35results about How to "Reduce drug resistance" patented technology

The invention relates to a fungicidal composition containing a prochloraz manganese complex, belonging to the technical field of pesticides. The fungicidal composition comprises a raw pesticide compounded by a fungicide A and a fungicide B, wherein the mixture ratio of the fungicide A to the fungicide B is (1-90): (90:1); the fungicide A is the prochloraz manganese complex; and the fungicide B is any one type of the following fungicides: copper preparations, strobilurins, triazoles, amides, pyrimidinamines, benzimidazoles, thiocarbamates, dimethyl imides, imidazoles, morpholines, oxazoles, ureas, pyridines, pyrimidines, pyrroles, phthalimides, carbamates, antibiotics, heterocycles and others. The fungicidal composition disclosed by the invention contains the raw pesticide compounded by the prochloraz manganese complex and the fungicide B, and can expand the fungicidal spectrum, slow down the drug resistance of pathogenic bacteria and realize an obvious sustained synergistic effect.

This invention provides compounds capable of reducing drug resistance in a subject undergoing cancer treatment, methods using the compounds, compositions, and methods for identifying such compounds.

The invention provides a mixed pesticide with spinosad, and the active ingredients thereof are the combination of spinosad and one or more compounds of profenofos, diafenthiuron, and cyhalothrin. The mixed pesticide is used for preventing and curing the damage caused by pests in agriculture or forestry, and has particularly good effects on preventing and curing the damage caused by cotton bollworms, vegetable diamondback moths, cabbage worms, and lima bean pod borers.

The invention discloses an oral liquid for treating air sacculitis caused by colibacillosis of chicken and a preparation method thereof, and aims at providing the oral liquid with convenience in use for treating the air sacculitis caused by the colibacillosis and the preparation method thereof. Every 100L of oral liquid comprises 5kg of poplar flower extract, 3-8kg of mequindox, 2-6kg of ofloxacin, 6-16kg of sodium salicylate, 0.1-0.3kg of asarin, 10L of 95 percent ethanol, 0.2-0.6L of 35 percent hydrochloric acid solution and the balance of water. In the oral liquid disclosed by the invention, the poplar flower, the mequindox and the ofloxacin are used as main antibacterial components and are combined to reduce the drug tolerance of escherichia coli, so that the oral liquid is sensitive to the escherichia coli; the poplar flower, the mequindox and the ofloxacin can be respectively and orally taken to enter the blood, have high blood concentration and can enter air sac blood vessels, so that the oral liquid has higher concentration and further kills the escherichia coli causing the air sacculitis and can be used for controlling the secondary infection of other bacteria and mycoplasma. The oral liquid can be used for pointedly treating the air sacculitis caused by the colibacillosis of chicken with a better effect.

The invention discloses a pharmaceutical composition for treating a heart failure with preserved ejection fraction. The pharmaceutical composition comprises two active components: (1) activity factors of mitochondria acetaldehyde dehydrogenase 2 enzymatic activity; and (2) a nitrate medicine. According to the pharmaceutical composition, left ventricular end diastolic pressure is effectively reduced; the symptom of myocardial hypertrophy of a heart failure patient is improved; the heart failure with preserved ejection fraction is treated; meanwhile, the tolerance of the nitrate medicine when the heart failure with preserved ejection fraction is effectively reduced; and the effective dose of each single medicine is reduced, so that the incidence rate of the side effect of the medicine is relatively low; the treatment cost is also reduced; the benefit / cost ratio of treatment is obviously improved; the compliance of a patient is increased; the living quality is obviously improved.

The invention provides a hydrophilic antibacterial degradable ureter stent and a preparing method thereof. The surface of the ureter stent is provided with a hydrophilic antibacterial layer, the contact killing effect on bacteria is realized through the effect of polycations of amino-terminated dendrimer, and protein adhesion is prevented by forming a hydration layer. The preparing method includesthe steps of soaking the ureter stent prepared from a degradable material in a Tris-HCl buffer solution of dopamine hydrochloride so that the auto-polymerization of dopamine hydrochloride can happento the surface of the stent, then grafting polyamide-amine dendrimer, and conducting cleaning and drying to obtain the degradable ureter stent grafted with the hydrophilic antibacterial layer. The ureter stent is easy to prepare, the hydrophilic antibacterial layer has a lubricating effect after being reliably grafted on the surface of the stent, the releasing of an antibacterial agent and the toxicity caused by the releasing of the antibacterial agent do not exist, and the ureter stent has high biocompatibility.

The invention provides a strain of probiotics from an environment, and through analysis and identification of morphological characteristics, physiological and biochemical characteristics and molecular biological characteristics of the strain, the strain is Lactobacillus helveticus and is named as Lactobacillus helveticus-S. The lactobacillus helveticus-S can resist acid and bile salt, so that the lactobacillus helveticus-S can be colonized in the digestive tract through oral administration; the lactobacillus helveticus-S has no hemolytic activity and high sensitivity to common antibiotics, so that the lactobacillus helveticus-S has no intestinal pathogenicity and does not diffuse antibiotic tolerance genes; animal model tests show that the lactobacillus helveticus-S can improve the structure and function of intestinal flora, improve the diversity of the intestinal flora and reduce the abundance of inflammation-related flora, and has the effects of treating diarrhea and loose stool and improving the symptom of spleen deficiency.

The invention relates to a farm-oriented insecticidal composition taking mineral oil and beauveria bassiana as main active ingredients and application thereof. The farm-oriented insecticidal composition contains active pharmaceutical ingredients, a pesticide carrier and an auxiliary agent, wherein the active pharmaceutical ingredients comprise the mineral oil and the beauveria bassiana, and the weight part ratio of the mineral oil to the beauveria bassiana is (0.06-6) to 100. The farm-oriented insecticidal composition provided by the invention is prepared by compounding the mineral oil and the beauveria bassiana, has a stable insecticidal effect and can be used for preventing and treating a plurality of types of insects which have drug resistance on chemical pesticides; and compared with traditional chemical pesticides, the farm-oriented insecticidal composition has no toxin residue, is applicable to an integrated control strategy, and has high safety and good environmental protection property.

The invention discloses application of methyl cinnamate or pharmaceutically acceptable salt thereof as a quorum sensing inhibitor in treatment of bacterial diseases. The methyl cinnamate has a stronginhibition effect on quorum sensing system related pathogenic phenotypes of pseudomonas aeruginosa PAO1 and pectobacterium carotovorum subsp. Carotovorum S1, and does not influence the normal growth of the two pathogenic bacteria at the same time, that is, the compound does not influence the growth of the pathogenic bacteria, but also does not influence the growth of the pathogenic bacteria. A pathogenic bacteria quorum sensing system can be strongly inhibited, the pathogenicity of pathogenic bacteria is remarkably reduced, and diseases caused by the pathogenic bacteria are prevented and / or treated; the compound can be used as a pathogenic bacteria quorum sensing system inhibitor or prepared into a related drug for preventing and / or treating bacterial diseases, also has the effects of reducing and delaying the generation of drug resistance of pathogenic bacteria to the compound, has a relatively long effective service life in the aspect of disease prevention and / or treatment, and has awide application prospect.

The invention discloses a feed additive capable of effectively reducing the number of somatic cells in milk. The feed additive is prepared from the following components in parts by weight: 10-20 parts of traditional Chinese medicine extracts, 1-3 parts of vitamin E, 5-10 parts of beta-carotene, 500-800 parts of zeolite powder and 200-500 parts of corn flour. After the feed additive is adopted, the occurrence of drug resistance is reduced, the number of the somatic cells in the milk is effectively reduced, the immunity is improved, the morbidity is reduced, and the quality of dairy products is improved; compared with antibiotics, the feed additive does not have application time limit, and does not cause abandonment of milk and the increased drug resistance; compared with Wan Rukang, the feed additive does not contain an insecticide-levamisol; compared with the common traditional Chinese medicine formula, the feed additive is prepared by using a reasonable extraction process and a compound formula, thus being more powerful in functions, and having the advantages of being safe, non-toxic, used at any time, reliable in effect, and the like.

The invention discloses a pesticide composition of imidacloprid and acetamiprid aqueous emulsion, wherein the composition comprises imidacloprid and acetamiprid as two effective components, and the mass ratio of the imidacloprid to the acetamiprid is 3:2. The accumulated mass percent of the imidacloprid and the acetamiprid accounts for 25 to 50 percent of the gross mass. The preparation form of the pesticide composition is aqueous emulsion. The pesticide composition of the imidacloprid and acetamiprid aqueous emulsion of the invention has strong security, environmental protection and low price and has the characteristics of low pesticide damage, low toxicity, easy dilution, difficult burning, difficult explosion, easy use, easy measurement, favorableness for environmental protection and the like.

The invention relates to a pesticide preparation for reducing drug resistance of plant diseases and insect pests and application thereof. The pesticide preparation provided by the invention comprisesthe following components by weight percent: 0.1%-70% of pesticide active ingredients, 0.5%-5% of cell penetrating peptide, 1%-20% of a surfactant, and a solvent supplementing to 100%. According to thepesticide preparation provided by the invention, the cell penetrating peptide is added to enable the pesticide active ingredients to penetrate cell membranes, thereby greatly improving a rate of penetrating the cell membranes of insects of the pesticide, and improving the fast-acting property and efficacy of the pesticide.

The invention discloses a tubulin inhibitor and a preparation method and application thereof. The tubulin inhibitor is a 1-methylindeno[1,2-c]pyrazoles small molecule compound with a novel structure,the structural formula is shown, and please see the specification for the formula. It is further confirmed by experiments that proliferative effect of human liver cancer cells, human non-small cell lung cancer cells, human colon cells and other tumor cells can be effectively inhibited. The mechanism of action is similar to that of colchicine, and the polymerization of tubulin can be inhibited. Thetubulin inhibitor and the preparation method and application thereof are of great significance for enhancing the specificity, effectiveness, reducing toxic side effects and preventing drug resistanceof drugs, and have good potential value for development and application.

The invention particularly relates to application of benserazide and a composition of the benserazide and fluconazole in preparation of antifungal products. In recent years, the fungal infection rateand the death rate caused by the fungal infection rate are in a rising trend, wherein candida threatens the human body most seriously. At present, azole drugs are first-line drugs for antifungal treatment, but the treatment effect is not ideal due to continuous appearance of drug-resistant bacteria. Aiming at the current situation, the invention provides an antifungal effect of the benserazide, and compound entities with the antifungal effect are enriched. Furthermore, research of the invention also shows that the benserazide can cooperate with the fluconazole, and has a good inhibition effecton candida with large harm such as candida albicans, candida krusei and candida glabrata, the drug sensitivity of drug-resistant strains is improved, and the drug dosage is reduced.

The invention discloses a Lactobacillus acidophilus capable of reducing the drug resistance, and a biological preparation prepared therefrom. The Lactobacillus acidophilus disclosed in the invention is a new Lactobacillus acidophilus XD13R, has a preservation number of CCTCCM2014216, can reduce the proportion of drug resistant bacteria in animals, and can reduce the resistance of animals and human bodies to various antibiotics. The invention also discloses the biological preparation prepared by using the Lactobacillus acidophilus XD13R, and a preparation method of the biological preparation. The biological preparation is used to feed domestic animals in order to reduce the proportion of bacteria resisting different antibiotics in the animals by 30-96%.

The invention discloses a preparation method of a layer-by-layer deposition antibacterial healing-promoting soluble microneedle patch, a microneedle belongs to the field of microneedle preparation methods, and the adopted preparation method is a layer-by-layer deposition micro-molding method. The preparation method has the advantage that materials which cannot be used together due to chemical reaction caused by blending can be used together. According to the antibacterial and healing-promoting soluble microneedle patch, the healing-promoting moisturizing layer is used as a needle tip, the antibacterial and anti-inflammatory layer is deposited on the needle tip, finally, the healing-promoting moisturizing layer is deposited, a functional layer is prepared, and a TPU medical adhesive tape is used as a backing layer. Wherein the healing promoting and moisturizing layer contains the following components: hyaluronic acid and sodium alginate. The antibacterial and anti-inflammatory layer comprises the following components: chitosan quaternary ammonium salt, gelatin, polyhexamethylene guanidine hydrochloride and polyvinyl alcohol. According to the invention, the excellent healing-promoting and moisturizing effects of polyanion polysaccharide and the excellent antibacterial and anti-inflammatory properties of polycation are deposited layer by layer, so that the healing-promoting, moisturizing, antibacterial and anti-inflammatory effects are synchronously carried out.

The invention provides a nocardia antibacterial composition. The effective components of the composition for inhibiting nocardia comprise a mangnolia officinalis extract, or a combination of the mangnolia officinalis extract and magnolol, or a combination of the mangnolia officinalis extract and honokiol, or a combination of the mangnolia officinalis extract, the magnolol and the honokiol. The other nocardia antibacterial composition comprises effective components of magnolol, or honokiol, or a combination of magnolol and honokiol. The invention discloses the inhibition activity of the mangnolia officinalis extract and the active component magnolol and honokiol thereof on nocardia for the first time, has the advantages of high efficiency, safety, no residue, easiness in degradation, low drug resistance and the like, and provides a new treatment method and way for nocardia infection of fishes (aquatic animals).

The invention provides a herbicidal composition containing trifluralin and pretilachlor. The active ingredients of the herbicidal composition comprise trifluralin and pretilachlor, and the mass ratioof trifluralin to pretilachlor is (5-30): (1-15). The herbicidal composition disclosed by the invention can be used for preventing and removing annual weeds in a crop field and has a remarkable synergistic effect.

The invention belongs to the technical field of traditional Chinese medicine formulas for skin diseases, and relates to traditional Chinese medicine for treating acne and a preparation method thereof. The traditional Chinese medicine is prepared from, by weight, 5-10 parts of honeysuckle, 2-8 parts of panax notoginseng, 5-10 parts of coptis chinensis, 30-50 parts of chayote, 12-25 parts of sunflower seeds, 20-30 parts of aloes, 3-5 parts of fresh ginger, 2-5 parts of sangusis draconis, 3-8 parts of curcuma zedoary, 3-10 parts of ligusticum wallichii and 5-10 parts of vaseline, wherein fresh fruit is adopted as the chayote, fresh aloe stems are adopted as the aloes, and dry traditional Chinese medicines are adopted as the other components. According to the traditional Chinese medicine for treating the acne and the preparation method thereof, the medicine resistance is low, and bacteria which cause the acne cannot generate the medicine resistance; the medicine itself has no toxic or side effect, the medicine property is mild, the acne can be effectively treated, and the medicine is suitable for patients of all ages; no scar is left while the acne is eliminated, the treating effect is stable, and relapse cannot occur.

The invention provides a gene medicine for promoting the differentiation of tumor stem cells. The gene medicine comprises a recombinant of which the target gene is a Nell-1 gene and can effectively induce the differentiation of the tumor stem cells, inhibit the multiplication of tumor cells, reduce the drug resistance of the tumor cells and improve the drug sensitivity and can be combined with chemical treatment to enhance the chemical treatment effect; and the gene medicine is low in toxic and side effects and safely used. A carrier of the recombinant can be an expression plasmid or a virus carrier, preferably the virus carrier; the virus carrier is preferably selected from one of an adenovirus carrier, a herpes simplex virus carrier, a retroviruse carrier, an adeno associated virus carrier and a slow virus carrier; and most preferably, the virus carrier is the adenovirus carrier.

The invention provides a combined medicine for treating non-small cell lung cancer. The medicine contains the active ingredients including american cockroach and gefitinib, wherein american cockroachadopts american cockroach extract or american cockroach medicinal powder, and the weight ratio of the active ingredients of the medicine, namely, the american cockroach extract to gefitinib is (4200-5000): 233, preferably, american cockroach extract to gefitinib is 4500 to 233; american cockroach medicinal powder to gefitinib is (2300-3200): 233, preferably, american cockroach medicinal powder togefitinib is 3000 to 233. The medicine has an obvious effect in treating cancer, especially has an obvious effect when taken as the medicine for treating non-small cell lung cancer, the obvious synergistic effect is achieved after american cockroach and gefitinib are combined for use, the efficiency is higher than that obtained by independently using gefitinib or american cockroach, meanwhile, thedrug tolerance generated when gefitinib or american cockroach is independently used can be reduced, and thus the effect of the medicine in treating cancer is guaranteed.

The invention discloses a special pitaya pesticide, which comprises following components in parts by weight: 10 to 12 parts of permethrin, 3 to 6 parts of mint oil, 4 to 6 parts of polypropylene, 2 to4 parts of triazophos, 6 to 12 parts of geranium wilfordii extract, 4 to 10 parts of biological prallethrin, 6 to 10 parts of missible oil, 10 to 14 parts of sodium hydroxide, 40 to 50 parts of ethanol, and 100 to 140 parts of deionized water. The provided pesticide can control the pests of pitaya, plant extracts and ester pesticides are combined; the pollution is reduced, the efficiency of killing pests is improved, the cost is reduced, and the goal of killing pests is realized.

The invention specifically relates to the application of benserazide and its composition with fluconazole in the preparation of antifungal products. In recent years, the rate of fungal infection and the resulting mortality have shown an upward trend, among which Candida is the most serious threat to the body. At present, azole drugs are the first-line drugs for antifungal treatment, but the treatment effect is not satisfactory due to the continuous emergence of drug-resistant bacteria. Aiming at the current situation, the present invention provides the antifungal effect of benserazide, which enriches the compound entities with antifungal effect. Further, the research of the present invention also shows that benserazide can cooperate with fluconazole to treat Candida albicans, Gram The more harmful Candida such as Candida tenida and Candida glabrata have a good inhibitory effect, improve the drug sensitivity of drug-resistant strains, and reduce the dosage of drugs.

The invention provides use of plant extracts for manufacturing an antiviral composition. The plant extract contains an Echinacea purpurea extract, a Salvia miltiorrhiza extract, or combinations thereof. The antiviral composition blocks adenoviruses and enterovirus infection through virucidal activity against adenovirus and inhibition of adenovirus and enterovirus attachment to and penetration intocells. Also provided is a method of preparing the antiviral composition resisting adenovirus and enterovirus.

A feed supplement for herbivora is characterized by being prepared from, by weight, 35-45 parts of bran, 25-25 parts of corn starch, 4-6 parts of tabia, 4-6 parts of camphora officinarum saw powder, 4-6 parts of thorn acacia leaf powder, 8-12 parts of white tea pieces, 8-12 parts of rice bran, 1.5-2.5 parts of artemisia carvifolia, 0.5-1.5 parts of chrysanthemum, 0.5-1.5 parts of antifeverile dichroa root, 0.01-0.05 part of biological active peptide, 0.5-1.5 parts of fructus quisqualis, 0.01-0.05 part of procyanidine, 0.4-1 part of active calcium, 0.4-0.6 part of semen arecae and 0.4-0.6 part of astragalus membranaceus. According to the feed supplement, original ecology Chinese herbal medicine is mainly utilized to prevent protozoal disease of the herbivora, the quality of the herbivora is guaranteed, and drug resistance from antibiotics is reduced. The feed supplement prevents protozoal disease, but also guarantees the quality, moreover, improves the survival rate of the herbivora and reduces the cost.

The invention provides a weeding composition containing pretilachlor, pyriminobac-methyl and bensulfuron methyl, the active ingredients comprise pretilachlor, pyriminobac-methyl and bensulfuron methyl, and the mass ratio of pretilachlor to pyriminobac-methyl to bensulfuron methyl is (1-50):(1-5):(1-5). The weeding composition disclosed by the invention can be used for preventing and removing annual weeds in crop fields and has a remarkable synergistic effect.

The invention relates to a beta-lactam compound and application and a preparation method thereof, and relates to a compound as shown in the following general formula (I), which has good antibacterial property on bacteria, especially gram-negative bacteria, low drug resistance and good prospect of effectively treating various diseases (in the formula (I), R1 and R2 each independently represent a hydrogen atom, a C1-10 linear or branched alkyl group optionally having a substituent, or both together form a cycloalkyl group having 3 to 8 ring carbon atoms; R3 and R4 each independently represent a hydrogen atom, a C1-10 linear or branched alkyl group optionally having a substituent, and a C6-C12 aryl group optionally having a substituent, or both together form a cycloalkyl group having 3 to 8 ring carbon atoms; X represents C or N; and Y represents a linear or branched alkenyl or alkynyl group having 2-6 carbon atoms, which may have a substituent, or a carboxyl group. ).

The invention provides a preparation method of an antibacterial and bactericidal functional surface. The preparation method comprises the following steps: preparing a bionic lotus leaf micron structure surface; preparing a quaternary ammonium salt cationic polymer monomer; carrying out pretreatment on the surface of the bionic lotus leaf micron structure, then soaking the bionic lotus leaf micron structure in a coupling agent overnight, and grafting bromine active sites on the surface of a substrate; and continuously adding a solvent, the quaternary ammonium salt cationic polymer monomer, a catalyst, a free initiator and a ligand, and removing oxygen, so as to grow a layer of nano polymer brush structure on the surface of the bionic lotus leaf micron structure. The prepared antibacterial and bactericidal functional surface can endow the bionic lotus leaf micron structure surface with super-hydrophobic performance, and the bacterial drug resistance can be reduced; through the synergistic effect between the quaternary ammonium salt cationic polymer monomer and the bionic lotus leaf micron structure surface, the antibacterial and bactericidal functional surface has high sterilization effect and sterilization efficiency, and through the interaction of the component proportion and the process, the antibacterial and bactericidal functional surface has the advantages of being more environmentally friendly, low in preparation cost and efficient in antibacterial effect.

The invention relates to the technical field of rhinitis treatment medicines, and particularly discloses a sustained-release pharmaceutical composition for treating allergic rhinitis. The sustained-release pharmaceutical composition is prepared from the following raw materials according to the mass-volume concentration: 0.5 to 1.2 mg / ml of loratadine, 16 to 23 mg / ml of disodium cromoglycate, 0.1 to 0.25 mg / ml of dexamethasone, 8 to 15 mg / ml of ephedrine hydrochloride and 4 to 7 mg / ml of levofloxacin. The invention also discloses a preparation method of the sustained-release pharmaceutical composition for treating allergic rhinitis. The invention also discloses an application of the sustained-release pharmaceutical composition for treating allergic rhinitis. Aiming at the defects of allergic rhinitis natural environment pathogenic factors, complex variability of body autoimmune conditions, single clinical medicine component, poor nasal cavity adhesion, low bioavailability and the like,the medicine is prepared into a compound preparation according to a certain proportion, and a film agent is prepared by using a slow release technology to treat allergic rhinitis, so that the bioavailability and the curative effect of the medicine are improved.