The invention provides a high-yield culture method for planting cotton in a high-risk cotton region. The technology adopts double-wide-film mulching, the influence caused by low temperature, rain damage, 
wind damage and the like in spring on the 
seedling emerging is effectively resisted, and the 
seedling emerging is fast, regular and uniform; the multi-time intertillage and few-time 
chemical control technology in the 
seedling period is combined, the earth temperature is raised, the early emerging of strong seedlings is effectively promoted, and the seedling retaining rate and the strong seedling rate are improved; the water control is used as a main measure, the 
chemical control is used as an auxiliary measure, the water is saved, the 
pesticide is saved, and the premature senility is prevented; organic fertilizers (
humic acid) and special fertilizers (special drip-
irrigation fertilizers) are heavily applied, few chemical fertilizers are applied, the 
fertilizer effect is enhanced, and the soil and environment 
pollution is reduced; first watering is carried out later at 
proper time, the watering is stopped early, the water 
utilization rate is improved, and the early 
ripeness is promoted; top 
pruning is carried out early at 
proper time, the useless fruit 
branch number is reduced, the 
plant height is reduced, and the falling is prevented; maturity acceleration is carried out early at 
proper time, the harvesting can be carried out for many times in the early period, the 
loss rate is reduced by 5 to 10 percent, and the yield is improved.