The invention discloses a low-loss large-effective area single mode 
fiber and a manufacturing method of the low-loss large-effective area single mode 
fiber, and relates to the field of optical fibers. The low-loss large-effective area single mode 
fiber comprises a 
quartz glass cladding, an internal 
coating and an external 
coating, wherein the 
quartz glass cladding, the internal 
coating and the external coating are arranged in sequence from inside to outside; the inside of the 
quartz glass cladding comprises a first fiber core area, a second fiber core area, a third fiber core area, a fourth fiber core area and a 
refractive index concave cladding, wherein the first fiber core area, the second fiber core area, the third fiber core area, the fourth fiber core area and the 
refractive index concave cladding are arranged in sequence from inside to outside; the 
refractive index concave cladding is subjected to deposition through a PCVD process; the quartz glass cladding is manufactured through an OVD process or a sleeving process. According to the low-loss large-effective area single mode fiber and the manufacturing method of the low-loss large-effective area single mode fiber, the 
scattering loss of the low-loss large-effective area single mode fiber and the additional loss of the low-loss large-effective area single mode fiber in a bent state can be reduced; due to the fact that the spire distribution of fiber core 
basic mode electromagnetic field power is adjusted into 
flattop distribution, 
optical power density is reduced, the effective area of the low-loss large-effective area single mode fiber is enlarged, the nonlinearity of the low-loss large-effective area single mode fiber is reduced, the incident power of an 
optical fiber communication 
system is increased by 0.4-2.6 dB, and the low-loss large-effective area single mode fiber is suitable for 
mass production.