The invention discloses a 3D gradient 
spin echo diffusion imaging method for 
inversion recovery preparation, a medium and equipment. The method comprises the following steps of firstly, in an 
inversion recovery preparation module, applying 180-degree inversion 
radio frequency pulse, and setting corresponding 
inversion recovery time to inhibit 
cerebrospinal fluid and 
free water signals; secondly, embedding a pair of trapezoidal cosine oscillation gradients or pulse gradients into 90-degree x-180-degree y-90-degree-x 
radio frequency pulses through a 
diffusion coding module, and separating 
diffusion coding from 
signal acquisition; then, inhibiting a fat 
signal by using a 
fat saturation module; and finally, collecting signals by adopting a 3D gradient 
spin echo reading mode. The time and the 
signal-to-
noise ratio of magnetic 
resonance diffusion imaging are improved, accurate measurement of 
brain tissue diffusion magnetic 
resonance signal time dependence is facilitated, the effect is especially obvious for a brain area which is near a 
ventricle and is influenced by the 
cerebrospinal fluid due to a partial 
volume effect, and the clinical transformation of a time-dependent diffusion magnetic 
resonance technology is effectively promoted.