The invention relates to the technical field of biological medicines, and discloses a high-refractive-index 
polymer microsphere, which is prepared from the following raw materials in parts by weight: 100 to 200 parts of aliphatic 
conjugated diene monomers, 10 to 100 parts of 
ethylene unsaturated 
carboxylic acid monomers, 20 to 40 parts of 
acrylonitrile monomers, 10 to 30 parts of medium-chain fatty 
glyceride and 5 to 15 parts of aluminum compound 
aqueous solution. According to the high-refractive-index 
polymer microsphere and the preparation method thereof, the latex prepared by the method is more stable in structure, lower in production cost, higher in safety and stability in the production process, and capable of effectively inhibiting generation of cracks, various characteristics such as waterproofness, 
chemical resistance and the like obtained by forming the rubber layer are sufficient, and the high-refractive-index 
polymer microsphere can be used for preparing the high-refractive-index polymer microsphere. According to the present invention, the prepared latex has the advantages of high tensile strength, sufficient tensile strength of the obtained film molding body such as the dipping molding body, excellent hand feeling and excellent elongation, the controllable production cost can be ensured while the 
adhesion strength of the latex is ensured, and the product has advantages of 
high reflectivity and good application effect.