178 results about "Acropustulosis" patented technology

The invention discloses a nanocomposite of silver, chitosan and / or a chitosan derivative and a preparation method thereof. The preparation method comprises the steps of evenly mixing the chitosan and / or the chitosan derivative fine powder with silver nitrate fine powder and fully grinding for 1-3 hours with the weight proportion of the chitosan and / or the chitosan derivative to the silver nitrate of 100: 0.0005-0.5; adding a reducing agent with the reduction equivalence ratio of the reducing agent to the silver nitrate of 1: 1-2: 1 and fully grinding for 2-6 hours, thereby obtaining the nanocomposite of the silver, chitosan and / or the chitosan derivative with the silver particle size of 1-100nm. The nanocomposite has the effects of promoting wound healing, stopping bleeding, alleviating pain, anti-inflammation and sterilization, can be used for treating female vaginitis, cervicitis, cervical erosion, bedsores, skin ulcers, burns, scalds, trauma and other skin inflammation, tinea manus and pedis and the like, and can also be used for preparing a variety of trauma dressings, such as thin films, sponges, gynecological suppositories, patches and the like.

The invention provides a method and compound for treating darkness and / or swelling / inflammation of the skin of humans. An antihistamine compound and a non-steroidal anti-inflammatory drug (NSAID) compound in combination have been found to effectively treat under eye darkness, swelling and puffiness in particular, when applied topically to the affected skin.

The invention discloses a solid phase synthesis method and a liquid phase synthesis method of chitosan and / or zinc, silver, bismuth and rare earth metal composite of chitosan derivative. The solid phase synthesis comprises the following steps: (1) grinding chitosan and / or chitosan derivative to fine powder; (2) grinding the oxides of zinc and / or silver and / or bismuth and rare earth metal to fine powder of which content is 0.0005-2wt% of the weight of chitosan and / or chitosan derivative; (3) mixing the fine powders obtained in step (1) and step (2) and fully grinding for 1-6h to obtain the chitosan and / or metal composite of chitosan derivative. The product of the preparation method can be used to cure diseases such as female vaginitis, cervicitis, cervical erosion, bedsore, skin ulcer, fireburn, empyrosis, trauma, other dermatitis disease, tinea of feet and hands and the like and can be used to prepare various surgical dressings such as film, sponge, gynecological suppository, adhesivefilm and the like.

Provided are methods for diagnosing the propensity of a subject to develop skin inflammation, in particular, psoriasis. Also provided are methods of treatment with antagonists of IL-17, IL-19, and / or IL-23.

The invention discloses a traditional Chinese medicine skin-care scented soap which is prepared by mixing a traditional Chinese medicine composition and soap pellets at the mass ratio of 1:1. The traditional Chinese medicine skin-care scented soap comprises the following constituents by weight: 5 to 8 parts of fructus ligustri lucidi, 6 to 10 parts of liquorice, 5 to 8 parts of angelica dahurica, 5 to 10 parts of chrysanthemum, 4 to 10 parts of costustoot, 3 to 8 parts of peach kernel, 3 to 5 parts of mugwort leaf, 5 to 18 parts of Chinese wingnut leaf, 4 to 8 parts of yellow cinnamon leaf,4 to 8 parts of radix sophorae flavescentis, 8 to 20 parts of cortex phellodendri and 8 to 20 parts of asparagus. The traditional Chinese medicine skin-care scented soap is made of various Chinese medicinal herbs, has the functions of whitening, removing freckle, holding moisture, removing acne, and curing dermatitis, and is effective in effect after being used on faces and bodies for a long term.

The invention discloses a liquid-phase synthesis method of silver-chitosan and / or chitosan derivative nanocomposite. The obtained product has the functions of promoting wound surface healing, arresting bleeding, relieving pain, resisting inflammation and sterilizing bacteria, is suitable for female vaginitis, cervicitis, cervical erosion, bedsore, dermal ulcer, burn, scald, trauma, other skin phlogosis, tinea of feet and hands and the like, and can also be used for preparing various trauma dressings such as thin films, sponges, suppositories for gynecology, application films and the like.

The invention provides whitening essence and a preparation method thereof. The whitening essence consists of the following components of glycerine, 1,3-butanediol, sodium hyaluronate, EDTA-2Na, polyglycerol-10, sodium polyacrylate, xanthan gum, hydroxyacetophenone, dipotassium glycyrrhizinate, hydrolyzed sclerotium gum, gluconic acid sodium salt, glycereth-26, caprylhydroxamic acid, glycerol caprylate, 3-o-ethyl ascorbic acid, tranexamic acid, ceramide, phenethyl resorcinol, diglucosyl gallic acid and water. The whitening essence disclosed by the invention can refrain conversion of tyrosine tomelanin before the tyrosine is in preparation of conversion to the melanin, so that the activity of the tyrosinase is also high, generation of more melanin cannot be caused, and transfer of skin melanin can also be restrained. Besides, the whitening essence has powerful antioxidant ability, has light protection effects on skin, can control dermatitis, and is a whitening product most comprehensivein action mechanism at present, so that whitening effects can be achieved.

The invention provides a method and composition for treating dermatoses by topical application of a composition containing an antihistamine, an NSAID and optionally a botanical medicinal compound. The compositions are useful for skin conditions such as inflammatory skin conditions, including eczema, atopic dermatitis, non-allergic dermatitis, psoriasis and rosacea, or any inflammation of the skin.

A preparing method of nano-silver containing medical chitosan thermosensitive hydrogel is disclosed. A product of the method is a novel medical material. The thermosensitive hydrogel has good bacteriostatic functions for Gram-negative bacteria represented by escherichia coli, Gram-positive bacteria represented by staphylococcus aureus and fungi represented by candida albicans, and is wide in bacteriostatic spectrum, free of cell toxicity, efficient and low in toxicity. After uniform spraying of the thermosensitive hydrogel, a gel film layer can be formed on the surface of a wound. The thermosensitive hydrogel is durable in bacteriostatic functions and good in gas permeability and hygroscopicity, has functions of promoting wound surface healing, arresting bleeding, arresting pain, reducing inflammation and sterilizing, can be used for burn, scald, trauma, and other large-area irregular wounds, is capable of rapidly arresting bleeding and pain, preventing infection and promoting wound healing, and can be used for bedsore, skin ulcer, tinea manus and pedis, woman colpitis, cervicitis, cervical erosion, and other skin inflammation diseases.

The invention relates to an antagonist of CB1 receptor for use in the treatment of a pathologic condition or disorder selected from the group consisting of bladder and gastrointestinal disorders; inflammatory diseases; cardiovascular diseases; nephropathies; glaucoma; spasticity; cancer; osteoporosis; metabolic disorders; obesity; addiction, dependence, abuse and relapse related disorders; psychiatric and neurological disorders; neurodegenerative disorders; autoimmune hepatitis and encephalitis; pain; reproductive disorders and skin inflammatory and fibrotic diseases.

An external Chinese medicine has obvious functions of diminishing inflammation, promoting granulation, stopping itch and stopping pain. It is prepared with five kinds of Chinese medicinal materials including gromwell, clam shell, catechu, gypsum and borneol, and is used widely for treating various bacterial inflammations, ulcer diseases, nonbacterial inflammations, burns and scalds dermatosis, bruise, piles, etc. It has obvious curative effect, no toxic side effect and no resistance.

The invention belongs to the field of biomedical materials, and particularly relates to a microneedle patch loaded with copper ions and doped with polydopamine as well as a preparation method and application of the microneedle patch. The microneedle patch comprises a substrate and a microneedle head attached to the substrate, the microneedle head is of a core-shell structure and comprises a hydrophobic core and a water-soluble shell covering the hydrophobic core, and the water-soluble shell contains copper ion doped polydopamine. Growth of skin superficial tumors is inhibited by means of good transdermal property of the microneedle array, photothermal effect of copper ion doped polydopamine and toxic free hydroxyl generated through active oxygen mediation, advantages of the coating microneedle are met, defects of the coating microneedle are overcome, the coating microneedle has the advantage of being capable of rapidly and accurately releasing medicine, and the application range of the coating microneedle is widened. The defect that in the dip-coating or spraying process of an existing coating microneedle array, oxygen plasma treatment needs to be carried out on a microneedle body material or a viscosity enhancer or a surfactant needs to be added into a medicine is overcome, and skin inflammation can be avoided.

The invention discloses plant oil external liniment capable of repelling mosquitos and a preparation method thereof. The plant oil external liniment comprises citronella oil, lavender essential oil, tea tree oil, folium artemisiae argyi oil, star anise oil, cinnamon oil, liquid paraffin and menthol. The plant oil external liniment has the advantages that the plant oil external liniment can prevent mosquito bites and treat skin inflammation caused by the mosquito bites; a large amount of experiments shows that the mosquito plant oil external liniment is good in mosquito repelling effect and good in curative effect on symptoms such as pain, itching, red and swollen skin and dermatitis caused by the mosquito bites; meanwhile, the other medicinal constituents of the plant oil external liniment have evident skin caring, inflammation diminishing, antibacterial and granulation promoting effects.

The invention relates to a composition with added natural antibacterial repairing components, a preparation method and application of the composition. The composition is composed of the following components in percentage by mass: 5.0 percent to 10.0 percent of butanediol, 3.0 percent to 5.0 percent of pentylene glycol, 3.0 percent to 4.0 percent of stearic acid modified nano-zinc oxide, 2.0 percent to 3.0 percent of hydrogenated lecithin, 2.0 percent to 3.0 percent of isononyl isononanoate, 2.0 percent to 3.0 percent of polydimethylsiloxane, 1.0 percent to 3.0 percent of cyclopentasiloxane, 1.0 percent to 2.0 percent of beta-dextran, 0.3 percent to 0.5 percent of sodium hyaluronate, 0.2 percent to 0.4 percent of allantoin, 0.2 percent to 0.4 percent of acrylic acid (ester) / C10-30 octacosanol acrylate cross-linked polymer, 0.1 percent to 0.2 percent of L-arginine, 0.1 percent to 0.2 percent of beta-mangostin, 0.1 percent to 0.2 percent of EDTA (Ethylene Diamine Tetraacetic Acid) disodium, 0.0001 percent to 0.1 percent of polyamine carbide nanoparticles aqueous solution, and the balance of water. According to the composition with the added natural antibacterial repairing components,the preparation method and application of the composition disclosed by the invention, the effect of inhibiting propionibacterium acne is obvious and the wound healing time is shortened obviously, andmeanwhile, the composition has a good antibacterial and corrosion-resistant functions, is non-irritating in skin wounds and eyes, and has no pollution and damage to ecological environments, and therefore, the composition is particularly suitable for long-term application to skins with seborrheic dermatitis.

The invention discloses a compound bergamot oil nano-emulsion composition, which is characterized in that: the granularity of the nano-emulsion is 1nm to 100nm, and comprises the following substances by weight mass: 23 to 35 percent of surface active agent, 0.3 to 8 percent of cosurfacant, 1.5 to 10 percent of bergamot oil, 0.5 to 5.5 percent of patchouli, 0.4 to 4.5 percent of tea tree oil, 0.3 to 2.2 percent of pennyroyal and distilled water, wherein the sum of the mass percentage of the ingredients is 100 percent. The compound bergamot oil nano-emulsion composition is broad-spectrum antimicrobic, has good treatment effect on eczema, psoriasis, herpes, dermatitis, blain, wound, acne, urinary infection and the like, the permeability is strong, the stability is good, content of active ingredients is high, transdermal absorption effect is remarkable, action time is durable, the preparation method is simple and is easy to popularize and use, and the medicine has vast application prospect on the medical market.

The invention discloses a method for liquid-phase synthesis of a nano complex of silver, chitosan and / or chitosan derivatives. The obtained product has the effects of promoting wound surface healing, stopping bleeding, relieving pain, resisting inflammation and killing bacteria, can be used for treating female colpitis, cervicitis and cervical erosion, decubitus, dermal ulcer, burn, scald, wound and other skin inflammation, tinea of feet and hands and the like, and can also be used for preparing various wound dressings such as thin films, sponge, gynecologic suppository, paster and the like.

The present invention further provides method of preparing nanocrystals of a hydrophobic therapeutic agent such as fluticasone or triamcinolone, pharmaceutical compositions (e.g., topical or intranasal compositions) thereof and methods for treating and / or preventing the signs and / or symptoms of disorders such as blepharitis, meibomian gland dysfunction or skin inflammation or a respiratory disease (e.g., asthma).

The invention provides a probiotic composition as well as a preparation method and application thereof, and belongs to the technical field of probiotic microorganisms. The probiotic composition comprises lactobacillus plantarum SEUNEU-101 and lactobacillus fermentum SEUNEU-102, the lactobacillus plantarum SEUNEU-101 and the lactobacillus fermentum SEUNEU-102 are both preserved in the China Center for Type Culture Collection, the preservation number of the lactobacillus plantarum SEUNEU-101 is CCTCC M 20211279, and the preservation number of the lactobacillus fermentum SEUNEU-102 is CCTCC (China Center For Type Culture Collection) M 20211280. The composition has the effects of regulating human flora balance, improving the skin state, promoting skin repair and relieving skin inflammation, especially self-inflammatory diseases in dermatological significance, and can be used for pharmaceuticals, food, skin care products or cosmetics.

Novel compositions comprising one or more of an acid protease and an acidic buffer, the acidic buffer comprising an acid and a pharmaceutically or cosmetically acceptable carrier, vehicle or excipient, useful for treating or preventing abnormal biological conditions, diseases or disorders, and / or for improving the texture or appearance of the skin, and / or for enhancing epidermal exfoliation and / or for enhancing epidermal cell renewal and to methods for the use of the compositions. The acid protease comprises one or more proteolytic enzymes which exhibit proteolytic activity at pH values below that of the surface of the skin, i.e., approximately pH 5.5. The acidic buffer comprises at least one acidic buffering component that can reversibly disassociate hydrogen ions and has buffering capacity at pH values below that of the surface of the skin, i.e., approximately pH 5.5. or mixtures thereof with a pharmaceutically or cosmetically acceptable carrier, vehicle or excipient. The buffer is capable of reducing the pH of the surface of the skin to less than pH 5.5 and is susceptible to neutralization by normal epidermal processes. Such types of abnormal biological conditions, diseases or disorders include skin atrophy, i.e., the thinning and / or general degradation of the dermis often characterized by a decrease in collagen and / or elastin as well as decreased number, size and doubling potential of fibroblast cells, and other maladies including, but are not limited to dry skin, severe dry skin, dandruff, acne, keratoses, psoriasis, eczema, skin flakiness, pruritus, age spots, lentigines, melasmas, wrinkles, warts, blemished skin, hyperpigmented skin, hyperkeratotic skin, inflammatory dermatoses, age-related skin changes and skin in need of cleansers.

The invention discloses traditional Chinese medicine lotion for curing gynecologic inflammation, scytitis and pruritus. The traditional Chinese medicine lotion comprises the following raw materials in parts by weight: 12 to 20 parts of flavescent sophora root, 6 to 16 parts of root of sessile stemona, 5 to 10 parts of argyi leaf, 6 to 16 parts of bark of amur corktree, 6 to 16 parts of broom cypress, 3 to 20 parts of cnidium fruit, 0.3 to 2 parts of alum, 0.3 to 2 parts of borneol, and 0.6 to 2 parts of pepermint oil. The traditional Chinese medicine lotion has the advantages that no chemical substance, such as surface active agent (abluent), foaming agent and the like, is added, the critical defect that the more conventional lotion is used, the drier skin is, the traditional Chinese medicine lotion is moist, natural wetness, gloss and elasticity of skin mucosa are recovered and kept, natural fragrant essential oil in the formula has great permeability, cutaneous penetration is realized, the efficacy directly reaches focus, surface infection and deep infection are radically cured, the problem that conventional lotion is noneffective for deep infection, disease prevention is enhanced, double effects of curing and nursing are realized, and the problem that the curative effect of conventional lotion is difficult to guarantee is solved.

The invention relates to a radiation-resistant skin cream composition, which comprises the following components in percentage by weight: 5.0% of aloe gel extractive, 3.0% of pyrrolidone, 5.0% of tea polyphenol, 1.0% of seabuckthorn seed oil, 8.0% of arbutin, 3.0% of hyaluronic acid, 1.0% of metallothionein, 0.5% of vitamin B3, 0.5% of vitamin E, 0.4% of vitamin C, 0.3% of vitamin A, and the balance of deionized water. The radiation-resistant skin cream composition disclosed by the invention can be used for effectively resisting ultraviolet light and skin injury by separable radiation and environmental pollution (waste gas, waste water and oily fume); and the radiation-resistant skin cream composition is particularly beneficial to caring skin of workers outdoors and in the front of a fluorescent screen, and has the effects of removing stain, preventing chromatosis, accelerating skin inflammation rehabilitation and relieving heavy metal toxicity and skin allergic reaction.

The invention discloses pyracantha fortuneana fruit procyanidine cream with the skin whitening effect and a preparing method of the pyracantha fortuneana fruit procyanidine cream. The pyracantha fortuneana fruit procyanidine cream is prepared from, by weight, 5-10 parts of pyracantha fortuneana fruit procyanidine extract liquid, 1-3 parts of shaddock peel essential oil extract liquid, 5-10 parts of stearic acid, 1-3 parts of glycerin monostearate, 5-10 parts of albolene, 6-12 parts of liquid paraffin wax, 1-3 parts of span-60, 8-15 parts of glycerinum, 3-9 parts of tween-80, 25-65 parts of distilled water and 2-5 parts of an ethanol solution with ethyparaben accounting for 5% by mass. Pure-natural plant pyracantha fortuneana fruits, extracted and purified procyanidine and shaddock peel essential oil in cooperation are added into a proper cream matrix, and the mixture is prepared into the cream with the skin whitening and anti-oxidation effects. The pyracantha fortuneana fruit procyanidine cream has the advantages that natural plant ingredients are adopted for skin whitening the skin and resisting oxidation, stains and pigementation which are caused by scytitis and irritability are effectively relieved, the formula is simple, raw materials are easy to obtain, and good economic value is achieved.

Provided are methods of sanitizing a subject, and methods of anesthetizing a subject. Further provided are methods of treating and / or preventing dermatological disorders, reducing skin inflammation, reducing pain, and / or reducing itch in a subject in need thereof. The methods may include administering to the subject an effective amount of a TRPA1 and / or TRPV4 inhibitor. Further provided are compositions including a TRPA1 and / or TRPV4 inhibitor compound in combination with a carrier, vehicle, or diluent that is suitable for topical application.

Topical compositions containing at least one solubilized dicarboxylic acid having 6 to 12 carbon atoms are prepared in pharmaceutically acceptable carriers in the presence of at least one 1,2-alkanediol having 5 to 7 carbon atoms. In particular, a topical composition containing solubilized azelaic acid is formulated in an aqueous carrier. In-vitro skin penetration and bioavailability study demonstrates higher bioavailability of the solubilized azelaic acid in the cutaneous organs. The topical composition is advantageous in treatment of skin disorders associated with skin inflammation such as rosacea, seborrheic dermatitis, perioral dermatitis, and facial dermatitis.

The invention relates to the technical field of cosmetic efficacy evaluation, and discloses a method for evaluating the efficacy of cosmetics for relieving or repairing skin inflammation in order to solve the problems that in an existing cosmetic skin inflammation relieving evaluation method, the subjectivity of evaluation index selection and treatment is high, and subjective factor interference is brought to an evaluation result. The method comprises the following steps: taking zebra fish as a test object, setting a normal control group, a model control group and a test group, culturing underthe same condition, photographing under a fluorescence microscope, storing a picture, and counting the number of neutrophils in a skin inflammation part of the zebra fish by adopting image processingsoftware based on a statistical method; and then calculating the inflammation relieving or repairing effect (%). Compared with the prior art, the evaluation index data is selected and analyzed by means of instruments and software, and the evaluation result can be quantified; the zebra fish breeding cost is low, the breeding period is short, the breeding amount is large, and the evaluation methodhas the advantages of being efficient, rapid and low in cost.

The invention provides a method of determining (or diagnosing) the presence or absence of a functional abnormality in the skin barrier, a kit therefor, a method of ameliorating a functional abnormality in the skin barrier based on the onset mechanism, and a drug therefor. The method of determining the presence or absence of a functional abnormality in the skin barrier comprises measuring the expression of a protease and / or an inhibitor thereof on the skin surface of a test object, and the like.

The invention discloses a Chinese herbal medicine for treating face dermatitis. The Chinese herbal medicine is prepared from 25-35 parts of angelica sinensis, 25-30 parts of ligusticum chuanxiong hort, 25-30 parts of radix rehmanniae, 25-30 parts of sophora flavescens ait, 15-25 parts of mint, 25-30 parts of fructus arctii, 15-25 parts of forsythia suspensa, 25-30 parts of saposhnikovia divaricata, 25-30 parts of radix paeoniae rubra, 25-30 parts of herba schizonepetae, 20-30 parts of goldthread root, 20-30 parts of akebiaquinata and 10-15 parts of alternanthera sessilis(L.)DC; 1500 parts of water is used for decocting the above drugs for three times, the decoctions are filtered, and the supernatants are collected, mixed, bottled and sterilized at a high temperature for standby use. Angelica sinensis and ligusticum chuanxiong hort function as the monarch drugs; radix rehmanniae and sophora flavescens ait function as the minister drugs; mint, fructus arctii, forsythia suspensa and saposhnikovia divaricata function as the assistant drugs; and radix paeoniae rubra, herba schizonepetae, goldthread root, akebiaquinata and alternanthera sessilis(L.)DC function as the guide drugs. The Chinese herbal medicine for treating the face dermatitis disclosed by the invention has obvious effect, and the clinical practice and application prove that the Chinese herbal medicine can achieve the effects of treating both manifestation and root cause.

The invention discloses a multi-herbal comfortable and refreshing skin care essential oil, and relates to the technical field of essential oil. The multi-herbal comfortable and refreshing skin care essential oil is prepared from the following raw materials in parts by weight: 20-30 parts of base oil, 5-9 parts of lavender, 5-9 parts of mint, 5-9 parts of eucalyptus, 5-9 parts of tea tree, 5-9 parts of rosemary, 5-9 parts of holly, 5-9 parts of rose, 5-9 parts of cananga odorata, 5-9 parts of lemon, 5-9 parts of lemon grass, 6-10 parts of sweet almond oil, 6-10 parts of jojoba oil, 6-8 parts of an organic solvent, 8-12 parts of a humectant, 10-14 parts of sodium hyaluronate, 4-8 parts of a fixative, 6-12 parts of polydimethylsiloxane, 4-8 parts of an antioxidant, 2-8 parts of dipotassium glycyrrhizinate, 8-14 parts of madecassoside and 10-16 parts of vitamin E. According to the multi-herbal comfortable and refreshing skin care essential oil, the herbal essential oil is added, so that the effects of sterilizing, diminishing inflammation, conditioning skin inflammation (such as skin infection, acne, dermatophytosis, skin itch and mosquito and insect bites) and refreshing and restoring consciousness are achieved, temples and the like can be massaged, driving, meeting and learning sleepiness can be prevented and treated, and meridian dredging and collateral dredging can be achieved when the multi-herbal comfortable and refreshing skin care essential oil is used for massaging.

The invention provides a biological polysaccharide with the effect of preventing and treating hormone dependent dermatitis and an application of the biological polysaccharide. In particular, the invention provides the use of beta-glucan for the preparation of a preparation or composition for the prevention and / or treatment of hormone dependent dermatitis. The beta-glucan has the effects of obviously relieving and improving the hormone-dependent dermatitis, effectively controlling the occurrence of the hormone-dependent dermatitis and accelerating the regression of the hormone-dependent dermatitis. Meanwhile, the beta-glucan can also enhance the active defense function of the skin, resist bacteria, diminish inflammation and repair the skin, treat or prevent skin mucosa inflammation or otherskin inflammatory diseases, and improve the conditions of dry skin or red and swollen skin and the like of a patient.