73 results about "Atheromatous Plaques" patented technology

The present invention relates to devices for detection and therapy of active atheromatous plaque and / or thin-capped fibro-atheroma ("vulnerable plaque"), using selectively targeted fluorescent, radiolabeled, or fluorescent and radiolabeled compositions. The present invention further relates to methods and devices for detection and theraphy of active atheromatous plaques and / or vulnerable plaques, using selectively targeted beta-emitting compositions, optionally comprising fluorescent compositions.

The present invention relates to devices for detection of active atheromatous plaque and / or thin-capped fibro-atheroma ("vulnerable plaque") using selectively targeted radiolabeled compositions, such as beta-emitting compositions.

A broad class of photosensitive compounds having enhanced in vivo target tissue selectivity and versatility in photodynamic therapy. Many furocoumarin compounds, such as psoralens, exhibit cytostatic activity when photoactivated but exhibit little in vivo specificity for selectively accumulating in any particular target tissue such as atheromatous plaques. Reactive Oxygen Producing Photosensitizers ("ROPPs") are photoactivatable compounds having an affinity for hyperproliferating cells (such as atheromatous plaque cells), which when photoactivated, produce cytotoxic reaction products. The photoactivity of a ROPP, such as a porphyrin, may be reduced by metalating the porphyrin while the selective affinity of the metalized ROPP for hyperproliferating tissue remains substantially unchanged. By linking a furocoumarin compound to a ROPP to form a F-ROPP, the cytostatic properties of the furocoumarin portion of the F-ROPP can be exploited while the selective affinity of the ROPP portion of the compound for hyperproliferating cells such as atheromatous plaque provides enhanced tissue selectivity without cytotoxicity. In vivo, certain F-ROPPs may be forced to selectively accumulate in a target tissue by illuminating only the target tissue with light having a wavelength operable for photoactivating the F portion of the F-ROPP thereby causing the F-ROPP to either form a monoadduct with or crosslink the cellular DNA in the target tissue. Light of a second wavelength can then be delivered to the target tissue to photoactivate the ROPP portion causing further interference with cellular activity.

The present invention relates to methods for the detection and therapy of active atheromatous plaques, and in particular vulnerable plaques, whereby immune modulators are used to increase the uptake of diagnostic or therapeutic compositions by the inflammatory cells associated with such plaques.

The invention relates to a polyamine micromolecular compound, comprising the following structures described in the specification, wherein M<x+> is 0, Zn<2+>, Ga<3+>, Gd<3+>, Ca<2+> or other divalent metal ions and trivalent metal ions; S is a reporter group (including a nuclide labeling prothetic group, a paramagnet, a fluorescein or a microvesicle), such as the nuclide labeling prothetic group: -<11>CH3, -CH2CH2<18>F, -CH2CH2(OCH2CH2)2NHCOC6H4<18>F-p or -CH2CH2(OCH2CH2)2NH-CH2CH2<18>F; R is -H, -OCH3, -OCH2CH3 or -Cl; and R1, R2, R3 and R4 are hydrogen, carboxyl, alkane, alkylene or heteroalkyl. The invention further relates to application of the compound in preparing cell death or apoptosis developers of target phosphatidyl serine (PS) and / or apoptotic cell early free Zn<2+>. The compound provided by the invention is a specific multiamine micromolecular developer for target phosphatidyl serine (PS) and / or apoptotic cell early free Zn<2+>, which can be used for monitoring curative effects of PS-related anti-tumor chemotherapy, radiotherapy, biological therapy and the like; the compound can be used for early differential diagnosis of neurodegenerative diseases (senile dementia and Parkinson's disease), cerebral apoplexy, AIDS (Acquired immune deficiency syndrome), thrombus, atheromatous plaque and myocardial infarction; and the compound can also be used for differential diagnosis and curative effect monitoring of other diseases related to PS expression in the cell death or apoptosis process, such as inflammation development and anti-inflammation therapeutic development.

The invention discloses nutritional eight ingredient porridge for reducing blood fat. Instant nutritional porridge is prepared by matching and processing various foods which have a blood fat reducing function and serve as raw materials. The nutritional eight ingredient porridge is convenient to eat and long in quality guarantee period, and has good preventing and health-care effects on the reduction of the blood fat, the remission of atheromatous plaque, and the like, so markets are enriched, and a new path is provided for the development of abundant agricultural product resources in China.

The invention discloses yam and hawthorn lipid-lowering nutritional tablets which are food capable of effectively preventing hyperlipidemia and are prepared from combination of yam and hawthorn through steps of pulping, emulsifying, homogenizing, drying, pelleting, drying again, packaging, inspecting and the like. The yam and hawthorn lipid-lowering nutritional tablets are convenient to eat and have good prevention and health care effects of reducing blood lipid, relieving the formation of carotid atheromatous plaque and the like. Not only is the market enriched, but also a novel approach is provided for developing rich agricultural resources in China.

A method for surgically restoring a coronary artery having an atheroma, to more normal structure by making an arteriotomy incision over the length of the atheroma, extracting plaque, inserting stent into the coronary artery at the incision and closing the coronary artery over the stent with sutures. An extravascular drug delivery material is applied over the stent implantation site to inhibit thrombosis and smooth muscle cell proliferation.

An apparatus and method is disclosed for an intravascular balloon device having a balloon and a handle where a catheter tube extends between the two. The handle assembly includes an inflation device in fluid communication with the balloon. A medical tool is provided on the outer surface of the balloon for the treatment of intravascular conditions. The medical tool may be configured to score or remove atherosclerotic material.

The invention relates to a percutaneous aorta bracket or an aortic valve bracket system with far-end protection, which comprises an outer sheath pipe, a limit pipe and an inner sheath pipe, wherein the inner sheath pipe is arranged in the limit pipe; the limit pipe is arranged in the outer sheath pipe; the inner sheath pipe is a hollow pipe; three handles are respectively arranged at the near ends of the inner sheath pipe, the limit pipe and the outer sheath pipe. The system further comprises a protector and a protector limiting device, wherein the protector is arranged between the far end parts of the outer sheath pipe and the inner sheath pipe; the near end of the protector is connected with the far end of the protector limiting device; the protector limiting device is arranged between the limit pipe and the outer sheath pipe; the near end of the protector limiting device is fixedly connected with the far end of the limit pipe; a retracing conducting wire is fixedly connected with the near end of the protector; the far end part of the end retracing conducting wire is arranged on the outer side of the outer sheath pipe. The system provided by the invention effectively prevents impurities such as valve leaflet tissue or atheromatous plaque touched to fall due to follow-up operations from entering into vessels such as carotid, remarkably reduces the complexity and the difficulty of the operation, and shortens the operation time and the recovery time after the operation.

The invention discloses a human body blood vessel detecting method based on laser photoacoustic spectrometry. The method includes the steps of system initial positioning, single-point testing, time domain distinguishing photoacoustic positioning and analyzing, photoacoustic single-point blood vessel measuring, profile atheromatous plaque component analyzing and photoacoustic three-dimensional blood vessel reestablishing. The method has the advantages that a light source and part of light path are reused in laser photoacoustic and laser Raman, the size and cost of a system are reduced, photoacoustic echo signals corresponding to blood flow, blood vessel inner tissue and blood vessel wall layered substances passing through a main axis route at the same moment can be analyzed through time domain distinguishing photoacoustic echo signal analysis with the blood flow photoacoustic echoes in blood vessels as the space analysis standard, the external morphology of the blood vessels and the form distribution of the inner tissue can be detected at the same time through photoacoustic, and all the blood vessel wall layered substance molecular components can be detected through the combinationof photoacoustic and laser Raman.

The invention discloses a method for making polygonatum odoratum yoghurt, rootstalks of polygonatum odoratum which is a liliaceous plant and milk powder are taken as main raw materials, and the steps such as pretreatment of the raw materials, mixing, homogenization, sterilization, inoculation, filling, culture, inspection and the like are adopted for preparation. By adopting the method, the original sweet and thick flavor of the polygonatum odoratum and various effective ingredients can be completely retained, the polygonatum odoratum yoghurt can be eaten conveniently, and the polygonatum odoratum yoghurt has better efficacy and health care effects of lowering blood sugar, reducing blood fat, reliving the atherosclerotic plaque formation and the like, thereby not only enriching market, but also providing a new way for developing abundant agricultural resources in China.

The invention discloses application of recombinant human cytoglobin (rhCYGB) in preparation of drugs treating hyperlipidemia and atherosclerosis. A hyperlipidemia rat model and an atherosclerosis rat model are respectively established by the inventor, and subcutaneous injection of rhCYGB is carried out for treatment. Experimental results show that the rhCYGB drug is non-toxic, compared with a model control group, the rhCYGB treatment group has significant improvement, the four items of blood lipid test are significantly decreased than those of a model group, and the four items of blood lipid test of a polysaccharide sulfate treatment group are significantly higher than normal, thus rhCYGB has better efficacy than polysaccharide sulfate in treatment of hyperlipidemia caused by high fat diet. In the atherosclerosis rat model, compared with the model group, the four items of blood lipid test of the treatment group are also significantly reduced, and atherosclerotic plaques also obviously decreased. Therefore, treatment of hyperlipidemia and atherosclerosis by the recombinant human cytoglobin has the advantages of low toxicity, safety and effectiveness.

The invention belongs to the field of biology, and discloses a pharmaceutical composition for treating atherosclerosis, and a preparation method and application thereof. The active components of the pharmaceutical composition comprise ginkgo leaf extract and earthworm fibrinolysin, wherein the dose ratio of the ginkgo leaf extract to the earthworm fibrinolysin is (200-900g):(800000-2700000uku). Proven by tests, after the pharmaceutical composition disclosed by the invention is used, compared with a single drug treatment group and a model group, the relative area of the aorta atheromatous plaque is notably reduced, macroscopic and microscopic pathological changes are the lightest, and the animal morbidity is the lowest. The levels of LDL (low density lipoprotein), TC (total cholesterol) and TG (triglyceride) of the pharmaceutical composition treatment group are notably reduced compared with the model group, and the level of HDL (high density lipoprotein) of the high-dose pharmaceutical composition group is notably raised. The pharmaceutical composition disclosed by the invention has two single drugs synergic in combined action property, has the effect of treating both principal and secondary aspects of disease on atherosclerosis, and is clinically proven especially by patients who have coronary heart disease and moderate and severe coronary artery stenosis.

The invention relates to a medicine for treating cardia-cerebrovascular diseases of middle aged and elderly people. According to the medicine, beans are taken as carriers, medicine liquid decocted from multiple Chinese herbal medicines is adsorbed to the beans, and the mixture is ground into powder, namely the orally medicine capable of treating the cardia-cerebrovascular diseases of middle aged and elderly people. According to the technical scheme, life beans are taken as a main material, and saffron crocus, cornua cervi pantotrichum, fructus schisandrae chinensis, cortex eucommiae and lucid ganoderma are taken as auxiliary materials; the auxiliary materials are prepared into a soak solution, the main material is soaked into the soak solution and is ground into powder, and the powder is packaged. The medicine has the beneficial effects that the physical quality of the middle aged and elderly people can be fundamentally improved, the health of heart and cerebral vessels is protected, and the waste in blood is cleared; dead endothelial cells in the blood vessels are eliminated, stenocardia is eliminated, the cholesterol level is improved, the elasticity of the blood vessels is restored, hemadostenosis caused by atherosclerosis is restored, and atheromatous plaques on the blood vessel walls are ablated; the blood pressure is adjusted, and hypertension and complications are improved; the oxygen transfer function of blood flow is enhanced, brain strengthening and intelligence improving effects are achieved, the sleeping quality is adjusted, and the senile dementia is prevented.

The invention provides a fleece-flower root life-prolonging tablet for treating baldness according to the theory that the baldness is treated in need of treating liver and kidney firstly. The formula of the fleece-flower root life-prolonging tablet is as follows according to the weight ratio: 300-400 parts of polygonum multiflorum, 18-22 parts of rehmannia, 14-20 parts of semen sesami nigrum, 30-50 parts of the root of bidentate achyranthes, 150-200 parts of mulberry, 30-50 parts of fructus ligustri lucidi, 200-250 parts of eclipta, 30-50 parts of folium mori, 70-90 parts of semen cuscutae, 230-280 parts of fructus rosae laevigatae, 30-50 parts of fructus psoraleae, 60-100 parts of phlomis bracteosa royle and 15-25 parts of honeysuckle. The modern pharmacology research shows that the fleece-flower root life-prolonging tablet has the functions of resisting free radicals, preventing lipid peroxidation, reducing activity of monoamine oxidase, enhancing the function of adrenal gland and the like; in addition, the fleece-flower root life-prolonging tablet can lessen the formation of experimental atheromatous plaques and lipid deposition, so as to exert the functions of reducing blood fat and resisting atherosclerosis.

The invention provides a novel llex A-cyclodextrin polymer (llex A-CDP) medicine composition for preventing and curing atherosclerosis (AS) and in particular relates to a preparation method of the novel water-soluble llex A-CDP medicine composition which takes CDP as the host molecule and llex A as the guest molecule. The invention obviously enhance the water-solubility of llex A and has regulating effect for dyslipidemia related to AS and inbibitional effect for inflammatory cell factor in vessel atheromatous plaque. The preparation method comprises the following steps: cyclodextrin polymer is taken as the raw material and is crosslinked with epoxy chloropropane under the condition of strong basicity to generate cyclodextrin polymer; the cyclodextrin polymer is taken as the host molecule, the llex A is taken as the guest molecule and water is taken as the reaction solvent to prepare the water-soluble llex A-CDP medicine composition by supermolecular reaction.

Methods for detecting the presence of atherosclerotic structures in order to diagnose or prevent atherosclerosis are provided herein. In particular, it has been found that methylene blue injected intravenously acts as an excellent indicator because the compound targets high-risk plaque, atheroma, macrophages, and other atherosclerotic structures formed within the endothelial walls of a vessel of a subject. Because the compound provides a unique binding profile with uptake only in plaque or atheroma, and not the normal or healthy vascular interstitial tissue, methylene blue maintains a good plaque-to-background ratio for imaging purposes. This enables healthcare providers to determine the status of atherosclerosis development in vivo within a patient with higher certainty and at lower costs. The disclosed methods allow for high-resolution mapping of plaque build-up, plaque pathobiology, and other atherosclerotic structures within a vessel of a subject by using methylene blue as an imaging agent.

The invention discloses application of a traditional Chinese medicinal composition to preparation of medicaments for improving hypercholesterolemia-induced cardiac dysfunction. The traditional Chinese medicinal composition comprises ginseng, leech, centipede, scorpion, ground beetle, cicada slough, red paeony root, borneol and the like and has the effects of tonifying qi and promoting blood circulation and removing blood stasis and meridian obstruction. A test proves that the traditional Chinese medicinal composition can reduce blood lipid level of a hypercholesterolemia patient, can improve endothelium-dependent vascular dilatation function and vascular flexibility, can enhance application of blood supply capacity from artery to cardiac muscular tissue, can enhance expression of vascular endothelial growth factor (VEGF) genes and protein, and can inhibit angiogenesis of atheromatous plaques so as to effectively improve the hypercholesterolemia-induced cardiac dysfunction.

The invention discloses application of an alcohol extract of viburnum sargentii koehne to preparation of medicines for treating AS (atherosclerosis) diseases. By taking C57BL / 6J mice as blank control and taking a simvastatin medicated group as positive control, observation of influences of the viburnum sargentii koehne on AS and exploration of corresponding mechanisms are carried out after a high fat diet-induced apoE<- / -> mouse AS model is intragastrically given with the alcohol extract of the viburnum sargentii koehne for 12 weeks. According to results, the alcohol extract of the viburnum sargentii koehne evidently lowers the level of lipids in serum, inhibits oxidative stress and inflammatory reaction, decelerates formation of atheromatous plaques and lipid accumulation on arterial walls of the high fat diet-induced apoE<- / -> mouse and inhibits AS occurrence and development. By application of the alcohol extract of the viburnum sargentii koehne to preparation of the medicines for treating the AS diseases, not only is a novel usage of the alcohol extract of the viburnum sargentii koehne is developed, but also a novel approach of AS treatment is provided.

The invention relates to the field of natural medicines, and particularly relates to use of beta-elemene and derivatives thereof in preventing atherosclerosis, and in particular relates to an application in preparation of medicines for treating atherosclerosis. Test results show that beta-elemene and derivatives can remarkably reduce the atherosclerotic plaque area in the coronary artery of an animal model, and meanwhile has remarkable improving effect on two key links in development process of atherosclerosis: adhesion of leukocyte and endothelial cells and peroxidation of lipids. Expression of adherence factors closely related to atherosclerosis can be reduced, so that peroxidation damage of endothelial cells in vitro and in vivo caused by high fat and H2O2 is avoided.

The invention discloses a composition for treating hyperlipidemia and atherosclerosis and application of the composition. The composition comprises atorvastatin or medicinal salt of the atorvastatin and artesunate which are of 1: 10 to 10: 1 in weight ratio. The composition can be used for preparing a medicine for treating and preventing the hyperlipidemia and atherosclerosis. Compared with the prior art, the medicine composition is capable of effectively reducing the lipid of a model animal suffering from atherosclerosis and lowering the area of atherosclerotic plaque, has the effect superior to single component in the composition, and also can decrease the usage amount of medicines under the synergistic interaction, thereby reducing the toxic and side effects and decreasing the medication cost.

The invention provides a Chinese medicinal composition for treating cardiovascular and cerebrovascular diseases, which is mainly prepared from bulk pharmaceuticals such as giant knotweed, white vitriol, honeysuckle flower and like with a medicinal excipient in a certain weight ratio. The Chinese medicinal composition can be prepared into a dosage form of any conventional oral preparation. The Chinese medicinal composition has the effects of clearing away heat and toxic materials, activating blood, dredging collaterals, lowering lipid and removing ecchymoses. As proved by clinical observation, the Chinese medicinal composition can be used for regulating blood fat and treating a plurality of cardiovascular and cerebrovascular diseases, and has a good treatment effect on the formation of hyperlipidemia incorporated artery atheromatous plaques.

The invention discloses an application of naringin in preparing medicaments for curing atherosclerosis. Tests prove that the naringin can decrease level of serum cholesterol, inhibit cholesterin on arterial vascular walls from depositing, obviously decrease level of serum TC, TG, LDL-C, remarkably raise level of serum HDL-C, improve activity of serum SOD and increase level of NO, obviously decrease level of MDA, effectively prevent atheromatous plaques from being formed or damaged, and have the obvious function of curing atherosclerosis.

The invention discloses a Chinese medicinal composition for treating cardiovascular and cerebrovascular atherosclerosis and its preparing process, wherein the composition is prepared from astragalus root, corktree bark, haw, dried ginger, job's tears, sarcodactylis swinple, root of herbaceous peony, Ligusticum wallichii, cyperus tuber, kudzu vine root, thunberg fritillary bulb, bitter orange, medicated leaven, pericarpium trichosanthis, atractylodes rhizome, root of red rooted saliva, chicken's gizzard-skin, pseudo-ginseng and Chinese trichosannthe powder through steps of boiling, extracting volatile oil, air-drying, disintegrating and proportioning.

The invention relates to traditional Chinese medicine decoction for treating carotid artery plaque, which is characterized by being prepared from the following traditional Chinese medicine raw materials: 10 g of gastrodia elata, 15 g of peach kernel, 30 g of astragalus membranaceus, 15 g of root of common peony, 15 g of lumbricus, 10 g of leech powder (taking after mixing with water), 10 g of wine-treated rhubarb, 15 g of carthamus tinctorius, 30 g of the root of red-rooted salvia, 15 g of the rhizome of chuanxiong, 50 g of the root of kudzu vine, 10 g of liquorice and 10 g of medicinal cyathula root. By means of dialectical compatibility of various raw materials, the traditional Chinese medicine decoction for treating carotid artery plaque disclosed by the invention has the effects of tonifying Qi, invigorating the circulation of blood and descending blood stasis and has obvious curative effect to patients suffering from carotid artery plaque, therefore, the traditional Chinese medicine decoction for treating carotid artery plaque is worthy of being popularized.

The invention belongs to the field of medicines and in particular relates to a Chinese patent medicine for treating sequelae of cerebral infarction, which can basically promote the recovery of the nerve functions of patients suffering from cerebral apoplexy hemiplegia, improve the living conditions of the patients and increase the living ability of the patients by taking multiple traditional Chinese medicinal materials as raw materials, as well as a preparation method thereof. The Chinese patent medicine is prepared from the following raw materials in parts by weight: 10-15 parts of prepared rehmannia root, 8-12 parts of morinda root, 10-15 parts of chuanxiong rhizome, 10-15 parts of leech, 4-10 parts of rhubarb, 8-12 parts of astragalus root, 8-12 parts of rhizoma acori graminei, 2-5 parts of borneol and 10-15 parts of talcum powder. The Chinese patent medicine is stable in medicine effect and directly acts on a focus through blood and blood vessels simultaneously to improve damaged brain cells and protect undamaged cells to create a favorable intracerebral environment, thereby achieving the effects of preventing thrombosis again and preventing the blood vessels from being clogged again by atheromatous plaque.

The invention relates to a novel use of a pharmaceutical composition comprising at least one methyl cyclodextrin having a molar substitution (MS) degree of between 0.05 and 1.5 in the treatment and / or prevention of diseases that can be treated and / or prevented by an increase in the HDL cholesterol level. The invention also relates to the use thereof in the treatment and / or prevention of atherosclerosis or complications relating to an atheroma, and / or diseases of the central nervous system. The pharmaceutical compositions of the invention can also be used to stimulate the reduction of circulating fatty acid and triglyceride levels and to reduce or prevent atheromatous plaques.

The invention relates to a suction catheter for sucking thrombotic substances, which comprises a front-end catheter, wherein the front-end catheter is composed of a spring tube, a polyurethane tube and a coating; the spring tube is provided with a developing head and is also provided with a suction region and an observation region; a suction hole is formed in the left part of the polyurethane tube; a metal wire penetrating through the front-end catheter is arranged in the front-end catheter; the right end of the front-end catheter is connected with a connecting tube; the right end of the connecting tube is connected with a two-way valve; a cylindrical valve plug is arranged at the upper part of the two-way valve; a threaded connector is arranged at the right part of the two-way valve; the threaded connector is connected with a rear-end catheter through threads; threaded butt joints matched with the threaded connector are respectively arranged at the left part and right part of the rear-end catheter; and the right part of the rear-end catheter is connected with a suction syringe through threads. The suction catheter is simple in structure, convenient in operation, low in manufacturing cost, convenient in clinical use, and capable of effectively eliminating thrombi and cataclastic atheromatous plaques in coronary arteries, recovering coronary artery blood flow and myocardial tissue perfusion as well as recovering cardiac functions.

The present invention provides an edible oil with an atherosclerosis-preventing effect a preparation method thereof. According to disclosed weight ratios of saturated fatty acid (SFA), monounsaturatedfatty acid (MUFA) and polyunsaturated fatty acid (PUFA) and weight ratios of omega-6 polyunsaturated fatty acid (omega-6 PUFA) and omega-3 polyunsaturated fatty acid (omega-3 PUFA), preparation raw materials are selected; the use amount ratios of the raw materials are determined; then according to the obtained use amount ratios, the selected raw materials are loaded into a material blending tank;and the materials are slowly stirred at an environment temperature of 20-40 DEG C for 30-40 min to prepare the edible blend oil with the atherosclerosis-preventing effect. Experiments confirm that the provided edible blend oil has functions of slowing formation of atherosclerotic plaques, relieving fatty liver, and lowering blood lipids and inflammatory factors. By using the edible blend oil as daily catering oil, the edible oil has the function of preventing atherosclerosis.