The invention relates to the technical field of preparation of Uygur medicinal material compositions, in particular to a Uygur medicinal material composition and a preparation method and application thereof. The raw materials of the Uygur medicinal material composition include, in parts by weight, 
nepeta bracteata and Iris halophila Pall. roots. The preparation method of the composition comprisesthe following steps: step 1, adding water to 
nepeta bracteata and Iris halophila Pall. roots of the required amount, performing 
reflux extraction so as to obtain a distillate and an extract, and thenfiltering the extract; step 2, adding water to the 
medicine dregs obtained after 
filtration in the previous step, performing 
reflux extraction continuously, filtering the extract, merging the two filtrates, and performing concentration so as to obtain a concentrated solution; and step 3, adding 
ethanol to the concentrated solution obtained in the previous step, performing still standing for 8-12 h, then removing the 
ethanol so as to obtain an alcoholized solution, adding the distillate obtained in the step 1 to the alcoholized solution, and performing mixing so as to prepare the Uygur medicinematerial composition. Through the Uygur 
medicine material composition, the 
lung function of 
COPD patients can be improved effectively, 
airway inflammatory factors can be reduced significantly, a significant 
curative effect is achieved during 
inflammation antagonism, and a new way is provided for treatment of 
COPD.