An edible and / or chewable article of manufacture containing at least one 
food grade substance having adsorption affinity towards at least one 
dental plaque (
biofilm) constituent and capable of reducing and / or removing the oral 
biofilm while present in the mouth. Particular articles of manufacture are chewing gums, sweets, candies, candy, and other nutritional bars, 
ice creams, chocolates, confectionery and bakery / pastry products, honey, dairy products and beverages, and 
oral hygiene products such as tooth pastes, oral gels and mouthwashes. A 
chewing gum having a conventional 
gum base and at least one 
food grade active substance having adsorption affinity towards at least one 
dental plaque (
biofilm) constituent (
bacteria and proteins and bacterial 
cell-free enzymes) and capable of reducing and / or removing the oral biofilm while present in the mouth. Active substances include polysaccharides and non-toxic salts thereof, such as alginates, 
chitosan, carboxymethylcellulose, 
agar and 
carrageenan, inorganic substances such as silica, hydroxyapatite and 
calcium carbonate and proteins, particularly 
gelatin and 
lectin. The article of manufacture removes and / or for prevents or reduces 
dental plaque (biofilm), and controlling oral, dental and periodontal diseases.