vaginitis according to different application and administration routes.

A highly storage-stable composition for vaginal administration of clindamycin is disclosed which is useful for the treatment of bacterial vaginosis. The composition is a vaginal suppository containing an antimicrobially effective amount of clindamycin dispersed in a Hard Fat NF suppository base. Hard Fat NF suppository bases provide a clindamycin product having long term storage stability while providing efficacy against bacterial vaginosis which is equivalent to clindamycin vaginal creams.

The invention discloses a fenticonazole nitrate vaginal suppository composition. By utilizing the high-efficiency antibacterial activity of the fenticonazole nitrate and adopting local vaginal administration, the antibacterial activity is greatly improved, and the toxic or side effect due to oral administration is remarkably reduced. The fenticonazole nitrate vaginal suppository composition is used for locally treating double infection caused by vulvovaginal candidiasis and gram positive bacteria. The invention also relates to a fenticonazole nitrate vaginal suppository composition and a preparation method thereof.

The invention discloses a vaginal suppository used for killing AIDS virus and sperms, relating to an external drug and belonging to the technical field of medicines. A vaginal suppository compound that is a compound preparation takes nonoxynol(NP-9) and PVP-I as two main drugs and a proper amount of carbowax, sodium bicarbonate and citric acid anhy as accessories, wherein, the suppository is prepared by all the components according to the following weight percentages; 1-3 percent of nonoxynol, 3-5 percent of PVP-I and the rest of carbowax, sodium bicarbonate and citric acid anhy and the like of the proper amount. The dosage form of the vaginal suppository compound is the suppository, which has remarkable effect in the use for killing AIDS virus and sperms.

The invention relates to a Zhimikang expandable vaginal suppository. The expandable suppository comprises a traditional Chinese medicine composition, a matrix and an expansion carrier. The traditional Chinese medicine composition and the matrix form a drug-containing matrix, which is coated on the surface of the carrier. The traditional Chinese medicine composition is prepared from golden cypress, sophora flavescens, catechu, dried alum and borneol. bulk drugs including cortex lycii and gentian are further required for preparation of the traditional Chinese medicine composition, and can improve treatment effect of the expandable vaginal suppository on cervical erosion and vulvovaginal candidiasis; and the traditional Chinese medicine composition is prepared into microcapsules to increase the solubility and stability of the traditional Chinese medicine composition and increase bioavailability of the suppository. The Zhimikang expandable vaginal suppository employs seven unique technologies, and has beneficial effects of prevention of outflow liquid, high stability, lasting curative effect and prevention of secondary infection.

The invention discloses a soy isoflavone vaginal suppository and a preparation method thereof. Raw materials for preparing the suppository comprise soy isoflavone solid dispersion and a water-soluble substrate, wherein the soy isoflavone solid dispersion is prepared from soy isoflavone and a hydrophilic solid dispersion carrier, and the mass ratio of the soy isoflavone and the carrier is 1:1-20. The invention designs and prepares a soy isoflavone solid dispersion suppository for vaginal drug administration on the premise of overcoming the defect of poor absorption effect of the oral administration of the soy isoflavone. The solid dispersion technology improves the dispersity and the hydrophilism of the soy isoflavone and improves the moisture degree on the vagina mucosa, thereby improving the infiltration rate of the prepared suppository by 2-3 times. The suppository greatly improves the curative effect of the soy isoflavone on treating and mitigating a series of diseases of women caused by maladjustment of estrogen level.

The invention relates to a tinidazole expandable vaginal suppository, and a preparation method and a detection method thereof. The expandable vaginal suppository comprises tinidazole, a matrix and an expansion carrier. After micronization treatment, tinidazole gains increased dissolution rate, so as to increase bioavailability of the suppository. A resin compound formed by the resin with micronized tinidazole can improve stability of the suppository, and a technology of medicament long-acting layered release is employed to prolong effect time of tinidazole on the vagina, extend therapeutic effect and maintain the specific acid environment and self-cleaning function of the vagina; and the pregelatinized starch can promote the mixing of each component in the suppository and improve the stability of the suppository. The tinidazole expandable vaginal suppository employs seven unique advanced technologies and has beneficial effects of prevention of outflow liquid, high stability, lasting curative effect and prevention of secondary infection.

The invention relates to a ketoconazole vaginal suppository as well as a preparation method and a detection method thereof. The suppository comprises a drug-containing base formed of ketoconazole and a base, a drug-containing mucous layer formed of ketoconazole and a mucous layer, and a swelling carrier. The oleaginous base and water soluble base are added, thereby ensuring that the whole body absorption and application risk of ketoconazole are reduced and the concentration and bioavailability of ketoconazole are effectively improved, so as to take full play of the efficacy of ketoconazole; an absorption promoting agent and chitosan are added, the absorption of a human body to ketoconazole is promoted; the solid disperse carrier can be used for improving the dissolution of ketoconazole, and further promoting absorption of the human body; the drug-containing mucous layer can be adsorbed on vaginal skin to promote skin absorption and can be used for further improving the bioavailability of ketoconazole. The ketoconazole vaginal suppository provided by the invention adopts six original advanced techniques, and has the beneficial effects of drug liquid outflow prevention, good human body absorption, high bioavailability, lasting curative effect, secondary infection prevention, and the like.

The invention discloses a preparation method for vaginal suppository having butoconazole nitrate and application therefor. The invention belongs to the field of new technology of drug, relating to a suppository of butoconazole nitrate, pharmaceutical preparation for treating candida vaginitis and preparation method thereof.

The invention belongs to the field of animal husbandry and veterinary medicine, and particularly relates to a silicone rubber slow-release drug cap for a vaginal suppository and a preparation method of the silicone rubber slow-release drug cap. The silicone rubber slow-release drug cap for the vaginal suppository is provided for overcoming the defects that a conventional vaginal suppository drug is difficult to remove after being used, prone to fall off in use, poor in drug releasing effect and the like. The silicone rubber slow-release drug cap is prepared from 15-25 parts of drug powder, 1.5-2.5 parts of p-hydroxybenzenesulfonic acid, 4-6 parts of a vulcanizing agent and 73.5-83.5 parts of silicone rubber. The preparation method comprises the steps that the drug powder is added into the silicone rubber to be rolled into a film, p-hydroxybenzenesulfonic acid is added, mixing and vulcanizing are conducted, the mixture is injected into a mold, and then the silicone rubber slow-release drug cap is formed. The drug cap can firmly combine a drug in the silicone rubber and is not prone to fall off when the drug cap is applied to the vaginal suppository, better in drug releasing effect, very easy to put in and take out, convenient to use and good in effect.

A pessary is made coil-like suppository through handing the fine cotton yarn or non-woven fabrics, high grade paper or the other material with water absorption and no stimulation, a pulling line being set on one end of suppository. The inner of the coil-like suppository absorbs the liquor manufactured by sophora flavescens ait, radix stemonae sremona, cnidium fruit, giant knotweed, shrubalthea bark and so on or nanometer silver solution or sterilization nursing medical liquor. The suppository is formed according to female physiological charateristic, so that it is easy to use, soft, elastic, comfort and nonirritative. Using the said suppository, the liquor can take sustained action on the vaginal wall to make the whole vaginal wall and posterior fornix of vagina contact the medicine, moreover the medical liquid may not poured off to contaminate the drawer.

A vaginal suppository for disinfecting and contraception is prepared from nonoxinol, povidone-iodine, water and polyvinyl alcohol. It features high effect.

The invention relates to an allicin vaginal suppository and a preparation method thereof. The allicin vaginal suppository comprises following components in percentages by weight: allicin 0.2-5%, substrate 20-79%, emulsifier 0.01-1%, acetic acid 0.1-15%, chitosan 0.1-10%, and distilled water 1-30%; wherein the sum of the percentages of the components is 100%, the substrate adopts glycerin and gelatin, or adopts polyethyleneglycol substances, and the polyethyleneglycol substances includes at least one of polyethyleneglycol 400, polyethyleneglycol 1000, polyethyleneglycol 1500 and polyethyleneglycol 4000; the emulsifier adopts tween substances, and the tween substances includes at least one of tween-80, tween-60 and tween-40. The invention further provides the preparation method of the allicin vaginal suppository; according to the allicin vaginal suppository, the gynecological inflammation can be treated effectively, synchronously the organism immunity of patients can be enhanced, the use of drugs is improved, the administration frequency is reduced, and the use is convenient.

The invention discloses a Yuqinggong vaginal suppository, which comprises, by weight, 45%-60% of sea buckthorn oil, 1%-4% of vitamin-E, 1%-5% of vitamin-C, 1%-5% of soy isoflavones, 20%-35% of shea butter, 1%-5% of seaweed polysaccharide, 5%-15% of yolk oil, 0.1%-3% of collagen, 0.1%-3% of ganoderma lucidum spore powder, 0.1%-3% of polyshvacchdrye and 0.1%-3% of hyaluronic acid. Active ingredients of the compositions of the Yuqinggong vaginal suppository can be absorbed by the vagina directly so as to protect the uterus, nourish the ovary, resist aging and beautify.

The invention relates to a method of estrus synchronization of embryo transplantation receptor cow, which belongs to the field of embryo engineering. The method of estrus synchronization of embryo transplantation receptor cow is characterized in that: Cue-Mate (vaginal suppository) is put into the body of the receptor cow on any day of estrus circle of the cow, then the cow is injected with 100microgram of GnRH and the day is set as a first day; on a fifth day to a seventh day, the vaginal suppository is taken out and the cow is injected with 500microgram of PG; two days later, the cow ovulates; and the transplantation is carried out 7 to 7.5 days after the ovulation. Using the method, time for treating the cow is shortened; application efficiency of the cow is enhanced and breeding cost is saved; the ovulation rate of the cow after the treating is enhanced to 85 to 90 percent from the original 75 to 80 percent.